• Journal of Life Science
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• v.27 no.12
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• pp.1515-1522
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• 2017

Most people have a desire to live longer. According to ancient Chinese and Korean mythology, Dongfang Shuo (Dongbang Sahk) lived for 18,000 years. According to a WHO report, the average longevity of humans has extended from 50-odd years in the 1960s to 75-85 years in 2016. Parabiosis, the joining to circulatory systems of two animals, was described as early as the 1860s. It provides a powerful experimental model to investigate the effects of one animal on its partner animal in vivo. Research on reverse aging is an immensely popular in parabiosis studies. In this review, the origin of the parabiosis model and important historical findings based on parabiosis models are presented. Surprising and debated discoveries in aging research are also introduced. Using heterochronic parabiosis of connecting circulatory systems of a young mouse and old mouse, various groups claim to have identified a reverse aging factor, growth differentiation factor 11 (GDF11), which was significantly reduced in blood of old mice. Although the potential existence of any one factor or factors that could reverse aging remains to be confirmed, studies have shown that the parabiosis model is powerful enough to detect reverse aging factors.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.4 no.4
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• pp.286-294
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• 2011

Cable modems typically are implemented by a forward error correction(FEC) scheme. The ITU-T Recommendation J-38 Annex B specifies using 64- and 256- quadrature amplitude modulation (QAM) and extended RS coding scheme. In implementing the cable modem, there are some problems to fabricate and fitting on FPGA chip. First, many clocks are needed in implementing cable modem because of different code rate and different modulation types. To reduce the number of clocks, we use the two memories, which are different clock speed for reading and writing data. Second, this system lost the bit-synchronization and frame-synchronization in decoder, the system recognize that all data is error. This paper solves the problems by using simple 5-stage registers and unique sync-word. Based on solutions for about problems, the cable modem is fabricated on FPGA chip name as Vertex II pro xc2vp30-5 by Xilinx, and we confirmed the effectiveness of the results.

• The Korean Journal of Physiology and Pharmacology
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• v.25 no.5
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• pp.395-401
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• 2021

Extended inflammation and cytokine production pathogenically contribute to a number of inflammatory disorders. Formosanin C (FC) is the major diosgenin saponin found in herb Paris formosana Hayata (Liliaceae), which has been shown to exert anti-cancer and immunomodulatory functions. In this study, we aimed to investigate anti-inflammatory activity of FC and the underlying molecular mechanism. RAW264.7 macrophages were stimulated with lipopolysaccharide (LPS) or pretreated with FC prior to being stimulated with LPS. Thereafter, the macrophages were subjected to analysis of the expression levels of pro-inflammatory mediators, including nitric oxide (NO), prostaglandin E₂ (PGE), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and IL-6, as well as two relevant enzymes, inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2). The analysis revealed that FC administration blunted LPS-induced production of NO and PGE in a dose-dependent manner, while the expression of iNOS and COX-2 at both mRNA and protein levels was inhibited in LPS-stimulated macrophages pre-treated with FC. Moreover, LPS stimulation upregulated mRNA expression and medium release of TNF-α, IL-1β, and IL-6, whereas this effect was blocked upon FC pre-administration. Mechanistic studies showed that inhibitory effects of FC on LPS-induced inflammation were associated with a downregulation of IκB kinase, IκB, and p65/NF-κB pathway. Taken together, these data suggest that FC possesses an inflammation-suppressing activity, thus being a potential agent for the treatment of inflammation-associated disorders.

• Journal of the Architectural Institute of Korea Planning & Design
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• v.34 no.9
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• pp.117-128
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• 2018

The United States understood the fostering of pro-U.S. elites in "free world" countries as an important Cold War weapon. From 1954 to 1962, the U.S provided considerable assistance to Seoul National University (SNU) for its postwar rehabilitation and future development in terms of repair and construction of campus buildings, equipment and book purchases, and faculty exchanges. With the aid of this educational assistance project widely known as the Minnesota Project, SNU was reborn with an academic orientation to the U.S., separating itself from the Japanese education that was its origin. This study argues that the Minnesota Project played an important role in crafting SNU's architecture program and the exchange program's recipients as key "knowledge brokers." For individual trainees, experience in the U.S., as opposed to a backwards situation in their homeland, had allowed them to recognize the U.S. as an ideal source of knowledge. Since the Minnesota Project, SNU's Architectural Engineering Department was filled with faculty members who had trained or studied in the U.S., which became a significant distinction of SNU's architecture program in sharp contrast to its counterparts at Hanyang University and Hongik University where most of the faculty members studied in Japan during the Japanese colonial period. As many graduates of SNU had been appointed as faculty members in newly-founded architecture programs in South Korea, a hierarchical diffusion path had emerged in architectural education that led from SNU to other school's architecture programs, with the U.S. at the apex. The legacy of the Minnesota Project extended over the next few decades, in which studying architecture in the U.S. was recognized as a shortcut to success in the field.

