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New Approach for Herbal Formula Research: Network Pharmacology (방제 연구를 위한 새로운 접근: 네트워크 약리학)

  • Han, Sang Yong;Kim, Yun Kyung
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.30 no.6
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    • pp.385-396
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    • 2016
  • It is a fact that the existing pharmacological research method is difficult to explain the effect and mechanism of action of herbal formula of Korean medicine. We are now very pleased with the development of modern science and the development of a methodology for studying herbal formula characterized by network targets and multi-component therapeutics over the human body. In this review, systems pharmacology or network pharmacology is demonstrated how these are applied to explain the effectiveness of herbal medicine. The post-genomic era provides a unique opportunity for the two fields to understand and benefit from each other. In particular, recent research trends, research methodology, useful databases and results of research on herbal formula are introduced. China already has a policy of scientific development of traditional chinese medicine (TCM) and the development of Chinese medicine industry with a focus on herbal formula research at national level, and in Korea, it is urgent to support and nurture the methodology appropriate to the characteristics of the herbal formula in order to study the safety and efficacy of Korean medicine.

Clinical and Biochemical Assessment of New-formula Shampoo for Scalp Seborrheic Dermatitis

  • Kim, Jin Hee;Kim, Jeong-Hwan;Shin, Hong-Ju;Lee, Yang Won
    • Journal of Mycology and Infection
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    • v.24 no.1
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    • pp.1-8
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    • 2019
  • Background: Scalp seborrheic dermatitis is a common disease characterized by flaking and itching of the scalp. Conventional treatment options, such as the use of topical corticosteroids and antifungal agents, may cause adverse effects and reduce user satisfaction rates; thus, it is important to explore other treatment options for scalp seborrheic dermatitis. Objective: We aimed to evaluate the efficacy and safety of a new-formula shampoo containing natural ingredients, including the extract of Rosa centifolia petals, epigallocatechin gallate, zinc pyrithione, and climbazole. Methods: A total of 50 patients with scalp seborrheic dermatitis were enrolled and divided into two groups: the new-formula shampoo-treated group and the 1.5% ciclopirox olamine shampoo-treated group. Clinical severity scores, sebum secretion, and inflammatory cytokines were assessed. In addition, patient satisfaction and adverse events were assessed using a questionnaire. Results: The new-formula shampoo was comparable with ciclopirox in reducing the clinical severity scores and sebum secretion. Patients' improvement scores and user satisfaction rates were higher in the new-formula shampoo group than in the 1.5% ciclopirox olamine shampoo-treated group. The inflammatory cytokine levels considerably changed in both groups during the course of the study. Conclusion: Thus, the new-formula shampoo can be considered a treatment option for patients with scalp seborrheic dermatitis.

The Product Formula For Nielsen Root number

  • Yang, Ki-Yeol
    • Communications of the Korean Mathematical Society
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    • v.15 no.2
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    • pp.357-370
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    • 2000
  • In [6], Cheng-Ye You gave a condition equivalent to the Nielsen number product formula for fiber maps. And Jerzy Jezierski also gave a similar condition for coincidences of fiber maps. The main purpose of this paper is to find the condition for which holds the product formula for Nielsen root numbers N(f;a) = N(f;a) N(fb;a).

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A MONOTONICITY FORMULA AND A LIOUVILLE TYPE THEOREM OF V-HARMONIC MAPS

  • Zhao, Guangwen
    • Bulletin of the Korean Mathematical Society
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    • v.56 no.5
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    • pp.1327-1340
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    • 2019
  • We establish a monotonicity formula of V-harmonic maps by using the stress-energy tensor. Use the monotonicity formula, we can derive a Liouville type theorem for V-harmonic maps. As applications, we also obtain monotonicity and constancy of Weyl harmonic maps from conformal manifolds to Riemannian manifolds and ${\pm}holomorphic$ maps between almost Hermitian manifolds. Finally, a constant boundary-value problem of V-harmonic maps is considered.

