• 한국임상수의학회지
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• 제9권2호
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• pp.401-406
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• 1992

돼지의 호흡기질병을 효과적으로 치료 및 예방하고자 Enrofloxacin(Baytril premix)를 사료에 혼합하여 호흡기질병이 산발적으로 발생하고 있는 돈군에 투여하여 호흡기질병의 치료여부, 증체량, 사료요구율, 폐병변치 등을 조사하여 다음과 같은 결과를 얻었다. 1. 육성돈군에 Enrofloxacin(Baytril premix)를 10일간 급여하였던 바 증체량은 33일동안 31kg이었으나 대조구에서는 20.5kg으로써 통계적 유의차를 보였으며(p<0.05), 사료요구율도 개선되었고(p<0.05), 호흡기질병의 임상증상도 없어졌다. 2. 폐병변조사에서 Baytril 급여구에서는 평균 폐병변의 형성정도는 전체 폐면적의 7.92%이었으나 대조구에서는 15.8%의 심한 병변이 형싱되어 있었다. 3. 공시농장에서 발생하고 있는 호흡기질병은 Actinobacillus pleuropneumoniae에 의한 흉막폐렴, Mycoplasma성 유행성폐렴 및 Pasteurella multocida에 의한 폐렴 등이었다.

• 한국수산과학회지
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• 제39권2호
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• pp.72-77
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• 2006

Enrofloxacin (ENRO) is one of the most commonly used fluoroquinolones for treating bacterial disease in olive flounder (Paralichthys olivaceus) farming, but its withdrawal time for industrial-scale farming has not been well established. Withdrawal times of ENRO following oral administration were evaluated in olive flounder under field conditions. Fish were held in an inland fish tank and fed a commercial mediated diet containing 5 mg/kg of ENRO for 9 days. Seven fish per sampling point were examined during and after treatment. ENRO and its major metabolite, ciprofloxacin (CIP), were analyzed using high-performance liquid chromatography with a fluorescence detector. The concentration of ENRO and CIP in muscle increased during the medication period, and then decreased rapidly The sum of ENRO and CIP concentration in olive flounder peaked on day 6, with a maximal concentration in muscle of 4.30 mg/kg. ENRO residues were eliminated rapidly; at 10 days post treatment, the level in muscle was 0.10 mg/kg, but it took about 50 days to be reduced to below 0.1 mg/kg. After 60 days, the residual concentration was below 0.1 mg/kg in all samples. The level of ENRO accumulation at the beginning of oral administration was variable, according to the farming conditions, but the overall exhaustion time was almost the same. We concluded that an adequate withdrawal period of enrofloxacin is 60 days in the case of oral administration.

• 한국식품과학회지
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• 제44권3호
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• pp.293-299
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• 2012

어류 및 갑각류 중에 잔류하는 fluoroquinolone계 항균제를 조사하기 위하여 HPLC-FLD와 LC-MS를 이용하여 분석을 실시하였다. HPLC-FLD를 이용하여 분석하였을 때 검출한계와 정량한계는 각각 0.0030-0.0083, 0.0090-0.0252 mg/kg이었고, LC-MS는 각각 0.0019-0.0040, 0.0059-0.0122 mg/kg으로 나타났다. ofloxacin, norfloxacin, pefloxacin, ciprofloxacin and enrofloxacin의 회수율은 76.4-104.6% 범위로 분석되었다. 총 268건에 대하여 fluoroquinolone계 항균제의 잔류량을 조사한 결과 7.5%의 검출율을 나타내었고, 동자개 1건에서 enrofloxacin과 ciprofloxacin의 합이 허용 기준치인 0.1 mg/kg보다 높게 검출되었다. Ofloxacin, norfloxacin과 pefloxacin은 모든 시료에서 검출되지 않았고 ciprofloxacin과 enrofloxacin은 각각 3.4%와 6.7%의 검출율을 보였다. 어종별 검출율은 장어(2.6%), 미꾸라지(2.2%), 동자개(1.5%), 붕어(0.7%), 가물치(0.4%) 순서로 나타났다.

• 한국임상수의학회지
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• 제30권3호
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• pp.172-177
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• 2013

본 연구는 개 외이염에 대한 enrofloxacin-silver sulfadiazine (Baytril$^{(R)}$ otic, Bayer, USA)의 치료효과를 평가하는 것이다. 24두의 외이염 이환견을 대상으로 처치군에는 바이트릴 오틱을, 대조군에는 증류수를 이도내 7일간 국소투약한 후 7일후에 임상증상, 미생물 및 효모균수를 통해 효과를 비교하였다. 또한 외이염에서 분리된 세균 및 효모균에 대한 바이트릴 오틱의 최소억제농도를 산출하였다. 주요 분리균으로는 Staphylococcus pseudintermedius, Pseudomonas aeruginosa, Proteus spp and Malassezia pachydermatis.이었다. 임상증상의 경감은 81%, 미생물수는 87% 감소하였다. 바이트릴 오틱은 분리된 균에 대한 살균효과가 충분하였고 국소투약에 대한 부작용은 관찰되지 않았다. 따라서 바이트릴 오틱은 개의 외이염 감염에 대한 효과적이며 안전한 제제로 판단된다.

