• The Journal of Dong Guk Oriental Medicine
• /
• v.4
• /
• pp.237-265
• /
• 1995

The inhibitory effects of Gleditschiae Spina, Cleditschia saponin, two complex prescriptions such as Takrisodokum and Kwaluubangtang, which contain Gleditschiae Spina, and their altered prescriptions on the activity of cyclooxygenase in vitro were investigated. The water extract of Gleditschiae Spina and Gleditschia saponin markedly inhibited the cyclo-oxygenase activity by 59% and 67%, respectively, at a concentration of $1mg/m{\ell}$, on the other hand, Takrisodokum and Kwaluubangtang showed 15% and 7% inhibition, respectively. The extracts with the substraction of Gleditschiae Spina and/or Platycodi Radix inhibited to a much smaller extent than Takrisodokum. However, in case of the extracts with the substraction of Gleditschiae Spina and/or Trichosanthis Semen, only one prescription, which does not contain Trichosanthis Semen, exhibited the same inhibition as Takrisodokum. From above results, Gleditschiae Spina was found to be most important for the effect of Takrisodokum and Kwaluubangtang on their antiinflammatory action. Instead of Gleditschiae Spina, another parts of this plant were added to both complex prescriptions and tested according to above methods, indicating that Gleditschiae Spina is more important than another parts for both prescriptions. When the administered dose of Gleditschiae Spina is increased(twofold and threefold) in both complex prescriptions, the inhibitory effect in Takrisodokum was diminished. however, the effect in Kwaluubangtang was increased.

• Herbal Formula Science
• /
• v.30 no.3
• /
• pp.145-154
• /
• 2022

Objective : This study aims to study core herbs and formulas in Internal medicine on Spleen system, to enhance efficiency in teaching Internal medicine on Spleen system, Herbalogy, Formula science, and to increase integration of the courses. Methods : Frequency notion, which was generally used in previous studies, was used in this study along with network analysis. Results : Frequently used herbs, herbs with high centrality, frequently combined herbs and core formula were found in this study. The herb with the highest frequency and centrality was 'Citri Unshius Pericarpium', and 'Atractylodis Rhizoma Alba - Citri Unshius Pericarpium' was the most frequent herb combination. The results of network analysis showed a total of 5 herbal communities of combination. Conclusion : Core herbs were found based on the frequency notion, which is a traditional analysis method. Also, core herbs, herbal combinations, formulas that can that may be overlooked when using frequency notions were found by using network analysis. The results may lead to enhancing efficiency in the education of Internal medicine on Spleen system, Herbalogy, Formula science courses and the integration of courses.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.20 no.4
• /
• pp.951-956
• /
• 2006

The purpose of this study is to prepare black ginseng and evaluate its antitumor activity. In order to achieve such aim, 5 year fresh ginsenges were steamed at 95'E for 3 hr in pottery apparatus and dried at $60^{\circ}C$ for 12-36 hr. This process was repeated again nine times in same condition. Among the ginseng saponins in black ginseng, the amount of Ginsenoside $Rg_3$ was examined by HPLC. 10.05 mE of Ginsenoside $Rg_3$ was obtained from 1 g of dried black ginseng prepared. The extract of black ginseng exhibited stronger cytotoxic activity against MCF-1, HT-1080 and Hepa 1C1C7 tumor cell lines in vitro than the extract of red ginseng. Also, the extract of black ginseng exhibited stronger antitumor activity(33%) in BDFl mice bearing Lewis lung carcinoma cells(LLC) than the extract of red ginseng(23%). From these results, it was concluded that Black ginseng had antitumor activity suggesting its application for the prevention and treatment of cancer.

