• IMMUNE NETWORK
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• v.8 no.4
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• pp.107-123
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• 2008

It has now been well documented in a variety of models that T regulatory T cells (Treg cells) play a pivotal role in the maintenance of self-tolerance, T cell homeostasis, tumor, allergy, autoimmunity, allograft transplantation and control of microbial infection. Recently, Treg cell are isolated and can be expanded in vitro and in vivo, and their role is the subject of intensive investigation, particularly on the possible Treg cell therapy for various immune-mediated diseases. A growing body of evidence has demonstrated that Treg cells can prevent or even cure a wide range of diseases, including tumor, allergic and autoimmune diseases, transplant rejection, graft-versus-host disease. Currently, a large body of data in the literature has been emerging and provided evidence that clear understanding of Treg cell work will present definite opportunities for successful Treg cell immunotherapy for the treatment of a broad spectrum of diseases. In this Review, I briefly discuss the biology of Treg cells, and summarize efforts to exploit Treg cell therapy for autoimmune diseases. This article also explores recent observations on pharmaceutical agents that abrogate or enhance the function of Treg cells for manipulation of Treg cells for therapeutic purpose.

• Genomics & Informatics
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• v.12 no.1
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• pp.12-20
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• 2014

The epithelial-mesenchymal transition (EMT) is one mechanism by which cells with mesenchymal features can be generated and is a fundamental event in morphogenesis. Recently, invasion and metastasis of cancer cells from the primary tumor are now thought to be initiated by the developmental process termed the EMT, whereby epithelial cells lose cell polarity and cell-cell interactions, and gain mesenchymal phenotypes with increased migratory and invasive properties. The EMT is believed to be an important step in metastasis and is implicated in cancer progression, although the influence of the EMT in clinical specimens has been debated. This review presents the recent results of two cell surface proteins, the functions and underlying mechanisms of which have recently begun to be demonstrated, as novel regulators of the molecular networks that induce the EMT and cancer progression.

• Annals of Clinical Neurophysiology
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• v.15 no.1
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• pp.30-33
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• 2013

• Journal of Plant Biotechnology
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• v.2 no.2
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• pp.97-99
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• 2000

Allergy to Brassica pollen has been reported in some countries. We have cloned a cDNA encoding a Brassica pollen allergen, Bra r 1. Bra r 1 belongs to a new family of $Ca^{2+}$-binding proteins, characterized by the presence of two EF-hand calcium-binding domains. Bra r 1 was detected in the tapetum, microspores, pollen coat and pollen tubes, indicating Bra r 1 is involved in pollen pistil interaction and pollen tube growth. We have engineered the hypoallergenic mutants of Bra r 1 for immunotherapy. Here we describe the review of molecular characterization of Bra r 1.

• Korean Journal of Veterinary Research
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• v.53 no.4
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• pp.225-230
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• 2013

To better understand the role of macrophages in early stages of experimental autoimmune myocarditis (EAM), we compared the expression of inducible nitric oxide synthase (iNOS) and arginase-1, markers for classically activated M1 and alternatively activated M2 macrophages, respectively, in the hearts of EAM-affected and control rats. Immunohistochemical evidence revealed that both iNOS-positive and arginase 1-positive macrophages were found in EAM lesions, while some cells were co-localized with both markers. This finding suggests that the increased level of arginase-1, which is partly from M2 macrophages, contributes to the modulation of EAM, possibly through the reduction of nitric oxide in the lesion.

• BMB Reports
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• v.45 no.11
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• pp.595-603
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• 2012

Human Ly-6/uPAR molecules are a superfamily composed of two subfamilies; one is the membrane bound proteins with a GPI-anchor and the other are secreted proteins without the GPI-anchor. Ly-6/uPAR molecules have remarkable amino acid homology through a distinctive 8-10 cysteine-rich domain that is associated predominantly with O-linked glycans. These molecules are encoded by multiple tightly linked genes located on Chr. 8q23, and have a conserved genomic organization. Ly-6/uPAR molecules have an interesting expression pattern during hematopoiesis and on specific tumors indicating that Ly-6/uPAR molecules are associated with development of the immune system and carcinogenesis. Thus, Ly-6/uPAR molecules are useful antigens for diagnostic and therapeutic targets. This review summarizes our understanding of human Ly-6/uPAR molecules with regard to molecular structure as well as what is known about their function in normal and malignant tissues and suggest Ly-6/uPAR molecules as target antigens for cancer immunotherapy.

