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http://dx.doi.org/10.14405/kjvr.2013.53.4.225

Alternatively activated M2 macrophages increase in early stages of experimental autoimmune myocarditis in Lewis rats  

Oh, Hanseul (Laboratory of Veterinary Anatomy, College of Veterinary Medicine and Veterinary Medical Research Institute)
Ahn, Meejung (School of Medicine, Jeju National University)
Matsumoto, Yoh (Department of Immunotherapy Development, Tokyo Metropolitan Institute of Medical Science)
Shin, Taekyun (Laboratory of Veterinary Anatomy, College of Veterinary Medicine and Veterinary Medical Research Institute)
Publication Information
Korean Journal of Veterinary Research / v.53, no.4, 2013 , pp. 225-230 More about this Journal
Abstract
To better understand the role of macrophages in early stages of experimental autoimmune myocarditis (EAM), we compared the expression of inducible nitric oxide synthase (iNOS) and arginase-1, markers for classically activated M1 and alternatively activated M2 macrophages, respectively, in the hearts of EAM-affected and control rats. Immunohistochemical evidence revealed that both iNOS-positive and arginase 1-positive macrophages were found in EAM lesions, while some cells were co-localized with both markers. This finding suggests that the increased level of arginase-1, which is partly from M2 macrophages, contributes to the modulation of EAM, possibly through the reduction of nitric oxide in the lesion.
Keywords
arginase-1; experimental autoimmune myocarditis; inducible nitric oxide synthase; macrophage;
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