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http://dx.doi.org/10.12925/jkocs.2019.36.4.1188

The Effects of Korea Ginger Essential oil on Chronic Mild Stress-induced Rats Model of Sympathetic Hyperactivity  

Ji, Joong-Gu (Division of Integrated Biotechnology, Joongbu University)
Publication Information
Journal of the Korean Applied Science and Technology / v.36, no.4, 2019 , pp. 1188-1197 More about this Journal
Abstract
Exposure to stress can lead to sympathetic hyperactivity, which include a systemic disease with lesions in a broad spectrum of organs and a psychiatric condition. The purpose aimed to evaluate the effect of the korea ginger essential oil on stress hormone and brain tissue response in chronic mild stress-induced rats model of sympathetic hyperactivity. Evaluation method carried out cytotoxicity assessment and component analysis, what observe the effects based on serum biomarker and histopathological analysis of brain tissue. As this time, the korea ginger essential oil was treatment at doses of 100 nl/㎖ for 2 weeks after make a chronic mild stress-induced rats model of sympathetic hyperactivity. As a result, the korea ginger essential oil was not toxic at less than 100 nl/㎖, contents of 6-gingerol was 345 ppm. Compared to the control rats, the korea ginger essential oil treatments significantly reduced the serum concentrations of stress hormone (i.e., ACTH, corticosterone, melatonin). Furthermore, The korea ginger essential oil treatments effectively preserved the TH-immune response was occasionally interrupted in the ventral tegmental area (VTA) and the substantia nigra pars compacta (SNpc). The results indicate that the korea ginger essential oil improved sympathetic hyperactivity. Thus, the korea ginger may be a novel material of aroma oils for the management of sympathetic hyperactivity.
Keywords
Brain tissue; Chronic mild stress; Korea ginger; Stress hormone; Sympathetic hyperactivity;
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