• 한국임상수의학회:학술대회논문집
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• 한국임상수의학회 2008년도 추계학술대회
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• pp.168-168
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• 2008

• 한국임상수의학회지
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• 제8권1호
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• pp.59-63
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• 1991

돼지의 이유자돈 설사병을 효과적으로 치료, 예방하고자 Enrofloxacin(Baytril premix)을 사료에 혼합투여하여 설사 발생여부, 증체량, 사료요구율, 돈분내 대장균수의 변화, 분리한 대장균의 항균물질에 대한 감수성을 조사하여 다음과 같은 결과를 얻었다. 1. 이유자돈에 Baytril premix를 급여하였던 바 대조구보다 62일령에서 체중은 3.2kg의 통계적 유의차이를 보여(p<0.01) 현저한 증체효과 나타내었으며, 사료요구율도 계선되었고 설사발생도 예방할 수 있었다. 2. Baytril Premix를 급여한 자돈의 분변내 대장균수는 3.14$\times$$10^{8}$에서 5일후 2$\times$$10^{7}$ 개/g 10일후 1$\times$$10^{5}$개/g으로 현저히 감소하였다. 3. 공시농장에서 분리한 E. coli 10중의 항균물질에 대한 감수성은 baytril, gentamicin 및 trimeoprim＋sulfamethoxazole에 감수성이 우수하였다.다.

• 한국수산과학회지
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• 제39권2호
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• pp.66-71
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• 2006

Fluoroquinoles have a wide range of antimicrobial properties and are effective in the treatment of bacterial diseases in fish. The use of fluoroquinoles continues to grow steadily. Fluoroquinolone antibiotics are probably the most important class used among synthetic antibiotics in human and veterinary medicines because of their broad activity spectrum and good oral absorption. This study was conducted to estimate the residue of antibiotics in four species of farmed fishes, including olive flounder (Paralichthys olivaceus), black rock fish (Sebastes schlegeli), red sea bream (Pagrus major), and sea bass (Lateolabrax japonicus), collected from fish farms located in the southern coastal area of Korea. The residues of fluoroquinolones were determined using high performance liquid chromatography (HPLC) with a fluorescence detector. Residuals of five fluoroquinolones in muscle tissue of farmed fish were analyzed. We found that enrofloxacin was the most common agent in fish muscle, and that ciprofloxacin was the next most common. The range of detected concentrations of fluoroquinolones in olive flounder muscle was 0-0.859 mg/kg in 32.6% of all samples. Enrofloxacin was commonly detected in sea bass muscle at a range of 0-0.143 mg/kg in 38.9% of all samples. Fluoroquinolones were detected in 6.9% of black rock fish muscle and in 16.6% of sea bream, although the detected concentration was below 0.01 mg/kg. The maximum detection value of enrofloxacin and ofloxacin in olive flounder at the time of shipping was 0.102 mg/kg and 0.09 mg/kg, respectively; no other antimicrobials were detected. We detected no antimicrobial substances in red sea bream.

• 한국동물위생학회지
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• 제43권3호
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• pp.189-196
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• 2020

This study was conducted to analyze feasibility of monitoring of fluoroquinolnes residual through feather analysis in broilers. The calibration curve showed good linearity (r²≥0.99) within the concentration range of 1~100 ㎍/kg. The limit of detection (LOD) and limit of quantification (LOQ) were validated at ≤0.66 and ≤1.99 ㎍/kg in broiler feather, respectively. The recoveries in feather samples ranged from 94.6 to 114.4% (5.1-15.8% RSD) at the 5 to 20 ㎍/kg spiking levels. The proposed new analytical method proved to be suitable and effective for fluoroquinolnes determination. We also monitored fluoroquinolones residue in 36 samples (broiler that were slaughtered in Gyonggi-do) using this method. Among tested feather samples, enrofloxacin and ciprofloxacin were detected in all samples. In muscle samples, enrofloxacin was detected in 20 (55.6%) samples and ciprofloxacin was not detected.

• 한국동물위생학회지
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• 제28권3호
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• pp.235-243
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• 2005

This surveies were carried out to investigate the residual levels of fluoroquinolones in chicken and quail eggs by bioassay and HPLC method. The eggs of 240 samples collected from market and farm in Gwangju Metropolitan city were examined from May to December in 2003. Residual antibiotic materials were detected from 47 samples of the 240 eggs by bioassay. Of the 240 eggs assayed, ciprofloxacin, danofloxacin, norfloxacin, ofloxacin, orbifloxacin and perfloxacin were not detected but enrofloxacin was detected from 5 samples in 228 chicken eggs and 1 sample in 12 quail eggs using HPLC with fluorescence detector by multi-residue method. 2 sample eggs in 6 sample which were detected by HPLC were not positive with bioassay. The average residual concentration of enrofloxacin was 0.494 mg/kg in 6 positive samples. The highest residual concentration of enrofloxacin was 1.83mg/kg.

• 한국동물위생학회지
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• 제28권3호
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• pp.245-251
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• 2005

The purposes of this study were to evaluate the distribution of quinolone and to investigate the effects of quinolones (enrofloxacin, ciprofloxacin) in blood(plasma) and eggs of laying hens. Animals were fed quinolones which supplemented with 20, 50, 80 mg/kg of body weight. Blood and egg samples were collected after oral administration and analyzed for quinolones (enrofloxacin, ciprofloxacin) by HPLC. In laying hens, the residue period of enrofloxacin were longer than that of ciprofloxacin and the levels of residues were elavated by drug dosage.