• The Journal of Internal Korean Medicine
• /
• v.22 no.4
• /
• pp.527-535
• /
• 2001

Objectives : To improve decreased erectile function as well as impotence, caused by physical fatigue, psychologic stress, too much alcohol and smoking, medication like antihypertensives, and geriatric change, by the prescription of BOWONDAN. Methods : 18 male-volunteers with decreased erectile function who are married 30 to 59 years old, were studied about the difference of a sexual function between before and after taking BOWONDAN 3 pills a day for a month. The results of IIEF(International Index of Erectile Function) and AVSS(Audio-Visual Sexual Stimulation) were reviewed statistically with paired samples t-test. Results : Based on the IIEF, 13(81.25%, p<0.01), 9(56.25%, p<0.05), 9(56.25%, p<0.05), 9(56.25%, p<0.05), 7(43.75%, p<0.05) and 15(93.75%, p<0.01) volunteers were improved in erectile function, orgasmic function, sexual desire, intercourse satisfaction, overall satisfaction and total score respectively, among 16 volunteers excluding 2 due to a false measurement. Through the Rigiscan of AVSS, 11 (68.75%, p<0.1)volunteers were improved in base tumescence, among 16 volunteers excluding 2 due to a false measurement. Conclusions : As a result of our work, BOWONDAN is expected to take effect to treat or improve both impotence and decreased erectile function.

• Korean Journal of Psychosomatic Medicine
• /
• v.7 no.1
• /
• pp.10-25
• /
• 1999

Children above age of two are able to have sexual excitement, and they actively seek the pleasure actively or passively through touch and masturbation. In late $60_s$ and early $70_s$, Masters, obstetrician, and Johnson, social worker, illustrated four phases of human sexual responses, namely excitement, plateau, orgasmic and resolution phases in both sexes, and multiple orgasms in the female. Their treatment principles of sexual dysfunctions were largely based on behavioral model, introducing the concepts of sensate focus, dual therapy and sex education. Following Masters and Johnson, Kaplan, psychiatrist and psychoanalyst, in the early and mid-$70_s$ introduced new sex therapy which was based on the combination of analytically-oriented psychotherapy and behavior therapy, and classified sexual dysfunctions into three categories such as desire excitement and orgasmic phase disorders. Since $1980_s$ other medical fields joined the stream, putting the concentrated effort on the treatment of the impotence in the male. They have developed penile prosthesis, local injection therapy, and the administration of oral medications. Nowadays Sildenafil(Viagra) seems the best choice for the treatment of the impotence in the male.

• Analytical Science and Technology
• /
• v.20 no.1
• /
• pp.78-83
• /
• 2007

To perform proficiency test for determining anti-impotence drug-like compounds in food, interlaboratory test has been done. Targets were 6 such as sildenafil, tadalafil, vardenafil, homosildenafil, hydroxy-homosildenafil and pseudo-vardenafilI. Total 13 institutes were participated and all is in charging of food analysis. To do double blind test, the reference materials were made as 13 different ginseng drink samples and each sample had random 3 targets. By the official method for anti-impotence drug-like compounds in food code, sample was just diluted in water, extracted in organic solvents, determined by HPLC/UV and then confirmed by LC/MS. The analytical duration was 60 days after receiving sample. Ten out of 13 institutes were satisfied by evaluation of Z-score and RSZ according to the regulation for managing analytical quality assurance.

• Tuberculosis and Respiratory Diseases
• /
• v.54 no.3
• /
• pp.304-310
• /
• 2003

Background : Recent discoveries on the physiology of an erection have demonstrated that the organic causes of impotence are more common, and psychogenic impotence is correspondingly less common than was formally believed. The incidence of sexual dysfunctions in chronic obstructive pulmonary disease (COPD) patients is largely unknown or may be perfunctorily attributed to the associated illness or to aging. This study investigated whether or not the impotence was related to the COPD itself as well as whether or not it nay stem from organic causes in a notable proportion of such patients. Methods : The sexual function was evaluated in 10 COPD patients and 10 normal control subjects. A nocturnal Rigi Scan was performed to evaluate the erectile function of each group. The level of hormones such as the free testosterone, prolactin and thyroid stimulating hormone (TSH) was measured, and a pulmonary function test and arterial blood gas analysis was performed. Results : The time duration and frequency of a penile erection were significantly lower in COPD patients than the controls (p<0.05). In addition, the $PaO_2$ levels correlated with the time duration of the penile erection. Conclusion : These results suggest that COPD is one of the causes of organic erectile dysfunction.

• Korean Journal of Food Science and Technology
• /
• v.43 no.6
• /
• pp.675-682
• /
• 2011

This study was conducted to monitor the concentrations of 24 anti-impotence drugs and their analogues in various foods and dietary supplements, with the aim of ensuring the safety of the foods and supplements. The measurements were done in 226 samples using high performance liquid chromatography/photodiode array detector (HPLC/PDA) and liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS). Five male sexual function enhancing products have been detected as follows: acethylvardenafil (21,476 mg/kg; 15 mg/capsule from one sample), sildenafil (52,778 mg/kg, 29 mg/capsule in one sample; 71,535 mg/kg, 48 mg/capsule in one sample), and tadalafil (9,772-55,545 mg/kg, 6-33 mg/capsule in four samples). A sustainable monitoring of anti-impotence drugs and their analogues in various foods and dietary supplement is recommended.

