• Title/Summary/Keyword: high isolation

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Design and experimental characterization of a novel passive magnetic levitating platform

  • Alcover-Sanchez, R.;Soria, J.M.;Perez-Aracil, J.;Pereira, E.;Diez-Jimenez, E.
    • Smart Structures and Systems
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    • v.29 no.3
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    • pp.499-512
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    • 2022
  • This work proposes a novel contactless vibration damping and thermal isolation tripod platform based on Superconducting Magnetic Levitation (SML). This prototype is suitable for cryogenic environments, where classical passive, semi active and active vibration isolation techniques may present tribological problems due to the low temperatures and/or cannot guarantee an enough thermal isolation. The levitating platform consists of a Superconducting Magnetic Levitation (SML) with inherent passive static stabilization. In addition, the use of Operational Modal Analysis (OMA) technique is proposed to characterize the transmissibility function from the baseplate to the platform. The OMA is based on the Stochastic Subspace Identification (SSI) by using the Expectation Maximization (EM) algorithm. This paper contributes to the use of SSI-EM for SML applications by proposing a step-by-step experimental methodology to process the measured data, which are obtained with different unknown excitations: ambient excitation and impulse excitation. Thus, the performance of SSI-EM for SML applications can be improved, providing a good estimation of the natural frequency and damping ratio without any controlled excitation, which is the main obstacle to use an experimental modal analysis in cryogenic environments. The dynamic response of the 510 g levitating platform has been characterized by means of OMA in a cryogenic, 77 K, and high vacuum, 1E-5 mbar, environment. The measured vertical and radial stiffness are 9872.4 N/m and 21329 N/m, respectively, whilst the measured vertical and radial damping values are 0.5278 Nm/s and 0.8938 Nm/s. The first natural frequency in vertical direction has been identified to be 27.39 Hz, whilst a value of 40.26 Hz was identified for the radial direction. The determined damping values for both modes are 0.46% and 0.53%, respectively.

Development of a novel reverse transcription PCR and its application to field sample testing for feline calicivirus prevalence in healthy stray cats in Korea

  • Kim, Sung Jae;Park, Yong Ho;Park, Kun Taek
    • Journal of Veterinary Science
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    • v.21 no.5
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    • pp.71.1-71.10
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    • 2020
  • Background: Feline calicivirus (FCV) is a major and highly infectious pathogen in cats worldwide. However, there have been limited studies about the status of FCV infections in Korea. Objectives: To investigate the current status of FCV infections in stray cats in Korea. Methods: A novel reverse transcription polymerase chain reaction (RT-PCR) assay was developed based on the conserved nucleotide sequences of reported FCV strains. Field swab samples were collected from 122 cats (2 hospital admitted cats and 120 stray cats) in 2016 and 2017. All the samples were tested by virus isolation and 2 different RT-PCRs, including the novel RT-PCR, for the detection of FCV. Results: The novel RT-PCR assay showed no cross-reactivity to the nucleic acids of the other feline pathogens tested, and the limit of detection was calculated as 100 TCID50/mL based on an in vitro assessment. The novel RT-PCR assay detected 5 positive samples from the 122 field samples, which showed perfect agreement with the results of the virus isolation method. In contrast, another RT-PCR assay used in a previous study in Korea detected no positive samples. The prevalence of FCV infection in stray cats was 2.5% (3/120) based on the results of virus isolation and the novel RT-PCR assays. Conclusions: The current study is the first report of the detection and prevalence of FCV in stray cats in Korea. The novel RT-PCR assay developed in this study showed high sensitivity and specificity, which indicates a useful diagnostic assay to identify FCV infection in cats.

Validation of the production quality and therapeutic efficacy of 47Sc through its anti-cancer effects against EGFR-targeted non-small cell lung cancer

  • Da-Mi Kim;So-Young Lee;Jae-Cheong Lim;Eun-Ha Cho;Ul-Jae Park
    • Journal of Radiopharmaceuticals and Molecular Probes
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    • v.8 no.1
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    • pp.9-15
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    • 2022
  • Anti-cancer and therapeutic effects using therapeutic radioisotopes have been demonstrated by various studies, and it is well-known that therapeutic radioisotopes are useful in cancer treatment. Recently, one of the therapeutic radioisotopes, scandium is emerging as a radioisotope applicable to PET imaging (43Sc, 44Sc) and therapy (47Sc) in cancer theranostic approach. However, 47Sc has little known radiobiological and therapeutic efficacy compared to other therapeutic radioisotopes. Here, we investigated the quality and therapeutic efficacy of 47Sc radioisotope produced by our production/isolation technology at the research reactor 'HANARO' in KAERI (Korea Atomic Energy Research Institute). We showed that the therapeutic efficacy of 47Sc, produced by our production/isolation technology, effectively suppressed epidermal growth factor receptor (EGFR)-targeted non-small cell lung cancer (NSCLC) cells. Consequently, these results suggest that the high quality of the produced 47Sc by our production/isolation technology enables the development of therapeutic strategies for cancer treatment and radiopharmaceuticals using 47Sc.

