• 한국응용과학기술학회지
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• 제36권4호
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• pp.1188-1197
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• 2019

스트레스는 인체의 다양한 기관과 정신적 상태에 영향을 미치는 교감신경 항진을 야기시킨다. 본 연구의 목적은 만성 스트레스로 교감신경을 항진시킨 동물 모델에서 국내산 생강 에센셜오일이 스트레스 호르몬 및 뇌 조직 반응에 미치는 효과를 평가하였다. 평가 방법은 세포독성 평가 및 성분 분석을 수행하였으며, 혈청 바이오 마커와 뇌 조직의 병리학적 분석이 기초한 효과를 관찰하였다. 동물 실험에서 국산 생강 에센셜오일의 처리는 만성 스트레스로 교감신경을 항진시킨 동물 모델 제작 후 2주간 100 nl/㎖로 처리하였다. 그 결과, 국산 생강 에센셜오일은 100 nl/㎖ 농도 이하에서 독성이 없었으며, 6-진저롤 함량이 345 ppm으로 확인되었다. 국산 생강 에센셜오일의 처리는 대조군과 비교하여 혈청에서 부신피질호르몬, 코르티코스테론, 멜라토닌과 같은 스트레스 호르몬의 농도를 크게 줄였으며, 복측피개부(VTA) 및 흑색질 치밀부(SNpc) 부분에서 TH-면역 반응이 때때로 중단되는 것을 효과적으로 보존하였다. 이와 같은 결과는 국산 생강 에센셜오일이 교감신경 항진을 개선했음을 나타내고 있다. 따라서 국산 생강은 교감신경 항진에 대한 아로마오일의 새로운 원료로 활용될 수 있다.

• 한국가정과교육학회지
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• 제15권4호
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• pp.147-157
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• 2003

본 연구는 아동의 식생활 행동 변인이 아동의 신체적 정신적 그리고 사회적 발달을 결정하는 직접적 혹은 간접적 요인으로, 이들이 사회적 능력 및 과잉 행동에 영향을 미칠 것이라는 가설 하에 진행되었다. 즉, 가정이라는 한정된 환경에서 아동 교육 기관이라는 새로운 환경에 노출되는 5∼6세의 아동을 대상으로 아동의 일반적인 특성 아동의 건강요인, 아동의 식생활 행동 등을 분석하였으며, 이들의 변인이 아동의 사회적 능력 및 과잉 행동과 어떤 관련성이 있는 지 분석하였다. 그 결과 아동의 식생활 행동은 어머니가 평가한 결과보다는 교사가 평가한 결과에서 유의적인 차이를 보여 영향력 있는 변인으로 작용하였다(P<0.05) 아동의 건강 상태는 교사가 측정한 아동의 식생활 행동과 밀접하게 관련되어 있었다(p<0.05). 아동의 사회적 능력은 아동의 활동 상태와 유의적인 관련성을 보였으며(p<0.05). 수면 상태는 과잉 행동과 유의적인 관련성을 가지고 있었다(p<0.001). 과잉 행동 가능성이 있는 아동과 그렇지 않은 아동을 분류하여 식행동을 비교한 결과, 과잉 행동 가능성이 있는 아동의 경우 교사가 측정한 아동의 식생활 행동 평가가 유의적으로 낮음을 알 수 있었다(p<0.05). 이러한 현상은 동일한 아동일지라도 어머니가 평가한 아동의 식생활 행동에서는 관찰되지 않았다. 본 연구 결과, 교사가 측정한 아동의 식생활 행동 변인은 아동의 사회적 능력과 과잉 행동에 직ㆍ간접적으로 유의적인 영향을 미치고 있음을 알 수 있었다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제28권2호
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• pp.46-57
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• 2017

Attention-deficit hyperactivity disorder (ADHD) is a common psychiatric disorder that can affect individuals across their lifespan. It is characterized by the core symptoms of inattention, impulsivity and hyperactivity. ADHD develops as a result of the complex interplay between genetic and environmental factors. Children and adults with ADHD usually suffer concomitantly from other psychiatric comorbidities, including both externalizing and internalizing disorders. It is associated with functional impairment and poor long-term outcomes. This review aims to summarize the key findings from recent research into ADHD and its prevalence, core symptoms, cause and comorbidities from childhood to adulthood.

