• The Journal of Pediatrics of Korean Medicine
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• v.19 no.2
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• pp.51-68
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• 2005

Objective : Rumenshiqin(儒門事親) was compiled by Zhang Zi Huo(張子和) of the Jin(金) Dynasty of China. He invented unique medical theory and treatment such as three excretive methods(perspiratory, vomitory and purgative therapy). The aim of this study was to make the best use of the therapeutic theory of Rumenshiqin(儒門事親) connected with pediatrics. Methods: We conducted literature search in detail for contents of Rumenshiqin(儒門事親) and reviewed various kinds of books. Results : Zhang Zi Huo(張子和) recognized that children had pure-yang bodies(純陽之體) and emphasized that children need to prevent heat-stagnation(鬱熱) and asthenic yin(損陰). He instructed that a principle of raising such as wearing thin clothes, eating fresh food, harboring little desire and little anger, and taking temperate medicine. He described that pathogenic factors were mistake of rearing, misuse of medicine, exogenous factor, and excessive emotion. Conclusion : According to the above results, it is concluded that his therapeutic theory should be used at present.

• BMB Reports
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• v.47 no.12
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• pp.691-696
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• 2014

${\alpha}$-Enolase is a glycolytic enzyme and a surface receptor for plasminogen. ${\alpha}$-Enolase-bound plasminogen promotes tumor cell invasion and cancer metastasis by activating plasmin and consequently degrading the extracellular matrix degradation. Therefore, ${\alpha}$-enolase and plasminogen are novel targets for cancer therapy. We found that the amino acid sequence of a peptide purified from enzymatic hydrolysates of seahorse has striking similarities to that of ${\alpha}$-enolase. In this study, we report that this peptide competes with cellular ${\alpha}$-enolase for plasminogen binding and suppresses urokinase plasminogen activator (uPA)-mediated activation of plasminogen, which results in decreased invasive migration of HT1080 fibrosarcoma cells. In addition, the peptide treatment decreased the expression levels of uPA compared to that of untreated controls. These results provide new insight into the mechanism by which the seahorse-derived peptide suppresses invasive properties of human cancer cells. Our findings suggest that this peptide could emerge as a potential therapeutic agent for cancer.

• Journal of Sasang Constitutional Medicine
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• v.11 no.2
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• pp.385-389
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• 1999

Acute diarrhea is fastly progressing and its most symptom are caused by virus. It usually continue within 3 weeks. And also it company fever, chilling sign, anorexia and vomitting. Mostly, it is getting better by basic treatment but must be cautious about progressing to dehydration, sepsis or other complications. In this study, it is experienced that acute diarrhea patient, got sick by food, became better by treating in the point of Sasang Medicine. 75 years old male patient having abdominal pain with aqueous diarrhea (about 10th a day before admission), chilling sign, general weakness was classed as Soyangin having Shinhanbocktongmangeumjeung(身寒腹痛亡陰證). I prescribed Hwalsuckgosamtang(滑石苦蔘湯) by Peueumganggy(表陰降氣) therapy and his symptom was getting better. So report it.

• Journal of Acupuncture Research
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• v.22 no.2
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• pp.155-162
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• 2005

Anemarrhenae Rhizoma (AR) has been widely used for the treatment of various diseases in Oriental medicine. To investigate whether AR possesses anti-inflammatory effects against lipopolysaccharide (LPS)-induced inflammation in the BV2 microglial cells, MTT (3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide) assay. reverse transcription -polymerase chain reaction (RT-PCR), and prostaglandin E2 (PGE2) assay, and nitric oxide (NO) detection assay were performed. From the present results, AR was shown to suppress PGE2 synthesis and NO production by inhibiting the LPS-stimulated enhancement of cyclooxygenase-2 and inducible nitric oxide synthase expression in BV2 microglial cells. These results suggest that AR may offer a valuable means of therapy in the treatment of inflammatory diseases by attenuating LPS-induced PGE2 synthesis and NO production.

• Korean Journal of Occupational Health Nursing
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• v.22 no.4
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• pp.343-351
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• 2013

Purpose: This study was to identify factors affecting mammography screening behavior in job women by attitude, social influence and self-efficacy model. Methods: The data were obtained from 171 job women in one residency area by structural questionnaire from March to June 2013 and analysed by using $x^2$-test, ANOVA, Spearman's correlation and logistic regression analysis. Results: The each performance rate was 45.1% in mammography, 44.9% in breast self examination and 48.5% in physical examination. The mammography performance rate in job women showed higher significance in the groups of 1) older age, urban residency, marital status or high economic state, 2) shorter office hours or higher job position, 3) childbirth experience or menopause and 4) preferring soy bean food, practicing regular exercise, suffering chronic disease or receiving radiation therapy. Attitude, social influences and self-efficacy made significant differences in mammography performance. Logistic regression analysis showed that 50 years or older, urban residency, social influences towards mammography and high self-efficacy were significant relationship. Conclusion: In order to increase the mammography performance rate, the intervention strategies are needed to increase positive social influences or self-efficacy and to offer public information to younger age.

