• 제목/요약/키워드: group representation.

검색결과 298건 처리시간 0.035초

Hemicastration induced spermatogenesis-related DNA methylation and gene expression changes in mice testis

  • Wang, Yixin;Jin, Long;Ma, Jideng;Chen, Li;Fu, Yuhua;Long, Keren;Hu, Silu;Song, Yang;Shang, Dazhi;Tang, Qianzi;Wang, Xun;Li, Xuewei;Li, Mingzhou
    • Asian-Australasian Journal of Animal Sciences
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    • 제31권2호
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    • pp.189-197
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    • 2018
  • Objective: Hemicastration is a unilateral orchiectomy to remove an injured testis, which can induce hormonal changes and compensatory hypertrophy of the remaining testis, and may influence spermatogenesis. However, the underlying molecular mechanisms are poorly understood. Here, we investigated the impact of hemicastration on remaining testicular function. Methods: Prepubertal mice (age 24 days) were hemicastrated, and their growth was monitored until they reached physical maturity (age 72 days). Subsequently, we determined testis DNA methylation patterns using reduced representation bisulfite sequencing of normal and hemicastrated mice. Moreover, we profiled the testicular gene expression patterns by RNA sequencing (RNA-seq) to examine whether methylation changes affected gene expression in hemicastrated mice. Results: Hemicastration did not significantly affect growth or testosterone (p>0.05) compared with control. The genome-wide DNA methylation pattern of remaining testis suggested that substantial genes harbored differentially methylated regions (1,139) in gene bodies, which were enriched in process of protein binding and cell adhesion. Moreover, RNA-seq results indicated that 46 differentially expressed genes (DEGs) involved in meiotic cell cycle, synaptonemal complex assembly and spermatogenesis were upregulated in the hemicastration group, while 197 DEGs were downregulated, which were related to arachidonic acid metabolism. Integrative analysis revealed that proteasome 26S subunit ATPase 3 interacting protein gene, which encodes a protein crucial for homologous recombination in spermatocytes, exhibited promoter hypomethylation and higher expression level in hemicastrated mice. Conclusion: Global profiling of DNA methylation and gene expression demonstrated that hemicastration-induced compensatory response maintained normal growth and testicular morphological structure in mice.

The Next Wave in Display Innovation

  • Webster, Steven C.
    • 한국정보디스플레이학회:학술대회논문집
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    • 한국정보디스플레이학회 2008년도 International Meeting on Information Display
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    • pp.4-4
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    • 2008
  • The progress in flat panel displays over the last two decades has been astonishing. In just 20 years, the LCD-TV grew up from a 2-inch curiosity, to an industry that will sell about 120 million flat panel TV's this year, with viewing area up to 4000 times larger. That success is based on continuous innovation, especially in manufacturing processes. For the next decade to bring another doubling of the business, progress will need to continue in four major areas: Human factors, ecological impact, visual quality, and of course continued drive towards affordability. This talk will detail the technology advances that can allow this industry to meet those challenges. Human factors. Today, we adapt our lifestyle to our technology. People organize their offices, and their homes, around displays. We pass around mobile phones to share images, rather than experiencing them as a group. Billions of newspapers continue to be sold daily. Advances in flexible displays can lead to large portable displays. "New era projection" includes the handheld Pico Projectors that are already on the market, and will ultimately appear integrated in mobile phones the same way cameras do today. "Eco" impact. Today TV's are one of the top energy consumers in a U.S. home, and the fastest growing. Watching a large flat panel TV can cost twice as much as running a large refrigerator. With today's concern about energy consumption, regulations are starting to emerge worldwide to limit TV electrical use. Fortunately, good solutions exist in using light management films to eliminate bulbs, saving power without increasing cost. Going forward, LED backlights will drive another step downward. OLED displays might be the ultimate solution. Visual quality. The color of an LCD-TV is still often considered inferior to a far less expensive CRT. And almost all displays suffer from representing a three-dimensional world on a two dimensional surface. The technology to improve color is available today, and will likely move from premium sets into the mainstream as costs come down. 3D is now arriving in movie theaters worldwide, and that will drive up the demand for similar realistic images in home theaters. And the technology is emerging today for 3D representation to move beyond specialized applications into everyday use, on screens large and small. Affordability. The world takes cost-down miracles for granted in consumer electronics. Each of these other advances will be balanced with a drive for affordability, especially as the market grows in emerging countries. The other three challenges must be met without increasing cost. Putting this all together, the next few years will emphasize "eco friendly" designs, and enhanced images such as 3D. By 2013 we will start to see serious penetration by emissive technologies (OLED, high efficiency plasma, or other), with the "ultimate display" likely not in the market for a decade. Lots of opportunities for innovation remain ahead of us.