• 생물정신의학
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• 제12권2호
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• pp.221-226
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• 2005

교통사고 등에 의한 외상성 뇌손상에서 이차적으로 주의력결핍 과잉행동장애가 나타나는 경우가 점차 증가하고 있으며, 이에따른 치료방법도 점차 다양화되고 있는 추세이다. 주의력결핍 과잉행동장애에서 많이 사용되어지는 OROS Methylphenidate를 환자에게 투여하여 인지적인 개선뿐만아니라 충동성, 산만함, 공격성 등의 증상에 효과가 있는지의 여부를 살펴보고자 하였다. 약물투여 전에 비하여 약물투여 후에 환자는 충동성, 공격성, 부주의의 개선효과를 나타내었다.

• 대한한방소아과학회지
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• 제15권2호
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• pp.141-165
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• 2001

Attention-deficit/hyperactivity disorder(ADHD) is one of the most common childhood-onset psychlatric disorders. It is distinguished by symptoms of inattention, hyperactivity, and impulsivity. ADHD may be accompanied by learning disabilities, depression, anxiety, conduct disorder, and oppositional defiant disorder. The etiology of ADHD is unknown, and the disorder may have several different causes. Individual with ADHD present in childhood and may continue to show symptoms as they enter adolescence and adult life. Public interest in ADHD has increased along with debate in the media concerning the diagnostic process and treatment strategies. The purpose of this study is oriental medical approach to ADHD. This study was progressed for oriental diagnosis and treatment for ADHD. In oriental medicine, the reason of ADHD was deficiency of the kidney, hyperactivity of the liver(腎虛肝亢), deficiency of the heart and the spleen(心脾不足), heart disturbed by phlegm and heat(痰熱擾心). The method of medical treatment was nourishing the kidney and checking exuberance of yang(滋腎潛陽), relieving mental stress and promoting wisdom(寧神益智), nourishing the heart and strengthening the spleen(養心健脾), tranquilzation(安神定志). removing heat-phlegm(淸熱化痰), inducing resuscitation and tranquilzation(開窮安神). The prescription was commonly used as Liuwei Dihuang Wan jiajian(六味地黃丸加減), Guipi Tang he Ganmai Dazao Tang jiajian(歸脾湯合甘麥大棗湯加減), Huanglian Wendan Tang jiawei(溫黃連溫膽湯加味). It should help primary care providers in their assessment of a common child health problem.

• Biomolecules & Therapeutics
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• 제16권4호
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• pp.312-319
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• 2008

Attention deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by hyperactivity, inattention, and impulsiveness. Current estimates suggest that 4-12% of school age children are affected by ADHD, which hampers proper social relationship and achievements in school. Even though the exact etiology of the disorder is still in the middle of active investigation, the availability of pharmacological treatments for the disorder suggest that at least the symptoms of ADHD are manageable. To develop drugs with higher efficacy and fewer side effects, it is essential to have appropriate animal models for in vivo drug screening processes. Good animal models can also provide the chances to improve our understanding of the disease processes as well as the underlying etiology of the disorder. In this review, we summarized current animal models used for ADHD research and discussed the point of concerns about using specific animal models.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제29권3호
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• pp.122-128
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• 2018

