Formosanin C attenuates lipopolysaccharide-induced inflammation through nuclear factor-κB inhibition in macrophages |
Yin, Limin
(Department of Pharmacy Intravenous Admixture Services, First People's Hospital of Wenling)
Shi, Chaohong (Department of Rehabilitation Center, First People's Hospital of Wenling) Zhang, Zhongchen (Department of Gastroenterology, First People's Hospital of Wenling) Wang, Wensheng (Department of Laboratory Medicine, First People's Hospital of Wenling) Li, Ming (Department of Pharmacy Intravenous Admixture Services, First People's Hospital of Wenling) |
1 | Xu Z, Lin R, Hou X, Wu J, Zhao W, Ma H, Fan Z, Li S, Zhu Y, Zhang D. Immunomodulatory mechanism of a purified polysaccharide isolated from Isaria cicadae Miquel on RAW264.7 cells via activating TLR4-MAPK-NF-κB signaling pathway. Int J Biol Macromol. 2020;164:4329-4338. DOI |
2 | Xiao X, Yang M, Xiao J, Zou J, Huang Q, Yang K, Zhang B, Yang F, Liu S, Wang H, Bai P. Paris Saponin II suppresses the growth of human ovarian cancer xenografts via modulating VEGF-mediated angiogenesis and tumor cell migration. Cancer Chemother Pharmacol. 2014;73:807-818. DOI |
3 | Bruscia EM, Bonfield TL. Cystic fibrosis lung immunity: the role of the macrophage. J Innate Immun. 2016;8:550-563. DOI |
4 | Rossol M, Heine H, Meusch U, Quandt D, Klein C, Sweet MJ, Hauschildt S. LPS-induced cytokine production in human monocytes and macrophages. Crit Rev Immunol. 2011;31:379-446. DOI |
5 | Chiang HC, Wang JJ, Wu RT. Immunomodulating effects of the hydrolysis products of formosanin C and beta-ecdysone from Paris formosana Hayata. Anticancer Res. 1992;12:1475-1478. |
6 | Gu I, Brownmiller C, Stebbins NB, Mauromoustakos A, Howard L, Lee SO. Berry phenolic and volatile extracts inhibit pro-inflammatory cytokine secretion in LPS-stimulated RAW264.7 cells through suppression of NF-κB signaling pathway. Antioxidants (Basel). 2020;9:871. DOI |
7 | Chen CC, Lin MW, Liang CJ, Wang SH. The anti-inflammatory effects and mechanisms of eupafolin in lipopolysaccharide-induced inflammatory responses in RAW264.7 macrophages. PLoS One. 2016;11:e0158662. DOI |
8 | Miller SI, Ernst RK, Bader MW. LPS, TLR4 and infectious disease diversity. Nat Rev Microbiol. 2005;3:36-46. DOI |
9 | Madrid LV, Mayo MW, Reuther JY, Baldwin AS Jr. Akt stimulates the transactivation potential of the RelA/p65 Subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38. J Biol Chem. 2001;276:18934-18940. DOI |
10 | Moncada S. Nitric oxide: discovery and impact on clinical medicine. J R Soc Med. 1999;92:164-169. DOI |
11 | Viatour P, Merville MP, Bours V, Chariot A. Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation. Trends Biochem Sci. 2005;30:43-52. DOI |
12 | Wu RT, Chiang HC, Fu WC, Chien KY, Chung YM, Horng LY. Formosanin-C, an immunomodulator with antitumor activity. Int J Immunopharmacol. 1990;12:777-786. DOI |
13 | Lin PL, Tang HH, Wu SY, Shaw NS, Su CL. Saponin formosanin C-induced ferritinophagy and ferroptosis in human hepatocellular carcinoma cells. Antioxidants (Basel). 2020;9:682. DOI |
14 | Lee JC, Su CL, Chen LL, Won SJ. Formosanin C-induced apoptosis requires activation of caspase-2 and change of mitochondrial membrane potential. Cancer Sci. 2009;100:503-513. DOI |
