• Journal of Industrial and Engineering Chemistry
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• 제68권
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• pp.282-292
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• 2018

This study aimed to compare the chemical composition of Morus nigra leaves extracts, obtained by maceration, accelerated solvent (ASE) and supercritical fluid extraction (SFE) under different extraction conditions. With regards to chemical composition, mainly phenolic acids and flavonoids were identified. HPLC-ESI-QTOF-MS allowed the identification of 13 new compounds reported in M. nigra leaves for the first time. ASE as a fast, green and innovative approach, seems to be the best choice for extracting compounds of different polarities within the shortest extraction time. The present study also highlights the potential application of M. nigra extracts as constituents of new added-value formulations.

• 식품과학과 산업
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• 제51권2호
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• pp.114-126
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• 2018

The production of high quality oil to meet new standard needs a 'next generation' innovative oil refining tool in paradigm shift. 'Nanoneutralization' using controlled hydrodynamic cavitation-assisted Nanoreactor is successfully being introduced and commercialized into edible oil industry and it plays a key driver for sustainable development of food processing. This emerging technology using bubble dynamics as a consequence of Bernoulli's principle by hydrodynamic cavitation in Venturi-designed multi-flow through cell is radically changing the conventionally chemical-oriented neutralization. Nanoneutralization derived by the creation of nanometer-sized bubbles formed through scientifically structured geometric channels under high pressure has been proven to improve mass transfer and reaction rate so substantially reduce the chemicals required for refined vegetable oil and to increase oil yield while even improving oil quality. More researches on science behind this revolutionary technology will help usto better understand the principle and process hence makes its potential applications expandable in extraction, refining and modification of fats and oils processing.

• Geomechanics and Engineering
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• 제29권2호
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• pp.171-182
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• 2022

Reusing the used pile has not yet been implemented due to the unpredictability of the bearing capacity evolution. This paper presents an analytic approach to estimate the sides shear setup after the dissipation of pore pressure. Long-term evolution of adjacent soil is simulated by viscoelastic-plastic constitutive model. Then, an innovative concept of quasi-overconsolidation is proposed to estimate the strength changes of surrounding soil. Total stress method (α method) is employed to evaluate the long term bearing capacity. Measured data of test piles in Louisiana and semi-logarithmic time function are cited to validate the effectiveness of the presented method. Comparisons illustrate that the presented approach gives a reasonably prediction of the side shear setup. Both the presented method and experiment show the shaft resistance increase by 30%-50%, and this highlight the potential benefit of piles reutilization.

• 한국재료학회지
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• 제32권8호
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• pp.333-338
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• 2022

In this work, we developed silver nanowires and a silicon based Schottky junction and demonstrated ultrafast broadband photosensing behavior. The current device had a response speed that was ultrafast, with a rising time of 36 ㎲ and a falling time of 382 ㎲, and it had a high level of repeatability across a broad spectrum of wavelengths (λ = 365 to 940 nm). Furthermore, it exhibited excellent responsivity of 60 mA/W and a significant detectivity of 3.5 × 10¹² Jones at a λ = 940 nm with an intensity of 0.2 mW cm^-2 under zero bias operating voltage, which reflects a boost of 50 %, by using the AC PV effect. This excellent broadband performance was caused by the photon-induced alternative photocurrent effect, which changed the way the optoelectronics work. This innovative approach will open a second door to the potential design of a broadband ultrafast device for use in cutting-edge optoelectronics.

• Biomolecules & Therapeutics
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• 제31권3호
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• pp.241-252
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• 2023

The era of innovative RNA therapies using antisense oligonucleotides (ASOs), siRNAs, and mRNAs is beginning. Since the emergence of the concept of ASOs in 1978, it took more than 20 years before they were developed into drugs for commercial use. Nine ASO drugs have been approved to date. However, they target only rare genetic diseases, and the number of chemistries and mechanisms of action of ASOs are limited. Nevertheless, ASOs are accepted as a powerful modality for next-generation medicines as they can theoretically target all disease-related RNAs, including (undruggable) protein-coding RNAs and non-coding RNAs. In addition, ASOs can not only downregulate but also upregulate gene expression through diverse mechanisms of action. This review summarizes the achievements in medicinal chemistry that enabled the translation of the ASO concept into real drugs, the molecular mechanisms of action of ASOs, the structure-activity relationship of ASO-protein binding, and the pharmacology, pharmacokinetics, and toxicology of ASOs. In addition, it discusses recent advances in medicinal chemistry in improving the therapeutic potential of ASOs by reducing their toxicity and enhancing their cellular uptake.

