• 제목/요약/키워드: guided selection

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Q-omics: Smart Software for Assisting Oncology and Cancer Research

  • Lee, Jieun;Kim, Youngju;Jin, Seonghee;Yoo, Heeseung;Jeong, Sumin;Jeong, Euna;Yoon, Sukjoon
    • Molecules and Cells
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    • 제44권11호
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    • pp.843-850
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    • 2021
  • The rapid increase in collateral omics and phenotypic data has enabled data-driven studies for the fast discovery of cancer targets and biomarkers. Thus, it is necessary to develop convenient tools for general oncologists and cancer scientists to carry out customized data mining without computational expertise. For this purpose, we developed innovative software that enables user-driven analyses assisted by knowledge-based smart systems. Publicly available data on mutations, gene expression, patient survival, immune score, drug screening and RNAi screening were integrated from the TCGA, GDSC, CCLE, NCI, and DepMap databases. The optimal selection of samples and other filtering options were guided by the smart function of the software for data mining and visualization on Kaplan-Meier plots, box plots and scatter plots of publication quality. We implemented unique algorithms for both data mining and visualization, thus simplifying and accelerating user-driven discovery activities on large multiomics datasets. The present Q-omics software program (v0.95) is available at http://qomics.sookmyung.ac.kr.

Where and Why? A Novel Approach for Prioritizing Implementation Points of Public CCTVs using Urban Big Data

  • Ji Hye Park;Daehwan Kim;Keon Chul Park
    • 인터넷정보학회논문지
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    • 제24권5호
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    • pp.97-106
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    • 2023
  • Citizens' demand for public CCTVs continues to rise, along with an increase in variouscrimes and social problems in cities. In line with the needs of citizens, the Seoul Metropolitan Government began installing CCTV cameras in 2010, and the number of new installations has increased by over 10% each year. As the large surveillance system represents a substantial budget item for the city, decision-making on location selection should be guided by reasonable standards. The purpose of this study is to improve the existing related models(such as public CCTV priority location analysis manuals) to establish the methodology foranalyzing priority regions ofSeoul-type public CCTVs and propose new mid- to long-term installation goals. Additionally, using the improved methodology, we determine the CCTV priority status of 25 autonomous districts across Seoul and calculate the goals. Through its results, this study suggests improvements to existing models by addressing their limitations, such as the sustainability of input data, the conversion of existing general-purpose models to urban models, and the expansion of basic local government-level models to metropolitan government levels. The results can also be applied to other metropolitan areas and are used by the Seoul Metropolitan Government in its CCTV operation policy

Imaging Evaluation of Peritoneal Metastasis: Current and Promising Techniques

  • Chen Fu;Bangxing Zhang;Tiankang Guo;Junliang Li
    • Korean Journal of Radiology
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    • 제25권1호
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    • pp.86-102
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    • 2024
  • Early diagnosis, accurate assessment, and localization of peritoneal metastasis (PM) are essential for the selection of appropriate treatments and surgical guidance. However, available imaging modalities (computed tomography [CT], conventional magnetic resonance imaging [MRI], and 18fluorodeoxyglucose positron emission tomography [PET]/CT) have limitations. The advent of new imaging techniques and novel molecular imaging agents have revealed molecular processes in the tumor microenvironment as an application for the early diagnosis and assessment of PM as well as real-time guided surgical resection, which has changed clinical management. In contrast to clinical imaging, which is purely qualitative and subjective for interpreting macroscopic structures, radiomics and artificial intelligence (AI) capitalize on high-dimensional numerical data from images that may reflect tumor pathophysiology. A predictive model can be used to predict the occurrence, recurrence, and prognosis of PM, thereby avoiding unnecessary exploratory surgeries. This review summarizes the role and status of different imaging techniques, especially new imaging strategies such as spectral photon-counting CT, fibroblast activation protein inhibitor (FAPI) PET/CT, near-infrared fluorescence imaging, and PET/MRI, for early diagnosis, assessment of surgical indications, and recurrence monitoring in patients with PM. The clinical applications, limitations, and solutions for fluorescence imaging, radiomics, and AI are also discussed.

