• Proceedings of the Korean Operations and Management Science Society Conference
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• 1996.04a
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• pp.30-35
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• 1996

Penalty technique perhaps is the most common technique used in the genetic algorithms for constrained optimization problems. In recent years, several techniques have been proposed in the area of evolutionary computation. However, there is no general guideline on designing penalty function and constructing an efficient penalty function is quite problem-dependent. The purpose of the paper is to give a tutorial survey of recent works on penalty techniques used in genetic algorithms and to give a better classification on exisitng works, which may be helpful for revealing the intrinsic relationship among them and for providing some hints for further studies on penalty techniques.

• Animal cells and systems
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• v.11 no.2
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• pp.93-98
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• 2007

Gonadotropin-releasing hormone (GnRH), synthesized in the hypothalamus, plays a pivotal role in the regulation of vertebrate reproduction. Since molecular isoforms of GnRH and their receptors (GnRHR) have been isolated in a broad range of vertebrate species, GnRH and GnRHR provide an excellent model for understanding the molecular co-evolution of a peptide ligand-receptor pair. Vertebrate species possess multiple forms of GnRH, which have been created through evolutionary mechanisms such as gene/chromosome duplication, gene deletion and modification. Similar to GnRHs, GnRH receptors (GnRHR) have also been diversified evolutionarily. Comparative ligand-receptor interaction studies for non-mammalian and mammalian GnRHRs combined with mutational mapping studies of GnRHRs have aided the identification of domains or motifs responsible for ligand binding and receptor activation. Here we discuss the molecular basis of GnRH-GnRHR co-evolution, particularly the structure-function relationship regarding ligand selectivity and signal transduction of mammalian and non-mammalian GnRHRs.

• Genomics & Informatics
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• v.11 no.1
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• pp.52-54
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• 2013

Proteins in DNAJ/K families are ubiquitous, from prokaryotes to eukaryotes, and function as molecular chaperones. For systematic phylogenomics of the DNAJ/K families, we developed the Eukaryotic DNAJ/K Database (EDD). A total of 12,908 DNAJs and 4,886 DNAKs were identified from 339 eukaryotic genomes in the EDD. Kingdom-wide comparison of DNAJ/K families provides new insights on the evolutionary relationship within these families. Empowered by 'class', 'cluster', and 'taxonomy' browsers and the 'favorite' function, the EDD provides a versatile platform for comparative genomic analyses of DNAJ/K families.

• Proceedings of the Korean Society of Sericultural Science Conference
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• 2003.04a
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• pp.49-49
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• 2003

DOPA decarboxylase (DDC), which converts DOPA to dopamine, is important for many biological event such as cuticular melanization, sclerotization and neurotransmission in insects. Recently, it has been also shown that DDC activity is correlated with pupal diapause in M. brassicae. The silkworm, Bombyx mori is a typical insect diapausing at early embryonic stage. (omitted)

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 1998.03a
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• pp.85-88
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• 1998

진화이론은 생명체들간의 투쟁과 적자생존의 원칙에 근거를 두고 있다. 그 중 협동으로의 진화는 공생이나 기생관계에 있는 생물들에서 발견되어 사화학, 생물학, 경제학 등의 분야에서 계속적인 관심의 대항이 되어 왔다. 특히 생명체들간에 존재하는 끊임없는 경쟁과 협동의 관계를 시뮬레이션하는 죄수의 딜레마 게임은 지금까지 많은 연구가 진행되어왔다. 죄수의 딜레마 게임이 시작된 근거는 협동으로의 진화에 관한 연구에서 시작되었다고 볼 수 있다. 대부분의 연구가 2명이 하는 죄수의 딜레마 반복게임인 2IPD에 집중되어 있는데 2IPD는 실제 세계에 적용시키는데 한계가 있기 때문에 보다 실세계에 가까운 형태를 모델링하는 N명 죄수의 딜레마 반복 게임(NIPD)에 관한 연구가 진행되고 있다. 이 논문에서는 진화 알고리즘을 이용하여 NIPD게임에서 게임자의 수와 협동으로의 진화와의 관계, 즉 죄수의 수가 증가함에 따라 협동의 정도는 어떻게 나타나는 가에 대해 고찰한다. 여러차례의 반복 시뮬레이션 결과 게임자의 수가 적을때는 대부분이 협동으로 진화하나 게임자의 수가 증가할수록 협동으로의 진화가 어렵다는 사실을 확인할 수 있었다.