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3차원 의료영상을 이용한 인체 외이도 특징에 관한 연구 (A Study of the Characteristics of the Human External Auditory Canal Using 3-Dimensional Medical Imaging)

  • 김형균
    • 한국방사선학회논문지
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    • 제11권6호
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    • pp.467-473
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    • 2017
  • 의료용 디지털 영상 및 통신 표준과 3차원 의료 영상 프로그램을 이용하여 외이도의 해부학적 특징들을 비교하였다. 실험은 연령과 성별이 다른 63귀의 영상을 이용하여 외이도의 횡축 길이, 내부 직경 둘레, 상하부 굴곡 각도를 측정한 후 비교하였다. 실험 결과 외이도 형태는 연령과 성별 뿐 만 아니라 동일인의 좌.우 에서도 다르게 나타났다. 성별 비교에서 남자 35귀, 여자 28귀에 대한 평균 길이는 남자가 4.75mm 길게 나타났다. 외이도 직경 둘레는 하부 굴곡 각도를 중심으로 내측이 외측 보다 평균 37.2% 감소된 형태로 나타났다. 상하부 굴곡 각도는 상부가 평균적으로 $25.7^{\circ}$ 높았으나 4귀에서 하부 각도가 높고, 연령이 낮은(4~14세) 8귀에서 상하부 굴곡 각도 차이가 크게 나타났다. 이는 성장하면서 외이도 굴곡 모양이 변화됨을 나타냈다. 본 연구는 기존 귀본 채취를 통한 간접 측정과 물리적 방법에 의한 직접 측정과 비교하여 안전성과 정밀성을 높일 수 있는 방법이다. 이는 3차원 의료 영상 표현 기술이 실제에 가깝게 표현할 수 있는 기술 향상 때문이며 더 발전하여 외이도 형태의 표준화 연구에도 활용될 수 있는 측정 방법이라 판단된다.

확장된 네이보어-제르니케 방법에 의한 광픽업의 파면수차 복원 알고리즘 (Aberration Retrieval Algorithm of Optical Pickups Using the Extended Nijboer-Zernike Approach)

  • 전재철;정기수;이건기
    • 융합신호처리학회논문지
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    • 제11권1호
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    • pp.32-40
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    • 2010
  • 확장된 네이보어-제르니케 방법을 이용하여 광학계의 동공함수(pupil function)를 추산하는 알고리즘을 제안한다. 동공함수로부터 광학계가 가진 파면수차를 복원하고 아울러 동공에 비추어지는 빛의 밝기분포를 분석할 수 있다. 이 방법은 브루-레이 광픽업의 생산현장에 적용하여 실시간으로 광학계의 수차를 복원할 수 있다. 아울러 이 방법이 여러 다른 광학계에 널리 이용될 수 있음을 다양하게 수차를 부여해서 생성한 데이터를 분석하여 검증하였다. 초점영역의 빔 데이터로부터 동공함수를 얻는 역변환의 여러 방법 중에서 수차이론에 근거한 기존의 네이보어-제르니케 방법을 최근에 네덜란드 연구진이 개량한 확장된 네이보어-제르니케(extended Nijboer-Zernike: ENZ) 방법을 제안하였다. ENZ 방법은 초점영역의 3차원 빔 데이터로부터 해석적인 접근을 통하여 동공의 제르니케 계수를 효율적으로 계산해 낸다. 그러나 이 방법에서는 개구수(NA)가 큰 경우에는 근사적인 접근을 하도록 되어 있다. 본 연구에서는 보다 일반적인 상황에서 적용할 수 있는 수치해석 알고리즘을 개발하고, 이를 GUI 환경에서 운용할 수 있는 윈도 기반의 프로그램을 작성하여 생성한 빔 데이터에 적용하여 이 알고리즘의 유효성을 검증하여 13개의 복소 수차인자 $\beta_n^m$이 모든 요소가 0.7까지 분석을 하였고, 아울러 광픽업의 3D 빔 데이터를 실측해서 간섭계로 측정한 데이터와 R=0.98 정도의 상관관계를 가지는 것을 확인하였다.