• 국제학술발표논문집
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• The 1th International Conference on Construction Engineering and Project Management
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• pp.886-891
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• 2005

The frequent maintenance required on some asphalt concrete (AC) pavement sections has made reconstruction with Portland Cement Concrete Pavement (PCCP) a feasible alternative. However, many constructability issues need to be addressed in order to realize the full potential of this alternative. Accelerated paving encompasses three classes of activities: methods to accelerate the rate of strength gain, methods to minimize the construction time, and traffic control strategies to minimize user delay. Three major AC intersections with severe rutting problems were reconstructed with PCCP. The entire reconstruction of each intersection, including demolition of the AC pavement and its replacement with PCCP, took place over a period of three days, starting on Thursday evening and opening the intersection to the traffic on Sunday afternoon. This paper discusses the use of PCCP for accelerated reconstruction of major urban intersections with minimal user and traffic disruption, using innovative construction techniques and traffic management optimization principles and demonstrates that concrete pavements can be constructed efficiently and quickly.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2021년도 가을 학술논문 발표대회
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• pp.230-231
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• 2021

In this study, Dr. Bae Kyu-woong of the Korea Institute of Construction Technology developed a concrete module that was lightweighted to 1700kN with KC modules and met housing performance standards. It solves Construction lifts problem that was the limit of the PC module, and is an innovative model that greatly improves Construction period and economics with boxed modules, and is manufactured in the factory by extruded molding in vibration, noise, fireproofing standards, etc., and has the advantage of excellent precision and high strength. Therefore, if the framing house of a precast concretecan only be standardized in construction, its potential for growth will be endless. To do this, standardization, standardization, and modularization of the design are essential.

• 한국프랜차이즈경영연구
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• 제2권1호
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• pp.61-73
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• 2011

Supermarket Franchising, as a relatively new mode of retail business, is often regarded as one of the two hallmarks of the "Modern Logistics Revolution". After more than ten years of development, franchise supermarkets have been a rising force in retail business in China. As a product of a highly-developed commercial economy, franchise supermarkets mainly deals in foodstuffs and other daily necessities, featuring low cost, high turnover rate, low prices and diversified inventory. Propelled by the conveniences that come with open shelves and self-service shopping, franchise supermarkets have been growing very rapidly and the rise of many franchise supermarket brands bears testimony to its growth potential and profitability. Meanwhile, in the backdrop of this boom, some franchise supermarkets are going bankrupt. This paper analyzes the current status of franchise supermarkets and some factors bearing on their core competencies, so as to close the competitiveness gap with international retail giants.

• Steel and Composite Structures
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• 제45권1호
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• pp.147-157
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• 2022

This study assessed the compressive and tensile strengths and modulus of elasticity of waste polyethylene terephthalate (PET) using the ASTM standard tests. In addition, short carbon and glass fibers were mixed with waste PET to examine the improvements in ductility and strength during compression. The bonding was examined via field-emission scanning electron microscopy. The strength degradation of the waste PET tested under UV was 40-50%. However, it had a compressive strength of 32.37 MPa (equivalent to that of concrete), tensile strength of 31.83 MPa (approximately ten times that of concrete), and a unit weight of 12-13 kN/m3 (approximately half that of concrete). A finite element analysis showed that, compared with concrete, a waste PET pile foundation can support approximately 1.3 times greater loads. Mixing reinforcing fibers with waste PET further mitigated this, thereby extending ductility. Waste PET holds excellent potential for use in foundation piles, especially while mitigating brittleness using short reinforcing fibers and avoiding UV degradation.

• 운동영양학회지
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• 제23권2호
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• pp.13-15
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• 2019

[Purpose] Functional beverages are a protective or enhancing factor influencing not only public health but also athletic performance. The purpose of this study was to highlight the new conditioning beverage of the Lactobacillus pentosus strain b240 (B240) with electrolytes or proteins, which strengthens immune functions to improve the quality of life. [Methods] ISeveral related studies systematically reviews three main issues associated with conditioning beverages: (a) utilization and availability of the functional beverage; (b) significance of B240 in immune strengthening; and (c) availability and application of conditioning drinks in the daily life and sports field. [Results] Intake of B240 led to greater enhancements, including blood T-helper, NK cell, IgA and IgG level in conjunction with strengthen immune functions. These results speculated that the practical application of B240 contained beverages on physiological health and performance. [Conclusion] BODYMAINTÉ, this novel conditioning beverage is expected biological utility responsible for improved sports performance as a functional drink and has potential health-related implications.