• The Journal of Korean Medicine
• /
• v.16 no.1 s.29
• /
• pp.475-498
• /
• 1995

For the purpose of developing Korean Herbalogy with the plants of Urticaceae which grow wild and is planted in Korea, the these and writings on herbalogy, from literature of successive generations, have been thoroughly investigative and the results obtained were as follows: 1. There were totaled 11 genera and 44 species in Korea and among them medecinal plants are 9 genera, 19 species, some 43% in total but the number of species may be added because of similar plants. 2. According to the oriental name which can be used for medical purpose, the medicinal plants beloning to the Urticaceae were classified as Herba 10, Radix 8, Folium 3, Cortex 1, Flos 1, Rhizoma 1. Thus it was noticed that Herba was the main kind. 3. According to sum of 44 species in Urticaceae they were classified into Boehemeria genera 18, Urtica genera 9, Pliea genera 5, Elastosma genera 3, Parietaria genera 2, Pellionia genera 2, Achudemia 1, Debregeasia genera 1, Girardinia genera 1, Laportea genera 1, Nanocnide genera 1 etc. Thus it was noticed that Boehemeria genera was the main kind, some 41% in total. 4. According to nature and flavour of medicinal plants, they were classified into cold, cool; 6 each, wormth, heat; 4 each, balance 3. Thus it was noticed that cold and cool is the main in nature and flavour of medicinal plants. 5. According to the Properties and Principal Curative action, they were classified into, clearing up heat and toxin 9, drugs for urination an removing abscess 7, drugs for circulating blood and hemostasis 7, drugs for expelling wind 5, drugs for comporting embryo 4, 6. Comparing to whole medicinal plants 44 kinds, toxic durgs include minor toxin were 2 kinds, 5% of the whole. Thus toxic durgs were rare. From this result, It was revealed that the plants for medical purpose in Urticaceae was 43% kinds of the whole, in which Herba was mostly abundunt, toxic plants were so rare that it will be used for clinical treatments more easily. It is considered that many clinical experiments and approaches must be continued to use widely.

• Korean Journal of Pharmacognosy
• /
• v.31 no.1
• /
• pp.51-56
• /
• 2000

This study was carried out to evaluate cytotoxic effects of the roots of Sophora flavescens Ait. extracts on murine leukemia tumor cells lines $(P388D_1\;and\;L1210)$. Disruptions in cell organelles were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. The comparison of $IC_{50}$ values of the ethyl acetate of Sophora flavescens Ait. extract in leukemia cell lines showed that their susceptibility to these extracts decreased in the following order : Adriamycin>Fr.4>Fr.5>Fr.3>Fr.1>Fr.2 by the MTT assay. These results suggest that the fraction 4 of the ethyl acetate soluble extract of Sophora flavescens Ait. may be a valuable choice for the studies on the treatment of murine leukemia cell lines.

• Journal of Korean Medical Ki-Gong Academy
• /
• v.7 no.2
• /
• pp.134-145
• /
• 2004

Qi. in ancient east Asian Philosophy and medicine, was the quintessential concept symbolizing material orgin of the world. It was considered as the original matter of the world, and the genesis, development and extinction of everything in heaven and earth was explained through the movement of Qi. Despite its importance, the interpretation of Qi has brought about various bifurcations in the history of Oriental medicine. It is comprehended either as ideal concept, or as actual entity. Also, there exists synthetic idea of considering both sides of Qi. These ideas results from obscure understanding based on textual interpretation apart from actual experince. When experincing Qi through discipline, however, man can understand Qi concretly and actually and even grasp the explanation of the cosmos and life. One problem of Qi discipline was that it couldn't ascend the stage of subjective experience. Now, with the method of 'Hanalmomjit'. a developed form of zifadonggong(自發動功), I could reach coherent results to offer the foundation of objective understanding of Qi. The testees, disciples of Hanalmomjit, could express the characters of herbs in their Qigong actions, and the expression was meaningful and coherent to be considered as expressing the effects described in the classics of herbalogy. This result comes from the capacity of grasping external Qi-status, not only expressing the internal communication of jingluo(經絡) in Hanalmomjit.

