• The Journal of Korean Institute of Communications and Information Sciences
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• v.28 no.5C
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• pp.443-451
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• 2003

We propose an appropriate approach of defining the linear complexities (LC) of sequences over unknown symbol set. We are able to characterize those p-ary sequences whose R-tuple versions now eve. GF($p^{R}$ ) have the same characteristic polynomial as the original with respect to any basis. This leads to a construction of $p^{R}$ -ary sequences whose characteristic polynomial is essentially over GF(p). In addition, we can characterize those $p^{R}$ -ary sequences whose characteristic polynomials are uniquely determined when symbols are represented as R-tuples over GF(p) with respect to any basis.

• Archives of Pharmacal Research
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• v.27 no.2
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• pp.217-224
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• 2004

Previously, we reported that water-extracted Acanthopanax senticasus exhibited anti-meta-static activity by stimulating the immune system. In this study, we fractionated glycoproteins (EN-SP) from the soluble protein layer (GF-AS) of A. senticasus and determined their basic chemical properties. We also investigated the anti-tumor and immunostimulating activities of the fractionated glycoprotein, EN-SP. We found that intravenous (i.v.) administration of GF-AS dramatically inhibited metastasis of colon26-M3.1 carcinoma cells to the lung in a dose-dependent manner. In vitro analysis showed GF-AS to enhance the proliferation of splenocytes. GF-AS also stimulated peritoneal macrophage, which was followed by the production of various cytokines such as IL-1$\beta$, TNF-$\alpha$, IL-12 and IFN-${\gamma}$. Furthermore, the production of these cytokines was partially blocked when peritoneal macrophage was cultured with the polyclonal antibodies against GF-AS. The depletion of NK cells by rabbit anti-asialo GM1 serum partly abolished the inhibitory effect of GF-AS on lung metastasis of colon26-M3.1 cells. Using gel filtration, EN-SP, an active glycoprotein fraction, is isolated from GF-AS. While both GF-AS and EN-SP stimulated the proliferatation of splenocytes of normal mice, EN-SP showed higher anti-metastatic activity and more potently stimulated the proliferation of splenocytes compared to GF-AS. These results suggest the use of EN-SP, the fractionated glycoprotein from A. senticasus, can be used as a therapeutical reagent to prevent or inhibit tumor metastasis.

• Journal of KIISE:Computer Systems and Theory
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• v.31 no.8
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• pp.453-464
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• 2004

In order to solve the well-known drawback of reduced flexibility that is associate with ASIC implementations, this paper proposes a novel arithmetic unit over GF(2$^{m}$ ) for field programmable gate arrays (FPGAs) implementations of elliptic curve cryptographic processor. The proposed arithmetic unit is based on the binary extended GCD algorithm and the MSB-first multiplication scheme, and designed as systolic architecture to remove global signals broadcasting. The proposed architecture can perform both division and multiplication in GF(2$^{m}$ ). In other word, when input data come in continuously, it produces division results at a rate of one per m clock cycles after an initial delay of 5m-2 in division mode and multiplication results at a rate of one per m clock cycles after an initial delay of 3m in multiplication mode respectively. Analysis shows that while previously proposed dividers have area complexity of Ο(m$^2$) or Ο(mㆍ(log$_2$$^{m}$ )), the Proposed architecture has area complexity of Ο(m), In addition, the proposed architecture has significantly less computational delay time compared with the divider which has area complexity of Ο(mㆍ(log$_2$$^{m}$ )). FPGA implementation results of the proposed arithmetic unit, in which Altera's EP2A70F1508C-7 was used as the target device, show that it ran at maximum 121MHz and utilized 52% of the chip area in GF(2$^{571}$ ). Therefore, when elliptic curve cryptographic processor is implemented on FPGAs, the proposed arithmetic unit is well suited for both division and multiplication circuit.

• Korean Journal of Food Science and Technology
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• v.34 no.3
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• pp.518-523
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• 2002

Administration of hot water extracts from Acanthopanax senticosus (GF-2) prophylactically and therapeutically inhibited the systemic anaphylactic shock induced by compound 48/80 in mouse. GF-2 significantly inhibited the production of histamine and eosinophyl in mouse serum through the injection of compound 48/80 in a dose-dependent manner. GF-2 inhibited dose dependently $TNF-{\alpha}$ production of peritoneal exudative cells activated by lipopolysaccharide. Intraperitoneal injection of GF-2 suppressed the production of IgG1 and IgE antibodies in mice immunized with a mixture of ovalbumin and aluminium hydroxide. These results suggest that GF-2 may be beneficial for the treatment of nonspecific and specific anaphylactic reactions and can be potentially applied to the treatment of allergic diseases.