재앙적 예술과 그 도구화된 선별체계: 헌터 조너킨과 댄 퍼잡스키의 작품으로부터 (Catastrophic Art and Its Instrumentalized Selection System : From work by Hunter Jonakin and Dan Perjovschi)

  • 심상용
    • 미술이론과 현장
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    • 제13호
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    • pp.73-95
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    • 2012
  • In terms of element and process, art today has already been fully systemized, yet tends to become even more systemized. All phases of creation and exhibition, appreciation and education, promotion and marketing are planned, adjusted, and decided within the order of a globalized, networked system. Each phase is executed, depending on the system of management and control and diverse means corresponding to the system. From the step of education, artists are guided to determine their styles and not be motivated by their desire to become star artists or running counter to mainstream tendency and fashion. In the process of planning an exhibition, the level of artist awareness is considered more significant than work quality. It is impossible to avoid such systems and institutions today. No one can escape or be freed from the influence of such system. This discussion addresses a serious distortion in the selection system as part of the system connotatively called "art museum system," especially to evaluate artistic achievement and aesthetic quality. Called "studio system" or "art star system," the system distinguishes successful minority from failed absolute majority and justifies the results, deciding discriminative compensations. The discussion begins from work by Hunter Jonakin and Dan Perjovschi. The key point of this discussion is not their art worlds but the shared truth referred by the two as the collusive "art market" and "art star system." Through works based on their experiences, the two artists refer to these systems which restrict and confine them. Jonakin's Jeff Koons Must Die! is avideo game conveying a critical comment on authoritative operation of the museum system and star system. In this work, participants, whether viewer or artist, are destined to lose: the game is unwinnable. Players take the role of a person locked in a museum where artist Jeff Koons' retrospective is held. The player can either look around and quietly observe the works, which causes a game-over, or he can blow the classical paintings to pieces and cause the artist Koons to come out and reprimand the player, also resulting in a game-over. Like Jonakin, Dan Perjovschi's some drawings also focuses on the status of the artist shrunken by the system. Most artists are ruined in a process of competition to survive within the museum system. As John Burger properly pointed out, out of the art systems today, public collections (art museums) and private collections have become "something unbearable." The system justifies the selection system of art stars and its frame of reference, disregarding the problem of producing numerable victims in its process. What should be underlined above all else is that the present selection system seriously shrinks art's creative function and its function of generating meaning. In this situation, art might fall to the level of entertainment, accessible to more people and compromising with popularity. This discussion is based on assumption and consciousness on the matter that this situation might cause catastrophic results for not only explicit victims of the system but also winners, or ones defined as winners. The system of art is probably possible only by desire or distortion stemmed from such desire. The system can be flourished only under the economic system of avarice: quantitatively expanding economy, abundant style, resort economy in Venice and Miami, and luxurious shopping malls with up-to-date facilities. The catastrophe here is ongoing, not a sudden emergence, and dynamic, leading the system itself to a devastating end.

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입자화 중심 자기구성 다항식 신경 회로망의 새로운 설계 (A new Design of Granular-oriented Self-organizing Polynomial Neural Networks)

  • 오성권;박호성
    • 전기학회논문지
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    • 제61권2호
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    • pp.312-320
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    • 2012
  • In this study, we introduce a new design methodology of a granular-oriented self-organizing polynomial neural networks (GoSOPNNs) that is based on multi-layer perceptron with Context-based Polynomial Neurons (CPNs) or Polynomial Neurons (PNs). In contrast to the typical architectures encountered in polynomial neural networks (PNN), our main objective is to develop a methodological design strategy of GoSOPNNs as follows : (a) The 1st layer of the proposed network consists of Context-based Polynomial Neuron (CPN). In here, CPN is fully reflective of the structure encountered in numeric data which are granulated with the aid of Context-based Fuzzy C-Means (C-FCM) clustering method. The context-based clustering supporting the design of information granules is completed in the space of the input data while the build of the clusters is guided by a collection of some predefined fuzzy sets (so-called contexts) defined in the output space. (b) The proposed design procedure being applied at each layer of GoSOPNN leads to the selection of preferred nodes of the network (CPNs or PNs) whose local characteristics (such as the number of contexts, the number of clusters, a collection of the specific subset of input variables, and the order of the polynomial) can be easily adjusted. These options contribute to the flexibility as well as simplicity and compactness of the resulting architecture of the network. For the evaluation of performance of the proposed GoSOPNN network, we describe a detailed characteristic of the proposed model using a well-known learning machine data(Automobile Miles Per Gallon Data, Boston Housing Data, Medical Image System Data).

