• Journal of radiological science and technology
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• v.45 no.6
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• pp.553-560
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• 2022

The purpose of this study is to evaluate the clinical risk according to the applicator heterogeneity, mislocation, and tissue heterogeneity correction through a dose verification program during brachytherapy of cervical cancer. We performed image processing with MATLAB on images acquired with CT simulator. The source was modeled and stochiometric calibration and Monte-Carlo algorithm were applied based on dwell time and location to calculate the dose, and the secondary cancer risk was evaluated in the dose verification program. The result calculated by correcting for applicator and tissue heterogeneity showed a maximum dose of about 25% higher. In the bladder, the difference in excess absolute risk according to the heterogeneity correction was not significant. In the rectum, the difference in excess absolute risk was lower than that calculated by correcting applicator and tissue heterogeneity compared to the water-based calculation. In the femur, the water-based calculation result was the lowest, and the result calculated by correcting the applicator and tissue heterogeneity was 10% higher. A maximum of 14% dose difference occurred when the applicator mislocation was 20 mm in the Z-axis. In a future study, it is expected that a system that can independently verify the treatment plan can be developed by automating the interface between the treatment planning system and the dose verification program.

• Progress in Medical Physics
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• v.27 no.1
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• pp.37-45
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• 2016

In proton therapy, in vivo proton beam range verification is very important to deliver conformal dose to the target volume and minimize unnecessary dose to normal tissue. For this purpose, a multi-slit prompt-gamma camera module made of 24 scintillation detectors and 24-channel signal processing system is under development. In the present study, we have developed and tested a dual-mode signal processing system, which can operate in the energy calibration mode and the fast data acquisition mode, to process the signals from the 24 scintillation detectors. As a result of performance test, using the energy calibration mode, we were able to perform energy calibration for the 24 scintillation detectors at the same time and determine the discrimination levels for the detector channels. Further, using the fast data acquisition mode, we were able to measure a prompt-gamma distribution induced by a 45 MeV proton beam. The measured prompt gamma distribution was found similar to the proton dose distribution at the distal fall-off region, and the estimated beam range was $17.13{\pm}0.76mm$, which is close to the proton beam range of 16.15 mm measured by an EBT film.

• Journal of radiological science and technology
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• v.46 no.2
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• pp.131-139
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• 2023

High-dose I-131 used for the treatment of thyroid cancer causes localized exposure among radiology technologists handling it. There is a delay between the calibration date and when the dose of I-131 is administered to a patient. Therefore, it is necessary to directly measure the radioactivity of the administered dose using a dose calibrator. In this study, we attempted to apply machine learning modeling to measured external dose rates from shielded I-131 in order to predict their radioactivity. External dose rates were measured at 1 m, 0.3 m, and 0.1 m distances from a shielded container with the I-131, with a total of 868 sets of measurements taken. For the modeling process, we utilized the hold-out method to partition the data with a 7:3 ratio (609 for the training set:259 for the test set). For the machine learning algorithms, we chose linear regression, decision tree, random forest and XGBoost. To evaluate the models, we calculated root mean square error (RMSE), mean square error (MSE), and mean absolute error (MAE) to evaluate accuracy and R² to evaluate explanatory power. Evaluation results are as follows. Linear regression (RMSE 268.15, MSE 71901.87, MAE 231.68, R² 0.92), decision tree (RMSE 108.89, MSE 11856.92, MAE 19.24, R² 0.99), random forest (RMSE 8.89, MSE 79.10, MAE 6.55, R² 0.99), XGBoost (RMSE 10.21, MSE 104.22, MAE 7.68, R² 0.99). The random forest model achieved the highest predictive ability. Improving the model's performance in the future is expected to contribute to lowering exposure among radiology technologists.

• Progress in Medical Physics
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• v.3 no.1
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• pp.19-24
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• 1992

We have desingned multi channel dosimetry system with Intel single-chip microprocessor. We considered that this system is very useful for patient dose measurement, measurement of sealed source dose distribution and calibration of small field for stereotatic radiosurgery system We have designed that this system use commercially available semicondutor detector and personal computer can control this system and process data through RS-232C serial port.

