• Title/Summary/Keyword: higher-pair

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Effect of Ethanol Consumption on Growth and Vitamin A Status in Rats Fed $\beta$-Carotene Supplemented Diets (에탄올 섭취가 $\beta$-Carotene을 급여한 흰쥐의 성장 및 비타민 A 상태에 미치는 영향)

  • 서정숙;임화자
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.27 no.4
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    • pp.731-738
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    • 1998
  • The present study was aimed to investigate the effect of dietary supplementation of $\beta$-carotene on vitamin A metabolism in ethanol-fed rats. Sprague-Dawley rats weighing 190~210g were fed a liquid diet containing 36% of total calories as ethanol for 6 weeks. The pair-fed control rats(1BP group, 2BP group) were given an isocaloric amount of diet containing sucrose instead of ethanol on the following day. Additionally, the liquid diet, contained different levels of $\beta$-carotene(1BE group: 2.1, 2BE group: 21mg/L liquid diet). Body weight gains and food efficiency ratios of ethanol groups were lower than those of pair-fed groups. This effect did not change with dietary supplementation of $\beta$-carotene. The levels of plasma and hepatic retionl were decreased after chronic ethanol feeding, but the values in 2BE group were higher than in 1BE group. The content of hepatic retinoic acid tended to increase in proportion to $\beta$-carotene supplementation. There results suggest that ethanol consumption may affect the vatamin A methabolism and reduce the conversion of $\beta$-carotene to retinol in rats.

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Bioinformatics Approach to Direct Target Prediction for RNAi Function and Non-specific Cosuppression in Caenorhabditis elegans (생물정보학적 접근을 통한 Caenorhabditis elegans 모델시스템의 생체내 RNAi 기능예측 및 비특이적 공동발현억제 현상 분석)

  • Kim, Tae-Ho;Kim, Eui-Yong;Joo, Hyun
    • KSBB Journal
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    • v.26 no.2
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    • pp.131-138
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    • 2011
  • Some computational approaches are needed for clarifying RNAi sequences, because it takes much time and endeavor that almost of RNAi sequences are verified by experimental data. Incorrectness of RNAi mechanism and other unaware factors in organism system are frequently faced with questions regarding potential use of RNAi as therapeutic applications. Our massive parallelized pair alignment scoring between dsRNA in Genebank and expressed sequence tags (ESTs) in Caenorhabditis elegans Genome Sequencing Projects revealed that this provides a useful tool for the prediction of RNAi induced cosuppression details for practical use. This pair alignment scoring method using high performance computing exhibited some possibility that numerous unwanted gene silencing and cosuppression exist even at high matching scores each other. The classifying the relative higher matching score of them based on GO (Gene Ontology) system could present mapping dsRNA of C. elegans and functional roles in an applied system. Our prediction also exhibited that more than 78% of the predicted co-suppressible genes are located in the ribosomal spot of C. elegans.

Evaluation of inactivation kinetics on pathogenic microorganisms by free chlorine/UV hybrid disinfection system (전해 염소수/자외선 결합 시스템을 이용한 병원성 미생물의 불활성화 키네틱스 평가)

  • Seo, Young-Seok;Kim, Aerin;Cho, Min
    • Journal of Korean Society of Water and Wastewater
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    • v.33 no.5
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    • pp.379-388
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    • 2019
  • Chlorination and UV illumination are being widely applied to inactivate a number of pathogenic microbials in the environment. Here, we evaluated the inactivation efficiency of individual and combined treatments of chlorination and UV under various aqueous conditions. UV dosage was required higher in waste water than in phosphate buffer to achieve the similar disinfecting efficiency. Free chlorine generated by electrolysis of waste water was abundant enough to inactivate microbials. Based on these, hybrid system composed of sequential treatment of electrolysis-mediated chlorination and UV treatment was developed under waste water conditions. Compared to individual treatments, hybrid system inactivated bacteria (i.e., E. coli and S. typhimurium) and viruses (i.e., MS-2 bacteriophage, rotavirus, and norovirus) more efficiently. The hybrid system also mitigated the photo re-pair of UV-driven DNA damages of target bacteria. The combined results suggested the hybrid system would achieve high inactivation efficiency and safety on various pathogenic microbials in wastewater.