Evaluation of the palatal soft tissue thickness by cone-beam computed tomography

  • Vu, Trang;Bayome, Mohamed;Kook, Yoon-Ah;Han, Seong Ho
    • 대한치과교정학회지
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    • 제42권6호
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    • pp.291-296
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    • 2012
  • Objective: The purposes of this study were to measure the palatal soft tissue thickness at popular placement sites of temporary anchorage devices (TADs) by cone-beam computed tomography (CBCT) and evaluate the age, gender, and positional differences in this parameter. Methods: The study sample consisted of 23 children (10 boys and 13 girls; mean age, $10.87{\pm}1.24$ years; range, 6.7 to 12.6 years) and 27 adults (14 men and 13 women; mean age, $21.35{\pm}1.14$ years; range, 20.0 to 23.8 years). Nine mediolateral and nine anteroposterior intersecting reference lines were drawn on CBCT scans of the 50 subjects, and the resultant measurement areas were designated according to their mediolateral (i.e., lateral, medial, and sutural) and anteroposterior (i.e., anterior, middle, and posterior) positions. Repeated-measures analysis of variance was performed to analyze intragroup and intergroup differences. Results: No significant age and gender differences were found (p = 0.309 and 0.124, respectively). Further, no significant anteroposterior change was observed (p = 0.350). However, the lateral area presented the thickest soft tissue whereas the sutural area had the thinnest soft tissue (p < 0.001). Conclusions: Clinical selection of the placement sites of TADs should be guided by knowledge of the positional variations in the palatal soft tissue thickness in addition to other contributing factors of TAD stability.

Hybrid Filter Based on Neural Networks for Removing Quantum Noise in Low-Dose Medical X-ray CT Images

  • Park, Keunho;Lee, Hee-Shin;Lee, Joonwhoan
    • International Journal of Fuzzy Logic and Intelligent Systems
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    • 제15권2호
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    • pp.102-110
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    • 2015
  • The main source of noise in computed tomography (CT) images is a quantum noise, which results from statistical fluctuations of X-ray quanta reaching the detector. This paper proposes a neural network (NN) based hybrid filter for removing quantum noise. The proposed filter consists of bilateral filters (BFs), a single or multiple neural edge enhancer(s) (NEE), and a neural filter (NF) to combine them. The BFs take into account the difference in value from the neighbors, to preserve edges while smoothing. The NEE is used to clearly enhance the desired edges from noisy images. The NF acts like a fusion operator, and attempts to construct an enhanced output image. Several measurements are used to evaluate the image quality, like the root mean square error (RMSE), the improvement in signal to noise ratio (ISNR), the standard deviation ratio (MSR), and the contrast to noise ratio (CNR). Also, the modulation transfer function (MTF) is used as a means of determining how well the edge structure is preserved. In terms of all those measurements and means, the proposed filter shows better performance than the guided filter, and the nonlocal means (NLM) filter. In addition, there is no severe restriction to select the number of inputs for the fusion operator differently from the neuro-fuzzy system. Therefore, without concerning too much about the filter selection for fusion, one could apply the proposed hybrid filter to various images with different modalities, once the corresponding noise characteristics are explored.

아동사고에 대한 어머니의 예방행위 영향요인 (Maternal Behavior to Preventing Childhood Accident in the Home)

  • 김귀분;손인아
    • 한국응급구조학회지
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    • 제6권1호
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    • pp.87-102
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    • 2002
  • Injury has now replaced disease as the biggest single cause of death in children after their first birthday. Each day child dies from preventable, unintentional injury and the medical cost of these injury is increasing remarkably. It is necessary to develope injury prevention models to explain, predict, manage, evaluate and analyze the information about accident. The purpose of this paper is, firstly, to investigate parent's actions regarding safety measures at home and secondly, to identify the influencing factors of parents' safety behaviors. The selection of such factors is guided by the theoretical framework of the Pender's Health Promotion Model. Method ; The questionnaire was developed on the basis of other investigations, through pilot testing, peer review, and review by field health workers. The questionnaire was completed by 231 mothers of young children. Data was collected between April and May 2002. Variable Use of three different domains of safety behavior, safety habits, supervision and perception of safety devices, were listed. Mothers were self reported on internal locus of control, mother & child relationships, and marital intimacy. Also the elements of the Health Promotion Model: perceived benefit, barrier, threat, and self-efficacy, were surveyed. Results & discussion The results indicate that most parents take considerable action to reduce household hazards. The constructs derived from the Model were statistically significant differences for a small part of the variables on parental behavior to reduce hazards in the home, such as age, education, economic status, self-efficacy, perceived benefit, internal locus of control. Future studies ought to include social influences, such as expectations, perceived norms, knowledge, and child-related variables, relevant to parental safety measures in their home.

