• Journal of Korean Medicine Rehabilitation
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• v.28 no.3
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• pp.27-38
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• 2018

Objectives The aim of this research is to analyze research trends on fracture animal experimental study in Korea. Methods For reviewing research, we constructed a key question as the effect of herbal medicine on fracture healing and selected fracture animal experimental research. We searched the following 6 databases: KoreaMed, Kmbase, Koreanstudies Information Service System (KISS), National Digital Science Library (NDSL), Korea Institute of Science and Technology Information (KISTI), Oriental Medicine Advanced Searching Integrated System (OASIS). Results A total of 283 potentially relevant studies were identified; only 12 studies were selected for reviewing research. Almost studies showed that herbal medicine had significant effect on fracture healing. Conclusions The research showed that herbal medicine could significantly stimulate fracture healing and reduced inflammation. In the future, more fracture animal experimental study should be actively conducted.

• Journal of Korean Academy of Oral and Maxillofacial Radiology
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• v.27 no.1
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• pp.123-140
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• 1997

The purpose of this study was to investigate effects of osteoporosis on fracture wound healing in the calcium deficient rat. To research the experiment some ten-week old Wistar strain rats with approximately 300 gms weight were selected. Then, the rats were divided into two groups: Normal diet group(rats given a normal diet before and after bone fracture) and Low calcium diet group(rats given a low calcium diet before and after bone fracture). Both groups had been provided with each diet for three weeks. When the rats became thirteen weeks old, the mandibular angle of rats in both groups was artificially fractured for test. The healing of fracture wounds was reviewed by using soft x-ray radiography and /sup 99m/Tc-MDP bone scan and also histopathologic examination. The obtained results were as follows : 1. The radiolucency of the fracture site for the Normal diet group started to decrease from the 14th day since the experiment was made, while the Low calcium diet group began decrease in the radiolucency from the 21st day of the experiment. The radiolucency for the Normal diet group disappeared at the 42nd day, but one for the Low calcium diet group disappeared at the 56th day of the experiment. 2. The highest uptake rate of /sup 99m/Tc-MDP stood at the 14th day of the experiment in the Normal diet group and the Low calcium diet group's maximum rate was recorded at the 21st day of the experiment. These both groups were gradually experiencing decrease in the uptake rate as the experiment time was going on. However, the uptake rate in the Low calcium diet group was lower than one in the Normal diet group. 3. For the Normal diet group, the newly formed trabeculae, which were similar to one of the surroundung bone, were seen at the 42nd day of the experiment. On the other hand, the Low calcium diet group showed at the 56th day of the experiment that the osteoporotic findings looked weak, irregular trabeculae, and also large bone marrow space were observed clearly. As a result of the above experiment, it is said that the healing of the fracture can be completed for both groups, the Normal diet group and the Low calcium diet group. However, the amount of the newly formed bone wound in the Low calcium diet group is rather decreased compared to one in the Normal diet group and at the same time the healing of the fracture is delayed in the Low calcium diet group. Consequently, for the successful healing of fracture in osteoporosis, it is considered that the management of the etiologic factors of osteoporosis must be preceded. The more study of calcium metabolism and functions of osteoblast and osteoclast needs to proceed on.

• Journal of Ceramic Processing Research
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• v.21 no.2
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• pp.200-207
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• 2020

The self-healing fiber-reinforced composite (abbreviation: shFRC) was made by adding SiC, a self-healing material, between an Al₂O₃ matrix and an Al₂O₃ continuous fiber. shFRC has the characteristic of healing the reduced strength by self-healing. The purpose of this study was to evaluate the damage and healing of new composite material, shFRC, and define new failure criteria. The test method used in this study was a high temperature creep test. The interface fracture behavior with time was investigated by analyzing the creep rate. The creep test conditions were 137 MPa and 150 MPa at 1,000 ℃, and 68.5 MPa, 100 MPa, and 137 MPa at 1,200 ℃, respectively. As a result, the crack propagation of 1,000 ℃ was stopped by healing, and the creep rate was zero. The crack healing part was higher than the strength before the crack formation. Due to the rapid hardening of the interface and the decrease in strength of the fiber, delayed fracture behavior was not observed at 1,200 ℃. If the crack is stopped by self-healing at a constant load, shFRC can use that load stress as the allowable stress. However, when the reaction rate of the interface is markedly rapid, crack propagation is difficult to control.