Discrimination between spontaneous and posed smile: Humans versus computers (자발적 웃음과 인위적 웃음 간의 구분: 사람 대 컴퓨터)

  • Eom, Jin-Sup;Oh, Hyeong-Seock;Park, Mi-Sook;Sohn, Jin-Hun
    • Science of Emotion and Sensibility
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    • v.16 no.1
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    • pp.95-106
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    • 2013
  • The study compares accuracies between humans and computer algorithms in the discrimination of spontaneous smiles from posed smiles. For this purpose, subjects performed two tasks, one was judgment with single pictures and the other was judgment with pair comparison. At the task of judgment with single pictures, in which pictures of smiling facial expression were presented one by one, subjects were required to judge whether smiles in the pictures were spontaneous or posed. In the task for judgment with pair comparison, in which two kinds of smiles from one person were presented simultaneously, subjects were to select spontaneous smile. To calculate the discrimination algorithm accuracy, 8 kinds of facial features were used. To calculate the discriminant function, stepwise linear discriminant analysis (SLDA) was performed by using approximately 50 % of pictures, and the rest of pictures were classified by using the calculated discriminant function. In the task of single pictures, the accuracy rate of SLDA was higher than that of humans. In the analysis of accuracy on pair comparison, the accuracy rate of SLDA was also higher than that of humans. Among the 20 subjects, none of them showed the above accuracy rate of SLDA. The facial feature contributed to SLDA effectively was angle of inner eye corner, which was the degree of the openness of the eyes. According to Ekman's FACS system, this feature corresponds to AU 6. The reason why the humans had low accuracy while classifying two kinds of smiles, it appears that they didn't use the information coming from the eyes enough.

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The Roles of Gold Plate (140${\mu}{\textrm}{m}$) Loaded on TLD-100 Chips in the High Energy Radiation Beams (고에너지 광자선속에서 TLD-100 chip 위에 있는 금박막(140 ${\mu}{\textrm}{m}$) 역할)

  • Vahc, Young-Woo;Park, Kyung Ran.
    • Progress in Medical Physics
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    • v.6 no.2
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    • pp.51-60
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    • 1995
  • Lithium Fluoride (LiF; TLD-100) crystal chips are normally used as thermolu minescence dosimeters (abbreviated as NC-100) for estimating the absorbed dose to the skin of a patient or in a solid water phantom undergoing radiotherapy with megavoltage photon (6 and 15MV) beams. In general, investigation has revealed a reduction in the sensitivity of NC-100 chips after many runs through heating cycles. A TLD-100 chip laminated with gold plate (140${\mu}{\textrm}{m}$) on the upper surface layer of its face toward the photon beam (abbreviated as GC-100) has properties different from that of a NC-100 chip activated by incident photons and contaminant electrons with various lower energies coming from the gantry head and air. Activation of the valence band electrons of GC-100 chips by incident photons, positrons and electrons-which come from the gold plate by mainly pair production process and partly from Compton scattering-results in more enhanced signal intensity, higher response per monitor unit, as well as a good linearity with monitor units and independence of dose rate. Since the electron beams (6 and 15 MeV) do not have the probability of pair production process with gold plate, there is only a small difference (about a 3.3% increase for 15 MeV) in the signal gaps in the TL readout for electron beams between GC- and NC-100 chips. The 3.3% increase is entirely due to the buildup caused by the 140 m gold plate. The sensitivity of GC-100 chips is much more susceptible to high energy photon beams than electron one because of pair production. The interaction of high energy photon with a material of high atomic number, such as the good plate in this case, results in a considerably significant probability of pair production. The gold plate on the NC-100 chips acts as not only an intensifier of their signals but also acts as a filter of contaminant electrons in therapeutic high energy X-ray beams.

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Effects of Psyllium Husk and Glucomannan on Serum Lipids, Fecal Fat Excretion and Body Fat in Rats Fed High-Fat Diet (차전자피와 글루코만난의 혼합 첨가가 고지방 식이를 한 흰쥐의 혈청지질과 변지방배설 및 체지방에 미치는 영향)

  • 임문이;장순애;이승근;이선영
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.32 no.3
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    • pp.469-473
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    • 2003
  • This study was conducted to determine the effect of a mixture of two water-soluble dietary fibers, psyllium husk and glucomannan, on serum lipids, fecal fat excretion and body fat. Twenty one female Sprague-Dawley rats were randomly assigned into three groups (control, pair-fed control and test group) and fed a high saturated fat (20% lard) diet (control diet) or a test diet (psyllium husk and glucomannan added to the control diet at the level of 0.9% and 0.68%, respectively) for 8 weeks. Pair-fed control rats were allowed to eat the amount of diet consumed by test group the preceding day. The body weight gain and food efficiency ratio of test group were significantly lower compared with these of control group. The mean values of body weight gain and food efficiency ratio were lower in test group than in pair-fed control group, but the difference was not significant. There were no differences in food intake. The dry weight and water content of feces and fecal fat excretion were markedly greater in test group than in control groups. Serum total cholesterol and triacylglycerol levels were significantly lower in test group than in two control groups.1'he rats of two control groups had higher body fat contents than that of test group. These results indicate that the combination of the two water-soluble dietary fibers, psyllium husk and glucomannan, can be used as a potent lipid-lowering agent in individuals consuming high saturated fat diet.

