• BMB Reports
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• v.32 no.6
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• pp.599-604
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• 1999

A highly conserved amino acid, glutamic acid (Glu), present at position 152 in the catalytic domain of the human immunodeficiency virus type 1 (HIV-1) integrase (IN) protein has been known to be critical for enzymatic function since substitution of Glu 152 with other residues results in a complete loss of enzymatic activities. In order to better understand the role of Glu 152 as a conserved residue in enzymatic action, intragenic second site mutations have been introduced around residue 152 of a mutant IN (E152A), and their biochemical properties were analyzed in terms of enzymatic activities. Disintegration activities were found to be significantly restored in several second site mutant INs, while integration activities were only recovered weakly. However, endonucleolytic activities were not discovered in all the mutant INs. These findings indicate that the second site mutations can partially restore that catalytic structure of the active site disturbed by the E152A mutation and lead to the regaining of integration and disintegration activities. In addition, it is also suggested that endonucleolytic activity requires a more accurate structure of the catalytic site than that for the integration and disintegration activities.

• Journal of the Korean Geographical Society
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• v.46 no.1
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• pp.81-99
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• 2011

The purpose of this paper is to systemize the spatial studies of logistics industry by arranging the partially scattered current studies on spatial studies of logistics industry overall. Logistics industry now builds a complex spatial organization which has been developed to the stages of independent optimization by materials management and physical distribution providing specialized logistics services, logistics, and supply chain management including IT and management step by step. The complex spatial organization of logistics industry has been systematized with geographical space and virtual space, disintegration and integration, and intermediation and disintermediation. The three areas reported a dynamic characteristic overlapped in space. The dynamic characteristic has a dose relationship with interaction between IT and space of economic activities.

• Journal of the Economic Geographical Society of Korea
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• v.11 no.3
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• pp.389-411
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• 2008

This paper have examined how industrial restructuring had been undertaken in response to economic crises in both Stuttgart, the hometown of the German automaker Daimler-Benz and Turin, that of the Italian automaker Fiat, in terms of changes in regional governances. Based upon this comparison, their micro dynamics have been examined that the transformation of automotive production systems from vertical integration to vertical disintegration had produced different regional development paths. It is argued that the recent transformation of auto production systems does not lead to a global convergence, but it reveals a local divergence based upon its locally embedded heritages, which is closely related to regional governances among the economic agents in question.

• Journal of the Korea Society of Computer and Information
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• v.24 no.3
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• pp.201-208
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• 2019

The government has proposed a development model for universities to strengthen the capacity of the College of Humanities as part of the university restructuring policy in line with the trend of the times, and encouraged each university to voluntarily induce the establishment of the humanities development plan through financial support under their own individual conditions. With the decline in the school-age population due to the declining fertility rate, the rapid change in the industrial structure has highlighted the decline in the employment rate of the students of the humanities. Therefore, the government is implementing university grading based on the results of the university structural reform evaluation, and pressing low-grade universities through reduction of capacity and reduction of support. In the course of this change, universities have designated the College of Humanities as the primary target of integration with other majors or and its disintegration. This study examines the direction of the government's attempt to change the humanities in the era of the Fourth Industrial Revolution, and suggests a precedent example during the reform of the humanities college. If the humanities college is integrated with practical studies such as management, design, IT, CT, and engineering, the strengths of the humanities can be highlighted. However, the results of this study suggest that many variables such as consideration of students' aptitudes and interests in the integration process of majors, autonomy in major selection, understanding between departments integrated, and demand for a single major before integration or disintegration should be considered. In addition, an example of a local private university shows that the hasty attempt to integrate or disintegrate the humanities can rather lead to various educational harms.

• YAKHAK HOEJI
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• v.47 no.1
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• pp.46-51
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• 2003

Baicalein and baicalin are flavonoid compounds isolated from medicinal herb Scutellaria baicalensis Georgi (Labiatae) and have been known to possess antiviral activities. In the present study, we investigated the in vitro effects of baicalein and baicalin on the three distinctive enzymatic activities of the human immunodeficiency virus type-1 (HIV-1) integrase-endonucleolytic, integration, and disintegration activities. Both compounds inhibited the three enzymatic activities in a dose-dependent manner. The 50％ inhibitory concentrations of baicalein and baicalin for endonucleolytic activities of HIV-1 integrase were 4.4$\pm$3.3 and 25.9$\pm$4.0$\mu$M, respectively. In general, baicalein exhibited nearly 6- to 10-fold stronger inhibition than baicalin for the three enzymatic activities. These data demonstrate that baicalein or baicalin can be used as a leading compound to develop anti-AIDS chemotherapeutic agents targeting to the HIV-1 integrase.