• Analytical Science and Technology
• /
• v.17 no.6
• /
• pp.520-526
• /
• 2004

To determine 6 anti-impotence drug-like compounds such as sildenafil, vardenafil, tadalafil, homosildenafil, hydroxyhomosildenafil and hongdenafil in food, simultaneously, high performance liquid chromatography was applied. In the case of solid sample, it was extracted in organic solvents after homogenizing with mortar and pestle. Whereas liquid sample was just diluted in water and then extracted in organic solvents. Maximum lengths of UV for targets have been identified on photodiode array spectra. As results, vardenafil, hongdenafil, hydroxyhomosildenafil, sildenafil, homosildenafil, and tadalafil were eluted in order using $C_{18}$ column in acetonitrile containing phosphoric acid as the mobile phase. The maximum wavelength (${\lambda}_{max}$) was 216 nm for vardenafil, 233 and 282 nm for hongdenafil, 222 and 293 nm for hydroxyhomosildenafil, sildenafil and homosildenafil, and 284 nm for tadalafil. The overall recoveries were ranged from 95% to 109% and the limit of detection was about 0.04 mg/kg at signal/noise>3. Levels of targets in the selected food samples were 1.7 (hongdenafil) ~ 63 (tadalafil) mg/one dose.

• Proceedings of the Korean Society of Sericultural Science Conference
• /
• 2001.10a
• /
• pp.56-56
• /
• 2001

no Abstract, See Full Text

• Journal of Society of Preventive Korean Medicine
• /
• v.20 no.3
• /
• pp.83-91
• /
• 2016

Objectives : The Levator Ani Muscles Training(LAMT) is one of the well known very effective prevention and treatment method of some specific diseases in the anal organs, digestion system, urinary organs and genital organs, which means LAMT could be considered as an independent exercise. Methods : Chinese databases were searched and found one good source named CNKI(China National Knowledge Infrastructure) where there were downloaded 154 articles, out of which were finally selected 82 used for the introduction of the historical background, health-effectiveness, working mechanism, training methods, etc. Results : LAMT as an independent exercise, is considered very effective for the prevention of diseases in the anal organs, e.g. hemorrhoids, anal fissure, rectal prolapse; urinary organs, e.g. urinary incontinence, frequent micturition; digestion system, e.g. visceroptosis, diarrhea, chronic enteritis; genital organs, e.g. prostatitis, impotence, premature ejaculation, feminine vaginal relaxation, sexual indifference, etc. It is also told LAMT is effective for coronary heart disease, hyperyension and varicose veins of lower extremity to a certain degree. LAMT is also very similar to the Kegel exercise in couple of aspects. They are equally effective for the urinary incontinence and impotence. Conclusions : LAMT as an independent exercise has developed and become more and more health-effective, especially through the combination with the Qigong exercise, and thus many training methods have been introduced. There are not many scientific research and development with very limited accomplishments even in China. It is strongly required to strengthen the research and development activities so that LAMT will become one of the very effective natural healing soonest possible.

• International Journal of Industrial Entomology and Biomaterials
• /
• v.20 no.2
• /
• pp.75-77
• /
• 2010

Until now, the main treatment for impotence has been the vasodilator injection, penile implants and etc. Among many methods, most effective way is known to be the medical therapy. The oral drug for an impotence remedy has to be above all, effective to the erection, and second, safety when taking in long-term. However, so far the drug in such condition and sufficiency has not been discovered. Consequently, it is crucial to develop the new medicine, made of natural materials only, without any uncertainty of side effect. The silkworm is very difference in physiological chemical change according to growth stage. Therefore the functional effect shows a very big difference according to preparation method with a growth stage. This research carry out the experiment with the pupa powder immediately before the eclosion, eclosion adult, the pupa extract immediately before the eclosion, and the silkworm powder of 5 instar 3rd day. The result showed not a big chance in weight, feed and water intake quantity. But testosterone hormone secretion effects of the freeze drying powder of the pupa immediately before the eclosion was very high 7.31 ng/ml, compared to 2.37 ng/ml of non treatment and 2.67 ng/ml of alcohol extraction method. As this result, the freeze drying pupa powder of the pupa immediately before the eclosion was confirmed to promote the secretion of the testosterone hormone more than alcohol extraction method of existing.

• Journal of Ginseng Research
• /
• v.20 no.2
• /
• pp.125-132
• /
• 1996

To investigate the effect of Korean red ginseng (KRG) on male sexual function and serum lipid level, the results of KRG treatments were compared to placebo group. A total of 35 patients with psychogenic impotence were assigned to medication group with KRG (n=28) and placebo (n=7). KRG and placebo were given to each group for 2 months. Changes in symptoms such as frequency of coitus, morning erection, penile rigidity and tumescence were significantly higher in the group receiving KRG than placebo group. The overall therapeutic efficacies on erectile function were 67% for KRG group and 28% for placebo group (p <0.05). In the group treated with 9 tablets of KRG, there was tendency of better efficacy as compared to the group treated with 6 tablets of KRG. The level of serum high density lipid- cholesterol (HDL-cholesterol) was significantly elevated (p < 0.05) while the other serum lipid such as total cholesterol, tiglyceride and low density lipid-cholesterol (LDL-cholesterol) , were not changed after administration of KRG. This effect was observed significantly in the group in which KRG exerted its effect on sexual function(p < 0.05). From the above results, the administration of Korean red ginseng has shown to have superior of facts as compared to the placebo. The tendency of good effect was increased when a large amount of KRG was administered. The mechanism of KRG in improving sexual function would be the result of elevating the level of geum HDL-cholesterol in impotent patients. The effect of KRG was produced when the level of cholesterol was high before starting KRG medication. Therefore, the effect of KRG could be observed more intensively when the patients have high serum cholesterol level.