• Nuclear Medicine and Molecular Imaging
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• v.41 no.1
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• pp.1-8
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• 2007

This review discusses the production of alpha-particle-emitting radionuclides in radioimmunotherapy. Radioimmunotherapy labeled with alpha-particle is expected to be very useful for the treatment of monocellular cancer (e.g. leukemia) and micrometastasis at an early stage, residual tumor remained in tissues after chemotherapy and tumor resection, due to the high linear energy transfer (LET) and the short path length in biological tissue of alpha particle. Despite of the expected effectiveness of alpha-particle in radioimmunotherapy, its clinical research has not been activated by the several reasons, shortage of a suitable a-particle development and a reliable radionuclide production and supply system, appropriate antibody and chelator development. Among them, the establishment of radionuclide development and supply system is a key factor to make an alpha-immunotherapy more popular in clinical trial. Alpha-emitter can be produced by several methods, natural radionuclides, reactor irradiation, cyclotron irradiation, generator system and elution. Due to the sharply increasing demand of $^{213}Bi$, which is a most promising radionuclide in radioimmunotherapy and now has been produced with reactor, the cyclotron production system should be developed urgently to meet the demand.

• Journal of Korean Physical Therapy Science
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• v.7 no.2
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• pp.439-457
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• 2000

The causes, risk factors and sequelae of mastectomy were studied, and the physical therapy approaches on post-mastectomy was discussed in this study. It was found that the patients taken mastectomy have experienced pins and needles in muscle, weakening of muscle, pains, deterioration of motion in joint region and activities of daily living, psychiatric sequelae, and etc even after the conservertive therapies like the chemical therapy, radiotherapy, immunotherapy, and hormone therapy. However, few study on the physical therapy approaches for patients with breast cancer has been carried in Korea at present. The followings were proposed as the physical therapy approaches. 1. Shoulder joint motion approach to relax the limit of range of motion 2. Control of breathing exercise for dealing with removal of the pectorailis muscle 3. Method to reduce the edema of arms for tackling the cut of lymph node 4. Method to reduce pains, pins and needles 5. Support home exercise program after discharging from hospital, sexual life and pregnancy, and activities of daily living training method.

• The Korean Journal of Applied Statistics
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• v.2 no.2
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• pp.27-35
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• 1989

This article deals with statistical inference on Interleukin-2 titer of which the clinical applications to cancer immunotherapy and some immunodeficiency diseases have been widely tried. A Linear model and the Bayesian approach are used to explain the bioassay which performs the measurements of IL-2 activity from an patient and an inference procedure including confidence intervals for the IL-2 titer of the patient through comparision with the Standard IL-2 is suggested and a real case of example is illustrated.

• Journal of the korean veterinary medical association
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• v.38 no.6
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• pp.549-558
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• 2002

3.5살짜리 래브라도 리트리버(Labrador Retriever)는 매일 처방되는 피질스테로이드제에 무반응으로 비계절적, 심한 소양증을 2년간 앓고 있는 병력을 갖고 있었다. 공기유래 알레르겐(알러젠; Allergens)들에 대한 시험관내 RAST1(Radioallergosorbent testing; 방사선 알레르기 흡착 시험법)에 양성으로 나타난 것을 기초로 한 면역요법(Immunotherapy)을 18개월 동안 시행했으나 성공적이지 않았다. 부신피질호르몬(Adrenocorticotropic Hormone, ACTH)자극 시험법은 이것이 본래 임상수의사에 의해 발생(Iatrogenic)된 것임을 예시하여준다. 피부 찰과물(Skin scrapings)을 검사한 결과 개 천공개선충(Sarcoptic mange)이라는 진단이 내려졌다. 이버맥틴(Ivermectin)치료효과와 피질스테로이드(Corticosteroid)의 투약중지에 대한 반응이 극적으로 나타났다. 10개월 추적기간(10-month follow-up period)동안에 이 질병은 재발되지 않았다. 이것은 비록 계절적인 알레르겐을 배제하기 위해 긴 기간동안 추적이 필요하였으나 개 천공개선충이 오히려 피질스테로이드요법에 대한 2차적인 것보다는 1차적인 질병이라는 것을 말해준다. 아토피의 진단을 위해 혈청학적 시험법의 이용이 논의되었다.