15 | Liu J, Man S, Liu Z, Ma L, Gao W. A synergistic antitumor effect of polyphyllin I and formosanin C on hepatocarcinoma cells. Bioorg Med Chem Lett. 2016;26:4970-4975. DOI |
16 | Li Y, Man S, Li J, Chai H, Fan W, Liu Z, Gao W. The antitumor effect of formosanin C on HepG2 cell as revealed by 1H-NMR based metabolic profiling. Chem Biol Interact. 2014;220:193-199. DOI |
17 | Man S, Gao W, Zhang Y, Liu Z, Yan L, Huang L, Liu C. Formosanin C-inhibited pulmonary metastasis through repression of matrix metalloproteinases on mouse lung adenocarcinoma. Cancer Biol Ther. 2011;11:592-598. DOI |
18 | Cui J, Man S, Cui N, Yang L, Guo Q, Ma L, Gao W. The synergistic anticancer effect of formosanin C and polyphyllin VII based on caspase-mediated cleavage of Beclin1 inhibiting autophagy and promoting apoptosis. Cell Prolif. 2019;52:e12520. DOI |
19 | Gao XH, Zhang SD, Wang LT, Yu L, Zhao XL, Ni HY, Wang YQ, Wang JD, Shan CH, Fu YJ. Anti-inflammatory effects of neochlorogenic acid extract from mulberry leaf (Morus alba L.) against LPS-stimulated inflammatory response through mediating the AMPK/Nrf2 signaling pathway in A549 cells. Molecules. 2020;25:1385. DOI |
20 | Wu RT, Lin WJ, Chiang HC, Horng LY, Chung YM. Modulation of experimental autoimmune uveitis with formosanin-C in guinea pigs. J Ocul Pharmacol. 1990;6:301-311. DOI |
21 | Gao H, Liu X, Sun W, Kang N, Liu Y, Yang S, Xu QM, Wang C, Chen X. Total tanshinones exhibits anti-inflammatory effects through blocking TLR4 dimerization via the MyD88 pathway. Cell Death Dis. 2017;8:e3004. |
22 | Rod-In W, Monmai C, Shin IS, You S, Park WJ. Neutral lipids, glycolipids, and phospholipids, isolated from sandfish (Arctoscopus japonicus) eggs, exhibit anti-inflammatory activity in LPS-stimulated RAW264.7 cells through NF-κB and MAPKs pathways. Mar Drugs. 2020;18:480. DOI |
23 | Liu XH, Pan LL, Jia YL, Wu D, Xiong QH, Wang Y, Zhu YZ. A novel compound DSC suppresses lipopolysaccharide-induced inflammatory responses by inhibition of Akt/NF-κB signalling in macrophages. Eur J Pharmacol. 2013;708:8-13. DOI |
24 | Tao MQ, Ji CL, Wu YJ, Dong JY, Li Y, Olatunji OJ, Zuo J. 1,7-Dihydroxy-3,4-dimethoxyxanthone inhibits lipopolysaccharide-induced inflammation in RAW264.7 macrophages by suppressing TLR4/NF-κB signaling cascades. Inflammation. 2020;43:1821-1831. DOI |
25 | Yoo S, Kim MY, Cho JY. Beauvericin, a cyclic peptide, inhibits inflammatory responses in macrophages by inhibiting the NF-κB pathway. Korean J Physiol Pharmacol. 2017;21:449-456. DOI |
26 | Oeckinghaus A, Ghosh S. The NF-kappaB family of transcription factors and its regulation. Cold Spring Harb Perspect Biol. 2009;1:a000034. DOI |
27 | Gao H, Cui Y, Kang N, Liu X, Liu Y, Zou Y, Zhang Z, Li X, Yang S, Li J, Wang C, Xu QM, Chen X. Isoacteoside, a dihydroxyphenylethyl glycoside, exhibits anti-inflammatory effects through blocking toll-like receptor 4 dimerization. Br J Pharmacol. 2017;174:2880-2896. DOI |
28 | Newton K, Manning G. Necroptosis and inflammation. Annu Rev Biochem. 2016;85:743-763. DOI |
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