• Journal of Microbiology
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• v.38 no.2
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• pp.62-65
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• 2000

Partial sequence comparisons of mitochondrial small subunit rDNA (mt SSU rDNA) were used to examine taxonomic and evolutionary relationships among seven Penicillium species : two monoverticillate species, two biverticillate species, and three terverticillate species. Amplified fragments of mt SSU rDNA highly varied among seven species in size, suggesting the existence of multiple insertions or deletions in the region. A phylogengtic tree was constructed by exhaustive search of parsimony analysis. The phylogenetic tree distinguished two statistically supported monophyletic groups, one for two monoverticillate species and the other for three terverticillate species and ont biverticillate species, P. vulpinum. The phylogenetic relationship of P. waksmanii, the biverticillate species, was not clear.

• Proceedings of the Korea Technology Innovation Society Conference
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• 2002.05b
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• pp.63-70
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• 2002

This paper is to illuminate the dynamic relationship between the technological learning mechanism and international political intervention. Besides conventional techno-economic factors, international political factors are emphasized as external factors in the technological learning mechanism. Being influenced by international political intervention, the evolutionary path of technological capabilities is not incrementally cumulated and organizational process is not autonomously performed, either. In order to mitigate the impact of the international political intervention, DCs make efforts to develop technological capabilities step-by-step in line with current and future civilian industrial demand.

• Journal of Microbiology
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• v.35 no.3
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• pp.159-164
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• 1997

The phylogenetic study of Penicilium chrysogenum was performed based on amino acid sequence comparison of chitin synthase. Phylogenetic trees were constructed with the deduced amino acid sequences of the highly conserved region of chitin synthease gene fragments amplified by PCR. The BlasP similarity searcch and the bootstrap analysis of the deduced amino acid sequences of chitin synthase from P. chrysogenum with those form other fungi showed a close evolutionary relationship of Penicillium to ascomycetous fungi, especially to genus Aspergilus. The result from bootstrap analysis of the deduced amino acid sequences of the Class II chitin synthase from ascomyceteous fungi supported the usefulness of the Class II chitin synthease for phylogenetic study of filamentous fungi.

• Molecules and Cells
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• v.28 no.5
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• pp.407-415
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• 2009

The sirtuins are a protein family named after the first identified member, S. cerevisiae Sir2p. Sirtuins are protein deacetylases whose activity is dependent on $NAD^+$ as a cosubstrate. They are structurally defined by two central domains that together form a highly conserved catalytic center, which catalyzes the transfer of an acetyl moiety from acetyllysine to $NAD^+$, yielding nicotinamide, the unique metabolite O-acetyl-ADP-ribose and deacetylated lysine. One or more sirtuins are present in virtually all species from bacteria to mammals. Here we describe a phylogenetic analysis of sirtuins. Based on their phylogenetic relationship, sirtuins can be grouped into over a dozen classes and subclasses. Humans, like most vertebrates, have seven sirtuins: SIRT1-SIRT7. These function in diverse cellular pathways, regulating transcriptional repression, aging, metabolism, DNA damage responses and apoptosis. We show that these seven sirtuins arose early during animal evolution. Conserved residues cluster around the catalytic center of known sirtuin family members.

• Cross-Cultural Studies
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• v.25
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• pp.529-548
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• 2011

Zu Wen-Zao(朱文藻), Li Tiao-Yuan(李調元), Hong Liang-Ji(洪亮吉), Peng Yuan-Rui(彭元瑞), Qian Dong-Huan(錢東垣), Sun Xing-Yan(孫星衍), Ruan Yuan(阮元), Chen Zhan(陳?), Wu Shi-Fen(嗚式芬), Feng Gui-Fen(馮桂芬), He Shao-Ji(何紹基), Fan Zu-Yin(潘祖蔭) made the contributions to the theoretical construction to the science of Chinese characters in their books "Shuwenxizhuankao(說文繫傳考異)", "Liushufenhao(六書分毫)", "Liushuzhuanzhulu(六書轉注錄)", "Xiqinggujian(西淸古鑒)", "Xiaoeryajiaozheng(小爾雅校證)", "Jiujingzhengsuzikao(九經正俗字考)", "Jiguzhaizhongdingyiqikuanshi(積古齋鐘鼎?器款識)", "Shuwenshengxi(說文聲繫)", "Shuwenjiuzizhengyi(說文解字正義)", "Jungulu(?古錄)", "Shuwenjiuzizhukaozheng (說文解字段注考正)", "Shuowenduanzhubozheng(說文段注駁正)", "Haidongjinshilu(海東金石錄)". They analyzed the rules behind character construction, and tried to find out the nature of Chinese characters, the relationship between Chinese characters, the evolutionary laws of Chinese characters, the characteristic of ancient Chinese characters etc.