• Proceedings of the Korean Society of Embryo Transfer Conference
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• 2002.11a
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• pp.110-110
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• 2002

Rapidly progressive interstitial renal fibrosis has recently been reported in young women who have been on a slimming regimen including chinese herbs. Aristolochic acid, suspected as the causal factor of this renal disease, is a well known carcinogen. It has been known that Madouling (Aristolochiae fructus) contains aristolochic acid. The objective of this study was to investigate the effects of Madouling, Madouling-tang, which are the extract mixture from 10 different chinese herbs including Madouling, and aristolochic acid on reproductive and developmental toxicity. Female rats were administered orally with the extracts of Madouling, madouling-tang, and aristolochic acid from 14 days before mating to day 17 of gestation. Madouling (8mg/kg) decreased fertility in the 8mg/kg group, but Madouling-tang and aristolochic acids did not. Significant decrease of mean fetal body weights were observed in the 16mg/kg group of aristolochic acids. External, visceral and skeletal malformation of fetuses were not observed with treatment. Histopathological examination showed the discrete damage of kidney in the 8mg/kg group of Madouling and 16mg/kg groups of aristolochic acid. In whole embryo culture, Madouling and Madouling-tang caused the retardation of growth and development of embryo in the dose of 1 $\mu$g/ml and 0.02 $\mu\textrm{g}$/kg, respectively while aristolochic acids showed the similar effect in the dose of 300 $\mu\textrm{g}$/kg. These results indicate that Madouling, up to 0.05mg/kg (prescription dose to human) has no adverse effects on the fertility, reproduction and development of Sprague-Dawley rats.

• Journal of Plant Biotechnology
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• v.33 no.4
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• pp.277-281
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• 2006

Fourier transform - infrared spectroscopy (FT-IR) provides biochemical profiles containing overlapping signals from a majority of the compounds that are present when whole cell extracts are analyzed. We attempted to determine the ripeness of strawberry fruit flesh by FT-IR. Fruit ripeness was divided into four developmental stages based on fruit skin color: 'yellow-green', 'pink-green', 'pink', and 'red' stages. Principal component analysis of FT-IR data of inside fruit flesh extracts clustered samples of four different developmental stages into three discrete groups: (1) 'yellow-green' group, (2) 'pink-green' group, and (3) 'pink' and 'red' group. The most remarkable difference between four different developmental stages was found in the carbohydrate fingerprint region $(1,000-1,100cm^{-1})$ of the FT-IR spectrum, indicating that differences in carbohydrate compounds represented the ripeness of strawberry fruit. Overall results indicate that FT-IR in combination with PCA enables discrimination of the ripeness of strawberry fruit flesh.

• Journal of the Korean Geotechnical Society
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• v.18 no.3
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• pp.43-50
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• 2002

This paper describes a simplified numerical procedure for analyzing the response of bridge pier foundations due to riverbed scouring. A computationally efficient algorithm to analyze the behavior of a pile group is proposed by considering soil-pile, pile-cap, and pile-fluid interactions. The complex phenomenon of the pile-soil interaction is modeled by discrete nonlinear soil springs (p-y, t-z and q-z curves). The pile-cap interaction is considered by geometric configuration of the piles in a group and connectivity conditions between piles and the cap. The pile-fluid interaction is incorporated into the procedure by reducing the stiffness of the soil-pile reactions as a result of nonlinearity and degradation of the soil stiffness with river bridge scouring. Through the numerical study, it is shown that the maximum bending moment increases with increasing scour depth. Thus it is desirable to check the stability elf pile groups based on soil-pile and pile-cap interactions by considering scouring depth in the riverbed.

• Journal of the Korea Institute of Military Science and Technology
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• v.25 no.6
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• pp.617-627
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• 2022

Military training is an essential item for the fundamental problem of war. However, there has always been a problem that many resources are consumed, causing spatial and environmental pollution. The concepts of defense modeling and simulation and CGF(Computer Generated Force) using computer technology began to appear to improve this problem. The Naval Operations, Resources Analysis Model(NORAM) developed by the Republic of Korea Navy is also a DEVS(Discrete Event Simulation)-based naval virtual force analysis model. The current NORAM is a battle experiment conducted by an operator, and parameter values such as maneuver and armament operation for individual objects for each situation are evaluated. In spite of our research conducted evolutionary, supervised, reinforcement learning, in this paper, we introduce our design of a scenario creation model based on evolutionary learning using genetic algorithms. For verification, the NORAM is loaded with our model to analyze wartime engagements. Human-level tactical scenario creation capability is secured by automatically generating enemy tactical scenarios for human-designed Blue Army tactical scenarios.