Design of Base Isolated Building Considering Performance Based Design (구조성능 목표를 고려한 면진설계)

  • Hwang, Kee-Tae;Lee, Hyun-Ho
    • Proceedings of the Korea Concrete Institute Conference
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    • 2004.05a
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    • pp.700-703
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    • 2004
  • The purpose of this study is to present the design methodology of base isolated buildings. To achieve the goal of this study, time-history analysis was performed with seismic performance level and recorded seismic data. From the analysis results of MDOF system, the maximum. displacement and base shear were evaluated as 25 cm and $4\%$ by the input level which is maximum velocity of 50 kine. By introducing hybrid isolation system, seismic energy can be concentrated consequently high seismic capacity of the total building is secured.

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Isolation of Angiotensin Converting Enzyme Inhibitory Peptide from Beef Bone Extract Hydrolysate

  • Park, Eun-Hee;Cho, Yong-Sik;Song, Kyung-Bin
    • Applied Biological Chemistry
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    • v.41 no.4
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    • pp.270-272
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    • 1998
  • Angiotensin converting enzyme (ACE) inhibitor was isolated from beef bone extract hydrolysate. After hydrolysis of beef bone extract with a commercial protease, ACE inhibitory peptide was purified by using ultrafiltration, gel permeation chromatography, and reverse-phase high pressure liquid chromatography. The purified ACE inhibitor was a pentapeptide, Gly-Pro-X-Gly-Pro.

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Prototype design of fiber optics based 765kV substation control system (광 LAN을 적용한 765kV변전소 감시제어 시범시스템 설계)

  • 송인호;박종화;최종협
    • 제어로봇시스템학회:학술대회논문집
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    • 1996.10b
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    • pp.996-999
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    • 1996
  • This paper introduces prototype design of 765kV Substation control system based on fiber optics LAN and distributed network protocol. Two major important facts, immunity of any surge which frequently occurs in Ultra High Voltage Substation and the most suitable communication protocol for substation control system, are considered on the system design conception. To meet the first fact, use of fiber optics cable and isolation transformer are considered, and to satisfy the second fact, DNP3.0(Distributed Network Protocol) which is IEC870-5 compatible is adopted.

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Active Vibration Control System Design for Nano-scale Stage (초정밀 스테이지용 능동 진동제어시스템 설계)

  • Lee, Joo-Hoon;Lee, Se-Han;Hwang, Don-Ha;Kim, Yong-Joo;Choi, Young-Kiu
    • Proceedings of the KIEE Conference
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    • 2004.07d
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    • pp.2495-2497
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    • 2004
  • A system, featuring the hybrid isolator for control in the vertical direction, of active microvibration control was proposed. The main components of this system are a stage vibration isolation table with built-in acceleration sensors for detecting microvibration, hybrid isolators and a digital controller with high precision signal converters. The vibration control algorithm is focused on settling-time critical application and feedback/feedforward combination.

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Active Microvibration Control System Using Maglev Actuator (자기부상방식의 능동 미세진동 제어시스템)

  • Lee, Joo-Hoon;Lee, Se-Han;Hwang, Don-Ha;Kim, Yong-Joo;Choi, Young-Kiu
    • Proceedings of the KIEE Conference
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    • 2004.07d
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    • pp.2492-2494
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    • 2004
  • A system, featuring the electromagnetic levitation actuator for control in the vertical direction, of active microvibration control was proposed. The main components of this system are a vibration isolation table with built-in acceleration sensors for detecting microvibration, electromagnetic levitation actuators with built-in permanent magnets and electromagnets, and a digital controller with high precision signal converters.

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Isolation of Kaempferol Glycoside from Lindera sericea and Anti-inflammatory Effect (털조장나무잎의 소염활성 및 Kaempferol 배당체의 분리)

  • 박종철;박주권;김종홍;김성환;김남재
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.25 no.3
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    • pp.519-522
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    • 1996
  • From the leaves of Lindera sericea Bl., kaempferol-3,7-0-di-a-L-rhamnopyranoside was isolated and characterized by spectral data and acid hydrolysis. This compound is reported for the first time from this plant. The content of kaempferol glycoside was high in May and June, and low in the fall. And the methoanolic extract of title plant showed the inhibitory effect on carrageenin-induced edema.

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