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http://dx.doi.org/10.4196/kjpp.2011.15.2.95

Regulation of DREAM Expression by Group I mGluR  

Lee, Jin-U (Department of Pharmacology, Yonsei University College of Medicine)
Kim, In-Sook (Division of Metabolic Disease, Department of Biomedical Science, National Institutes of Health)
Oh, So-Ra (Department of Pharmacology, Yonsei University College of Medicine)
Ko, Suk-Jin (Department of Pharmacology, Yonsei University College of Medicine)
Lim, Mi-Kyung (Department of Pharmacology, Yonsei University College of Medicine)
Kim, Dong-Goo (Department of Pharmacology, Yonsei University College of Medicine)
Kim, Chul-Hoon (Department of Pharmacology, Yonsei University College of Medicine)
Publication Information
The Korean Journal of Physiology and Pharmacology / v.15, no.2, 2011 , pp. 95-100 More about this Journal
Abstract
DREAM (downstream regulatory element antagonistic modulator) is a calcium-binding protein that regulates dynorphin expression, promotes potassium channel surface expression, and enhances presenilin processing in an expression level-dependent manner. However, no molecular mechanism has yet explained how protein levels of DREAM are regulated. Here we identified group I mGluR (mGluR1/5) as a positive regulator of DREAM protein expression. Overexpression of mGluR1/5 increased the cellular level of DREAM. Up-regulation of DREAM resulted in increased DREAM protein in both the nucleus and cytoplasm, where the protein acts as a transcriptional repressor and a modulator of its interacting proteins, respectively. DHPG (3,5-dihydroxyphenylglycine), a group I mGluR agonist, also up-regulated DREAM expression in cortical neurons. These results suggest that group I mGluR is the first identified receptor that may regulate DREAM activity in neurons.
Keywords
Calcium; DREAM; Group I mGluR; mGluR5; mGluR1; Pain;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By Web Of Science : 1  (Related Records In Web of Science)
Times Cited By SCOPUS : 1
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