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Fe3O4 magnetic nanoparticles provide a novel alternative strategy for Staphylococcus aureus bone infection

  • Youliang, Ren;Jin, Yang;Jinghui, Zhang;Xiao, Yang;Lei, Shi;Dajing, Guo;Yuanyi, Zheng;Haitao, Ran;Zhongliang, Deng;Lei, Chu
    • Advances in nano research
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    • v.13 no.6
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    • pp.575-585
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    • 2022
  • Due to its biofilm formation and colonization of the osteocyte-lacuno canalicular network (OLCN), Staphylococcus aureus (S.aureus) implant-associated bone infection (SIABI) is difficult to cure thoroughly, and may occur recurrently subsequently after a long period dormant. It is essential to explore an alternative therapeutic strategy that can eradicate the pathogens in the infected foci. To address this, the polymethylmethacrylate (PMMA) bone cement and Fe3O4 nanoparticles compound cylinder were developed as implants based on their size and mechanical properties for the alternative magnetic field (AMF) induced thermal ablation, The PMMA mixed with optimized 2% Fe3O4 nanoparticles showed an excellent antibacterial efficacy in vitro. It was evaluated by the CFU, CT scan and histopathological staining on a rabbit 1-stage transtibial screw model. The results showed that on week 7, the CFU of infected soft tissue and implants, and the white blood cells (WBCs) of the PMMA+2% Fe3O4+AMF group decreased significantly from their controls (p<0.05). PMMA+2% Fe3O4+AMF group did not observe bone resorption, periosteal reaction, and infectious reactive bone formation by CT images. Further histopathological H&E and Gram Staining confirmed there was no obvious inflammatory cell infiltration, neither pathogens residue nor noticeably burn damage around the infected screw channel in the PMMA+2% Fe3O4+AMF group. Further investigation of nanoparticle distributions in bone marrow medullary and vital organs of heart, liver, spleen, lung, and kidney. There were no significantly extra Fe3O4 nanoparticles were observed in the medullary cavity and all vital organs either. In the current study, PMMA+2% Fe3O4+AMF shows promising therapeutic potential for SIABI by providing excellent mechanical support, and promising efficacy of eradicating the residual pathogenic bacteria in bone infected lesions.

Analysis on the Characteristics of Academic Achievement About 'properties of matter' and 'change of matter': Focusing on the Results of the National Assessment of Educational Achievement (NAEA) in the 2009 Revised Curriculum (물질의 성질 및 물질의 변화 영역에서 중학생들의 학업성취 특성 분석 : 2009 개정 교육과정 시기 국가수준 학업성취도 평가 결과를 중심으로)

  • Jongho, Baek;Wonho, Choi
    • Journal of the Korean Chemical Society
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    • v.66 no.6
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    • pp.493-508
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    • 2022
  • Chemistry is the subject which includes properties, change, and composition of matter. Chemistry has the system which explains observable properties and change with microscopic level, it explains them using scientific theory and laws. In the national-level curriculum, the properties and changes of matter are continuously dealt with from elementary school to high school, and the curriculum are organized so that students could strengthen their understanding about matter. In other words, understanding of the properties and changes of matter is the base to explain everyday life with the view of chemistry, and these two are classified as domains of chemistry in the 2015 revised science curriculum. In this study, we confirmed students' understanding about properties of matter and change of matter, through the analysis about results of the National Assessment of Educational Achievement (NAEA). For that purpose, this study analyzed the 12 items about properties of matter, and 19 items about change of matter, which were used in the NAEA from 2015 to 2019. According to the results of classifying and analyzing questions according to the core concept, the understanding about the two domains significantly changed between the proficient achievement-level students and basic achievement-level students. Depending on the achievement-level, there was a difference in explaining the phenomenon by using the perspective of particles, and by associating scientific concepts and models, or there was a difference in understanding the inquiry related to these two domains. Based on this analysis, this study discussed some implications to be improved on teaching-learning for 'properties of matter', and 'change of matter'.

