• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제35권1호
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• pp.1-6
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• 2009

DNA double-strand breaks (DSBs) occur commonly in the all living and in cycling cells. They constitute one of the most severe form of DNA damage, because they affect both strand of DNA. DSBs result in cell death or a genetic alterations including deletion, loss of heterozygosity, translocation, and chromosome loss. DSBs arise from endogenous sources like metabolic products and reactive oxygen, and also exogenous factors like ionizing radiation. Defective DNA DSBs can lead to toxicity and large scale sequence rearrangement that can cause cancer and promote premature aging. There are two major pathways for their repair: homologous recombination(HR) and non-homologous end-joining(NHEJ). The HR pathway is a known "error-free" repair mechanism, in which a homologous sister chromatid serves as a template. NHEJ, on the other hand, is a "error-prone" pathway, in which the two termini of the broken DNA molecule are used to form compatible ends that are directly ligated. This review aims to provide a fundamental understanding of how HR and NHEJ pathways operate, cause genome instability, and what kind of genes during the pathways are associated with head and neck cancer.

• 한국게임학회 논문지
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• 제9권5호
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• pp.105-115
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• 2009

본 논문에서는 증강현실 게임에서의 동작 기반 상호작용의 설계 및 구현 기법을 기술한다. 증강현실에서는 상호작용의 도구로 고전적인 입력 장치보다 사용자의 동작에 의존한다. 동작 기반 증강현실 게임은 신체적 움직임에 의한 상호작용을 사용하는 실감 게임의 유망한 분야이나 현재의 동작 인식 기술의 불안정성으로 인해서 증강현실 응용에서 동작 인식 장치를 주 입력 장치로 사용하는 데에는 한계가 있다. 이러한 한계에 대처하기 위해서 각 증강현실 응용들은 여러 보완수단들을 동원하고 있고 이로 인해서 증강현실 게임의 구조가 불규칙적이며 비효율적으로 설계되는 경향이 있다. 본 논문에서는 동작 기반 증강현실 게임의 효율적인 개발 방법론을 제시한다. 실제 탁구채를 사용하는 동작 인터페이스를 가지는 증강현실 탁구게임의 프로토타입을 제시된 방법론에 따라서 설계하고 이를 구현하였다. 구현된 증강현실 게임에서의 상호작용에 있어서 탁구채를 고속으로 인식하고 지연 없이 상호작용 됨을 확인하였다.

• 한국정보통신학회논문지
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• 제13권2호
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• pp.348-354
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• 2009

본 논문은 p-MOS 트랜지스터에서 음 바이어스 온도 불안정(NBTI) 전류 스트레스 인가에 의해서 드레인 전류, 문턱 전압, 문턱 전압아래 기울기, 게이트유기 드레인 누설(GIDL) 전류가 변화하는 열화특성을 측정하고 분석하였다. 스트레스 시간, 온도와 전계 의존에 연관된 열화 크기는 실리콘/산화막 계면에서 계면 트랩 생성에 좌우된다는 것으로 나타났다. 문턱 전압의 변화와 문턱 전압아래 기울기 사이에 상관관계로부터, 소자 열화에 대한 중요한 메카니즘이 계면 상태의 생성과 관련이 있다는 것을 분석하였다. GIDL 측정 결과로부터, NBTI 스트레스에 기인한 계면상태에서 전자 정공쌍의 생성이 GIDL 전류의 증가를 가져온다. 그러므로 초박막 게이트 산화막 소자에서 NBTI 스트레스 후에 GIDL 전류 증가를 고려하여 야만 한다. 또한, 신뢰성 특성과 dc 소자 성능을 동시에 고려함이 초고집적 CMOSFET의 스트레스 공학기술에서 상당히 필수불가결하다.

• 한국분무공학회지
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• 제3권3호
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• pp.33-41
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• 1998

In recently, a study on the lean combustion is investigated intensively, because it is expected that this method may decrease the harmful exhaust gas and improve fuel economy in gasoline engine. The problems of lean combustion system in gasoline engine are ignition difficulty, misfire and instability of combustion. The investigation on the optimization of fuel metering and the control of mixing gas flow may be critical to improve the performance of lean combustion. In the fuel injection gasoline engine, the formation of mixture influences strongly on the engine performance such that the importance of fuel metering system becomes apparent. First of all, a study on the fuel breakup characteristics of gasoline fuel injector was carried out in this paper. Fuel injectors are pintle and 4hole-2spray type. The purpose of this study is to clarify the atomization mechanism of spray injected into atomosphere field through electronic controlled-fuel injectors, and to analyze spray characteristics such as drop size distribution and mean drop diameter produced at fuel injector. In this paper, the spray development is observed by taking photograps using 80mm still-camera system, and drop sizes are measured by PMAS. From these experiment, spray pattern injected from gasoline fuel injectors was investigated clearly. Also, it was found that SMD and drop size distribution of injected fuel spray from gasoline fuel injectors.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2001년도 춘계학술대회 논문집
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• pp.551-554
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• 2001