• Biomolecules & Therapeutics
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• v.20 no.3
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• pp.352-356
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• 2012

The present study was undertaken to determine whether ethanol influences on the agonist-induced vascular smooth muscle contraction and, if so, to investigate the related mechanism. The measurement of isometric contractions using a computerized data acquisition system was combined with molecular experiments. Ethanol significantly inhibited thromboxane $A_2$ mimetic-induced contraction with intact endothelial function, but there was no relaxation on thromboxane $A_2$ mimetic U-46619-induced contraction irrespective of endothelium suggesting that the pathway such as Rho-kinase activation, $Ca^{2+}$ entry or thin filament regulation was not affected. In addition, ethanol didn't decrease thromboxane $A_2$ mimetic-induced increase of phospho-myosin phosphatase targeting subunit protein 1 (pMYPT1) or pERK1/2. Interestingly, ethanol didn't inhibit significantly phorbol ester-induced contraction in denuded muscles suggesting that thin filament regulation is less important on the ethanol-induced regulation in the muscle than endothelial NO synthesis. In conclusion, this study provides the evidence and possible related mechanism concerning the effect of ethanol on the agonist-dependent contraction in rat aortic rings with regard to endothelial function.

• The Korean Journal of Health Service Management
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• v.7 no.1
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• pp.167-177
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• 2013

This study was to evaluate the influences of swallowing function on quality of life and activity of daily living of inpatients in geriatric hospital. The subjects were consisted of elderly patients over the age of 65, 50 people in geriatric hospital of gwangju and jeonnam area. The results are as follows: First, swallowing function score of the subjects is $29.90{\pm}5.27$, SWAL-QOL score is $158.12{\pm}33.36$, ADL score is $80.40{\pm}22.91$. Second, swallowing function, SWAL-QOL details and ADL details of each other showed a statistically significant correlation. Third, the items of swallowing function affecting on quality of life are 'oral cavity in residue', 'to eat solid food', and 'phlegm obstructs the throat'. In conclusion, this study showed that swallowing function of inpatients in geriatric hospital is closely associated with the quality of life and the activity of daily living. Therefore, future development of programs for the improvement of swallowing function is required in order to improve the quality of life of inpatients in geriatric hospital.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.23 no.1
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• pp.282-288
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• 2010

In our review, the conclusions on the concept and principle of perspiration are as follows. 1. It is the physiological perspiration that Qingyang(淸陽) from Jing(精), Qi(氣), Xie(血) synthesized by digestion of food and drink(水穀), is increased and secreted from pores on the skin(腠理). 2. The main center to control perspiration is heart(心), but lver(肝), stomach(胃), spleen(脾), lung(肺), bladder(膀胱), kidney(腎) and triple energizer(三焦) can be also related to perspiration indirectly. 3. As Weiqi(衛氣) make the body warm and keep the body temperature constant by controlling perspiration, it is very important to make a diagnosis of Weiqi(衛氣) Xushi(虛實) by skin temperature. 4. We guess that perspiration can be secreted by the control of BiaoLi-YinYang(表裏陰陽) such as centrifugal(氣) and centrifetal force(形) of Qi(氣). 5. Sweating therapy can make the level of Biaoyang(表陽) correct and control the balance between centrifugal(氣) and centrifetal force(形) of Qi(氣).

• Journal of the Korean Medical Association
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• v.61 no.12
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• pp.758-764
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• 2018

Dementia is a clinical syndrome characterized by a cluster of symptoms and signs that manifest as difficulties in cognitive functions such as memory, psychological and psychiatric changes, and impairments in activities of daily living. As a result of worldwide trends of population aging, dementia has had a huge impact on public health in almost all countries. Disease modification therapies for dementia have not yet been developed. However, pharmacotherapy is essential in patients with dementia to combat delays in their cognitive and functional decline. In this article, we review the current pharmacotherapy for dementia. Three acetylcholinesterase inhibitors-donepezil, rivastigmine, galantamine-and memantine are the only medications that have been approved for the treatment of dementia. We present the indications, dose recommendations, side effects, and criteria for National Health Insurance coverage in Korea of these medications for dementia treatment. Although the Ministry of Food and Drug Safety in Korea has not approved any medications for managing the behavioral and psychological symptoms of dementia, some antipsychotics and antidepressants have been studied and used clinically for those purposes. Clinicians may consider vitamin E, Ginkgo biloba extract, choline alfoscerate, or omega-3 fatty acids as additional treatment options. Non-steroid anti-inflammatory drugs, estrogen hormone therapy, and statins are not generally recommended for dementia treatment. We believe that our findings will aid clinicians in the treatment of patients with cognitive decline.

• International journal of advanced smart convergence
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• v.8 no.1
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• pp.184-195
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• 2019

This study investigates the hair restoration efficacy of selected radish saponin extracts on nude mice. Nude mice genetically predisposed to pattern balding were used in this study. Our study revealed the underlying mechanism of stimulating hair growth in athymic nude mice by repair the nu/nu follicular keratin differentiation defect. Thus, the topical application of radish saponin may represent a novel strategy for the management and therapy of certain forms of alopecia. The term of hair density of PEE treated nude mice were significantly increase as compared with of control nude mice. Histological observation of skin sample showed no hair follicle or only distorted hair follicles were observed in the control samples, in contrast, by the PEE treatment groups showed a fully formed and increased the number of hair follicles up to three times higher than that of control group in terms of the number of hair follicles in nude mouse skin.PEE treated mice the number of BrdU-labeled keratinocytes per anagen follicle increased significantly, especially in the follicular bulbs and outer root sheath compared with the control mice. Moreover, PEE-treated nude mice also exhibited a significant increase in the number of BrdU-labeled epidermal keratinocyte proliferation.