• The Journal of Korean Obstetrics and Gynecology
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• v.27 no.1
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• pp.1-16
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• 2014

Objectives: The purpose of this study was to investigate the effects of Gardeniae Fructus Water Extract (GF) on the production of inflammatory mediators in RAW 264.7 cell treated with lipopolysaccharide (LPS). Methods: Gradeniae Fructus was extracted with distilled water (2,000 ml) for 2 hours. In order to evaluate cytotoxicity of GF, 3 - (4,5-dimethylthiazol-2-yl) - 2,5 - diphenyltetrazolium bromide (MTT) assay was performed. To investigate antiinflammatory effects, the concentration of nitric oxide (NO) was measured with No assay, calcium (Ca) was measured with Fluo-4 Ca assay, and cytokine was measured by Bio-Plex cytokine assay in RAW 264.7 cell. And when p-value is below 0.05, it is judged to have the significant difference statistically. Results: 1. GF did not show any cytotoxicity. 2. GF suppressed the production of NO and Ca at the concentration of 25, 50, 100 and $200{\mu}g/ml$. 3. GF suppressed the production of interleukin (IL)-$1{\beta}$, IL-10, IL-12p40, macrophage-colony stimulating factor (M-CSF), macrophage inflammatory protein (MIP)-$1{\beta}$ and keratinocyte chemoattractant(KC) at the concentration of 25, 50, 100 and $200{\mu}g/ml$. 4. GF suppressed the production of vascular endothelial growth factor (VEGF), granulocyte-colony stimulating factor (G-CSF) and monocyte cheomattractant protein (MCP)-1 at the concentration of 25, 50 and $100{\mu}g/ml$. 5. GF suppressed the production of granulocyte macrophage-colony stimulating factor (GM-CSF) and regulated on activation, normal T cell expressed and secreted (RANTES) at the concentration of 25 and $50{\mu}g/ml$. 6. GF suppressed the production of MIP-2 at the concentration of 50 and $100{\mu}g/ml$, and tumor necrosis factor (TNF)-${\alpha}$ at the concentration of 50 and $200{\mu}g/ml$. Conclusions: These results suggest that GF has anti-inflammatory effect and immuno-modulating activity.

• Carbon letters
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• v.22
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• pp.42-47
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• 2017

In this paper, the in vitro biocompatibility of graphene film (GF) with osteoblasts was evaluated through cell adhesion, viability, alkaline phosphatase activity, F-actin and vinculin expressions, versus graphite paper as a reference material. The results showed that MG-63 cells exhibited stronger cell adhesion, better proliferation and viability on GF, and osteoblasts cultured on GF exhibited vinculin expression throughout the cell body. The rougher and wrinkled surface morphology, higher elastic modulus and easy out-of-plane deformation associated with GF were considered to promote cell adhesion. Also, the biomineralization of GF was assessed by soaking in simulated body fluid, and the GF exhibited enhanced mineralization ability in terms of mineral deposition, which almost pervaded the entire GF surface. Our results suggest that graphene promotes cell adhesion, activity and the formation of bone-like apatite. This research is expected to facilitate a better understanding of graphene-cell interactions and potential applications of graphene as a promising toughening nanofiller in bioceramics used in load-bearing implants.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.25 no.5
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• pp.979-984
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• 2015

In this paper, we proposed a Semi-Systolic multiplier of $GF(2^n)$ with Type II optimal Normal Basis. Comparing the complexity of the proposed multiplier with Chiou's multiplier proposed in 2012, it is saved $2n^2+44n+26$ in total transistor numbers and decrease 4 clocks in time delay. This means that, for $GF(2^{333})$ of the field recommended by NIST for ECDSA, the space complexity is 6.4% less and the time complexity of the 2% decrease. In addition, this structure has an advantage as applied to Chiou's method of concurrent error detection and correction in multiplication of $GF(2^n)$.

• Journal of IKEEE
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• v.7 no.1 s.12
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• pp.56-62
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• 2003

In this paper, we designed a adder and a multiplier using current mode T-gate on $GF(2^2)$. The T-gate is consisted of current mirror and pass transistor, the designed 4-valued T-gate used adder and multiplier on $GF(2^2)$. We designed its under 1.5um CMOS standard technology. The unit current of the circuits is 15㎂, and power supply is 3.3V VDD. The proposed current mode CMOS operator have a advantage of module by T-gate`s arrangement, and so we easily implement multi-valued operator.

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.41 no.6
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• pp.27-35
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• 2004

Finite or Galois fields have been used in numerous applications such as error correcting codes, digital signal processing and cryptography. These applications often require exponetiation on GF(2$^{m}$ ) which is a very computationally intensive operation. Most of the existing methods implemented the exponetiation by iterative methods using repeated multiplications, which leads to much computational load, or needed much hardware cost because of their structural complexity in implementing. In this paper, we present an effective VLSI architecture for exponentiation on GF(2$^{m}$ ). This circuit computes the exponentiation by multiplying product terms, each of which corresponds to an exponent bit. Until now use of this type algorithm has been confined to a primitive element but we generalize it to any elements in GF(2$^{m}$ ).

• Korean Journal of Food Science and Technology
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• v.31 no.2
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• pp.448-457
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• 1999

Citrus fruits are consumed worldwide due to their unique flavor and nutrition value. It is necessary to remove the haze material as well as to minimize the loss of major compounds such as organic acids, sugars, and ascorbic acid in membrane processes for clarification of juice. The objective of our research was to select the best membrane among one surface filter (Whatman No.4) and five microfiltration filters (GF/A, GF/D, GF/F, Gelman, and SM). Tangerine fresh blended with three times of water was partially clarified with 170 mesh followed by prefiltration in a Samduck filtration system. The best membrane was selected by measuring the amounts of major compounds in the permeates as well as the flux which were statistically analyzed with SAS program. The foulants on the membrane surface were observed by SEM. The flux of GF/A and GF/F decreased with time at probability 0.10. Gelman, SM, and GF/D maintained the stable flux. Gelman showed the highest total scores including nutritive value (the amounts of citrate, malate, and ascorbic acid) and purchasing need (brix and color). Therefore, the microfiltration membrane process was a very effective method in tangerine juice clarification and Gelman type A/E was proved to be the best membrane among the five microfiltration membranes.