A necessity of remote control robots or various searching robots etc. that accomplish works given instead of human under long distance and extreme environment such as volcano, universe, deep-sea exploration and nuclear power plant etc. is increasing, and so the development and the research regarding these mobile robots are actively progressing. The wheel mobile robot or the track mobile robot have a sufficient energy efficiency under this en, but also have a lot of limits to accomplish works given which are caused from the restriction of mobile ability. Therefore, recently many researches for the walking robot with superior mobility and energy efficiency on the terrain, which is uneven or where obstacles, inclination and stairways exist, have been doing. The research for these walking robots is separated into fields of mechanism and control system, gait research, circumference environment and system condition recognition etc. greatly. It is a research field that the gait research among these is the centralist in actual implementation of walking robot unlike different mobile robots. A research field for gait of walking robot is classified into two parts according to the nature of the stability and the walking speed, static gait or dynamic gait. While the speed of a static gait is lower than that of a dynamic gait, a static gait which moves the robot to maintain a static stability guarantees a superior stability relatively. A dynamic gait, which make the robot walk controlling the instability caused by the gravity during the two leg supporting period and so maintaining the stability of the robot body spontaneously, is suitable for high speed walking but has a relatively low stability and a difficulty in implementation compared with a static gait. The quadruped walking robot has a strong point that can embody these gaits together. In this research, we will develope an autonomous quadruped robot with an asaptibility to the environment by selectry appropriate gait, element such as duty factor, stride, trajectory, etc.

• Wind and Structures
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• 제23권2호
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• pp.91-107
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• 2016

Flow-excited acoustic resonance in ducted cavities can produce high levels of acoustic pressure that may lead to severe damage. This occurs when the flow instability over the cavity mouth, which is created by the free shear layer separation at the upstream edge, is coupled with one of the acoustic modes in the accommodating enclosure. Acoustic resonance can cause high amplitude fluctuating acoustic loads in and near the cavity. Such acoustic loads could cause damage in sensitive applications such as aircraft weapon bays. Therefore, the suppression and mitigation of these resonances are very important. Much of the work done in the past focused on the fluid-dynamic oscillation mechanism or suppressing the resonance by altering the edge condition at the shear layer separation. However, the effect of the downstream edge has received much less attention. This paper considers the effect of the impingement edge geometry on the acoustic resonance excitation and Strouhal number values of the flow instabilities in a ducted shallow cavity with an aspect ratio of 1.0. Several edges, including chamfered edges with different angles and round edges with different radii, were investigated. In addition, some downstream edges that have never been studied before, such as saw-tooth edges, spanwise cylinders, higher and lower steps, and straight and delta spoilers, are investigated. The experiments are conducted in an open-loop wind tunnel that can generate flows with a Mach number up to 0.45. The study shows that when some edge geometries, such as lower steps, chamfered, round, and saw-tooth edges, are installed downstream, they demonstrate a promising reduction in the acoustic resonance. On the other hand, higher steps and straight spoilers resulted in intensifying the acoustic resonance. In addition, the effect of edge geometry on the Strouhal number is presented.

• Advances in aircraft and spacecraft science
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• 제2권2호
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• pp.125-168
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• 2015

Dynamic aeroelastic behavior of structurally nonlinear Joined Wings is presented. Three configurations, two characterized by a different location of the joint and one presenting a direct connection between the two wings (SensorCraft-like layout) are investigated. The snap-divergence is studied from a dynamic perspective in order to assess the real response of the configuration. The investigations also focus on the flutter occurrence (critical state) and postcritical phenomena. Limit Cycle Oscillations (LCOs) are observed, possibly followed by a loss of periodicity of the solution as speed is further increased. In some cases, it is also possible to ascertain the presence of period doubling (flip-) bifurcations. Differences between flutter (Hopf's bifurcation) speed evaluated with linear and nonlinear analyses are discussed in depth in order to understand if a linear (and thus computationally less intense) representation provides an acceptable estimate of the instability properties. Both frequency- and time-domain approaches are compared. Moreover, aerodynamic solvers based on the potential flow are critically examined. In particular, it is assessed in what measure more sophisticated aerodynamic and interface models impact the aeroelastic predictions. When the use of the tools gives different results, a physical interpretation of the leading mechanism generating the mismatch is provided. In particular, for PrandtlPlane-like configurations the aeroelastic response is very sensitive to the wake's shape. As a consequence, it is suggested that a more sophisticate modeling of the wake positively impacts the reliability of aerodynamic and aeroelastic analysis. For SensorCraft-like configurations some LCOs are characterized by a non-synchronous motion of the inner and outer portion of the lower wing: the wing's tip exhibits a small oscillation during the descending or ascending phase, whereas the mid-span station describes a sinusoidal-like trajectory in the time-domain.