Objectives: This study evaluated the psychometric properties of the Korean version of the attention-deficit/hyperactivity disorder (ADHD) Stigma Questionnaire (ASQ) and the effect of the source of information about mental health on ADHD stigma. Methods: The Korean translation of the ASQ was prepared, and 673 participants, 20-64 years of age, completed the questionnaire using an online panel survey in South Korea. The participants also completed questionnaires detailing sociodemographic variables and the source of their mental health knowledge. Cronbach's alpha coefficient was used to explore the internal consistency of the ASQ. Factor analysis using Varimax rotation was conducted to investigate the structure of the ASQ. Results: The 26-item ASQ demonstrated excellent internal consistency (Cronbach's alpha=0.940). Factor analysis supported a three-factor structure, including Concerns with Public Attitudes, Negative Self-Image, and Disclosure Concerns. There were no significant differences in the total ASQ scores according to sociodemographic characteristics. Participants who reported the internet as their major source of information about mental health showed higher ASQ scores compared to those who used other sources for mental health information. Conclusion: The Korean translation of the ASQ has acceptable psychometric properties among Korean adults. Inaccurate information from the internet could increase the stigma toward ADHD.

• 한국식생활문화학회지
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• 제10권4호
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• pp.269-279
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• 1995

The purpose of this study was to examine the relationships of nutritional and social factors among 100 children aged $5{\sim}6$ years. Forty five children (45%) were selected from families with low socioeconomic status, while 55 children (55%) were from those with high socioeconomic status. Cognitive performance of the children was measured by the Draw a man test and the degrees of hyperactivity were assessed by both children's mothers and their teachers using two different Check List (Behavior check list and Conner's rating scale). There were few associations between cognitive performance and nutritional variables. However, levels of hyperactivity were related positively to diversity of food intake and weight percentage for age, and negatively to animal and processed food preferences. These results indicate a possible role of nutrition on psychological development.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1995년도 춘계학술대회
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• pp.102-102
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• 1995

The present study was undertaken to investigate the behavioral and biochemical effects of ginseng total sponin (GTS) on methamphetamine-treated mice. GTS (50 or 100 mg/kg) was administered intraperitoneally two times with 2 hour interval. Two hours after the second injection of GTS, methamphetamine (2 mg/kg) was administered subcutaneously. The ambulatory activity of mice was measured by the ti1ting-type ambulometer every 10 min. for 1 hour. Methamphetamine-induced hyperactivity was reduced by GTS. in a dose-dependent manner. To study the neurochemical mechanism underlying the GTS effects, monoamine contents were measured from brain tissues. After 45 min. of methamphetamine injection. mice were sacrificed and monoamine contents were determined from the striatum. Biochemical analysis revealed that GTS reduced the methamphetamine- induced increase in striatal dopamine contents. These observations indicate that inhibition of methamphetamine-induced hyperactivity by GTS is mediated by the modulation of dopaminergic nervous system, and it could be helpful for the therapy of hyperactivity.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제31권4호
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• pp.207-213
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• 2020

Objectives: Although aggressive behavior in children and adolescents with attention-deficit/hyperactivity disorder (ADHD) has previously shown correlations with hyperactivity/impulsivity, few studies have examined its association with inattention or the effect of working memory on aggressive behavior. This study aimed to assess the relationship between inattention and aggressive behavior and the effect of working memory on the relationship between inattention and aggressive behavior in children and adolescents with ADHD. Methods: Thirty-one children and 26 adolescents with ADHD were retrospectively investigated. The subjects completed the Korean Wechsler Intelligence Scale for Children-Fourth Edition (K-WISC-IV), the Korean Child Behavior Checklist (K-CBCL), and the Korean Children's Depression Inventory (CDI). Results: Inattention was positively correlated with aggressive behavior in children and adolescents with ADHD and working memory showed an insignificant correlation. However, working memory had a significant moderating effect on aggressive behavior by interacting with inattention. The moderating effect of working memory manifested when the working memory index score on the K-WISC-IV was 73.5 points or higher, and it had a significant effect on aggressive behavior. Conclusion: This study shows that the severity of inattention and hyperactivity/impulsivity should be addressed to provide appropriate treatment to children and adolescents with ADHD who exhibit aggressive behavior.