글로벌 전자무역의 실현을 위한 eUCP의 역할과 개정방안 (A Study on the Roles and Revision of eUCP for Global Electronic Trading)

  • 최석범;홍성규
    • 무역상무연구
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    • 제18권
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    • pp.105-134
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    • 2002
  • In the Spring of 2000, the Banking Commission of the ICC decided to appoint a working group to draft a supplement to the UCP 500 to clarify the position regarding electronic presentation under a documentary credit. Provisions was drafted to supplement its existing rules for documentary credit, that is, UCP 500. These new provisions known as Supplement to UCP 500 for Electronic Presentation was approved by the ICC Banking Commission at the beginning of November 2001 and came in force as of 1 April 2002 The eUCP covers matters such as definitions of key terms such as electronic record, electronic signature, format, paper document, received. An eUCP Credit must specify the formats in which electronic records are to be presented and if not, electronic records may be presented in any format. Electronic records may be presented separately and need not be presented at the same time. The purpose of this paper is to understand the main substance of eUCP and to facilitate the introduction of electronic letter of credit by studying the problems and revision of eUCP and new electronic UCP. The main substances of eUCP are electronic address as place for presentation of electronic records, flexibility of the formats of electronic records to be presented, endowment of the notice of completeness of presentation to the beneficiary, one electronic record satisfying one or more originals or copies of an electronic record, the electronic records to be examined including the electronic record at the hyperlink to an external system or the referenced system, no remark as to the time period for the examination of documents. The Roles of eUCP are the Promotion of the Electronic Trade, the Supply of Basis on the Uniform Rules for Electronic Letter of Credit, the introduction of Electronic Trade Model. The characteristics of eUCP are a supplement to the UCP, no address of any issues relating to the issuance or advice of Credit electronically, independence of specific technologies and developing electronic commerce system, that is, Bolero Service. The Problems of eUCP are flexibility of format of electronic record, heavy burden on the side of banks, and the problems regrading the number of presentation, the notice of completeness of presentation, no provision in regard to the time to examine the electronic records, and representation of the electronic records. In the revision of eUCP to resolve the problems, the things to be taken into consideration are as follows; the designation of the format allowing the banks to examine electronically, prohibition of the paper documents, the development of the system receiving the electronic records, the addition of the reception notice on the side of the banks, the setting of the time to examine the electronic records, the construction of the backup system or the dual processing system.

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전통적 알고리즘 교수법과 다양한 표상을 활용한 교수법의 비교: 분수, 소수, 퍼센트 내용을 중심으로 (The Use of Traditional Algorithmic Versus Instruction with Multiple Representations: Impact on Pre-Algebra Students' Achievement with Fractions, Decimals, and Percent)

  • 한선영
    • 대한수학교육학회지:학교수학
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    • 제18권2호
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    • pp.257-275
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    • 2016
  • 본 연구는 수학의 다양한 표상이 학습자의 분수, 소수 및 퍼센트에 대한 이해에 어떤 영향을 주는지 분석하는 것을 목적으로 하였다. 다양한 표상을 활용한 교수법을 전통적 알고리즘 교수법과 비교하고자 87명의 중학교 학생들을 대상으로 사전, 사후 검사를 실시하였다. 사전, 사후 검사는 각각 5개의 비슷한 문항으로 구성되었으며, 문항에 대한 학생들의 답안을 양적, 질적으로 분석하였다. 양적 분석 결과에 따르면, 전통적 알고리즘 교수법으로 지도 받은 학생들이 다양한 표상을 활용한 교수법에 의해 지도받은 학생들에 비하여 높은 점수를 나타내었다. 또한, 다양한 표상을 활용한 교수법이 학생들의 수학적 개념에 대한 이해를 보장해 주지는 못함이 드러났다. 질적 분석 결과에 따르면, 수학 교실에서 다양한 표상을 제한적으로 활용할 경우, 오히려 다양한 수학적 표상은 학생들이 문장제 문제를 푸는 과정에서 응용을 방해하는 것으로 나타났다. 본 연구결과에 따르면, 교사는 수학 교실에서 다양한 표상을 활용함에 있어서 반드시 여러 가지 예시와 연습을 통해 학습자들이 다양한 표상을 제대로 이해하고, 연습할 수 있도록 도와야 할 것이다.

한국인 수면장애 환자의 최근 3년간 한방 진료 양태 (Oriental Medical Treatment Pattern of Korean Patients with Sleep Disorders)

