• Proceedings of the KSCN Conference
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• 2005.10a
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• pp.85-85
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• 2005

• Tuberculosis and Respiratory Diseases
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• v.47 no.2
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• pp.239-246
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• 1999

Hyperhomocysteinemia is an independent risk factor for cardiovascular, cerebrovascular and peripheral vascular diseases complicated with atherosclerosis and thromboembolism. Increased plasma homocystein level develops from genetic defect of enzyme for homocystein metabolism or vitamine deficiency, has direct toxic effect for vascular endothelium and makes damages to antithrombotic action of vascular endothelial cell. Most of hyperhomocysteinemia is asymptomatic, but rarely develops cardiopulmonary or cerebrovascular accidents. In case of thromboembolism with unknown cause, the hyperhomocysteinemia should be considered as one of the many etiologies. The authors, first in korea, report a case of multiple thromboembolisms of deep vein of lower extremity, pulmonary vessels, superior sagittal and transverse sinus of brain in a patient with the hyperhomocysteinemia with a review of literature.

• Journal of the East Asian Society of Dietary Life
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• v.18 no.1
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• pp.104-110
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• 2008

This research was designed and implemented to evaluate how the composition of yaksuncha can affect the health of individuals suffering from diet-related diseases such as obesity and hyperlipidemia by prescribing Yaksun as a nutritional supplement with daily meals. The yaksunucha was prepared as Koekac, Sansa, Heshouwu and Woolong tea and the tea's effects on serum lipids and oxidative stress were evaluated by clinical procedures. The yaksuncha significantly increased HDL-cholesterol and decrease of LDL-cholesterol concentrations in serum. It also had significant effects on decreasing oxidative stress and homocystein levels. The physical characteristics of the yaksunucha were also examined, showing. Brix, pH and titratable acidity values of 1.4, 5.50 and 0.05% respectively. It is thought that scientific and objective evaluations were completed on the components of the yaksuncha prescription. Thus one can concluded that the components could be applied not only in the form of tea, but also various food. The data derived from this study provides basic information that will aid in the application of oriental medicinal resources to other foods as well as facilitate the study of medicinal herbs within the field of functional food research, which already draws sizable attention worldwide.

• Proceedings of the Korean Society of Crop Science Conference
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• 2006.04a
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• pp.448-449
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• 2006

• Journal of Sasang Constitutional Medicine
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• v.18 no.1
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• pp.132-137
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• 2006

1. Objectives The purpose of this research is to find out the Constitutional difference between the amount of Plasma Homocysteine, Total cholesterol, and Triglyceride which are factor of Cerebrovascular disease. 2. Methods We enrolled 132 patients inexperienced Strokes who visited our hospital for a medical examination from April 26, 2004 to June 29, 2005 except patients whose body constitusions were undetermined according to QSCOII. This research investigated the Constitutional difference between the amount of Plasma Homocysteine, Total cholesterol and Triglyceride. 3. Results & Conclusions This research has shown that there is a statistical significance between the average amount of Plasma Homocystein level that is higher in Taeumin. But there is no significant difference between the average amount of Total Cholestrol and Triglyceride in Sasang Constitution.

• Animal cells and systems
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• v.11 no.2
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• pp.161-164
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• 2007

Oxidative stress is prerequisite for the development of atherosclerosis. Apart from the traditional risk factors that contribute to this devastating condition, in the past few decades, much attention has been focused on plasma total homocysteine mainly because of its strong association with coronary artery disease. It has been suggested that homocysteine induces oxidative stress and hence the present work was undertaken to assess the total homocysteine status and plasma total antioxidant capacity in the acute myocardial infarction (AMI) patients among Tamil population. The study subjects included only the Tamil population. Blood samples were collected from 100 AMI patients and 100 controls. Plasma was separated and the total antioxidant status was assessed as a measure of ferric reducing power of antioxidants using spectrophotometric method. Plasma total homocysteine concentrations were assessed by automated chemiluminescence method. While Total antioxidant status was significantly decreased, the plasma homocysteine concentrations were elevated in AMI patients compared to the controls. However, there was no correlation between the homocysteine levels and total antioxidant status. The findings of this study may have therapeutic implications, including food sources rich in antioxidants for all AMI patients to minimize the effect of free radicals formed during oxidative stress among Tamil population.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.20 no.3
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• pp.248-258
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• 2013

Purpose: The purpose of this study was to compare the associations of body mass index (BMI) and waist circumference (WC) with coronary artery diseases (CAD) in women patients with chest pain. Method: BMI, WC, and flow-mediated vasodilation (FMD) were measured for 162 women patients with chest pain whose mean age was $54.9{\pm}9.2$ years. CAD was diagnosed by coronary angiography. Results: In comparing BMI and WC, WC was found to be more strongly associated with cardiovascular risk factors. For example, correlations with the high density lipoprotein cholesterol were r=-.266, p=.001 (WC) vs. r=-.131, p=.104 (BMI), and for homocystein, r=.378, p<.001 (WC) vs. r=.150, p=.068 (BMI). Obstructive CAD develops more frequently in women patients with abdominal obesity than in patients without abdominal obesity. Conclusion: The results of the study indicate that WC is a better index of adiposity than BMI.

