• Asian Pacific Journal of Cancer Prevention
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• v.17 no.7
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• pp.3527-3531
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• 2016

Recombinant human bone morphogenetic protein-2 (rhBMP-2 ), a member of the TGF-${\beta}$ family, has been used widely in recent years to regenerate defects of the maxillary and mandible bones. Such defects are sometimes caused by resection of oral squamous cell carcinoma (OSCC) yet the biologic effects of rhBMP-2 on these carcinomas are not fully clear. The objective of this study was to determine histologically whether rhBMP-2 produces adverse effects on angiogenesis during induction of OSCC, a biologic process critical for tumor formation in an experimental model in the buccal pouch of golden Syrian hamsters. Buccal cavities were exposed to painting with 0.5% DMBA in liquid paraffin three times a week for 14 weeks, then biopsies were taken. Division was into 2 groups: a study group of 10 hamsters receiving $0.25{\mu}g/ml$ of rhBMP-2 in the $3^{rd}$ and $6^{th}$ weeks; and a control group of 10 hamsters which did not receive any additional treatment. VEGF expression and microvessel density were measured but no differences were noted between the two groups. According to this study, rh-BMP-2 does not stimulate angiogenesis during induction of OCSSs.

• Journal of Digital Convergence
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• v.13 no.1
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• pp.563-574
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• 2015

The aim of this study was to examine the relationship between the physical exercise needs, exercise commitment and exercise addiction based on the degree of participation by health club members and furthermore to verify the suitability of the structural model of variables based on these relationships. The subjects for this study include adults aged over 20 years old who exercised for over 3 months in 2014 Random sampling of data from subjects at their convenient time and place known as the convenience sampling method was used to analyze a total of 151 surveys. The collected data was statistically processed using SPSS 18.0. The results of the analysis reached the following conclusions. Firstly, depending on the degree of participation of the health club member, a significant variation was perceived between physical exercise needs, exercise commitment and addiction. Secondly, physical exercise needs had a significant influence on exercise commitment. Thirdly, physical exercise needs had a significant influence on exercise addiction. Finally, exercise commitment had a significant influence on exercise addiction.

• The Journal of Korean Society for School & Community Health Education
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• v.12 no.2
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• pp.113-127
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• 2011

Background: University health services have provided comprehensive medical care, counseling, health promotion, and public health services to their students and several other local institutions. To their faculty and staff, university health care centers have served occupational health services and employee assistant program. Purpose: We performed this study to review the health promotion services on two kinds of health care center with different style of university formate. Methods: We tried to collect the data by literature review and interview with executive and provider at health care center in University of California at Berkeley and San Jose State University. Results: Our results were as followed. First, students could use the medical services just as they would their regular doctor's office and urgent care center. Second, the health promotion unit offered programs and services for keeping students healthy and safe, including many opportunities for students to get involved in shaping the public health of the campus. Third, the health promotion recommendation offered from ACHA was useful guideline to improve health status of their member in university campus. Finally, the student satisfaction surveys were used for evaluation and quality improvement. Conclusions: The systematic approach to improve health status of students, faculty and staff can use to maintain a state of optimum health among the diverse student community in support of academic excellence. Coupled with health promotion and public health programs, university health service have to reach all segments of the healthy campus community. To achieve study goals in university, the health care center contributes to promote accountability and responsibility for the health and well being of the members in their campus.

• Steel and Composite Structures
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• v.33 no.4
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• pp.489-507
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• 2019

In order to obtain high bearing capacity and good ductility simultaneously, a structural column with hybrid normal and high strength steel (HNHSS) welded box section has been developed. Residual stress is an important factor that can influence the behaviour of a structural member in steel structures. Accordingly, the magnitudes and distributions of residual stresses in HNHSS welded box sections were investigated experimentally using the sectioning method. In this study, the following four box sections were tested: one normal strength steel (NSS) section, one high strength steel (HSS) section, and two HNHSS sections. Based on the experimental data from previous studies and the test results of this study, the effects of the width-to-thickness ratio of plate, yield strength of plate, and the plate thickness of the residual stresses of welded box sections were investigated in detail. A unified residual stress model for NSS, HSS and HNHSS welded box sections was proposed, and the corresponding simplified prediction equations for the maximum tensile residual stress ratio (${\sigma}_{rt}/f_y$) and average compressive residual stress ratio (${\sigma}_{rc}/f_y$) in the model were quantitatively established. The predicted magnitudes and distributions of residual stresses for four tested sections in this study by using the proposed residual stress model were compared with the experimental results, and the feasibility of this proposed model was shown to be in good agreement.

• Journal of Digital Convergence
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• v.17 no.10
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• pp.77-84
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• 2019

The purpose of this study is to examine about various barriers recognized by university faculty members while implementing PBL. By adopting the inductive content analysis, this study has analyzed the contents related with the barriers about PBL implementing in the teaching reflection reports submitted by 32 professors of B university. After the analysis, the barriers have been summarized into 5 major topics such as 'teaching beliefs,' 'classroom culture,' 'learning facilitation,' 'assessment,' 'school environment.' Results suggest: First, a study on the specific solutions for the barriers summarized by 5 major topics should be launched. Second, a teaching competency development program to resolve the barriers should be supported. Third, an innovation of physical school environment and school policy appropriate for PBL implementing should be involved. Fourth, a study on the barriers about PBL implementing should be further expanded.