  • 정선영;김재영;고영탁;안건상;이차로
    • 동의신경정신과학회지
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    • 제25권4호
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    • pp.389-400
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    • 2014
  • Objectives: Though there are many studies about sleep disorder, no research has been performed on the utilization of oriental medicine as a treatment. Therefore, the oriental medical treatment pattern of Korean patients with sleep disorders was examined herein using the Health Insurance Review and Assessment Service (HIRAS). Methods: The medical records of patients with sleep disorders (G47) or nonorganic sleep disorders (F51) as a main diagnosis were adopted from the HIRAS database from 2011 to 2013. Analysis was performed on the number of patients and cost per patient, with comparison between oriental and western medicine in terms of gender, age, patient care service type, and hospital type. Results: 1) Regarding sleep disorders, the medical visits and insurance charges have been increasing. Western medicine was utilized 8 times more often than oriental medicine during 3 years. 2) There were 2.5 times more women than men. 3) Among all ages, the 50~59 year group had the highest representation. 4) In comparison of average portions of patient care type over 3 years, outpatients were the majority, while the number of visits of outpatients and hospitalization has been increasing. 5) Comparison of average portion of oriental hospital type over 3 years revealed oriental clinics to be used most. The use of general hospitals was higher in western medicine treatment, while public health centers used oriental medicine more. 6) Regarding average oriental medical cost per patient over 3 years, the total was 88,000 won, with 353,000 won for hospitalization and 85,000 won for outpatients. The outpatient cost has been increasing. 7) In line with 6, oriental medical hospitals cost 126,000 won, local clinics were 85,000 won, and etc. was 95,000 won. Average costs of all types have increased during 3 years, except oriental medical hospitals in 2013. Conclusions: This study provided objective information about the epidemiologic characteristic of oriental medicine used for treatment of sleep disorder. For expansion of oriental medical demand for sleep disorder, this study would be helpful in understanding the recent status.

신종교의 영상 콘텐츠 활용 현황과 과제, 그리고 제언 - 영화 <화평의 길>과 대순진리회박물관의 영상물을 중심으로- (Current Status, Challenges, and Suggestions for Utilizing Daesoon Jinrihoe's Video Content: Focusing on the Film, The Road of Peace and Harmony, and the Videos of the Museum of Daesoon Jinrihoe)

  • 박종수
    • 대순사상논총
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    • 제48집
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    • pp.239-268
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    • 2024
  • 영상 콘텐츠는 매체적 특성인 재현과 정보 전달, 몰입과 경험 등으로 교육의 수단으로 자주 활용되곤 한다. 특히, 종교영화의 경우, 종립학교나 신앙공동체에서 신앙의 이해와 고취를 위해서 더 많이 활용되고 있다. 본 연구는 대순진리회가 영상 콘텐츠를 어떻게 활용하고 있는지를 영화 <화평의 길>과 대순진리회박물관의 영상 콘텐츠의 활용 현황을 살펴보고, 과제와 제언을 하는 것에 목적이 있다. 연구의 제2장에서는 대순진리회 영상 콘텐츠를 영화 <화평의 길>과 대순진리회박물관의 영상 콘텐츠의 현황을 살펴보고 어떻게 활용되고 있는지를 분석하였다. 그리고 제3장에서는 대순진리회의 영상콘텐츠가 현재 종단 내부의 종교교육 자료로만 기능하고 있다는 한계를 장르영화로서의 '예수 영화'를 통해서 어떻게 활용 가능한지에 대해서 살펴보았다. 그리고 마지막 제4장에서는 대순진리회의 영상 콘텐츠가 종교교육을 넘어선 다문화 종교교육의 자료로 활용될 가능성을 제안해 보았다. 이를 통해서 대순진리회가 영상 콘텐츠를 활용할 때 좀 더 시의성 있는, 지역 종교를 넘어서 세계 종교로서의 확장 가능성을 탐색하는 데 기여할 수 있기를 바란다.

IFRS 공시 실태 개선방안에 대한 소고 - 보고기업, 정보이용자 요인을 고려한 통합적 접근 - (A Study on Practices and Improvement Factors of Financial Disclosures in early stages of IFRS Adoption - An Integrative Approach of Korean Cases: Embracing Views of Reporting Entities and Users of Financial Statements)