• The Korean Journal of Food And Nutrition
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• v.27 no.3
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• pp.470-477
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• 2014

The purpose of this study was to investigate the association of homocysteine and antioxidant nutrients with obesity in Korean middle aged women. The study subjects included were middle-aged obese women (n=36) whose body mass index (BMI) was greater than $25kg/m^2$. A total of 36 participants were randomly divided into two groups. They were assigned to either the Nutritional Management and Exercise (NME) program or the Exercise Management (EM) program, which were both conducted for 3 months. We measured serum homocysteine, total cholesterol and HDL cholesterol levels of the participant. We also measured the dietary intakes of antioxidant nutrient, cholesterol, body weight, body mass index, blood pressure, and $VO_2$. At the end of both programs, please confirm this change. It was unclear when these measurements were shown to have decreased. The body weight and BMI of NME group were decreased compared to those of EM group. The serum total cholesterol levels of the participants in NME group were significantly decreased, in contrast to EM group. Also, serum homocysteine levels of NME group participants were decreased compared to EM group, but the difference was not statistically significant. In the NME group, there were significant differences in the change of dietary cholesterol and vitamin C intake. These results showed that participating NME program will continuously promote the healthy status of the middle aged obese women, compared to participating only in the EM program.

• Preventive Nutrition and Food Science
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• v.8 no.4
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• pp.390-394
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• 2003

In the post-genome period, the technique for identifying gene expression has been progressed to high throughput screening. In the field of molecular nutrition, the use of screening techniques to clarify molecular function of specific nutrients would be very advantageous. In this study, we have evaluated Zn-regulated gene expression in Zn-deficient, homocystein-treated EA.hy926 cells, using cDNA microarray, which can be used to screen the expression of many genes simultaneously. The information obtained can be used for preliminary assessment of molecular and signaling events modulated by Zn under pro-atherogenic conditions. EA.hy926 cells derived from human umbilical vein endothelial cells were cultured in Zn-adequate (control, 15 $\mu$M Zn) or Zn-deficient (experimental, 0 $\mu$M Zn) Dulbecco's MEM media under high homocysteine level (100 $\mu$M) for 3 days of post-confluency. Cells were harvested and RNA was extracted. Total RNA was reverse-transcribed and the synthesized cDNA was labeled with Cy3 or Cy5. Fluorescent labeled cDNA probe was applied to microarray slides for hybridization, and the slide was then scanned using a fluorescence scanner. The expression of seven genes was found to be significantly decreased, and one significantly increased, in response to treatment of EA.hy926 cells with Zn-deficient medium, compared with Zn-supplemented medium. The upregulated genes were oncogenes and tumor suppressor genes, cell cycle-related genes and transporter genes. The down-regulated gene was RelB, a component of the NF-kappaB complex of transcription factors. The results of this study imply the effectiveness of cDNA microarray for expression profiling of a singly nutrient deficiency, namely Zn. Furthur study, using tailored-cDNA array and vascular endothelial cell lines, would be beneficial to clarify the molecular function of Zn in atherosclerosis, more in detail.

• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.5
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• pp.1180-1186
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• 2006

This research was planned and executed to evaluate how the composition of Yak-sun(oriental diet therapy) can effect health conditions of people who are suffering from diet-related diseases like obesity and hyperlipidemia by taking Yak-sun in a form of nutritional supplement with our daily meals. We produced Jangswucha with Koekac, Sansa, Heshouwu, Wulong and evaluated how this tea effects on serum lipids and oxidative stress by clinical practices. Also we examined physical characteristics of Jangswucha. Brix, pH and titratable acidity of Jangswucha were 1.4, 5.50 and 0.05%. With this observation, we found out that this tea has significant effect on increase of HDL-cholesterol, decrease of LDL-cholesterol concentration in serum. Also this tea significant effect on decrease oxidative stress and homocystein content. We think that scientific and objective evaluation was done on the components of Yak-sun tea prescription. We concluded that we could apply the components not only in a form of tea, but also in other forms of various food. The information we received from this conclusion will be a basic information on how we can apply oriental medicinal resources into other food and will also be a steppingstone for medicinal herbs to step foot in the field of functional food research, which already draws sizable attention world-wide.