• The Korean Journal of Physiology and Pharmacology
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• v.15 no.2
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• pp.95-100
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• 2011

DREAM (downstream regulatory element antagonistic modulator) is a calcium-binding protein that regulates dynorphin expression, promotes potassium channel surface expression, and enhances presenilin processing in an expression level-dependent manner. However, no molecular mechanism has yet explained how protein levels of DREAM are regulated. Here we identified group I mGluR (mGluR1/5) as a positive regulator of DREAM protein expression. Overexpression of mGluR1/5 increased the cellular level of DREAM. Up-regulation of DREAM resulted in increased DREAM protein in both the nucleus and cytoplasm, where the protein acts as a transcriptional repressor and a modulator of its interacting proteins, respectively. DHPG (3,5-dihydroxyphenylglycine), a group I mGluR agonist, also up-regulated DREAM expression in cortical neurons. These results suggest that group I mGluR is the first identified receptor that may regulate DREAM activity in neurons.

• Journal of Advanced Marine Engineering and Technology
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• v.25 no.4
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• pp.817-824
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• 2001

In the present study, flow characteristics of turbulent oscillatory flows in the exit region connected to the square-sectional $180^{\circ}$curved duct was investigated experimentally. The experimental study for air flows was conducted to measure velocity profiles, shear stress distributions by using the Laser Doppler Velocimetry(L.D.V) system with the data acquisition and processing system of Rotating Machinery Resolver(R.M.R) and PHASE software. The results obtained from the experimentation were summarized as follows : The critical Reynolds number for a change from transitional oscillatory flow to turbulent oscillatory flow was about 75,000 in the 90 region of dimensionless axial position (x/Dh) which was considered as a fully developed flow region. In the turbulent oscillatory flow, velocity profiles of the inflow period in the entrance region were gradually developed, but those of the outflow period were not changed nearly. Shear stress distributions of turbulent oscillatory flow was gradually increased as the flow proceeds to downstream.

• Journal of the Korean institute of surface engineering
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• v.45 no.5
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• pp.206-211
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• 2012

Process analysis was carried out during deposition of MgO by inductively coupled plasma assisted reactive magnetron sputtering in Ar and $O_2$ ambient. At the initiation of Mg sputtering with bipolar pulsed dc power in Ar ambient, total pressure showed sharp increase and then slow fall. To analyse partial pressure change, QMS was used in downstream region, where the total pressure was maintained as low as $10^{-5}$ Torr during plasma processing, good for ion source and quadrupole operation. At base pressure, the major impurity was $H_2O$ and the second major impurity was $CO/N_2$ about 10%. During sputtering of Mg in Ar, $H_2$ soared up to 10.7% of Ar and remained as the major impurity during all the later process time. When $O_2$ was mixed with Ar, the partial pressure of Ar decreased in proportion to $O_2$ flow rate and that of $H_2$ dropped down to 2%. It was understood as Mg target surface was oxidized to stop $H_2$ emission by Ar ion sputtering. With ICP turned on, the major impurity $H_2$ was converted into $H_2O$ consuming $O_2$ and C was also oxidized to evolve CO and $CO_2$.

• Molecules and Cells
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• v.45 no.7
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• pp.435-443
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• 2022

In response to environmental changes, signaling pathways rewire gene expression programs through transcription factors. Epigenetic modification of the transcribed RNA can be another layer of gene expression regulation. N⁶-adenosine methylation (m⁶A) is one of the most common modifications on mRNA. It is a reversible chemical mark catalyzed by the enzymes that deposit and remove methyl groups. m⁶A recruits effector proteins that determine the fate of mRNAs through changes in splicing, cellular localization, stability, and translation efficiency. Emerging evidence shows that key signal transduction pathways including TGFβ (transforming growth factor-β), ERK (extracellular signal-regulated kinase), and mTORC1 (mechanistic target of rapamycin complex 1) regulate downstream gene expression through m⁶A processing. Conversely, m⁶A can modulate the activity of signal transduction networks via m⁶A modification of signaling pathway genes or by acting as a ligand for receptors. In this review, we discuss the current understanding of the crosstalk between m⁶A and signaling pathways and its implication for biological systems.

• Korean Journal of Remote Sensing
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• v.39 no.4
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• pp.395-407
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• 2023

Super-resolution (SR) has great significance in image processing because it enables downstream vision tasks with high spatial resolution. Recently, SR studies have adopted deep learning networks and achieved remarkable SR performance compared to conventional example-based methods. Deep-learning-based SR models generally require low-resolution (LR) images and the corresponding high-resolution (HR) images as training dataset. Due to the difficulties in obtaining real-world LR-HR datasets, most SR models have used only HR images and generated LR images with predefined degradation such as bicubic downsampling. However, SR models trained on simple image degradation do not reflect the properties of the images and often result in deteriorated SR qualities when applied to real-world images. In this study, we propose an image degradation model for HR satellite images based on the modulation transfer function (MTF) of an imaging sensor. Because the proposed method determines the image degradation based on the sensor properties, it is more suitable for training SR models on remote sensing images. Experimental results on HR satellite image datasets demonstrated the effectiveness of applying MTF-based filters to construct a more realistic LR-HR training dataset.

• Membrane Journal
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• v.34 no.2
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• pp.124-131
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• 2024

Viruses have various applications in the biopharmaceutical industry. They are used in pesticide production, production of vaccines, gene transfers, cancer therapeutics, and more. The downstream processing of viruses is an essential step for their biological and pharmaceutical applications. Among the various processes, the purification of viruses is critical. Membrane chromatography plays a vital role in this process. While ion exchange membrane chromatography is a primarily used method, it has various limitations regarding size exclusion and insufficient purification. Also, it cannot be applied to the rapidly changing strains of viruses such as influenza. This review examines various improved methods of membrane chromatography or alternatives. It focuses on purification, viral recovery rates, and scalability of the methods.

