Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Ever Increasing Number of the Animal Model Systems for Attention Deficit/Hyperactivity Disorder: Attention, Please

  • Kim, Hee-Jin (Department of Pharmacy, Sahmyook University) ;
  • Park, Seung-Hwa (Department of Pharmacology, School of Medicine and IBST, Konkuk University) ;
  • Kim, Kyeong-Man (Department of Pharmacology, College of Pharmacy, Chonnam National University) ;
  • Ryu, Jong-Hoon (Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University) ;
  • Cheong, Jae-Hoon (Department of Pharmacy, Sahmyook University) ;
  • Shin, Chan-Young (Department of Pharmacology, School of Medicine and IBST, Konkuk University)
  • Published : 2008.12.31
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Abstract

Attention deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by hyperactivity, inattention, and impulsiveness. Current estimates suggest that 4-12% of school age children are affected by ADHD, which hampers proper social relationship and achievements in school. Even though the exact etiology of the disorder is still in the middle of active investigation, the availability of pharmacological treatments for the disorder suggest that at least the symptoms of ADHD are manageable. To develop drugs with higher efficacy and fewer side effects, it is essential to have appropriate animal models for in vivo drug screening processes. Good animal models can also provide the chances to improve our understanding of the disease processes as well as the underlying etiology of the disorder. In this review, we summarized current animal models used for ADHD research and discussed the point of concerns about using specific animal models.

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References

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