• Archives of Pharmacal Research
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• v.27 no.2
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• pp.259-264
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• 2004

The purpose of the present study was to investigate the pharmacokinetics of PEG-hemoglobin SB 1, a modified bovine hemoglobin with polyethylene glycol, after its single and multiple administration in beagle dogs. For this purpose, the analytical method of free hemoglobin in the plasma was developed and validated. Excellent linearity ($r^2$=0.999) was observed in the calibration curve data, with the limit of quantification of 0.005 g/dL. The precision and the deviation of the theoretical values for accuracy were always within $\pm$15％ in both the between-and the within-day results. The method was tested by measuring the plasma concentrations following intravenous administration to beagle dogs and was shown to be suitable for pharmacokinetic studies. In a single dose study, the plasma half-life (t$_{1}$2/) increased and the total body clearance (Cl$_{t}$) decreased with the dose (i.e., 0.017 to 0.75 gHb/kg as PEG-hemoglobin SB1) in both sexes. The volume of distribution at steady-state (Vd$_{ss}$ ) showed no difference with the dose. In contrast, the values of t$_{1}$2/, CL$_{t}$ and the area under the plasma concentration-time curve (AUC) after the multiple dose were significantly different from those of the single dose administration. The values of t$_{1}$2/ in the multiple administration were about two times higher-than that of the single dose. As a result, t$_{1}$2/ of hemoglobin after the administration of PEG-hemoglobin SB1 was about 15-30 h, indicating the PEG modification of the hemoglobin lead to a prolongation of plasma concentration of the protein. Therefore, these observations suggested that the PEG modification of hemoglobin is potentially applicable in the hemoglobin-based therapeutics.tics.

• The Korean Journal of Food & Health Convergence
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• v.4 no.1
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• pp.15-22
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• 2018

A radiation dosimeter is important to assess quality assurance (QA) of radiation therapy devices and to estimate the radiation dose in vivo dosimetry. Recently, optically stimulated luminescence detector (OSLD) is widely used in clinical filed. Therefore, the purpose of this study is to evaluate dose, energy, and angular dependence of OSLD and EBT3 film. The absorbed dose in clinical linear accelerator (Linac) beam is calibrated for dose per monitor unit (MU). Dose, energy, and angular dependence of OSLD and EBT3 film are estimated after the calibration procedure. The absorbed dose is measured at 50, 100, 150, and 200 cGy in an 6 MV X-ray beam for dose dependence. A dose of 150 cGy is delivered to OSLD and EBT3 film with 6 and 10 MV photon energies for energy dependence. For measurements of angular dependence, angular positions of gantry are $0^{\circ}{\pm}80^{\circ}$ with 6 MV at 150 cGy. The results of dose dependence is linear for OSLD and EBT3 film. For the results of energy dependence, errors were 0.39% and 0.03% for OSLD and EBT3 film, respectively. The results of dose for angular is decreased from $0^{\circ}$ to ${\pm}80^{\circ}$ for both OSLD and EBT3 film. When angle of $0^{\circ}$ is normalized to 1, and the dose is decreased to 60 and 66% at $80^{\circ}$ for OSLD and EBT3 film, respectively. Dose and energy dependence of OSLD and EBT3 film are measured within the recommendation of manufacturer. Angular dependence is increased from $0^{\circ}$ to ${\pm}80^{\circ}$ for OSLD and EBT3 film. The characteristics of OSLD and EBT3 film are similar and expected to useful for clinical field.

