• Journal of Microbiology
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• v.39 no.4
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• pp.334-337
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• 2001

The degradative pathway of homoprotocatechuate (HPC) is the bacterial routhe wherby 3,4-dihydrox-yphenylactic acid is catabolized to pyruvate and succinate by a series of sequential reactions . The HPC is catalzed by homoprotocatechuate 2, 3-dioxygenase(HPC-2,3O) to from 5-carboxymethy1-2-hydroxy-muco semialdehyde. In this study, the hha D gene encoding. HPC, 2, 3O was Cloned from the chromo-somal DNA of Pseudomonas sp. DJ-12 and its nucleotide sequence was analyzed. The open reding frame of hpaD gene was found to be composed of 864 nucleotide pairs and to encode a poypetide with 287 amino acide residues. The deduced amino acid sequence of the HPC-2,3O from Pseudomonas. sp. DJ-12 exhibited 60~64% homology with those of the corresponding enzymes from E. coli. Salmonella enterica, and Klebsiella pneumoniae.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.12
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• pp.8643-8648
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• 2015

In this paper presents the design and demonstrate 8 W 3-stage HPA(High Power Amplifier) MMIC(Monolithic Microwave Integrated Circuits) for Ka-band down link satellite communications payload system at 19.5 GHz ~ 22 GHz frequency band. The HPA MMIC consist of 3-stage GaN HEMT(Hight Electron Mobility Transistors). The gate periphery of $1^{st}$ stage, $2^{nd}$ stage and output stage is determined $8{\times}50{\times}2$ um, $8{\times}50{\times}4$ um and $8{\times}50{\times}8$ um, respectively. The fabricated HPA MMIC shows size $3,400{\times}3,200um^2$, small signal gain over 29.6 dB, input matching -8.2 dB, output matching -9.7 dB, output power 39.1 dBm and PAE 25.3 % by using 0.15 um GaN technology at 20 V supply voltage in 19.5~22 GHz frequency band. Therefore, this HPA MMIC is believed to be adaptable Ka-band satellite communication payloads down link system.

• Electronics and Telecommunications Trends
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• v.18 no.2 s.80
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• pp.53-66
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• 2003

고출력 증폭기(HPA)는 위성통신 등 무선통신 시스템의 송신단에서 필수적으로 요구되는 요소 중의 하나이다. 그러나, 대부분의 HPA들은 비선형적인 출력 특성을 가지고 있으므로 이로 인한 신호의 왜곡으로 전송 손실을 야기하게 된다. 이러한 문제점을 해결하기 위하여 HPA를 선형화하는 가장 효율적인 방법으로 제안되어온 것이 사전왜곡(predistortion) 기법이다. 본 고에서는 고출력 증폭기의 비선형성을 보상하기 위한 사전왜곡 방식의 기본 개념과 다양한 사전왜곡 방식에는 어떤한 것들이 있는지 그 기본 원리 및 기술 개발 동향에 관하여 고찰한다.

• Journal of Acupuncture Research
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• v.22 no.6
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• pp.85-92
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• 2005

Objectives : This study is to evaluate the efficacy of Hominis Placenta Herbal Acupuncture(HPA) on dysmenorrhea. Methods : Volunteers of fourteen subjects who used to feel pains in menstrual period were employed to answer the questionnaire. Subjects were divided into two groups Hominis Placenta Herbal Acupuncture(HPA) treatment group(Sample Group) and Normal Saline(N/S) treatment group(Control Group). HPA and N/S were injected on the Cheonchu(ST25), Gwanwon(CV4), Joksamni(ST36) and Hyeolhae(SP10) acupuncture points. Subjects were treated depending on menstrual period, two times a weeks, in total four times after ovulation cycle. Digital Infrared Thermal Imaging(D.I.T.I.) was taken and Visual Analog Scale(VAS) was examined before and after each treatment. Results : The VAS score of Sample Group were decreased significantly compared to that of Control Group.(p<0.05) The changes of difference of abdominal mean temperature of Control Group and Sample Group were significancy. HPA therapy reduced difference of right and left abdomial thermal temperature more than N/S therapy in dysmenorrheic patients. Conclusion : The Hominis Placenta Herbal Acupuncture therapy may be good effects on the Dysmenorrhea.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.14 no.6
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• pp.543-549
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• 2003

It is important to consider the nonlinear effects of the HPA(High Power Amplifier) in the OFDM communication systems and other digital communication systems as well. In this paper, we investigate a new performance figure-of$.$merit(D) that reflects both power and spectrum efficiencies. The performance figure-of-merit is expressed to include the spectrum and power efficiencies that depend on the magnitude of IBO(Input Backoff) and the number of subcarriers. So, we analyze the variation characteristics of the power efficiency and spectrum efficiency which has the tradeoff relationship.

