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http://dx.doi.org/10.22643/JRMP.2022.8.1.9

Validation of the production quality and therapeutic efficacy of 47Sc through its anti-cancer effects against EGFR-targeted non-small cell lung cancer  

Da-Mi Kim (Radioisotope Research Division, Department of Quantum and Convergence Sciences, Korea Atomic Energy Research Institute)
So-Young Lee (Radioisotope Research Division, Department of Quantum and Convergence Sciences, Korea Atomic Energy Research Institute)
Jae-Cheong Lim (Radioisotope Research Division, Department of Quantum and Convergence Sciences, Korea Atomic Energy Research Institute)
Eun-Ha Cho (Radioisotope Research Division, Department of Quantum and Convergence Sciences, Korea Atomic Energy Research Institute)
Ul-Jae Park (Radioisotope Research Division, Department of Quantum and Convergence Sciences, Korea Atomic Energy Research Institute)
Publication Information
Journal of Radiopharmaceuticals and Molecular Probes / v.8, no.1, 2022 , pp. 9-15 More about this Journal
Abstract
Anti-cancer and therapeutic effects using therapeutic radioisotopes have been demonstrated by various studies, and it is well-known that therapeutic radioisotopes are useful in cancer treatment. Recently, one of the therapeutic radioisotopes, scandium is emerging as a radioisotope applicable to PET imaging (43Sc, 44Sc) and therapy (47Sc) in cancer theranostic approach. However, 47Sc has little known radiobiological and therapeutic efficacy compared to other therapeutic radioisotopes. Here, we investigated the quality and therapeutic efficacy of 47Sc radioisotope produced by our production/isolation technology at the research reactor 'HANARO' in KAERI (Korea Atomic Energy Research Institute). We showed that the therapeutic efficacy of 47Sc, produced by our production/isolation technology, effectively suppressed epidermal growth factor receptor (EGFR)-targeted non-small cell lung cancer (NSCLC) cells. Consequently, these results suggest that the high quality of the produced 47Sc by our production/isolation technology enables the development of therapeutic strategies for cancer treatment and radiopharmaceuticals using 47Sc.
Keywords
Scandium-47; HANARO research reactor; Therapeutic efficacy; Epidermal growth factor receptor(EGFR)-targeted NSCLC;
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Times Cited By KSCI : 2  (Citation Analysis)
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