• Mycobiology
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• 제35권1호
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• pp.16-20
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• 2007

Hypolipidemic effect of biopolymers extracted from culture broth (CP), mycelia (MP), and fruiting bodies (FP) of Auricularia auricula-judae was investigated in dietary-induced hyperlipidemic rats. The experimental animals were administrated (100 mg/kg body weight) with different biopolymers, daily for 4 weeks. Hypolipidemic effects were achieved in all the experimental groups, however, FP was proved to be the most potent one. The administration of the FP reduced the plasma triglyceride, total cholesterol, low-density lipoprotein cholesterol, and atherogenic index by 24.3, 28.5, 36.4, and 40.9%, respectively, while increased the high-density lipoprotein cholesterol level (9.0%), when compared to the saline (control) administered group.

• 농업과학연구
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• 제47권3호
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• pp.437-443
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• 2020

The aim of this study was to evaluate the effect of Lactobacillus acidophilus probiotic (LAP) product supplementation on the blood profile, fecal noxious gas emission, and fecal shedding of lactic acid bacteria and coliform bacteria in healthy adult Beagle dogs. In total, 14 Beagle dogs with an average initial body weight of 10.19 ± 0.61 kg were randomly assigned into two dietary treatments,with and without LAP supplementation, for a 28-day feeding trial. At the end of the experiment, there was no significant (p > 0.05) difference in the concentration of serum total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), white blood cell (WBC), red blood cell (RBC), blood lymphocyte percentage, fecal hydrogen sulfide (H₂S) and total mercaptans (R.SH) emission, and fecal coliforms counts. However, the serum concentrations of the triglyceride and fecal ammonia (NH₃) emission of the LAP treatment were significantly (p < 0.05) decreased in the group compared with the CON dogs. Fecal total lactic acid bacteria counts were significantly (p < 0.05) increased in the LAP treatment. In conclusion, the supplementation of LAP in Beagle dog diets could decrease the blood triglyceride level and enhance the gut Lactobacillus count which may have positive effects on dogs.

• Journal of Nutrition and Health
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• 제26권6호
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• pp.672-679
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• 1993

This study was designed to determine changes of serum glucose and lipid levels in noninsulin dependent diabetes mellitus patients during different doses of docosahexaenoic acid (DHA)-rich fish oil supplementation. All patients had a fasting blood glucose of less than 180mg/dl, a LDL-cholesterol of less than 160mg/dl, and a triglyceride of more than 160mg/dl. None had clinical evidence of renal, hepatic or coronary vascular disease. Sixteen patients served as control. Seven patients ingested 2.00g of fish oil(low dose group), consisting of 0.30g eicosapentaenoic acid(EPA) and 0.55g DHA. The group of modest dose(n=9) was provided 3.91g of fish oil, consisting 0.59g EPA and 1.08g DHA. After 4 weeks, serum triglyceride concentration showed a mild but nonsignificant elevation in control group, a 9% decrease(194 to 177mg/dl) in the group of low dose of fish oil and a 28% decrease(206 to 161mg/dl) in the group of modest dose. The level of high density lipoprotein(HDL), HDL2, HDL3 and total cholesterol in all groups were not changed. There was a mild increase in malondialdehyde and low density lipoprotein(LDL)-cholesterol concentration and decrease in $\alpha$-tocopherol concentration. However, these changes were not significant.

• Nutrition Research and Practice
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• 제2권2호
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• pp.62-67
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• 2008

The present study was carried out to evaluate the physiological effects of seaweed supplementation on blood glucose levels, lipid profile, and antioxidant enzyme activities in subjects with type 2 diabetes mellitus. Subjects were randomized into either a control group or a seaweed supplementation group. Pills with equal parts of dry powdered sea tangle and sea mustard were provided to the seaweed supplementation group three times a day for 4 weeks. Total daily consumption of seaweed was 48 g. We found that total dietary fiber intake was 2.5 times higher in subjects receiving seaweed supplementation than in the control group. Accordingly, fasting blood glucose levels (p<0.01) and 2-hour postprandial blood glucose measurements (p<0.05) were decreased significantly in those ingesting seaweed. Furthermore, the serum concentrations of triglycerides were decreased and high-density lipoprotein cholesterol was increased significantly in seaweed supplement group (p<0.05). However, the concentrations of total cholesterol and low-density lipoprotein cholesterol were not affected by seaweed supplementation. The level of thiobarbituric acid reactive substances in erythrocytes was significantly lower with seaweed supplementation compared to controls (p<0.05). Catalase and glutathione peroxidase activities with seaweed supplementation were higher than the controls (p<0.05), but superoxide dismutase activity was not affected. We, therefore, conclude that ingestion of seaweed influences glycemic control, lowers blood lipids, and increases antioxidant enzyme activities.

