Journal of the Korean Applied Science and Technology (한국응용과학기술학회지)

The Korean Society of Applied Science and Technology (한국응용과학기술학회)
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Effects of Turmeric (Curcuma longa L.) on Lipid Component and Protein Concentration in Dyslipidemic Rats

울금(Curcuma longa L.) 첨가 식이가 이상지질혈증 흰쥐의 지질성분 및 단백질 농도에 미치는 영향

  • Oh, Da-Young (Department of Food Science and Technology, Pusan National University,) ;
  • Kang, Dong-Soo (1Department of Marine Bio Food Science, Chonnam National University,) ;
  • Lee, Young-Geun (Department of Food Science and Technology, Pusan National University,) ;
  • Kim, Han-Soo (Department of Food Science and Technology, Pusan National University,)
  • 오다영 (부산대학교 식품공학과) ;
  • 강동수 (전남대학교 해양바이오식품학과) ;
  • 이영근 (부산대학교 식품공학과) ;
  • 김한수 (부산대학교 식품공학과)
  • Received : 2019.01.23
  • Accepted : 2019.03.26
  • Published : 2019.03.31
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Abstract

This study aimed to investigate the improvement effect of turmeric (Curcuma longa L.) on the lipid component, protein and electrolyte concentration in dyslipidemic rats. Sprague-Dawley rats (24 male) were divided into four groups, namely the ND (normal-nondyslipidemic diet), NT (normal-nondyslipidemic diet+5% turmeric), DD (control-dyslipidemic diet), and DT groups (dyslipidemic diet+5% turmeric). Rats were sacrificed at the end of 5 weeks after experiment diet. In this study, turmeric diet (NT, DT) groups in lipid composition as evidenced from the significantly reduction of serum total cholesterol, low density lipoprotein-cholesterol (LDL-cholesterol), atherosclerotic index (AI), cardiac risk factor (CRF), triglyceride (TG), phospholipid (PL), free cholesterol, cholesteryl ester, blood glucose and non esterified fatty acid (NEFA), and elevation of high density lipoprotein-cholesterol (HDL-cholesterol) (p<0.05). The serum globulin concentration was significantly decreased (p<0.05), and the albumin concentrations were increased in turmeric diet than dyslipidemic rats. Concentrations of sodium (Na) and chlorine (Cl) in sera were lower in the DT group than DD group. Concentrations of total calcium (T-Ca), phosphorus (Pi) and potassium (K) in sera were higher in the ND, NT and DT groups than DD group. Therefore, it was concluded that the 5% turmeric diet used in the condition of this study had a beneficial effect on dyslipidemia.

울금(Curcuma longa L.)이 이상지질혈증 유발 흰쥐의 지질성분과 단백질 및 전해질 농도에 미치는 영향을 확인하기 위하여 기본 식이를 섭취시킨 ND군, 정상 실험군에 5% 울금 급여군(NT군), 이상지질혈증 유발 실험군(DD군)과 DD군에 5% 울금을 섭취시킨 실험군(DT군)으로 나누어 실험을 행하였다. 혈청 지질성분(총 콜레스테롤, LDL-콜레스테롤, 중성지질, 인지질, 유리 콜레스테롤, 콜레스테롤 에스테르), 혈당 및 유리지방산(non esterified fatty acid, NEFA)의 농도와 동맥경화지수(atherosclerotic index, AI), 심혈관 위험지수(cardiac risk factor, CRF)는 이상지질혈증군에서 여타 실험군과 비교하였을 때 유의적인 증가를 나타내었으며(p<0.05), 5% 울금 급여군에서 감소시키는 것으로 나타났다. DD군에 비해 DT군에서 고밀도 지단백 콜레스테롤(high density lipoprotein-cholesterol, HDL-콜레스테롤) 및 총 콜레스테롤에 대한 HDL-콜레스테롤 농도 비는 유의적인 증가를 보였다(p<0.05). 혈청 단백질의 농도에 있어서, DT군은 DD군에 비하여 흰쥐의 혈청 알부민(albumin) 농도와 알부민/글로불린 비(albumin/globulin ratio, A/G 비)의 증가 및 글로불린(globulin) 농도는 감소되는 것으로 관찰되었다. 나트륨(Na) 및 염소(Cl)는 DT군에서 DD군 보다 농도가 감소된 것으로 확인하였다. 이상의 결과, 5% 울금은 흰쥐의 혈청 지질성분 개선과 단백질 및 전해질 농도 조절에 도움이 되는 것으로 사료된다.

Keywords

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Fig. 1. Effects of turmeric (Curcuma longa L.) on serum blood glucose concentration in dyslipidemic rats.

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Fig. 2. Effects of turmeric (Curcuma longa L.) on serum non esterified fatty acid (NEFA) concentration in dyslipidemic rats.

Table 1. Compositions of experimental diet and groups

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Table 2. Effects of turmeric (Curcuma longa L.) on serum biochemical parameters, ratio of HDL-cholesterol to total cholesterol, AI and CRF in dyslipidemic rats

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Table 3. Effects of turmeric (Curcuma longa L.) on serum biochemical parameters and ratio of cholesteryl ester in dyslipidemic rats

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Table 4. Effects of turmeric (Curcuma longa L.) on serum total protein, albumin, globulin concentration and ratio of A/G in dyslipidemic rats

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Table 5. Effects of turmeric (Curcuma longa L.) on serum electrolyte concentration in dyslipidemic rats

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