• Journal of Haehwa Medicine
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• v.16 no.1
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• pp.157-166
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• 2007

Objectives : The purpose of this study is to search for more effective methods of diagnosis and treatment of Fracture. Methods : Literature review on Fracture in view of oriental and western medicine. Conclusions : Fracture is classified by anatomical location, grade, shape of line, displacement and cause. The symptom of Fracture is pain, tenderness, deformity, attitude, abnormal mobility, crepitus, neurovascular injury. Fracture is not the same in Healing process by location. The age, endocrine system, chronic debilitating disease, stabilization is effect on healing period and process. Treatment of Fracture is classified emergency care, definite treatment and rehabilitation.

• Journal of Veterinary Clinics
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• v.20 no.3
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• pp.328-333
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• 2003

This study was performed to investigate the effects of electrical stimulation on femoral fracture healing in dogs. Eight healthy dogs from 4 to 5 $\beta^3$ were used in this experiment. In the treatment group, anode and cathode were connected to proximal and distal site apart from the fracture line by 2 cm and electrical stimulation was applied to the fracture site for l5minutes by 2 V, 25 Hz and for a month. The control group was connected to electrostimulator as the treatment group, but no electrical stimulation was applied. Various parameters were evaluated including radiograph and serum levels of total-ALP(TALP), bone-ALP(BALP) and osteocalcin. The radiography revealed more rapid callus formation in the treatment group than in the control by about a week. The total-ALP levels of the treatment group were higher than those of the control group from the 2nd to the 24th day(p< 0.05). The bone-ALP levels of the treatment group were significantly higher than those of the control from the 2nd to the 24th day(p< 0.05). The bone-ALP/ total-ALP ratios of the treatment group were higher than those of control throughout this experiment but there were no significance. There were no significance in the osteocalcin levels between two groups. In conclusion, the electrical stimulation on femoral fracture site was effective for bone healing in dogs.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.32 no.3
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• pp.250-261
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• 2006

Diabetes mellitus, as a major health problem for the elderly, is associated with an extensive list of complications involving nearly every tissue in the body and has been shown to alter the properties of bone and impair fracture healing in both human and animals. The objective of this study was to examine the healing process of a mandibular fracture in the streptozotocin-induced rats histomorphometrically and histologically. A standardized fracture model was chosen and based on blood-glucose value at the time of surgery. A total of 11-weeks old 36 rats were divided into 2 groups; One is a streptozotocin-induced diabetic group and the other is a non-diabetic group. All was fractured experimentally. Three animals from each group were killed 1, 2, 4, 6, 8 and 12 weeks after fracture and specimens were processed undecalcified for quantitative bone histomorphometric and histologic studies. The diabetic group showed a significant decrease of histomorphometry-based parameter including trabecular bone volume, trabecular thickness in comparison to the non-diabetic rat. This was confirmed histologically. In conclusion, this study suggests that in streptozotocin-induced diabetics, the healing process of bone fracture was impaired and delayed about 2-3 weeks comparing to non-diabetics.