Synchronous Price Discovery of Cross-Listings

  • Chen, Haiqiang;Choi, Moon Sub
    • Management Science and Financial Engineering
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    • v.20 no.1
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    • pp.11-16
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    • 2014
  • Extending from Grossman and Stiglitz (1980), we provide an asset pricing model of a synchronously traded cross-listed pair under information asymmetry. Following Garbade and Silber (1983), the model further embraces multi-market price discovery in a dynamic framework. The implications are as follows: The price sensitivity of holdings is higher for informed traders than for uninformed traders; the largest cross-border price spread occurs in the absence of arbitrageurs; price discovery is more likely in markets with a larger population of informed traders; and parity convergence accelerates with a higher price elasticity of demand of arbitrageurs.

An anomalous dissociation of protonated cluster ions of DNA guanine-cytosine base-pair

  • Seong, Yeon-Mi;Han, Sang-Yun;Jo, Sung-Chan;Oh, Han-Bin
    • Mass Spectrometry Letters
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    • v.2 no.3
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    • pp.73-75
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    • 2011
  • In the collisionally-activated dissociation of the proton-bound cluster ions of DNA base guanine (G) and cytosine (C), $G{\bullet}{\bullet}H^+{\bullet}{\bullet}C$, the abundance of [$CH^+$] ions was found to be higher than that of [$GH^+$] despite the fact that G has a higher proton affinity than C. This unexpected observation seems to demonstrate another example that the simple kinetic method scheme does not work. We suggest that a kinetic factor or detailed dynamics governing the proton transfer and dissociation should be carefully considered in the applications of the kinetic method to the proton affinity measurements.

Effectiveness of a Motion Picture Contents in Middle School Career Education (중학교 진로교육에서 동영상 콘텐츠의 교육효과성 및 선호도에 대한 연구)

  • Chung, Yon-Soon;Yu, Byeong-Min;Roh, Kyung-Ran;Lee, Seung-Chul;Park, Hye-Jin
    • Journal of Agricultural Extension & Community Development
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    • v.18 no.1
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    • pp.101-128
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    • 2011
  • The purpose of this study is to find out the effectiveness of instructional method using by a motion picture at cognitive and affective learning domain, and students' preferences for instructional methods in middle school career education. The nonequivalent control group pretest-posttest research design was applied to an experimental group and to a control group. A pair of 75students from four classes participated in an experiment. The results show higher learning achievements both of cognitive and affective domains in experimental group than in control group. Higher students' preferences for instructional methods were found in experimental group than in control group. It is concluded that a motion picture could give a more concrete experience and a more pleasure to students than traditional lecture. Higher learning achievements in cognitive and affective learning domain of career education and higher preferences were came out in consequence of using a motion picture.

Distribution of Polycyclic Aromatic Hydrocarbon at Kongsfjorden in Spitsbergen, Svalbard Islands (북극 스발바드 군도 스피츠베르겐섬 콩스피요르드에서의 다환 방향족 탄화수소화합물의 분포 특성)

  • Kim, Gi Beom;Ha, Seong Yong;An, In Yeong
    • Journal of Environmental Science International
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    • v.13 no.9
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    • pp.819-826
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    • 2004
  • In order to elucidate the polycyclic aromatic hydrocarbon concentration and its origin in arctic area, four arctic brown algae (Laminaria saccharina, L. digita, Alaria esculenta, Desmarestia aculeata), one marine invertebrate (Echinoidea) and sediments were collected from Kongsfjorden in Spitsbergen from the late July to early August, 2003. In case of macroalgae, the young blade part above growth point and the old stipes and blades beneath growth point were separated and analyzed for polycyclic aromatic hydrocarbons (PAHs) in an attempt to check the mechanism of uptake in macroalgae to accumulate PAH. There was no difference in PAH concentrations between sampling sites (Stations B and C), species, and blades beneath and above growth point. PAH concentrations in all samples collected in this study were relatively higher than those reported in other areas of arctic. Especially, station C, which is known as an unpolluted area, showed 10 times higher PAH concentration (8,765 ng/g) in sediment than station A (694 ng/g) around harbor. In addition high PAH concentration, station C had very higher proportion of methylated PAH to parent PAH in sediment than station A. Source analysis using PAH isomer pair ratios as indicators showed that Kongsfjorden area seemed to be relatively contaminated with PAH derived from direct petroleum input.