• Biomolecules & Therapeutics
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• v.32 no.3
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• pp.390-398
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• 2024

FoxO1, a member of the Forkhead transcription factor family subgroup O (FoxO), is expressed in a range of cell types and is crucial for various pathophysiological processes, such as apoptosis and inflammation. While FoxO1's roles in multiple diseases have been recognized, the target has remained largely unexplored due to the absence of cost-effective and efficient inhibitors. Therefore, there is a need for natural FoxO1 inhibitors with minimal adverse effects. In this study, docking, MMGBSA, and ADMET analyses were performed to identify natural compounds that exhibit strong binding affinity to FoxO1. The top candidates were then subjected to molecular dynamics (MD) simulations. A natural product library was screened for interaction with FoxO1 (PDB ID-3CO6) using the Glide module of the Schrödinger suite. In silico ADMET profiling was conducted using SwissADME and pkCSM web servers. Binding free energies of the selected compounds were assessed with the Prime-MMGBSA module, while the dynamics of the top hits were analyzed using the Desmond module of the Schrödinger suite. Several natural products demonstrated high docking scores with FoxO1, indicating their potential as FoxO1 inhibitors. Specifically, the docking scores of neochlorogenic acid and fraxin were both below -6.0. These compounds also exhibit favorable drug-like properties, and a 25 ns MD study revealed a stable interaction between fraxin and FoxO1. Our findings highlight the potential of various natural products, particularly fraxin, as effective FoxO1 inhibitors with strong binding affinity, dynamic stability, and suitable ADMET profiles.

• International Journal of Railway
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• v.2 no.2
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• pp.60-69
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• 2009

In recent years, technology developments in different countries, especially in newly industrialized countries, are extremely indebted to appropriate technology transfer by these countries. Nevertheless the technology transfer process in the present situation is complex, and its success is related to the coordination rate with the political, economic, social, and environmental objectives of countries. Today debates related to the transfer of the technical know how accompanied by equipment hardware has found remarkable importance such that countries seek increasing comprehensive capabilities in the field of transferred technology for which Preventive Maintenance (PM) is one of the aspects. This research with the purpose to determine the technological capability level and to study the role of PM in the effective & appropriate technology transfer in subway industry is carried out for presenting a suitable model for the technology transfer in this industry with an attitude towards the effects of principal PM factors. For this purpose, after the study of different and relevant models existing in the field of suitable methods for technology transfer, some equipment PM theories and models were selected as the base for the compilation of the questionnaire. With the help of questionnaire, main PM factors that are effective in the field of technology transfer were extracted, and finally, their effects on technology transfer were analyzed, identified and a comprehensive model suggested in this connection.

• Steel and Composite Structures
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• v.16 no.2
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• pp.135-156
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• 2014

In this research the effect of seismic design level as a practical approach for progressive collapse mitigation and reaching desired structural safety against it in seismically designed concentric braced frame buildings was investigated. It was achieved by performing preliminary and advanced progressive collapse analysis of several split-X braced frame buildings, designed for each seismic zone according to UBC 97 and by applying various Seismic Load Factors (SLFs). The outer frames of such structures were studied for collapse progression while losing one column and connected brace in the first story. Preliminary analysis results showed the necessity of performing advanced element loss analysis, consisting of Vertical Incremental Dynamic Analysis (VIDA) and Performance-Based Analysis (PBA), in order to compute the progressive collapse safety of the structures while increasing SLF for each seismic zone. In addition, by sensitivity analysis it became possible to introduce the equation of structural safety against progressive collapse for concentrically braced frames as a function of SLF for each seismic zone. Finally, the equation of progressive collapse safety as a function of bracing member capacity was presented.

• Journal of the Korean Society of Safety
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• v.21 no.3 s.75
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• pp.67-72
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• 2006

This study is to investigate the related materials such as domestic law regulation, research paper, research report, and the other material, and to suggest suitable counter measures, to find out hazard degree for its works of workers and work place through direct survey, in order to determine risk score of each hazardous work which is designated by the Government, without consideration of labour's consciousness against risk level at a site. Therefore, a new questionnaire survey related to the decision of risk level are made and distributed to find out what risk level each worker recognizes. Also, the authors tried to approach reasonable conclusions after discussing reasonability of qualification standard and improving ideas of worker at hazardous work places with worker, faculty member, H&S manager, labour union. And the results show hazard degrees by each work kind of the above: 3.75 for working with machinery, 3.7 for steel structure, 3.5 for operation of tower crane, 3.51 for retaining wall, 3.85 for form work, 3.46 for scaffolding are obtained. This quantified risk can be applied to establishing a reasonable system to keep safe against hazardous works.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.6
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• pp.2949-2953
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• 2012

The glutathione S transferase (GST) family is a major part of cellular defense mechanisms against endogenous and exogenous substances, many of which have carcinogenic potential. Alteration in the expression level or structure of the glutathione-S-transferase (GST) enzymes may lead to inadequate detoxification of potential carcinogens and consequently contribute to cancer development. A member of the glutathione-S-transferase (GST) family, GSTP1, is an attractive candidate for involvement in susceptibility to carcinogen-associated colorectal cancer. An $Ag{\rightarrow}G$ transition in exon 5 resulting in an Ile105Val amino acid substitution has been identified which alters catalytic efficiency. The present study investigated the possible impact of Ile105Val GSTP1 polymorphism on susceptibility to colorectal cancer. in Jordan We examined 90 tissue samples previously diagnosed with colorectal carcinoma, and 56 non-cancerous colon tissues. DNA was extracted from paraffin embedded tissues and the status of the GSTP1 polymorphism was determined using a polymerase chain reaction restriction fragment length polymorphism (RFLP) method. No statistically significant differences were found between colorectal cancer cases and controls for the GSTP1 Ile/Ile, Ile/Val and Val/Val genotypes. The glutathione S-transferase polymorphism was not associated with risk in colorectal cancer cases in Jordan stratified by age, sex, site, grade or tumor stage. In conclusion, the GSTP1 Ile105Val polymorphism is unlikely to affect the risk of colorectal cancer.