• Journal of Agricultural Extension & Community Development
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• v.20 no.2
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• pp.315-339
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• 2013

This study aims to suggest methods to estimate the agriculture related added value created in the agricultural production sector and the up/downstream agribusiness of Chungcheongnam-do by using the transaction table at producer's price, the domestic transaction table, the wholesale-retail profit table and the freight charge table in the input-output tables, and further aims to estimate regional and industrial agriculture related added values created in the agricultural production sector and the agribusiness of Chungcheongnam-do by using the input-output tables of the year 2005. This thesis suggests the consideration of overall and holistic policy regarding public welfare facilities in healthcare, commission sale market places for fishery products, fishery processing factories, processing factories for medicines, cosmetics, feedstuff, and tobacco leaves and the innovative distribution system with regard to wholesale/retail that Chungnam lacks in. It is also proposed to make comprehensive and cohesive policy to enhance growth and competitiveness of agricultural, forestry and fishery industry.

• The Transactions of the Korea Information Processing Society
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• v.7 no.11
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• pp.3479-3489
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• 2000

Most of the study on fairness control method for Distributed-Queue Dual-Bus(DQDB) have been performed under specific load types such as equal probability load types or symmetric load types. On Web-based internet enviroments client-server load types are more practical traffic patlerns than specrfic load types. In this paper, an effiective fairness control method to distribute DQDR network bandwidth fairly to all stations under a client-server load is proposed. In order to implement a dynamic bandwidth timing capabihty needed to distribute the bandwidth fairty at heavy loads, the proposed method uses two pararnetexs, one is an access hrnit to legulate each station's packet transmission and the other is the number of extra emply slots that are yielded to downstream stations. In point of implementation this mechanism is simpler and easier than Bandwidth Tuning Mechanism(BTM) that uses an intermediate pattern and an adptation function. Simulation results show that it outperforms othen mecharusms.

• Journal of Microbiology and Biotechnology
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• v.32 no.3
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• pp.365-377
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• 2022

Mammalian target of rapamycin (mTOR) is a serine-threonine kinase member of the cellular phosphatidylinositol 3-kinase (PI3K) pathway, which is involved in multiple biological functions by transcriptional and translational control. mTOR is a downstream mediator in the PI3K/Akt signaling pathway and plays a critical role in cell survival. In cancer, this pathway can be activated by membrane receptors, including the HER (or ErbB) family of growth factor receptors, the insulin-like growth factor receptor, and the estrogen receptor. In the present work, we congregated an electronic network of mTORC1 built on an assembly of data using natural language processing, consisting of 470 edges (activations/interactions and/or inhibitions) and 206 nodes representing genes/proteins, using the Cytoscape 3.6.0 editor and its plugins for analysis. The experimental design included the extraction of gene expression data related to five distinct types of cancers, namely, pancreatic ductal adenocarcinoma, hepatic cirrhosis, cervical cancer, glioblastoma, and anaplastic thyroid cancer from Gene Expression Omnibus (NCBI GEO) followed by pre-processing and normalization of the data using R & Bioconductor. ExprEssence plugin was used for network condensation to identify differentially expressed genes across the gene expression samples. Gene Ontology (GO) analysis was performed to find out the over-represented GO terms in the network. In addition, pathway enrichment and functional module analysis of the protein-protein interaction (PPI) network were also conducted. Our results indicated NOTCH1, NOTCH3, FLCN, SOD1, SOD2, NF1, and TLR4 as upregulated proteins in different cancer types highlighting their role in cancer progression. The MCODE analysis identified gene clusters for each cancer type with MYC, PCNA, PARP1, IDH1, FGF10, PTEN, and CCND1 as hub genes with high connectivity. MYC for cervical cancer, IDH1 for hepatic cirrhosis, MGMT for glioblastoma and CCND1 for anaplastic thyroid cancer were identified as genes with prognostic importance using survival analysis.

• Korean Chemical Engineering Research
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• v.51 no.5
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• pp.561-567
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• 2013

Mixed hardwood chips were pre-pulping extracted with green liquor prior to kraft pulping in order to recover hemicelluloses for use as biofuels. This green liquor solution containing mainly sodium sulfide and sodium carbonate was applied at different alkali charges (expressed as $Na_2O$) of 0, 1, 3, and 5% on dry wood weight. The extractions were performed at $160^{\circ}C$ for residence times ranging from about 1-2 h to determine the effect of extraction severity on composition of the pre-pulping extract. The severity of hemicellulose extraction time and green liquor charge controls the concentration of acetic acid and monosaccharide sugars available for downstream processing, the accumulation of degradation products such as organic acids and furans in the extract. As the alkali charge was increased, the amount of acetate side chains on the hemicelluloses and the dissolved lignin in the extract increased but the carbohydrate and sugars in the extract decreased appreciably. Hot water extraction (0% alkali addition) released the greatest amount of carbohydrates, up to 29.80 g/L measured as component sugars, but resulted in the greatest decrease in pulp yield. Meanwhile, pre-pulping extraction with 3% green liquor increased the pulp yield while greatly reducing the component sugars to 7.08 g/L. Fundamental data obtained in this study will allow selection of optimum hemicellulose extraction conditions for integrating the extraction operation into the Kraft pulping process.