Analysis of Influencing Factors on Subjective Health Status by Life Cycle (KNHANES VII-3) (생애주기별 대상의 주관적 건강상태에 미치는 영향 요인 분석 (KNHANES VII-3))

  • Hae-Ryoung, Park;Hong-young, Jang
    • Journal of Advanced Technology Convergence
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    • v.1 no.2
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    • pp.69-73
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    • 2022
  • The purpose of this study was to identify the influencing factors of subjective health status among the subjects of the 7th year 3 (2018) National Health and Nutrition Examination Survey, and to help provide programs for improving subjective health status in the future. Data from the 7th Korea National Health and Nutrition Examination Survey(2018) were used. Variables were age, gender, age, subjective health status, subjective body shape recognition, weight change over the past year, usual stress level, walking days per week, and strength training days per week. The higher the number of walking days per week, the lower the usual stress perception level. As the number of strength training days per week increased, the level of stress perception was lower (p<.001). The subjects' subjective health status was found to have a negative effect on their usual stress perception (β=-.759), subjective body shape (β=.111), age (β=.421), and number of days walking per week. (β=.968). Based on this study, it is intended to provide basic data for preparing programs to help improve stress perception and subjective health status in the future.

Designation, Preservation, Management, and Utilization of National Prehistoric Sites (선사시대 사적의 지정·보존·관리 현황과 활용 방안)

  • HWANG, Jaehoon
    • Korean Journal of Heritage: History & Science
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    • v.55 no.2
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    • pp.232-249
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    • 2022
  • The purpose of this article is to review the status of designation and preservation, management of national prehistoric sites and to suggest future applications. Prior to the discussion, the overall status of national prehistoric sites was reviewed. Specifically, the current status of designation, designated area, and distribution by region of national prehistoric sites according to the period and nature of the sites were examined in detail. Next, in order to understand the preservation and management of national prehistoric sites, I report the results of field trips to several sites, such as Geomdan-ri in Ulju, Songguk-ri in Buyeo, and Seoktaek-ri in Hongseong, and propose some measures for preservation, maintenance, and management of the remains. Finally, by referring to cases of US national historic sites such as protection, conservation, operation and management system and academic research project of cultural heritage, it is necessary to consider the need for a direction of the utilization that considers both socio-economic aspects as well as education and research on cultural heritage. The active use of cultural heritage can be a measure that leads to the continuous preservation and management of the sites, and ultimately will be a shortcut to increasing the value of national prehistoric sites.

The effect of social support and resilience of middle-aged men and women on retirement readiness (신중년 남녀세대의 사회적지지와 회복탄력성이 노후준비도에 미치는 영향)

  • Kim, Geon-hui;Hong, Sang-Ook
    • Industry Promotion Research
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    • v.7 no.4
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    • pp.75-84
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    • 2022
  • This study aims to examine the relative effects of social support and resilience on retirement readiness in the prudent male and female generations through hierarchical regression analysis. The results of the study first, As a result of verifying the difference between men and women in social support, resilience, and retirement readiness, there was a significant difference between the overall social support and the subvariables of emotional, intelligence, material, and retirement readiness, the physical. especially, Women had higher averages of social support, resilience, and retirement readiness than men. second, The relative impact of social support and resilience on retirement readiness is In model 1, men have family type, living conditions, and final education, and women have living conditions, average monthly income, In Model 2 and Model 3, both men and women showed the same trend. Model 2 shows living conditions, average monthly income, social support, Model 3 had a significant effect on living conditions, social support, and resilience. Namely, Both men and women recognized that social support and resilience had the greatest relative effect on retirement readiness, which was the main variable. Through this study, the middle-aged generation especially, It is significant in suggesting the need to find ways of social support for women and to increase resilience.

