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http://dx.doi.org/10.5808/GI.2013.11.1.52

Eukaryotic DNAJ/K Database: A Comprehensive Phylogenomic Analysis Platform for the DNAJ/K Family  

Cheong, Kyeongchae (Fungal Bioinformatics Laboratory, Seoul National University)
Choi, Jaehyuk (Center for Fungal Pathogenesis, Seoul National University)
Choi, Jaeyoung (Fungal Bioinformatics Laboratory, Seoul National University)
Park, Jongsun (Fungal Bioinformatics Laboratory, Seoul National University)
Jang, Suwang (Fungal Bioinformatics Laboratory, Seoul National University)
Lee, Yong-Hwan (Fungal Bioinformatics Laboratory, Seoul National University)
Abstract
Proteins in DNAJ/K families are ubiquitous, from prokaryotes to eukaryotes, and function as molecular chaperones. For systematic phylogenomics of the DNAJ/K families, we developed the Eukaryotic DNAJ/K Database (EDD). A total of 12,908 DNAJs and 4,886 DNAKs were identified from 339 eukaryotic genomes in the EDD. Kingdom-wide comparison of DNAJ/K families provides new insights on the evolutionary relationship within these families. Empowered by 'class', 'cluster', and 'taxonomy' browsers and the 'favorite' function, the EDD provides a versatile platform for comparative genomic analyses of DNAJ/K families.
Keywords
database; HSP40 heat-shock proteins; HSP70 heat-shock proteins;
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1 Qiu XB, Shao YM, Miao S, Wang L. The diversity of the DnaJ/Hsp40 family, the crucial partners for Hsp70 chaperones. Cell Mol Life Sci 2006;63:2560-2570.   DOI   ScienceOn
2 Walsh P, Bursac D, Law YC, Cyr D, Lithgow T. The J-protein family: modulating protein assembly, disassembly and translocation. EMBO Rep 2004;5:567-571.   DOI   ScienceOn
3 Brocchieri L, Conway de Macario E, Macario AJ. hsp70 genes in the human genome: conservation and differentiation patterns predict a wide array of overlapping and specialized functions. BMC Evol Biol 2008;8:19.   DOI   ScienceOn
4 Lin BL, Wang JS, Liu HC, Chen RW, Meyer Y, Barakat A, et al. Genomic analysis of the Hsp70 superfamily in Arabidopsis thaliana. Cell Stress Chaperones 2001;6:201-208.   DOI
5 Zhu X, Zhao X, Burkholder WF, Gragerov A, Ogata CM, Gottesman ME, et al. Structural analysis of substrate binding by the molecular chaperone DnaK. Science 1996;272:1606- 1614.   DOI   ScienceOn
6 Miernyk JA. The J-domain proteins of Arabidopsis thaliana: an unexpectedly large and diverse family of chaperones. Cell Stress Chaperones 2001;6:209-218.   DOI
7 Rasssow J, von Ahsen O, Bomer U, Pfanner N. Molecular chaperones: towards a characterization of the heat-shock protein 70 family. Trends Cell Biol 1997;7:129-133.   DOI   ScienceOn
8 Park J, Park B, Jung K, Jang S, Yu K, Choi J, et al. CFGP: a web-based, comparative fungal genomics platform. Nucleic Acids Res 2008;36:D562-D571.
9 Enright AJ, Van Dongen S, Ouzounis CA. An efficient algorithm for large-scale detection of protein families. Nucleic Acids Res 2002;30:1575-1584.   DOI   ScienceOn
10 Hendrick JP, Hartl FU. Molecular chaperone functions of heat-shock proteins. Annu Rev Biochem 1993;62:349-384.   DOI   ScienceOn
11 Lindquist S, Craig EA. The heat-shock proteins. Annu Rev Genet 1988;22:631-677.   DOI   ScienceOn
12 Georgopoulos C, Welch WJ. Role of the major heat shock proteins as molecular chaperones. Annu Rev Cell Biol 1993;9: 601-634.   DOI   ScienceOn
13 Langer T, Lu C, Echols H, Flanagan J, Hayer MK, Hartl FU. Successive action of DnaK, DnaJ and GroEL along the pathway of chaperone-mediated protein folding. Nature 1992;356: 683-689.   DOI   ScienceOn
14 Wild J, Altman E, Yura T, Gross CA. DnaK and DnaJ heat shock proteins participate in protein export in Escherichia coli. Genes Dev 1992;6:1165-1172.   DOI   ScienceOn
15 Cheetham ME, Caplan AJ. Structure, function and evolution of DnaJ: conservation and adaptation of chaperone function. Cell Stress Chaperones 1998;3:28-36.   DOI   ScienceOn
16 Yochem J, Uchida H, Sunshine M, Saito H, Georgopoulos CP, Feiss M. Genetic analysis of two genes, dnaJ and dnaK, necessary for Escherichia coli and bacteriophage lambda DNA replication. Mol Gen Genet 1978;164:9-14.   DOI
17 Greene MK, Maskos K, Landry SJ. Role of the J-domain in the cooperation of Hsp40 with Hsp70. Proc Natl Acad Sci U S A 1998;95:6108-6113.   DOI   ScienceOn