• BMB Reports
• /
• v.53 no.9
• /
• pp.453-457
• /
• 2020

The right-handed double-helical structure of DNA (B-DNA), which follows the Watson-Crick model, is the canonical form of DNA existing in normal physiological settings. Even though an alternative left-handed structure of DNA (Z-DNA) was discovered in the late 1970s, Z-form nucleic acid has not received much attention from biologists, because it is extremely unstable under physiological conditions, has an ill-defined mechanism of its formation, and has obscure biological functions. The debate about the physiological relevance of Z-DNA was settled only after a class of proteins was found to potentially recognize the Z-form architecture of DNA. Interestingly, these Z-DNA binding proteins can bind not only the left-handed form of DNA but also the equivalent structure of RNA (Z-RNA). The Z-DNA/RNA binding proteins present from viruses to humans function as important regulators of biological processes. In particular, the proteins ADAR1 and ZBP1 are currently being extensively re-evaluated in the field to understand potential roles of the noncanonical Z-conformation of nucleic acids in host immune responses and human disease. Despite a growing body of evidence supporting the biological importance of Z-DNA/RNA, there remain many unanswered principal questions, such as when Z-form nucleic acids arise and how they signal to downstream pathways. Understanding Z-DNA/RNA and the sensors in different pathophysiological conditions will widen our view on the regulation of immune responses and open a new door of opportunity to develop novel types of immunomodulatory therapeutic possibilities.

• Journal of the Korean School Mathematics Society
• /
• v.1 no.1
• /
• pp.131-138
• /
• 1998

The aims of mathematical education are to improve uniformity and rigidity, and to apply to an information age which our society demands. One of the educational aims in the 6th educational curriculum emphasizes on the expansion of mathematical thought and utility, But, The change of contents in the text appears little. This means that mathematical teachers must actively develop the new types of problems. That the interests and concerns about mathematics lose the popularity and students recognize mathematics burdensome is the problems of not only teaching method, unrealistically given problems but abstractiveness and conceptions. Mathematical Modeling is classified exact model, almost exact theory based model and impressive model in accordance with the realistic situation and its equivalent degree of mathematical modeling. Mathematical Modeling is divided into normative model and descriptive model according to contributed roles of mathematics. The Modeling Applied Problems in the present text are exact model and stereotyped problems. That the expansion of mathematical thought in mathematics teaching fell into insignificance appears well in the result of evaluating students. For example, regardless of easy or hard problems, students tend to dislike the new types of mathematical problems which students can solve with simple thought and calculation. The ratings of the right answer tend to remarkably go down. If mathematical teachers entirely treat present situation, and social and scientific situation, students can expand the systematic thought and use the knowledge which is taught in the class. Through these abilities of solving problems, students can cultivate their general thought and systematic thought. So it is absolutely necessary for students to learn the Modeling Applied Problems.

• Journal of the Society of Naval Architects of Korea
• /
• v.43 no.4 s.148
• /
• pp.484-493
• /
• 2006

Recently, direct load analysis using ship motion program is required to confirm structural safety for the Post-Panamax class large container carrier. However, there is no exact comparative study data for structural response between 20 and 30 wave load. So, in this paper, to compare the hull girder stress response between 20 versus 3D wave load calculation method, direct load analysis and global F.E analysis have been performed for three kinds of large container vessels using each 20 and 30 wave load calculation program. The results of 2D wave load RAO(Response Amplitude Operator) of each dominant load parameter(vertical, torsional and horizontal moment) are generally bigger than that of 30 results, especially in vertical wave bending moment. And the results of structural analysis based on the equivalent design wave method shows that there is a big difference in view of stress, but the stress distribution is very similar for each wave load case.

• Journal of Korean Society on Water Environment
• /
• v.21 no.5
• /
• pp.516-519
• /
• 2005

An useful protocol coiled load duration curve methodology to estimate contaminant loading to a river on an exceedance probability scale was developed in this research. The technique was further applied to estimate total coliform loading to the Geum River, using the daily mean flow rate and total coliform concentration data during January, 1996 and July, 2004 for the Gongju where an automated monitoring station is located. Drought flow of the Gongju (=50.3 cms) was equivalent to 40% on an exceedance probability scale. Load duration curve for total coliform loading at the Gongju was constructed. Standard duration curve was constructed with the water quality criteria for the class 2 (total coliform concentration = 1000 MPN/100 mL). By plotting load duration curve with standard duration curve, it could be revealed that water quality do not meet the desired water quality for 47% on an exceedance probability scale. If linearity between flow rate and coliform concentration is assumed, it can be interpretated that water quality exceeds desired criteria when average mean flow rate is over 51 cms.

• Journal of The Korean Association of Information Education
• /
• v.11 no.3
• /
• pp.267-279
• /
• 2007

The purpose of this study is to design and practice teaching and learning method for routing algorithm among computer science principle which is difficult to be taught to elementary school students and understood by students. And we find out whether elementary school students can understand those learning contents. Intellectual area was assessed through equivalent test paper before and after the test and emotional area was assessed through students' impressions after class. The test showed that routing algorithm could be taught to children. Therefore, this study presents the learnability of routing algorithm as a learning element of elementary school computer education.