• 식품보건융합연구
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• 제8권6호
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• pp.1-10
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• 2022

Hypercholesterolaemia is one of the risk factors of coronary health in humans; hence this research was to investigate the effect of Parkia biglobosa seeds fermented with Lactobacillus plantarum on the cardiac risk factors of diet-induced hypercholesterolaemic Wistar rats. Hypercholesterolaemia in rats were experimentally induced and the hypercholesterolaemic Wistar rats were treated with iru samples. The total cholesterol, triglyceride, high density lipoprotein (HDL), low density lipoprotein (LDL), liver biomarkers and cardiac risks factors were determined after inducement and treatment with iru. Fourteen (14)-days after inducement, the rats in the group induced had the highest weight of 112.40 g while the control group had 94.30 g. The total cholesterol (TC) in the induced group was 100.80 mg/dl while the control had 51.40 mg/dl, triglyceride (TG) in the induced group was 111.75 mg/dl while the control group had 68.45 mg/dl. After 28 days of treatment, the group treated with fermented samples showed a reduction in the TC (100.80 to 56.99 mg/dl), Triglyceride (111.75 to 32.53 mg/dl), LDL (49.48 to 6.65 mg/dl), cardiac risk ratio (3.36 to 1.28), atherogenic coefficient (3.13-0.29) and atherogenic index (0.57 to 0.11). The result from this study reveals that fermented Parkia biglobosa sample reduced the cardiac risk of rats significantly.

• 한국응용과학기술학회지
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• 제37권2호
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• pp.162-172
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• 2020

녹두(Phaseolus aureus L.)가 당뇨 유발 흰쥐에 있어서 혈당 및 지질성분, 단백질, 전해질 농도 등에 미치는 영향을 확인하기 위하여 기본 식이를 섭취시킨 BD군, 기본 식이군에 5% 녹두 급여군(BM군), 당뇨 유발 실험군(BS군)과 BS군에 5% 녹두를 섭취시킨 실험군(SM군)으로 나누어 실험을 수행하였다. 혈청 지질성분(총 콜레스테롤, LDL-콜레스테롤, 중성지질, 인지질, 유리 콜레스테롤, 콜레스테롤 에스테르), 혈당 및 유리지방산(non esterified fatty acid, NEFA)의 농도와 동맥경화지수(atherosclerotic index, AI), 심혈관 위험지수(cardiac risk factor, CRF)는 당뇨 유발군에서 여타 실험군과 비교하였을 때 유의적인 차이를 보이며 증가를 나타내었고(p<0.05), 5% 녹두 급여군에서 감소되는 것으로 나타났다. 당뇨유발군인 BS군에 비해 5% 녹두를 첨가시킨 SM군에서 고밀도 지단백 콜레스테롤(high density lipoprotein-cholesterol, HDL-콜레스테롤) 및 총 콜레스테롤에 대한 HDL-콜레스테롤의 농도 비는 유의적인 차이를 보이며 증가를 나타내었다(p<0.05). 혈청 단백질 농도에 있어서, 당뇨 유발군(BS군)에 5% 녹두를 급여(SM군)한 흰쥐의 혈청 알부민(albumin) 농도와 알부민/글로불린 비(albumin/globulin ratio, A/G 비)는 증가 하는 것으로 관찰되었다. 나트륨(Na) 및 염소(Cl)는 SM군에서 BS군 보다 농도가 감소된 것으로 확인하였다. 이상의 결과, 5% 녹두는 흰쥐의 혈당 및 지질대사 기능 개선에 도움이 되는 것으로 판단된다.

• 한국응용과학기술학회지
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• 제36권1호
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• pp.47-58
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• 2019

울금(Curcuma longa L.)이 이상지질혈증 유발 흰쥐의 지질성분과 단백질 및 전해질 농도에 미치는 영향을 확인하기 위하여 기본 식이를 섭취시킨 ND군, 정상 실험군에 5% 울금 급여군(NT군), 이상지질혈증 유발 실험군(DD군)과 DD군에 5% 울금을 섭취시킨 실험군(DT군)으로 나누어 실험을 행하였다. 혈청 지질성분(총 콜레스테롤, LDL-콜레스테롤, 중성지질, 인지질, 유리 콜레스테롤, 콜레스테롤 에스테르), 혈당 및 유리지방산(non esterified fatty acid, NEFA)의 농도와 동맥경화지수(atherosclerotic index, AI), 심혈관 위험지수(cardiac risk factor, CRF)는 이상지질혈증군에서 여타 실험군과 비교하였을 때 유의적인 증가를 나타내었으며(p<0.05), 5% 울금 급여군에서 감소시키는 것으로 나타났다. DD군에 비해 DT군에서 고밀도 지단백 콜레스테롤(high density lipoprotein-cholesterol, HDL-콜레스테롤) 및 총 콜레스테롤에 대한 HDL-콜레스테롤 농도 비는 유의적인 증가를 보였다(p<0.05). 혈청 단백질의 농도에 있어서, DT군은 DD군에 비하여 흰쥐의 혈청 알부민(albumin) 농도와 알부민/글로불린 비(albumin/globulin ratio, A/G 비)의 증가 및 글로불린(globulin) 농도는 감소되는 것으로 관찰되었다. 나트륨(Na) 및 염소(Cl)는 DT군에서 DD군 보다 농도가 감소된 것으로 확인하였다. 이상의 결과, 5% 울금은 흰쥐의 혈청 지질성분 개선과 단백질 및 전해질 농도 조절에 도움이 되는 것으로 사료된다.