• The Journal of Korean Medicine
• /
• v.23 no.1
• /
• pp.61-66
• /
• 2002

목적： 본 연구는 감미의 작용에 관한 "감보" 등의 이론적 바탕과 약물의 이화학적인 특성을 통해 약효를 어느 정도 예측하고자 하였다. 방법： 한약재의 오미별 이화학적 특성을 구명하기 위하여 수소이온농도(pH), $200^{\circ}C$와 $550^{\circ}C$에서의 질량감소량, 전기전도도, 가시부 및 자외부 흡수 spectrum의 전자전이에 따른 비율, TLC에 의한 주요 성분의 이동율($R_{f}{\;}value$)과 낮은 성분의 이동율($R_{f}{\;}value$)을 측정하였다. 결과： 전탕에 따른 수소이온농도(pH)의 평균은 $5.24{\pm}0.56$이었으며. 약재의 휘발 성분 및 수분 함유량은 $288{\pm}125mg$이었고, 유기물함량의 평균은 $867{\pm}116g$이었으며, 전기전도도의 평균은 $5.46{\pm}0.93S/cm$이었으며, 가시부 및 자외부 흡수 spectrum의 전자전이에 따른 흡광도 비율($\pi{\\rightarrow}\pi^{*}/n{\rightarrow}\pi^{*}$)의 평균은 $3.043{\pm}0.679$이었으며, TLC에 의한 주요 성분의 이동율($R_{f}{\;}value$)의 평균은 $0.553{\pm}0.317$이었고, TLC에 의한 낮은 성분의 이동율($R_{f}{\;}value$)의 평균은 $0.136{\pm}0.122$ 이었다. 결론：약재의 pH는 모두 7보다 낮은 약산성 이었으며, 약재의 휘발 성분 및 수분 함유량은 대략 10~50%정도를 나타내었다. 유기물함량은 대략 80~95%정도를 나타내었다. 전기전도도를 통하여 산약이나 감초는 이온성 물질을 많이 포함하고 있으리라 추정된다.

• Proceedings of the Zoological Society Korea Conference
• /
• 2001.10a
• /
• pp.195.1-195
• /
• 2001

No Abstract, See Full Text

• Herbal Formula Science
• /
• v.9 no.1
• /
• pp.207-214
• /
• 2001

For the purpose of developing KOREA herbalogy and prescription therapeutics I study the prescriptions among the DONG-UE-BO-GAM. The conclusions are as fallows; 1. There were total 97 prescriptions contended the Bupleurum as gunyak among the DONG-UE-BO-GAM. 2. The currental prescriptions contended the Bupleurum as gunyak were HAN period :1 disease 1 prescription, SONG period :6 diseases 6 prescriptions, GUEM and WON period: 14 diseases 23 prescriptions, MYONG period: 30 diseases 63 prescriptions. 3. The most high frequency of currental effect of the Bupleurum were HAN period: sang-han(傷寒), GUEM and WON period: hak(?), sang-han(傷寒) and gol-gueng-yel(骨蒸熱), MYONG period: sang-han(傷寒), hak(?), on-yek(溫疫), juek-chui(積聚) and an(眼). 4. The most high frequency effect of the Bupleurum as gunyak were sang-han(傷寒): 15 prescriptions, hak(?): 12 prescriptions, on-yek(溫疫) 7 prescriptions etc.

• Herbal Formula Science
• /
• v.5 no.1
• /
• pp.85-98
• /
• 1997

Samhwaja-hyangyakbang has been known as the book of herbalogy published by the man, Samhwaja. But there are no records about the additor, and the absence of the document, it is so difficult to be informed about the time when it published and other details. But in this document and Hyangyakgugeubbang, there are similar prescriptions to Sublingual Inflammation, Aphtose, Anthrax, Furoncle, Ulcer, Dysentery, etc. So the time it published is estimated to Goryo-dynasty Gojong epoch(1232-1251) when the Hyangyakgugeubbang was published. In addition, this document seems to be basis of Hyangyakjipseongbang, Because, Hyangyakjipseongbang quoted more than 140 provisions from this document. Prescriptions that are different from other books in dosage or taking method, took those of Biyebaekyobang. In explanation or classification of disease, this document almost copied those of Biyebaekyobang, so this document take Biyebaekyobang for origin and take Sikeuisimkam, Taepyungseonghyebang, etc, for reference.