• Earthquakes and Structures
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• 제7권4호
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• pp.587-607
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• 2014

Progressive collapse, which is referred to as the collapse of the entire building under local damages, is a common failure mode happened by earthquakes. The collapse process highly depends on the whole structural system. Since, asymmetry of the building plan leads to the local damage concentration; it may intensify the progressive collapse mechanism of asymmetric buildings. In this research the progressive collapse of regular and irregular 6-story RC ordinary moment resisting frame buildings are studied in the presence of the earthquake loads. Collapse process and collapse propagation are investigated using nonlinear time history analyses (NLTHA) in buildings with 5%, 15% and 25% mass asymmetry with respect to the number of collapsed hinges and story drifts criteria. Results show that increasing the value of mass eccentricity makes the asymmetric buildings become unstable earlier and in the early stages with lower number of the collapsed hinges. So, with increasing the mass eccentricity in building, instability and collapse of the entire building occurs earlier, with lower potential of the progressive collapse. It is also demonstrated that with increasing the mass asymmetry the decreasing trend of the number of collapsed beam and column hinges is approximately similar to the decreasing trend in the average story drifts of the mass centers and stiff edges. So, as an alternative to a much difficult-to-calculate local response parameter of the number of collapsed hinges, the story drift, as a global response parameter, measures the potential of progressive collapse more easily.

• 한국세라믹학회지
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• 제46권6호
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• pp.596-601
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• 2009

Double-layered ZnO nanostructures have been synthesized by aqueous solution method on (001) plane of ZnO nanorod. A stepwise changing of aqueous solution concentration gave rise to a new nano-structured layer consisting of either multiple of nanorods or nanowires with much smaller radii than that of the ZnO nanorod on which the new layer was grown. As the first step the ZnO nanorods have been grown to have the (001) preferential orientation in the aqueous solution consisting of 0.1M zinc nitrate and 0.1 M HMT. This preferentially aligned ZnO nanorods have been regrown in either a less diluted solution of 0.01M zinc nitrate and 0.01 M HMT or a more diluted solution of 0.005M zinc nitrate and 0.01 M HMT. A new nano-layer consisting of numerous aligned nanorods or nanowires has been produced on the (001) planes of ZnO nanorods. The growth mechanism for this double layered ZnO nanostructure is ascribed to the (001) polar surface energy instability and inhibition of (001) plane growth due to the step-wise change of aqueous solution concentration; ZnO nuclei formed on the (001) plane grow preferentially in (010) plane instead of (001) plane to reduce the total surface energy. Surface area of ZnO nanostructure can be increased in orders of magnitudes by forming a new layer consisting of smaller nanorods/nanowires on (001) plane of ZnO nanorods.

• Journal of Trauma and Injury
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• 제22권2호
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• pp.254-259
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• 2009

Purpose: Pelvic trauma is a serious skeletal injury with high mortality. Especially in cases of severe injury trauma, treatment outcomes depend on early diagnosis and intervention. We expect trauma surgeon to play an important role in the management of severe multiple trauma patients. Methods: A retrospective study was performed on pelvic trauma patients with hemodynamic instability between March 2005 and September 2009. We divided the time period into period I (March 2005~Feburary 2009) and period II (March 2009~September 2009). The trauma surgeon and team started to work from period II. Data were collected regarding demographic characteristics, mechanism of injury, type of pelvic fracture, ISS(injury severity score), treatment modality, transfusion requirement, time to definitive treatment, and mortality. Results: During period I, among 7 hemodynamically unstable patients, 4(57.1%) patients died. However during Period II, only one of 6(16.6%) patients died. The demographic data and injury scores showed no differences between the two time periods, but the time to definitive treatment was very short with trauma team intervention(14.4 hrs vs. 3.9 hrs). Also, the amount of transfusion was less(41.1 U vs. 13.9 U). With arterial embolization, early pelvic external fixation led to less transfusion and made patients more stable. Conclusion: This study demonstrated the importance of the trauma surgeon and the trauma team in cases of hemodynamically unstable pelvic trauma. Even with the same facility and resources, an active trauma team approach can increase the survival of severely injured multiple trauma patients.