• Proceedings of the KSRS Conference
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• 2004.10a
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• pp.498-500
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• 2004

QPSK (Quaternary Phase Shift Keying) will be adopted as the modulation of HRIT (High Rate Information Transmission) which is transmitted to COMS (Communication, Ocean and Meteorological Satellite) through HPA (High Power Amplifier) in ground segment. Due to the nonlinearity of HPA, IMD (Inter-Modulation Distortion) of multi-carrier signals and PAPR (Peak-to-Average Power Ratio) of modulated HRIT must be considered to estimate the output power of HPA. In this paper, we measured the PAPR to various the roll-off factor of RRC (Root Raised Cosine filter) which is filtering the modulated HRIT signal for reducing ISI (Inter-Symbol Interference) and bandwidth. It was found that the minimum PAPR is 2.78dB at 0.5 of roll-off factor for scrambled data. It's 2.78dB of P APR will be in output power selecting in COMS earth station.

• Proceedings of the IEEK Conference
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• 2002.06a
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• pp.153-156
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• 2002

An adaptive predistorr is proposed to compensate for the nonlinear distortion of a high power amplifier (HPA) in 16 QAM system. It fumed out that the proposed predistorter using a variable step-size least mean square (VSSLMS) algorithm is stable and can reduce the Total Distortion (TD) to 0. 1dB at the HPA output backoff=0.0 dB.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.25 no.8B
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• pp.1341-1347
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• 2000

For the DRT satellite transponder system, BER and total SNR to be required in the earth terminal are evaluated under the condition of HPA nonlinearity in the FBJ(full-band jamming) or PBJ(partial-band jamming) of uplink and downlink. In case that the satellite Inter bandwidth( Ws) is same to the earth terminal bandwidth($W_r$),in conditions of uplink JSR 10[dB], downlink JSR 10[dB] and processing gain 30[dB], linear transponder system shows that uplink SNR needs to be 14.2[dB] to achieve the total SNR 10[dB] requirement in downlink SNR 14[dB]. However, Nonlinear transponder system with OBO(output backoff) 2[dB] requires 20.1 [dB] uplink SNR. From the above results, the nonlinearity of HPA in the satellite transponder causes the degradation of BER performance so that it is of interest to consider the power increase.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.17 no.1
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• pp.11-17
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• 2017

Purpose: Phenylketonuria (PKU) results from a deficiency of phenylalanine hydroxylase (PAH). The mutation of the PAH gene results in decreased phenylalanine hydroxylase enzyme activity in hyperphenylalaninemia (HPA) patients. This study reports ten cases of patients with the benign HPA genotype c.158G>A (p.Arg53His, R53H) variant in the PAH gene and aims to evaluate the clinical significance of the R53H variant. Methods: Ten Korean patients with the HPA genotype the R53H variant were included in this study. A retrospective medical record review was conducted. We characterized the phenotypes of the patients with HPA with the R53H variant using the following system: classic PKU, moderate PKU, mild PKU, Mild HPA, and benign HPA. Results: Five patients had the R53H variant with the "Pathogenic" variants (R413P, R241C, $Y356^*$, c.442-1G>A, $Y325^*$), Two patients had the "Likely pathogenic" variants ($W187^*$, A259T), Two patients had the "Uncertain significance" variants (R53H, G344D), and One patient had the "Not provided" variant (c.1066-14C>G). Nine patients genotyped with the R53H variant were the patient with benign HPA and One patient genotyped with the R53H homozygote was within normal range of plasma phenylalanine. None of the ten patients required dietary restriction of phenylalanine or pharmacotherapy to maintain their plasma phenylalanine levels and showed no clinical symptoms of HPA. Conclusion: Ten patients with HPA genotype the R53H variant were the patient with benign HPA and showed no clinical symptoms of HPA. Thus, the R53H variant, which was previously classified as an "Uncertain significance" mutation in HPA patients, should be re-classified as "Benign."

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.10 no.7
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• pp.1044-1052
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• 1999

A 2-stage 1 watt MMIC(Monolithic Microwave Integrated Circuits) HPA(High Power Amplifiers) at 20 GHz band has been designed and fabricated. The $0.15\mu\textrm{m}$ with the width of $400\mu\textrm{m}$for single device pHEMT technology was used for the fabrication of this MMIC HPA. Due to the series feedback technique from source to ground, bias circuits and stabilization circuits on the main microstrip line, the stability factors(Ks) are more than one at full frequency. The independent operation for each stage and excellent S11, S22 less than -20 dB have been obtained by using lange couplers. For beginning the easy design, linear S-parameters have been extracted from the nonlinear equivalent circuit in foundry library, and equivalent circuits of devices at in/output ports were calculated from this S-parameters. The measured performances, which are in well agreement with the predicted ones, showed the MMIC HPA in this paper has the minimum 15 dB of linear gain, -20 dB of reflection coefficients and 31 dBm of output power over 17~25 GHz.