• Journal of the Korean Society of Radiology
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• v.5 no.5
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• pp.261-265
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• 2011

The purpose of this study is to calculate correction factors for energy dependence of a nanoDotdosimeter to measure patient's skin dose in diagnostic radiography. The correction factors were calculated by using the values of mean energy for the RQR standard radiation qualities of IEC publicated by Rosado et al. and the energy response graph of dosimeter relative X-ray on phantom calibration provided by landaur corporation. Results showed the correction factors of 1-1.33 over the tube voltage range of 40-50 kVp. Acquired correction factors are considered to be useful in the clinics for the measurement of accurate skin dose at each tube voltage.

• Nuclear Engineering and Technology
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• v.8 no.1
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• pp.9-17
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• 1976

Dosimetrical properties of polycarbonate film for high-level dosimetry of electrons have been examined. Polycartonate film of 0.1mm in thickness was chosen for this purpose. It can cover the dose range of 1.0-130 Mrad and the measurable range can be extended up to 200 Mrad by using calibration curve. The measurement error was within 3.5%. The radiation induced optical density at 330nm shows rapid initial fading of 7-l3n for one day after irradiation at room temperature and subsequent fading rate is very small, about 0.6% per day. The fading depends on the absorbed dose, storage temperature, and wavelengths. The effects of storage time and temperature during and after irradiation of this film are presented. For practical dosimetry, it is necessary to stabilize the induced optical density by storing the irradiated film for a day or by heat treatment at 10$0^{\circ}C$ for an hour.

• Nuclear Engineering and Technology
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• v.56 no.7
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• pp.2698-2703
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• 2024

A bilateral comparison was conducted between the International Atomic Energy Agency (IAEA) and the Korea Research Institute of Standards and Science (KRISS) to measure the absorbed dose to water in accelerator photon beams. KRISS served as a linking laboratory to compare the IAEA standard with the key comparison reference value (KCRV) of the BIPM.RI(I)-K6 program, in which KRISS participated in 2017. Two ionization chambers from the IAEA were used as transfer instruments for the comparison. Both laboratories measured the calibration coefficients of these instruments and calculated the ratios. The ratio of the KRISS standard to the KCRV was applied to obtain the degree of equivalence of the IAEA, along with its uncertainty. The largest deviation of the IAEA measurement from the KCRV was 3.4 mGy/Gy, significantly smaller than the expanded uncertainty of 10.7 mGy/Gy (k = 2, 95% level of confidence). This study demonstrates the equivalence of IAEA's measurement standard for accelerator photon beams to other primary standard dosimetry laboratories. It provides evidence for the satisfactory operation of IAEA's quality management system and enhances the international credibility of the IAEA SSDL network, particularly in high-energy accelerator photon beams from linear accelerators.

• Progress in Medical Physics
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• v.30 no.4
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• pp.160-166
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• 2019

This study examined the clinical use of two newly installed computed tomography (CT) simulators in the Department of Radiation Oncology. The accreditation procedure was performed by the Korean Institute for Accreditation of Medical Imaging. An Xi R/F dosimeter was used to measure the CT dose index for each plug of the CT dose index phantom. Image qualities such as the Hounsfield unit (HU) value of water, noise level, homogeneity, existence of artifacts, spatial resolution, contrast, and slice thickness were evaluated by scanning a CT performance phantom. All test items were evaluated as to whether they were within the required tolerance level. CT calibration curves-the relationship between CT number and relative electron density-were obtained for dose calculations in the treatment planning system. The positional accuracy of the lasers was also evaluated. The volume CT dose indices for the head phantom were 22.26 mGy and 23.70 mGy, and those for body phantom were 12.30 mGy and 12.99 mGy for the first and second CT simulators, respectively. HU accuracy, noise, and homogeneity for the first CT simulator were -0.2 HU, 4.9 HU, and 0.69 HU, respectively, while those for second CT simulator were 1.9 HU, 4.9 HU, and 0.70 HU, respectively. Five air-filled holes with a diameter of 1.00 mm were used for assessment of spatial resolution and a low contrast object with a diameter of 6.4 mm was clearly discernible by both CT scanners. Both CT simulators exhibited comparable performance and are acceptable for clinical use.