Browse > Article
http://dx.doi.org/10.14456/apjcp.2016.129/APJCP.2016.17.7.3527

Lack of Effects of Recombinant Human Bone Morphogenetic Protein-2 on Angiogenesis in Oral Squamous Cell Carcinoma Induced in the Syrian hamster Cheek Pouch  

Zaid, Khaled Waleed (Department of Oral Histology and Pathology, Faculty of Dentistry, University of Damascus)
Nhar, Bander Mossa (Al -Farabi Colleges Hospital)
Alanazi, Salman Mohammed Ghadeer (Al -Farabi Colleges Hospital)
Murad, Rashad (Faculty of Pharmacy, University of Damascus)
Domani, Ahmad (Al -Farabi Colleges Hospital)
Alhaf, Awadh Jamman (Al -Farabi Colleges Hospital)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.17, no.7, 2016 , pp. 3527-3531 More about this Journal
Abstract
Recombinant human bone morphogenetic protein-2 (rhBMP-2 ), a member of the TGF-${\beta}$ family, has been used widely in recent years to regenerate defects of the maxillary and mandible bones. Such defects are sometimes caused by resection of oral squamous cell carcinoma (OSCC) yet the biologic effects of rhBMP-2 on these carcinomas are not fully clear. The objective of this study was to determine histologically whether rhBMP-2 produces adverse effects on angiogenesis during induction of OSCC, a biologic process critical for tumor formation in an experimental model in the buccal pouch of golden Syrian hamsters. Buccal cavities were exposed to painting with 0.5% DMBA in liquid paraffin three times a week for 14 weeks, then biopsies were taken. Division was into 2 groups: a study group of 10 hamsters receiving $0.25{\mu}g/ml$ of rhBMP-2 in the $3^{rd}$ and $6^{th}$ weeks; and a control group of 10 hamsters which did not receive any additional treatment. VEGF expression and microvessel density were measured but no differences were noted between the two groups. According to this study, rh-BMP-2 does not stimulate angiogenesis during induction of OCSSs.
Keywords
Recombinant human bone morphogenetic protein-2; oral squamous cell carcinoma; angiogenesis;
Citations & Related Records
Times Cited By KSCI : 4  (Citation Analysis)
연도 인용수 순위
1 Fiorelli G, Orlando C, Benvenuti S, et al (1994). Characterization, regulation, and function of specific cell membrane receptors for insulin-like growth factor I on bone endothelial cells. J Bone Miner Res, 9, 329-37.
2 Gao Q, Tong W, Luria JS, et al (2010). Effects of bone morphogenetic protein-2 on proliferation and angiogenesis in oral squamous cell carcinoma. Int J Oral Maxillofac Surg, 39, 266-71.   DOI
3 Gomes-Ferreira PH, Okamoto R, Ferreira S, et al (2016). Scientific evidence on the use of recombinant human bone morphogenetic protein-2 (rhBMP-2) in oral and maxillofacial surgery. Oral Maxillofac Surg, 1-10.
4 Hakki SS, Bozkurt B, Hakki EE, et al (2014). Bone morphogenetic protein-2, -6, and -7 differently regulate osteogenic differentiation of human periodontal ligament stem cells. J Biomed Mater Res B Appl Biomater, 102, 119-30.   DOI
5 Hanasono MM (2014). Reconstructive Surgery for Head and Neck Cancer Patients. Adv Med, 2014, 795483.
6 Hoeben A, Landuyt B, Highley MS, et al (2004). Vascular endothelial growth factor and angiogenesis. Pharmacol Rev, 56, 549-80.   DOI
7 Jain R, Li D, Gupta M, et al (2015). HEART DEVELOPMENT. Integration of Bmp and Wnt signaling by Hopx specifies commitment of cardiomyoblasts. Science, 348, 6071.   DOI
8 Jiang L, Zeng X, Yang H, et al (2008). Oral cancer overexpressed 1 (ORAOV1): a regulator for the cell growth and tumor angiogenesis in oral squamous cell carcinoma. Int J Cancer, 123, 1779-86.   DOI
9 Kim BR, Oh SC, Lee DH, et al (2015). BMP-2 induces motility and invasiveness by promoting colon cancer stemness through STAT3 activation. Tumour Biol.
10 Krishna A, Singh RK, Singh S, et al (2014). Demographic risk factors, affected anatomical sites and clinicopathological profile for oral squamous cell carcinoma in a north Indian population. Asian Pac J Cancer Prev, 15, 6755-60.   DOI
11 Langenfeld EM, Langenfeld J (2004). Bone morphogenetic protein-2 stimulates angiogenesis in developing tumors. Mol Cancer Res, 2, 141-9.