• Journal of Life Science
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• v.12 no.4
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• pp.433-441
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• 2002

There has been an increasing public concern about environmental safety and human health of field crops while customer consumes more and more field crops, to which overdose and residual chemicals were applied. As a solution for the problems, construction of sustainable agroecosystem is spreading out to pursuit the economic value of agricultural management as well as to meet environment concern. Public has extended their understanding on the preservation of environment and safeness of agricultural products, and governmental policy toward sustainable agriculture drives rapid increase of the production of sustainable agricultural products. Under this circumstances, it is time to encourage more consumption and to activate market system for the sustainable agricultural products. This study was initiated to diagnose the problems and future direction of domestic sustainable agriculture by analyzing the overall opinions of consumer on the sustainable agriculture. The results are as follows: The pursuit of low input management is a prerequisite to creat high valued agricultural products, and serious consideration should be taken to produce clean crops using natural products. Consummers are willing to pay 10∼50% more prices if the products get certified by official eco-label programs. It is believed that practice of sustainable agriculture using biopesticide and natural pesticide would accelerate the rapid extension of this pro-environmental agricultural management. To activate production and consumption of sustainable agricultural products correct informations on safety should be addressed to customer, and confidence has to be brought about from customer. This could be done by obtaining various and efficient distribution route, product competency for quality, upgraded sales strategy, maximum utilization of certificate system, and practice of recall system, so on.

• The Journal of the Korea Contents Association
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• v.10 no.8
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• pp.266-273
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• 2010

In terms of worldwide rapid change in medical world, the purpose of this study is to investigate perception and attitude of students in dental hygienics concerning the opening of domestic medical market to overseas, so that it can prepare a chance to correctly identify positive and negative aspects of such change in medical market. For questions about effects of opening domestic medical market to overseas as well as pros and contras about it, it was found that there were significant differences in 'improved level of medical technology', 'reduced national medical expenses', 'extended supply of medical facilities' and 'facilitated medicine and medical equipment industry.'(p<0.00). For a question about perception of potential crisis from opening of domestic medical market to overseas, it was found that 55.6% of pro group had no mind of such crisis, whereas 52.3% of contra group had such a mind of crisis. Both cases showed significant differences on a statistical basis (p<0.003). It is recommended that follow-up studies should make a comparative analysis involving students in public health as well as dental hygienics so as to explore even possible ways to take measures for opening of domestic medical market to overseas.

• Journal of the Korean Society for Computer Game
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• v.31 no.4
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• pp.61-70
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• 2018

In this paper, we propose a synchronized playback method of 3D reference model and video by extracting golf swing information from learner's golf video to precisely compare and analyze each motion in each position and time in the golf swing, and present the implementation result. In order to synchronize the 3D model with the learner's swing video, the learner's golf swing movie is first photographed and relative time information is extracted from the photographed video according to the position of the golf club from the address posture to the finishing posture. Through applying time information from learners' swing video to a 3D reference model that rigs the motion information of a pro-golfer's captured swing motion at 120 frames per second through high-quality motion capture equipment into a 3D model and by synchronizing the 3D reference model with the learner's swing video, the learner can correct or learn his / her posture by precisely comparing his or her posture with the reference model at each position of the golf swing. Synchronized playback can be used to improve the functionality of manually adjusting system for comparing and analyzing the reference model and learner's golf swing. Except for the part where the image processing technology that detects each position of the golf posture is applied, It is expected that the method of automatically extracting the time information of each location from the video and of synchronized playback can be extended to general life sports field.

• Journal of Life Science
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• v.21 no.7
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• pp.953-960
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• 2011