A STUDY ON THE INFLUENCE OF INFANT FORMULAS ON PLAQUE pH (유아용 조제 분유가 치태 pH에 미치는 영향에 관한 연구)

  • Chung, Woo-Jin;Lee, Sang-Hoon;Hahn, Se-Hyun
    • Journal of the korean academy of Pediatric Dentistry
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    • v.25 no.1
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    • pp.93-102
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    • 1998
  • Infant formula in nursing bottle, with inappropriate feeding habits, is major factor associated with the development of nursing caries. Although each infant formula has different carbohydrate and protein composition, studies comparing cariogenic potential of many Korean-branded infant formulas are deficient. In addition, it is on the point of being difficult to evaluate the cariogenecity of milk due to development of many infant formulas. In this study, to evaluate the cariogenic potential of many infant formulas, after oral rinse with six Korean-branded infant formulas(three milk based formulas, one soy based formula and two specific formulas for infants with allergy to milk protein and with lactose intolerance) for ten adult volunteers(eight males and two females), plaque pH change was measured with In vivo/In vitro combination technique and results were as follows. 1. All six different kinds of Korean-branded commercial infant formulas dropped the plaque pH significantly(p<0.05) and at an hour after rinse, plaque pH was not recovered in most of subjects. 2. Soy based infant formula and casein-hydrolyzated infant formula containing no casein dropped the plaque pH significantly more than milk based infant formula containing casein (p<0.05). 3. In the milk protein of infant formulas, casein had more effect on buffering the pH change of the infant formula than whey protein and casein-hydrolyzated infant formula had a reduced effect of casein. 4. In infant formulas with similar protein composition, infant formula containing sucrose dropped plaque pH more than infant formula containing lactose, but there was no significant difference (p>0.05).

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RELATIONSHIP BETWEEN THE WIENER INTEGRAL AND THE ANALYTIC FEYNMAN INTEGRAL OF CYLINDER FUNCTION

  • Kim, Byoung Soo
    • Journal of the Chungcheong Mathematical Society
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    • v.27 no.2
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    • pp.249-260
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    • 2014
  • Cameron and Storvick discovered a change of scale formula for Wiener integral of functionals in a Banach algebra $\mathcal{S}$ on classical Wiener space. We express the analytic Feynman integral of cylinder function as a limit of Wiener integrals. Moreover we obtain the same change of scale formula as Cameron and Storvick's result for Wiener integral of cylinder function. Our result cover a restricted version of the change of scale formula by Kim.

NORM CONVERGENCE OF THE LIE-TROTTER-KATO PRODUCT FORMULA AND IMAGINARY-TIME PATH INTEGRAL

  • Ichinose, Takashi
    • Journal of the Korean Mathematical Society
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    • v.38 no.2
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    • pp.337-348
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    • 2001
  • The unitary Lie-Trotter-Kato product formula gives in a simplest way a meaning to the Feynman path integral for the Schroding-er equation. In this note we want to survey some of recent results on the norm convergence of the selfadjoint Lie-Trotter Kato product formula for the Schrodinger operator -1/2Δ + V(x) and for the sum of two selfadjoint operators A and B. As one of the applications, a remark is mentioned about an approximation therewith to the fundamental solution for the imaginary-time Schrodinger equation.

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THE DUAL OF A FORMULA OF VISKOV

  • Szafraniec, Franciszek Hugon
    • Bulletin of the Korean Mathematical Society
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    • v.40 no.4
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    • pp.699-701
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    • 2003
  • This minipaper offers a formula which is dual to that of Viskov [5]. While Viskov's can be thought of as a rising formula for Laguerre polynomials, ours is precisely the lowering one. Besides documenting the formula, which seems to be missing, we want to provide a (rather elementary) operator theory argument instead of making crude calculations. In other words, the annihilation and creation operators are confronted with lowering and rising formulae; they are often failed to be distinguished.

INFINITE SERIES RELATION FROM A MODULAR TRANSFORMATION FORMULA FOR THE GENERALIZED EISENSTEIN SERIES

  • Lim, Sung-Geun
    • Journal of the Chungcheong Mathematical Society
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    • v.25 no.2
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    • pp.299-312
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    • 2012
  • In 1970s, B. C. Berndt proved a transformation formula for a large class of functions that includes the classical Dedekind eta function. From this formula, he evaluated several classes of infinite series and found a lot of interesting infinite series identities. In this paper, using his formula, we find new infinite series identities.

SIMPLIFYING COEFFICIENTS IN A FAMILY OF ORDINARY DIFFERENTIAL EQUATIONS RELATED TO THE GENERATING FUNCTION OF THE MITTAG-LEFFLER POLYNOMIALS

  • Qi, Feng
    • Korean Journal of Mathematics
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    • v.27 no.2
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    • pp.417-423
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    • 2019
  • In the paper, by virtue of the $Fa{\grave{a}}$ di Bruno formula, properties of the Bell polynomials of the second kind, and the Lah inversion formula, the author simplifies coefficients in a family of ordinary differential equations related to the generating function of the Mittag-Leffler polynomials.