• Nutrition Research and Practice
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• 제17권6호
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• pp.1099-1112
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• 2023

BACKGROUND/OBJECTIVES: Dyslipidemia causes metabolic disorders such as atherosclerosis and fatty liver syndrome due to abnormally high blood lipids. Purple perilla frutescens extract (PPE) possesses various bioactive compounds such as α-asarone, chlorogenic acid and rosmarinic acid. This study examined whether PPE and α-asarone improved dyslipidemia-associated inflammation and inhibited atheroma formation in apolipoprotein E (apoE)-deficient mice, an experimental animal model of atherosclerosis. MATERIALS/METHODS: ApoE-deficient mice were fed on high cholesterol-diet (Paigen's diet) and orally administrated with 10-20 mg/kg PPE and α-asarone for 10 wk. RESULTS: The Paigen's diet reduced body weight gain in apoE-deficient mice, which was not restored by PPE or α-asarone. PPE or α-asarone improved the plasma lipid profiles in Paigen's diet-fed apoE-deficient mice, and despite a small increase in high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein (LDL)-cholesterol, and very LDL were significantly reduced. Paigen's diet-induced systemic inflammation was reduced in PPE or α-asarone-treated apoE-deficient mice. Supplying PPE or α-asarone to mice lacking apoE suppressed aorta atherogenesis induced by atherogenic diet. PPE or α-asarone diminished aorta accumulation of CD68- and/or F4/80-positive macrophages induced by atherogenic diet in apoE-deficient mice. Treatment of apoE-deficient mice with PPE and α-asarone resulted in a significant decrease in plasma cholesteryl ester transfer protein level and an increase in lecithin:cholesterol acyltransferase reduced by supply of Paigen's diet. Supplementation of PPE and α-asarone enhanced the transcription of hepatic apoA1 and SR-B1 reduced by Paigen's diet in apoE-deficient mice. CONCLUSIONS: α-Asarone in PPE inhibited inflammation-associated atheroma formation and promoted hepatic HDL-C trafficking in dyslipidemic mice.

• 동의생리병리학회지
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• 제17권3호
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• pp.693-699
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• 2003

This present study was carried out to investigate the body weight-regulatory effects of Chekamhanghyuluiyiin-tang plus Zeae Stigma in high fat diet-induced obese rats. Control group rats were fed with high fat diet and administered normal saline for 8weeks. Experimental groups rats were fed with high fat diet and administered extract of 2 kind of Chekamhanghyuluiyiin-tang plus Zeae Stigma each other for 8 weeks. And observed that, body weight of rats and total cholesterol, triglyceride, free fatty acid, total lipid, phospholipid, high density lipoprotein(HDL)-cholesterol, low density lipoprotein(LDL)-cholesterol in serum of rats, and glucose, insulin of rats. The results were as follows; 1. There were significant decrease of serum total cholesterol level in 7CH10 group. 2. There were significant decrease of serum total lipid level in 7CH5 group. 3. There were significant decrease of serum total lipid level in 7CH5 group. According to above mentioned results. Chekamhanghyuluiyiin-tang plus Zeae Stigma was expected to be applied to the prevention or treatment of obesity and its complications.

• 대한본초학회지
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• 제33권5호
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• pp.89-103
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• 2018

Objectives : This study is aimed to compare the changes in Antioxidative capacity of Liriopis Tuber by steaming process and to compare the effects in hyperlipidemia induced rats fed high cholesterol diet between Simvastatin and Liriopis Tuber by steaming process. Methods : The SD rats were divided into six groups: normal diet (Nor), high cholesterol diet (Veh), high cholesterol diet plus Simvastatin 5 mg/kg (Sim), high cholesterol diet plus LT0 extract 200 mg/kg (LT0), high cholesterol diet plus LT6 extract 200 mg/kg (LT6) and high cholesterol diet plus LT9 extract 200 mg/kg (LT9). We compared the total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL), low density lipoprotein cholesterol (LDL) contents and reactive oxygen species (ROS) from each serums. Protein expression in liver tissues related to antioxidant and cholesterol was analyzed. Results : The Antioxidant activity of Liriopis Tuber increased by steaming process. In vivo, TC, TG, LDL-c, atherogenic index (AI) and cardiac risk factor (CRF) decreased and HDL-c increased with increasing steaming frequency. aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine, and blood urea nitrogen (BUN) decreased with increasing steaming frequency. ROS decreased only in LT9, and SOD, catalase and glutathione peroxidase (GPx) increased with increasing steaming frequency. phospho-AMP-activated protein kinase (p-AMPK) increased and sterol regulatory element-binding protein 2 (SREBP-2), Phospho-Acetyl-CoA Carboxylase (p-ACC) and HMG-CoA reductase (HMGCR) decreased with increasing steaming frequency. Liver staining showed a decrease in hepatic fat accumulation of LT9. LT9 showed significant results in all experiments. Conclusions : LT9 showed significance of anti-lipid effect and improved fatty liver of hyperlipemia induced rats fed on high cholesterol diet, In conclusion, LP9 can be effectively used for the treatment of hyperlipidemia.