• Proceedings of the Korean Information Science Society Conference
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• 2005.07a
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• pp.745-747
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• 2005

컴포넌트 기반 미들웨어에서 기본 단위를 이루는 컴포넌트가 특정 동일 목적을 위하여 그룹을 생성하고 정해진 서비스를 제공할 수 있다. 이렇게 생성된 그룹은 멤버들간에 리소스를 공유하는데, 이에 따른 상호배제(mutual exclusion) 문제가 그룹 멤버들 사이에서 발생한다. 커뮤니티 컴퓨팅과 같은 그룹 서비스에서는 환경이 다양하고 변화가 심하기 때문에 그룹의 구조 또한 생성, 삭제, 통합, 분리가 빈번히 일어난다. 본 논문에서는 분산 시스템에서의 상호배제 알고리즘을 컴포넌트 기반 미들웨어에서 생성된 그룹에 적용하고, 상호배제 기법이 적용된 상태에서 그룹이 통합하거나 분할될 때 상호배제의 일치성을 유지 할 수 있는 방법을 제시하였다.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.29 no.11B
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• pp.1001-1011
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• 2004

The structure of info-communications industry has been changing from vertical integration to horizontal layered disintegration as the Internet technology has been rapidly developed. Considering with this background, EU has decided to introduce new regulatory framework called 2003 framework and asked member states to shift to new framework by July 2003. The key words of the new framework is to be denoted by the following three characteristics: Introduction of cross-media regulatory framework Alleviation of entry regulation by general authorization, Transition from ex ante regulation to ex post regulation.

• The Journal of the Korea Contents Association
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• v.18 no.8
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• pp.51-61
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• 2018

This study was conducted to propose regional policy for reducing suicide rate by confirming the change of local suicide rate for 10 years from 2005 to 2015 and the effect of change of local environmental factors influencing the change. The main results are as follows. First, the change of city, county, and province suicide rate in 10 years showed that the suicide rate decreased in order of military district, city area, and district. Second, in the case of economic factors, local suicide rate decreased as the local tax burden per capita increased, and as the financial self - reliance increased. Third, in the case of the social integration factors, the local suicide rate decreased as the ratio of the basic livelihood recipient decreased. In addition, local suicide rate decreased as the number of elderly leisure welfare facilities increased. Fourth, in the case of the social demolition factor, the region where the divorce rate is increased, the depression experience rate is increased, and the region where the rate of one person is increasing, the local suicide rate is increased. Therefore, it is expected that the local suicide rate can be reduced through efforts to improve the economic capacity of the whole region, social integration and reduction of the social disintegration phenomenon in the region.

• Korean Journal of Childcare and Education
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• v.9 no.6
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• pp.171-196
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• 2013

The purpose of this study was to examine the characteristics of classroom culture in a toddler class of 2 year olds. Data was collected through 16 sessions of non-participatory observations and teacher interviews of toddlers in H daycare center. Collected data was carefully read and categorized accordingly to fit the theme of this qualitative study. Data analysis yielded four conclusions regarding the toddlers' classroom culture: behavior to advance together as a group, communicating through body language, complete reliance and responses towards the instructor, and a dichotomy between disintegration and integration. The result of this study suggests a need for instructor's proper guidance and establishing an appropriate childcare environment, as well as a reconsideration regarding toddlers as a host of the classroom culture, to increase the understanding of toddler's interactions in classrooms and social trends.

• ALGAE
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• v.29 no.1
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• pp.35-45
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• 2014

Palmaria palmata was integrated with Atlantic halibut Hippoglossus hippoglossus on a commercial farm for one year starting in November, with a temperature range of 0.4 to $19.1^{\circ}C$. The seaweed was grown in nine plastic mesh cages (each $1.25m^3$ volume) suspended in a concrete sump tank ($46m^3$) in each of three recirculating systems. Two tanks received effluent water from tanks stocked with halibut, and the third received ambient seawater serving as a control. Thalli were tumbled by continuous aeration, and held under a constant photoperiod of 16 : 8 (L : D). Palmaria stocking density was $2.95kg\;m^{-3}$ initially, increasing to $9.85kg\;m^{-3}$ after a year. Specific growth rate was highest from April to June (8.0 to $9.0^{\circ}C$), 1.1% $d^{-1}$ in the halibut effluent and 0.8% $d^{-1}$ in the control, but declined to zero or less than zero above $14^{\circ}C$. Total tissue nitrogen of Palmaria in effluent water was 4.2 to 4.4% DW from January to October, whereas tissue N in the control system declined to 3.0-3.6% DW from April to October. Tissue carbon was independent of seawater source at 39.9% DW. Estimated tank space required by Palmaria for 50% removal of the nitrogen excreted by 100 t of halibut during winter is about 29,000 to $38,000m^2$, ten times the area required for halibut culture. Fifty percent removal of carbon from the same system requires 7,200 to $9,800m^2$ cultivation area. Integration of P. palmata with Atlantic halibut is feasible below $10^{\circ}C$, but is impractical during summer months due to disintegration of thalli associated with reproductive maturation.