Differences of Teachers and Students' Perceptions on Teaching Skills (교사의 수업전문성에 관한 교사와 학생의 인식 차이)

  • Lee, Okhwa
    • Korean Educational Research Journal
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    • v.43 no.1
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    • pp.125-152
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    • 2022
  • The purpose of this study is to examine the differences of perceptions of teachers and students regarding teaching skills. For the analysis, data was collected by ICALT(International Comparative Analysis of Learning and Teaching) class observation tool and students survey called My Teacher Questionnaire. a student survey. The data of teachers and students can be compared because as the two tools have seven common domains(Safe and stimulating learning climate, Efficient organization, Clear and structured instructions, Intensive and activating teaching, Adjusting instructions and learner processing to inter-learner differences, Teaching learning strategies, Learner engagement). In 2016, in Daejeon, Chungbuk and Chungnam. trained teachers collected data from 106 classes, and 2,866 students responded the survey. The reliability and validity of the two tools, class observation and MTQ(My Teacher Questionnaire) are proven to be satisfactory for use in Korean schools. Students perception on teaching was high, particularly when students are in lower grades and learning major subjects like English, Korean, and math. The domain of higher teaching skills, male students show higher perceptions while female students reported higher perceptions on lower-level teaching skill domains. To compare the perceptions of teachers and students, the predictive reliability of students engagement against teaching skill domains was used. Teachers showed higher predictive reliability on lower teaching skill domains while students showed higher predictive reliability on higher teaching skill domains. It is recommended for further study to develop a professional development model using a teacher class observation tool and the My Teacher Questionnaire for pre-service teachers and school teachers.

Survey for Diagnostic Radiography Examination in Veterinary Hospital (동물병원 영상의학적검사 실태조사)

  • Lee, Won-Jeong;Jo, Sung-Mi
    • Journal of the Korean Society of Radiology
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    • v.16 no.2
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    • pp.177-184
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    • 2022
  • The purpose of this study is surveyed diagnostic radiography (DR) examination in veterinary hospital (VC) including non-ionization radiation such as ultra-sonography and magnetic resonance imaging. From June 1 to June 20. 2021, we surveyed the VC in 00 metropolitan city by using a structural questionnaire which are location of VC and X-ray unit et al.. Data are expressed as a mean with standard deviation for continuous variable or percent for categorical variable using SPSS ver. 26.0. As the first animal to be visited, dogs were the highest with 61.9%, followed by cats with 12.9%. In 87.1% fo cases, DR units were used, and 4 VCs did not. In 27 VCs using DR units, 48.1% separated examination room and control room, 19.8% examined in animal visited, protective clothing was in all VCs, 55.6% were measured radiation exposure dose, 92.6% was responded a necessary for examination education. From the above results, it will help to revise the guidelines for DR units and examination in korea VCs.

Comparing the Effects of Regional Household Expenditure Burden on Childbirth Intention of Married Women: The Case of Capital and Non-Capital Regions (지역별 가계지출 부담이 기혼여성의 출산 의사에 미치는 영향: 수도권과 비수도권 비교를 중심으로)

  • Lee, Da-Eun;Seo, Wonseok
    • Journal of Cadastre & Land InformatiX
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    • v.51 no.2
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    • pp.151-168
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    • 2021
  • This study compared and analyzed the effect of the burden of household expenditure in the metropolitan and non-metropolitan areas on the intention to childbirth intention to married women using a panel logit model. To this end, this analysis targeted married women aged 25 to 39 who are highly likely to be fertile. The main results are as follows; First of all, it was confirmed that the economic power of spouse can be an important factor in the childbirth intention regardless of region. Second, it was found that the higher the satisfaction of marriage had a positive effect on the childbirth intention, and also higher the value that children must have, the higher the childbirth intention. Third, it was confirmed that the burden of household expenditure is the most important factor in the willingness to childbirth intention, excluding factors such as the number of existing children. In particular, the burden on education spending in both the capital region and non-capital region was found to be a key reason for the decrease in the childbirth intention. Lastly, the burden of household expenditure showed different effects on childbirth intention on depending on the region. Specifically, in the capital region, medical spending and loans had a greater impact, while, in the non-capital region, transportation and communication costs had a greater impact on childbirth intentions. Through the results, this study confirmed the implication that easing the burden on household expenditure is continuously necessary to enhance childbirth, and that discriminatory policy approaches are required depending on the area of residence.