12 Le Page C, Puiffe ML, Meunier L, et al (2009). BMP-2 signaling in ovarian cancer and its association with poor prognosis. J Ovarian Res, 2, 4.   DOI
13 Lee KB, Folger JK, Rajput SK, et al (2014). Temporal regulation of mRNAs for select bone morphogenetic proteins (BMP), BMP receptors and their associated SMAD proteins during bovine early embryonic development: effects of exogenous BMP2 on embryo developmental progression. Reprod Biol Endocrinol, 12, 67.   DOI
14 Luo T, Chen L, He P, et al (2013). Vascular endothelial growth factor (VEGF) gene polymorphisms and breast cancer risk in a Chinese population. Asian Pac J Cancer Prev, 14, 2433-7.   DOI
15 Li GC, Zhang HW, Zhao QC, et al (2016). Mesenchymal stem cells promote tumor angiogenesis via the action of transforming growth factor beta1. Oncol Lett, 11, 1089-94.   DOI
16 Liao Z, Wang CH, Cui WL (2016). Comparison of allograft and autograft in lumbar fusion for lumbar degenerative diseases: a systematic review. J Invest Surg, 1-10.
17 Lou J, Tu Y, Li S, et al (2000). Involvement of ERK in BMP-2 induced osteoblastic differentiation of mesenchymal progenitor cell line C3H10T1/2. Biochem Biophys Res Commun, 268, 757-62.   DOI
18 Mancino M, Strizzi L, Wechselberger C, et al (2008). Regulation of human Cripto-1 gene expression by TGF-beta1 and BMP-4 in embryonal and colon cancer cells. J Cell Physiol, 215, 192-203.   DOI
19 Mattinzoli D, Rastaldi MP, Ikehata M, et al (2016). FGF23-regulated production of Fetuin-A (AHSG) in osteocytes. Bone, 83, 35-47.   DOI
20 Marx RE, Armentano L, Olavarria A, et al (2013). rhBMP-2/ACS grafts versus autogenous cancellous marrow grafts in large vertical defects of the maxilla: an unsponsored randomized open-label clinical trial. Int J Oral Maxillofac Implants, 28, 243-51.   DOI
21 Miyata M, Furukawa M, Takahashi K, et al (2001). Mechanism of 7,12-dimethylbenz[a]anthracene-induced immunotoxicity: role of metabolic activation at the target organ. Jpn J Pharmacol, 86, 302-9.   DOI
22 Sadigh PL, Wu CJ, Feng WJ, et al (2016). New doublelayer design for 1-stage repair of orocutaneous and pharyngocutaneous fistulae in patients with postoperative irradiated head and neck cancer. Head Neck, 38, 353-9.   DOI
23 Nishida N, Yano H, Nishida T, et al (2006). Angiogenesis in cancer. Vasc Health Risk Manag, 2, 213-9.   DOI
24 O'Malley MJ, Sayres SC, Saleem O, et al (2014). Morbidity and complications following percutaneous calcaneal autograft bone harvest. Foot Ankle Int, 35, 30-7.   DOI
25 Raida M, Clement JH, Leek RD, et al (2005). Bone morphogenetic protein 2 (BMP-2) and induction of tumor angiogenesis. J Cancer Res Clin Oncol, 131, 741-50.   DOI
26 Xie H, Wang Z, Zhang L, et al (2016). Development of an angiogenesis-promoting microvesicle-alginatepolycaprolactone composite graft for bone tissue engineering applications. Peer J, 4, 2040.   DOI
27 Zaid KW (2014). Immunohistochemical assessment of E-cadherin and beta-catenin in the histological differentiations of oral squamous cell carcinoma. Asian Pac J Cancer Prev, 15, 8847-53.   DOI
28 Buser Z, Brodke DS, Youssef JA, et al (2016). Synthetic bone graft versus autograft or allograft for spinal fusion: a systematic review. J Neurosurg Spine, 1-8.
29 Bamberger ES, Perrett CW (2002). Angiogenesis in epithelian ovarian cancer. Mol Pathol, 55, 348-59.   DOI
30 Bolander ME (1992). Regulation of fracture repair by growth factors. Proc Soc Exp Biol Med, 200, 165-70.   DOI
31 Carinci F, Pezzetti F, Locci P, et al (2005). Apert and Crouzon syndromes: clinical findings, genes and extracellular matrix. J Craniofac Surg, 16, 361-8.   DOI
32 Cole CJ, Garden AS, Frankenthaler RA, et al (1995). Postoperative radiation of free jejunal autografts in patients with advanced cancer of the head and neck. Cancer, 75, 2356-60.   DOI
33 Deckers MM, Karperien M, van der Bent C, et al (2000). Expression of vascular endothelial growth factors and their receptors during osteoblast differentiation. Endocrinol, 141, 1667-74.   DOI
34 Deckers MM, van Bezooijen RL, van der Horst G, et al (2002). Bone morphogenetic proteins stimulate angiogenesis through osteoblast-derived vascular endothelial growth factor A. Endocrinol, 143, 1545-53.   DOI
35 Epstein NE (2013). Complications due to the use of BMP/INFUSE in spine surgery: The evidence continues to mount. Surg Neurol Int, 4, 343-52.   DOI
36 Zaid KW, Chantiri M, Bassit G (2016). Recombinant human bone morphogenetic protein-2 in development and progression of oral squamous cell carcinoma. Asian Pac J Cancer Prev, 17, 927-32.   DOI
37 Epstein NE (2014). Basic science and spine literature document bone morphogenetic protein increases cancer risk. Surg Neurol Int, 5, 552-60.   DOI
38 Ferrara N, Gerber HP, LeCouter J (2003). The biology of VEGF and its receptors. Nat Med, 9, 669-76.   DOI