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Comparison of Pre-Operation Diagnosis of Thyroid Cancer with Fine Needle Aspiration and Core-needle Biopsy: a Meta-analysis

  • Li, Lei;Chen, Bao-Ding;Zhu, Hai-Feng;Wu, Shu;Wei, Da;Zhang, Jian-Quan;Yu, Li
    • Asian Pacific Journal of Cancer Prevention
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    • 제15권17호
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    • pp.7187-7193
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    • 2014
  • Background: The aim of this meta-analysis was to compare sensitivities and specificities of fine needle aspiration (FNA) and core needle biopsy (CNB) in the diagnosis of thyroid cancer. Materials and Methods: Articles were screened in Medline, the Cochrane Library, EMBASE and Google Scholar, and subsequently included and excluded based on the patient/problem-intervention-comparison-outcome (PICO) principle. Primary outcome was defined in terms of diagnostic values (sensitivity and specificity) of FNA and CNB for thyroid cancer. Secondary outcome was defined as the accuracy of diagnosis. Compiled FNA and CNB results from the final studies selected as appropriate for meta-analysis were compared with cases for which final pathology diagnoses were available. Statistical analyses were performed for FNA and CNB for all of the selected studies together, and for individual studies using the leave-one-out approach. Results: Article selection and screening yielded five studies for meta-analysis, two of which were prospective and the other three retrospective, for a total of 1,264 patients. Pooled diagnostic sensitivities of FNA and CNB methods were 0.68 and 0.83, respectively, with specificities of 0.93 and 0.94. The areas under the summary ROC curves were 0.905 (${\pm}0.030$) for FNA and 0.745 (${\pm}0.095$) for CNB, with no significant difference between the two. No one study had greater influence than any other on the pooled estimates for diagnostic sensitivity and specificity. Conclusions: FNA and CNB do not differ significantly in sensitivity and specificity for diagnosis of thyroid cancer.

Affinity Maturation of an Epidermal Growth Factor Receptor Targeting Human Monoclonal Antibody ER414 by CDR Mutation

  • Chang, Ki-Hwan;Kim, Min-Soo;Hong, Gwang-Won;Seo, Mi-Sun;Shin, Yong-Nam;Kim, Se-Ho
    • IMMUNE NETWORK
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    • 제12권4호
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    • pp.155-164
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    • 2012
  • It is well established that blocking the interaction of EGFR with growth factors leads to the arrest of tumor growth, resulting in tumor cell death. ER414 is a human monoclonal antibody (mAb) derived by guided selection of the mouse mAb A13. The ER414 exhibited a ~17-fold lower affinity and, as a result, lower efficacy of inhibition of the EGF-mediated tyrosine phosphorylation of EGFR when compared with mAb A13 and cetuximab. We performed a stepwise in vitro affinity maturation to improve the affinity of ER414. We obtained a 3D model of ER414 to identify the amino acids in the CDRs that needed to be mutated. Clones were selected from the phage library with randomized amino acids in the CDRs and substitution of amino acids in the HCDR3 and LCDR1 of ER414 led to improved affinity. A clone, H3-14, with a ~20-fold increased affinity, was selected from the HCDR3 randomized library. Then three clones, ER2, ER78 and ER79, were selected from the LCDR1 randomized library based on the H3-14 but did not show further increased affinities compared to that of H3-14. Of the three, ER2 was chosen for further characterization due to its better expression than others. We successfully performed affinity maturation of ER414 and obtained antibodies with a similar affinity as cetuximab. And antibody from an affinity maturation inhibits the EGF-mediated tyrosine phosphorylation of EGFR in a manner similar to cetuximab.