• Journal of Korean Medicine Rehabilitation
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• v.30 no.4
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• pp.17-30
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• 2020

Objectives The purpose of this study is to evaluate the healing effect of Yukmijihwang-tang (YM) on femur fractured mice. Methods Mice were randomly divided into 6 groups: normal, control, positive control, YM with low, medium, high dosage each. All groups were prepared with femur fracture and treated diffrently. In order to measure bone regeneration effects, we analysed the levels of cyclooxygenase-2 (COX2), bone morphogenetic protein-2 (BMP2), collagen type II alpha 1 chain (Col2a1), Sox9, runt-related transcription factor 2 (Runx2), and osterix genes expressed in bone. For morphological analysis, muscles were removed and femur was observed with naked eye. Results COX2 gene expression in bone marrow significantly decreased. BMP2 gene expression significantly increased. Col2a1 gene expression significantly increased. Sox9 gene expression increased as well. Runx2 gene expression in bone marrow increased, but there was no statistical significance. Osterix gene expression significantly increased. Union of the fracture site progressed more in YM group compared to the control group. The fracture union score was significantly decreased in YM group compared to the control group. Conclusions YM showed anti-inflammatory effect, promoted bone regeneration by stimulating the bone regeneration factor. In conclusion, YM can help fracture healing and it well be applied clinically to patients with fracture.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.33 no.4
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• pp.397-400
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• 2007

In an open reduction of the mandibular angle fracture, it is crucial to approximate each fracture segment as closer as possible for the reduction of the healing period. In this case report, we proposed a new technique for the mandibular angle fracture. This was designed to minimize the gap between two separated segments using mini-implants and surgical wires. Mini-implants were placed around the fracture line, followed by wire ligation to minimize the fracture gap. And then internal fixation was easily employed with plates and screws. The advantages of this technique were reduced time for operation, the promotion of healing, rapid functional recovery, and few complications.

• The Journal of the Korea Contents Association
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• v.11 no.10
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• pp.286-292
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• 2011

This study investigated the degree of fracture healing using cathode stimulation of microcurrent, cathode and anode stimulation of High Voltage Pulsed Galvanic Current (HVPGC). Measures were performed by X-ray test and Hematoxylin-Eosin stain and Masson's trichrome stain and osteocalcin-positive immunoreactivity. In the measure of X-ray, microcurrent stimulation group revealed more rapid recovery than the groups of HVPGC's cathode and anode stimulation in bone union degrees. Microcurrent group showed significant difference statistically (p<0.05). However, the groups of HVPGC's cathode and anode stimulation didn't show significant difference statistically(p>0.05). In the histologic examination with Hematoxylin-Eosin and Masson's trichrome, microcurrent stimulation group was observed more proliferation of irregular woven bones than the groups of HVPGC's cathode and anode stimulation. Osteocalcin-positive immunoreactivity was observed more osteoblast, osteocyte, osteoclast, bone matrix than the groups of HVPGC's cathode and anode stimulation. Microcurrent stimulation can be considered an effective way during healing of fresh fracture and it can show more effective method than HVPGC's cathode and anode stimulation in the fracture healing.

• Journal of Veterinary Science
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• v.21 no.1
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• pp.10.1-10.12
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• 2020

Blood perfusion of skeletal muscle and callus was evaluated using contrast-enhanced ultrasonography (CEUS) in a canine osteotomy model to determine the applicability of CEUS in the assessment of neovascularization during fracture healing and to compare the vascular signals on CEUS between external skeletal fixation and cast-applied dogs. In 6 Beagle dogs, a simple transverse osteotomy was performed at the left tibial shaft and external skeletal fixation (n = 3) or a cast (n = 3) was applied. Radiography, power Doppler ultrasonography (power Doppler), and CEUS were performed until complete union was achieved. On CEUS, vascular changes were quantitatively evaluated by measuring peak intensity (PI) and time to PI in the soft tissue and callus and by counting the vascular signals. Vascular signals from the soft tissue were detected on power Doppler and CEUS on day 2. Significantly more vascular signals were detected by CEUS than by power Doppler. On CEUS, PI in the surrounding soft tissue was markedly increased after the fracture line appeared indistinctively changed on radiography in all dogs. In the cast-applied dogs, vascular signals from the periosteal and endosteal callus were detected on CEUS before mineralized callus was observed on radiography. CEUS was useful in assessing the vascularity of soft tissue and callus, particularly in indirect fracture healing, and provided indications of a normally healing fracture.