• Transactions of the Korean hydrogen and new energy society
• /
• v.17 no.3
• /
• pp.338-346
• /
• 2006

In this paper, the test results of medium-size(120 kW class) PV system which was installed in the Taeahn thermal power station of Korea Western Power Co., Ltd., were summarized for developing the practical technology to applicate high voltage grid connection PV system. The 120 kW photovoltaic system which was consisted of 1,300 modules, PCS, and 150 kVA transformer station has been operated since Aug. 05, 2005. For verifying the modeling results of PV system, the operation data was compared with modeling results which was executed commercial PSCAD/EMTD and Psim tools. An equivalent circuit model of a solar cell has been also used for solar array modeling. A series of parameters required for array modeling have been estimated from general specification data of a solar module. A PWM voltage source inverter(VIS) and its current control scheme have been analyzed by using P&O (perturbation and Observation) MPPT algorithms technique.

• Journal of Advanced Marine Engineering and Technology
• /
• v.8 no.2
• /
• pp.51-66
• /
• 1984

The cost percentage of engine part in the total building cost of a ship is about 30-40% and the main engine occupies about 50% of the engine part cost. For certain ships the fuel bill can be as high as about 60-70% of the total operating cost after two oil shocks and its amount for one year is nearly equivalent to her main engine price. This fact has further increased the pressure on the engine builders to develop engines of higher efficiency and better possibilities to burn further deteriorated fuel qualities. But the energy-saving plants are ordinarily more expensive and their available amount of exhaust gas energy is less and therefore, they are not always profitable and optimum systems. This paper is prepared to decide the most economical and efficient engine systems by presenting reasonable selecting and economical evaluation methods of the main engine, which is the largest single unit and the most expensive, and its auxiliaries. In order to demonstrate the application of investigated methods in a practical case, a 46, 000 DWT class bulk carrier is selected as a model ship and her main engine and its auxiliaries are selected and evaluated. The result shows that the optimum determined has one year three months POP, 0.903 IRR at a year, 4, 116, 000 dollars PW in 15 years (for 5% escalation rate of fuel cost) and 9.522 BCR for same condition, when the engine plant of a same existing ship is taken as the basis.

• Communications of the Korean Mathematical Society
• /
• v.33 no.4
• /
• pp.1341-1356
• /
• 2018

The author devotes this paper to defining a new class of generalized soft open sets, namely soft somewhere dense sets and to investigating its main features. With the help of examples, we illustrate the relationships between soft somewhere dense sets and some celebrated generalizations of soft open sets, and point out that the soft somewhere dense subsets of a soft hyperconnected space coincide with the non-null soft ${\beta}$-open sets. Also, we give an equivalent condition for the soft csdense sets and verify that every soft set is soft somewhere dense or soft cs-dense. We show that a collection of all soft somewhere dense subsets of a strongly soft hyperconnected space forms a soft filter on the universe set, and this collection with a non-null soft set form a soft topology on the universe set as well. Moreover, we derive some important results such as the property of being a soft somewhere dense set is a soft topological property and the finite product of soft somewhere dense sets is soft somewhere dense. In the end, we point out that the number of soft somewhere dense subsets of infinite soft topological space is infinite, and we present some results which associate soft somewhere dense sets with some soft topological concepts such as soft compact spaces and soft subspaces.

• KEPCO Journal on Electric Power and Energy
• /
• v.2 no.2
• /
• pp.273-278
• /
• 2016

In order to evaluate the lifespan of high-temperature parts with thermal barrier coating in gas turbines used for power generation, this study was performed on an 80 MW-class gas turbine exceeding 24 k equivalent operating hours. Degradation characteristics were evaluated by analyzing the YSZ (Yttria Stabilized Zirconia) top coat, which serves as the thermal barrier coating layer, the NiCrAlY bond coat, and interface layers. Microstructural analysis of the top, middle, and bottom sections showed that Thermal Growth Oxide (TGO) growth, Cr precipitate growth within the bond coat layer, and formation of diffusion layer occur actively in high-temperature sections. These microstructural changes were consistent with damaged areas of the thermal barrier coating layer observed at the surface of the used blade. The distribution of Cr precipitates within the bond coat layer, in addition to the thickness of TGO, is regarded as a key indicator in the evaluation of degradation characteristics.

• Journal of the Institute of Electronics Engineers of Korea SP
• /
• v.44 no.6
• /
• pp.93-99
• /
• 2007

Robust nonlinear image denoising algorithms for the class of ${\alpha}$-stable distribution are introduced. The proposed amplitude-limited sample average filter(ALSAF) proves to be the maximum likelihood estimator under the heavy-tailed Gaussian noise environments. The error norm for this estimator is equivalent to Huber#s minimax norm. It is optimal in the respect of maximizing the efficacy under the above noise environment. It is mired with the myriad filter to propose an amplitude-limited myriad filter(ALMF). The behavior and performance of the ALSAF and ALMF in ${\alpha}$-stable noise environment are illustrated and analyzed through simulation.