A Study on the Factors Affecting the Use of Senior Center Applying Andersen and Newman's Behavior Model: Analysis of Mediating Effect of User Satisfaction (Andersen과 Newman의 행동모델을 적용한 경로당 이용 영향요인에 관한 연구: 이용자 만족도 매개효과 분석)

  • Kim, Jeong Keun
    • 한국노년학
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    • v.40 no.2
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    • pp.291-309
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    • 2020
  • In this study, the behavioral model of Andersen and Newman(1973) was applied to identify the factors influencing the use of senior centers by the elderly in the community, and the mediating effect of user satisfaction was improved to improve the satisfaction of seniors using the Senior Center and operate the Senior Center. This study attempted to suggest policy and practical alternatives for activation. The subjects were 578 elderly people using 2,283 senior centers in Busan. As a result, the factors influencing the total usage period of the Senior Center were analyzed by age and type of potential factors among the leading factors, and the factors affecting the total number of days of senior center usage during the week were gender, age, and education level among the preceding factors. Appeared. Factors affecting user satisfaction as a parameter were analyzed as subjective health status among gender, age, and desire factors among preceding factors. As a result of verification of mediating effect of user satisfaction, there was a partial mediating effect between age and total use of Senior Center, full mediating effect between gender and days of Senior Center use, and partial mediating effect between age and Senior Center use days. Analyzed. According to the purpose and main findings of the study, the policy and practical suggestions for activating the satisfaction and use of Senior Center are as follows. First, program development and support according to the characteristics of senior center users are required. Second, there is a need to characterize per-path according to senior center type and regional environment. Third, there is a need to improve and raise the support standards for senior center operating expenses.

Working in a Risky Environment: Coping and Risk Handling Strategies Among Small-scale Miners in Ghana

  • Wireko-Gyebi, Rejoice Selorm;Arhin, Albert Abraham;Braimah, Imoro;King, Rudith Sylvana;Lykke, Anne Mette
    • Safety and Health at Work
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    • v.13 no.2
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    • pp.163-169
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    • 2022
  • Background: It is estimated that about 13 million artisanal and small-scale miners carry out their activities under harsh, precarious, unfriendly, and risky conditions. Yet, our understanding of the extent to which these workers use personal protective equipment (PPE) and navigate through the various risks and hazards they face is still limited. This article has two main objectives. First, it explores the extent of usage of PPE among artisanal and small-scale miners for the prevention of hazards and risks. Second, it examines the coping strategies used by these miners as a response to experiences of occupational injuries and risks Methods: A cross-sectional survey of small-scale miners was conducted in six communities across three districts in Ghana, West Africa. The mixed methods approach was adopted. A total of 148 small-scale miners participated in the study. Six focus group discussions (FGDs) were held across the six communities. The data were analysed using descriptive statistics. Chi-square tests were used to analyse the relationship between some socio-demographic characteristics (sex, age, and educational background) and the usage of PPE. Open-ended questions and responses from FGDs were analysed based on the content and verbatim quotations from miners. Results: Findings suggest that 78% of the miners interviewed do not use the appropriate PPE citing reasons such as cost, and their personal discomfort associated with use of PPE. There was no significant relationship between socio-demographic characteristics (i.e., sex, age, education and major mining activity) and the usage of PPE. The study further revealed four main coping strategies used by miners to handle the risks. These are rest, taking unprescribed medication and hard drugs, registration with health insurance scheme and savings and investments. Conclusion: This study shows that very few artisanal miners use PPE despite the significant hazards and risks to which they are exposed. The study recommends to the government to put in place measures to ensure that miners adhere to health and safety regulations before undertaking mining activities. This means that health and safety plans and use of PPE should be linked to the license acquisition process for miners.