Korean Journal of Fisheries and Aquatic Sciences (한국수산과학회지)

The Korean Society of Fisheries and Aquatic Science (한국수산과학회)
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Withdrawal Time of Enrofloxacin in Oliver Flounder (Paralichthys olivaceus) after Oral Administration

양식 넙치 (Paralichthys olivaceus)의 Enrofloxacin 휴약기간

  • Kim Poong-Ho (Food Sanitation Research Team, National Fisheries Research and Development Institute) ;
  • Lee Hee-Jung (Food Sanitation Research Team, National Fisheries Research and Development Institute) ;
  • Jo Mi-Ra (Food Sanitation Research Team, National Fisheries Research and Development Institute) ;
  • Lee Tae-Seek (Food Sanitation Research Team, National Fisheries Research and Development Institute) ;
  • Ha Jin-Hwan (Department of Food Science and Engineering, Cheju National University)
  • 김풍호 (국립수산과학원 식품위생팀) ;
  • 이희정 (국립수산과학원 식품위생팀) ;
  • 조미라 (국립수산과학원 식품위생팀) ;
  • 이태식 (국립수산과학원 식품위생팀) ;
  • 하진환 (제주대학교 식품공학과)
  • Published : 2006.04.01
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Abstract

Enrofloxacin (ENRO) is one of the most commonly used fluoroquinolones for treating bacterial disease in olive flounder (Paralichthys olivaceus) farming, but its withdrawal time for industrial-scale farming has not been well established. Withdrawal times of ENRO following oral administration were evaluated in olive flounder under field conditions. Fish were held in an inland fish tank and fed a commercial mediated diet containing 5 mg/kg of ENRO for 9 days. Seven fish per sampling point were examined during and after treatment. ENRO and its major metabolite, ciprofloxacin (CIP), were analyzed using high-performance liquid chromatography with a fluorescence detector. The concentration of ENRO and CIP in muscle increased during the medication period, and then decreased rapidly The sum of ENRO and CIP concentration in olive flounder peaked on day 6, with a maximal concentration in muscle of 4.30 mg/kg. ENRO residues were eliminated rapidly; at 10 days post treatment, the level in muscle was 0.10 mg/kg, but it took about 50 days to be reduced to below 0.1 mg/kg. After 60 days, the residual concentration was below 0.1 mg/kg in all samples. The level of ENRO accumulation at the beginning of oral administration was variable, according to the farming conditions, but the overall exhaustion time was almost the same. We concluded that an adequate withdrawal period of enrofloxacin is 60 days in the case of oral administration.

Keywords

References

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