  • 김희석
    • 벤처창업연구
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    • 제7권2호
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    • pp.113-127
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    • 2012
  • IFRS에 따른 재무제표 작성은 연결재무제표의 주재무제표화, 원칙중심의 회계처리기준 등으로 인해 재무제표 본문의 간략화 및 다양화, 상세내역 및 비재무사항 주석기재 요구량 증대 등 공시 전반에 걸친 중요성이 높아지고 있다. 한편 K-IFRS체제하의 적정공시 방향에 대한 기존의 연구와 검토들은 IFRS 전면도입의 당위론적 배경과 제도변화 초기상황이라는 시기적 요인에 따라 기준제정기구나 감독기관 중심으로 공시요구사항 증대나 정보의 완전성(completeness) 측면에 초점을 두고 전개되어 온 것이 사실이다. 이에, 본 연구는 기존의 접근에 더하여 보고기업 및 정보이용자의 관점에서 보다 균형적인 IFRS 적용에 따른 적정공시 방향성을 도출하고자 하였다. 먼저 주요기업 재무공시 실태 검토 결과, 2010년, 2011년 재무공시에서 다수의 미준수사항 또는 권고할 사항이 지적되었다. 이러한 원인으로는 IFRS 기준의 성격에 따른 문제, 업종별 기업별 특성에 따른 문제, IFRS 도입비용 및 촉박한 공시기한 등 공시기업의 부담 측면이 지적될 수 있으며, 이는 정보이용자 입장에서의 이해가능성 및 활용도, 비교가능성 저하를 일으키는 것으로 나타났다. 이러한 실태의 개선을 위해, 제도의 완화/지원 측면에서 적용대상 기업의 추가 세분화 필요성 검토, 주석공시 내용과 범위 조정, 공시시기 조정 및 다원화, 공시환경 및 인센티브 지원 방안이 제안되었으며, 공시요구 강화 측면에서 기업, 정보이용자 참여비중 확대를 반영한 K-IFRS 제정체계 개선과 표준화된 세부양식 정의 및 적용의무화 필요성이 제시되었다.

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인도네시아 현대미술에 있어서의 설치미술 - 미디엄과 사회적 공간을 위한 탐색 (Installation Art In Indonesian Contemporary Art; A Quest For Medium and Social Spaces)

  • A. 릭릭 쿠스마라
    • 미술이론과 현장
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    • 제5호
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    • pp.217-229
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    • 2007
  • Many historical research and facet about modern art in Indonesia which formulating background of contemporary Indonesian Art. Indonesian art critic Sanento Yuliman states that Modern art has been rapidly developing in Indonesia since the Indonesian Independence in 1945. Modern Art is a part of the super culture of the Indonesian metropolitan and is closely related to the contact between the Indonesian and Western Cultures. Its birth was part of the nationalism project, when the Indonesian people consists of various ethnics were determined to become a new nation, the Indonesian nation, and they wished for a new culture, and therefore, a new art. The period 1960s, which was the beginning of the creation and development of the painters and the painters associations, was the first stage of the development of modern art in Indonesia. The second stage showed the important role of the higher education institutes for art. These institutes have developed since the 1950s and in the 1970s they were the main education institutes for painters and other artists. The artists awareness of the medium, forms or the organization of shapes were encouraged more intensely and these encouraged the exploring and experimental attitudes. Meanwhile, the information about the world's modern art, particularly Western Art; was widely and rapidly spread. The 1960s and 1970s were marked by the development of various abstractions and abstract art and the great number of explorations in various new media, like the experiment with collage, assemblage, mixed media. The works of the Neo Art Movement-group in the second half of the 1970s and in the 1980s shows environmental art and installations, influenced by the elements of popular art, from the commercial world and mass media, as well as the involvement of art in the social and environmental affairs. The issues about the environment, frequently launched by the intellectuals in the period of economic development starting in the 1970s, echoed among the artists, and they were widened in the social, art and cultural circles. The Indonesian economic development following the important change in the 1970s has caused a change in the life of the middle and upper class society, as has the change in various aspects of a big city, particularly Jakarta. The new genre emerged in 1975 which indicates contemporary art in Indonesia, when a group of young artists organized a movement, which was widely known as the Indonesian New Art Movement. This movement criticized international style, universalism and the long standing debate on an east-west-dichotomy. As far as the actual practice of the arts was concerned the movement criticized the domination of the art of painting and saw this as a sign of stagnation in Indonesian art development. Based on this criticism 'the movement' introduced ready-mades and installations (Jim Supangkat). Takes almost two decades that the New Art Movement activists were establishing Indonesian Installation art genre as contemporary paradigm and influenced the 1980's gene ration like, FX Harsono, Dadang Christanto, Arahmaiani, Tisna Sanjaya, Diyanto, Andarmanik, entering the 1990's decade as "rebellion period" ; reject towards established aesthetic mainstream i.e. painting, sculpture, graphic art which are insufficient to express "new language" and artistic needs especially to mediate social politic and cultural situation. Installation Art which contains open possibilities of creation become a vehicle for aesthetic establishment rejection and social politics stagnant expression in 1990s. Installation art accommodates two major field; first, the rejection of aesthetic establishment has a consequences an artists quest for medium; deconstruction models and cross disciplines into multi and intermedia i.e. performance, music, video etc. Second aspect is artists' social politic intention for changes, both conclude as characteristics of Indonesian Installation Art and establishing the freedom of expression in contemporary Indonesian Art until today.

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