Necrosis is characterized by the cell membrane rupture and release of the cellular contents, including high-mobility group box 1 protein (HMGB1), into the extracellular microenvironment. HMGB1 acts as a transcriptional regulator in nuclei, but exerts a pro-inflammatory and tumor-promoting cytokine activity when released into the extracellular space. Its overexpression is associated with tumor progression and chemoresistance. Thus, HMGB1 acts as a clinically important molecule in tumor biology. In this study, we examined whether HMGB1 affects cell death induced by anti-cancer drugs. Here we show that HMGB1 prevented cisplatin (alkylating agent)-induced apoptosis and switched the cell fate to necrosis in MCF-7, MDA-MB231, and MDA-MB361 cells. Similar apoptosis-to-necrosis switch effects of HMGB1 were observed in cells treated with 4-HC, another alkylating agent. In contrast, HMGB1 did not exert any significant effects on docetaxel (DOC)-induced apoptosis in MCF-7 cells. We also show that cisplatin-induced apoptosis was switched to necrosis in MCF-7 multicellular tumor spheroids (MTS) that were cultured for 8 days and had necrotic cores, but DOC-induced apoptosis was prevented without the apoptosis-to-necrosis switch. Finally, the levels of RAGE, a receptor of HMGB1, were increased with extended culture of MTS. These findings demonstrate that HMGB1 switches alkylating agent-induced apoptosis to necrosis, suggesting that the strategy to prevent necrosis occurring as an undesirable action of alkylating agent-based chemotherapy should be delineated to improve the efficacy of chemotherapy for cancer.

• Korean Journal of Heritage: History & Science
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• v.46 no.3
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• pp.16-31
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• 2013

This study addresses how the main group of community ritual changed as the regional community changed during the period of Japan's colonial rule of Korea with emphasis on Gwanseongmyo in Jangchung-dong, Seoul. First, almost every regional community was changed because of city planning which was carried out by Japan in Korea for colonial exploitation and for the use of military bases. Mapo-dong and Seobinggo-dong were the appropriate examples. The city planning projects by the Japanese colonial government selected Jangchung-dong as the place of settlement of many Japanese people. The stream, Cheonggyecheon, made a border between the Korean and Japanese settlements and the traditional system of regional community in Jangchung-dong was changed and reorganized considerably. Second, the Japanese government used the rituals of regional community purposefully to combine them with the ceremony in the Japanese shrine. Those who supported Japan performed the regional rituals and tried to follow the policy of 'Rule of Culture' required by the Japanese colonial government. However, most regional rituals continued as they were before Japan's colonial rule of Korea without any change. Under this new trend the ritual of Gwanseongmyo was changed from the ritual for worshipping Guan Yu to that of the regional community. Last, the main groups that led the rituals of regional community were diversified during the period of Japan's colonial rule of Korea. In other words, the rituals of community used to be led by the families that lived in the region for generations before Japan's colonial rule of Korea. However, they were later led by various groups that emerged as a result of the colonial rule, urbanization, commercial development, regional differentiation, and so on. As an example,Yeongsinsa of Gwanseongmyo,which was the main group to lead the ritual of Gwanseongmyo, shows that the regional community rituals were extended to worshipping Guan Yu. The members of the main group to lead the ritual were pro-Japanese senior officials who were formerly military officers. This shows that the main groups leading the regional community rituals were further diversified.

• (The) Research of the performance art and culture
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• no.34
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• pp.133-172
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• 2017

Mansuseongjeol was originally a term that referred to the birthday of Chinese emperors. In October 1897, when Emperor Gojong ascended the throne, his birthday could be called mansuseongjeol. The celebratory events for mansuseongjeol took place throughout various levels of society and regions. Various places and classes including government officials, foreigners, students, religious people, journalists, merchants, civic groups, and nation-wide open ports celebrated the birth of Emperor Gojong, and the classes celebrating the day became stronger and wider. In other words, in the sense that the celebration had the nature of being universal, national, and global in terms of classes, regions, and races, the event was distinguished. Due to such nature, celebrating culture proceeded in various ways and the imperial family provided donation. Celebration on mansuseongjeol extended to respect toward the emperor and patriotism so it contributed to strengthening the emperor's power and solidifying the unity of the people. Also, such an event was reported around the world through diplomats and reporters living in Korea, raising the national status of Korea in the world. However, after the breakout of Russo-Japanese War, Japan controlled the finance of the royal family, reduced the power of the emperor, and the celebration of mansuseongjeol was also reduced. Due to the suspension of royal family's financial support, crackdown from Japan, and the dethronement of Emperor Gojong, events for mansuseongjeol disappeared and only inside the palace, did formal celebrations continue centering on pro-Japan officials and Japanese people. The abdication of Emperor Gojong came with the collapse of Korean Empire and along with that, celebration of mansuseongjeol came to an end. In the circumstances, the culture of court banquet disintegrated, and the best performers of Korean Empire degenerated into mere entertainers. Though mansuseongjeol, the medium of expressing respect toward the emperor and patriotism, lost its status, it is significant that the cultural achievements, which were created during the process established with the support of the financial power of the royal family, serve as internal power that drove Korea's modern and contemporary cultural history.