• Journal of the Korean Mathematical Society
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• v.59 no.3
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• pp.571-594
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• 2022

Let D be an integral domain with quotient field K, Pic(D) be the ideal class group of D, and X be an indeterminate. A polynomial overring of D means a subring of K[X] containing D[X]. In this paper, we study almost Dedekind domains which are polynomial overrings of a principal ideal domain D, defined by the intersection of K[X] and rank-one discrete valuation rings with quotient field K(X), and their ideal class groups. Next, let ℤ be the ring of integers, ℚ be the field of rational numbers, and 𝔊f be the set of finitely generated abelian groups (up to isomorphism). As an application, among other things, we show that there exists an overring R of ℤ[X] such that (i) R is a Bezout domain, (ii) R∩ℚ[X] is an almost Dedekind domain, (iii) Pic(R∩ℚ[X]) = $\oplus_{G{\in}G_{f}}$ G, (iv) for each G ∈ 𝔊f, there is a multiplicative subset S of ℤ such that RS ∩ ℚ[X] is a Dedekind domain with Pic(RS ∩ ℚ[X]) = G, and (v) every invertible integral ideal I of R ∩ ℚ[X] can be written uniquely as I = XnQe11···Qekk for some integer n ≥ 0, maximal ideals Qi of R∩ℚ[X], and integers ei ≠ 0. We also completely characterize the almost Dedekind polynomial overrings of ℤ containing Int(ℤ).

• Proceedings of the IEEK Conference
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• 2004.08c
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• pp.477-481
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• 2004

High Quality CD, OAT audio requires that large amount of data. Currently, multi channel preference has been rapidly propagated among latest users. The MPEG(Moving Picture Expert Group) is provides data compression technology of sound and image system. The MPEG standard provides multi channel and 5.1 sounds, using the same audio algorithm as MPEG-l. And MPEG-2 audio is forward and backward compatible. The MDCT (Modified Discrete Cosine Transform) is a linear orthogonal lapped transform based on the idea of TDAC(Time Domain Aliasing Cancellation). In this paper, we proposed the micro-program type vector processor architecture a benefit in MDCT/IMDCT of MPEG-II AAC. And it's reduced operating coefficient by overlapped area to bind. To compare original algorithm with optimized algorithm that cosine coefficient reduced $0.5\%$multiply operating $0.098\%$ and add operating 80.58\%$. Algorithm test is used C-language then we designed hardware architecture of micro-programmed method that applied to optimized algorithm. This processor is 20MHz operation 5V.

• Journal of Radiation Protection and Research
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• v.10 no.1
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• pp.41-49
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• 1985

Neutron Streaming analysis in 1300 MWe pressurized water reactor cavity was performed. In this calculation, the discrete ordinates transport codes, ANISN and DOT 3.5, and the Monte Carlo code, TRIPOLI-02 were used with the coupling code, DOTTRI. In this study IBM 3033 type computer was used. The calculated neutron fluxes and dose rates were compared with the measured data in a 900MWe pressurized water reactor cavity to show a good agreement, although some deviations in the results for each energy group were noticed. These results will be applied in the radiation shielding design of high capacity nuclear power reactors and, to the means of radiation protection in case of the reactor maintenance and the access of the reactor cavity.

• Korean Journal of Clinical Laboratory Science
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• v.40 no.2
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• pp.94-97
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• 2008

The human leukocyte antigen (HLA) is the name of the major histocompatibility complex (MCH) in humans. The superlocus contains a large number of genes related to immune system function in humans. This group of genes resides on chromosome 6. and encode cell surface antigen-presenting proteins and many other genes. HLA class I antigen (A, B & C) present peptides from inside the cell. These peptides are produced from digested proteins that are broken down in the lysozymes. Most expressed HLA loci exhibit a remarkable degree of allelic polymorphism, which derives from sequence differences predominantly localized to discrete hypervariable regions of the amino terminal domain of the molecule. In this sutdy, the HLA-A genotypes were determined in twenty students unrelated koreans using the PCR-SSP (Polymerase Chain Reaction-Sequence Specific Primer) technique. Several specific primer pairs in assigning the HLA-A gene were used (A*0201, A*33, A*2401). The results of PCR-SSP, the HLA-A*0201 primer was detected eleven (55%), the HLA-A*33 were detected seven (35%) and the HLA-A*2401 were detected seven (35%). This study shows that the PCR-SSP technique is relatively simple, fast and a practical tool for the determination of the HLA-A genotypes.

• Herbal Formula Science
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• v.25 no.3
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• pp.349-362
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• 2017

Objectives : We investigated whether the components of Ailanthus altissima induced apoptotic cell death in Jurkat acute lymphoblastic leukemia (ALL) cells. Methods : Regulation of cell proliferation is a complex process involving the regulated expression and/or modification of discrete gene products, which control transition between different stages of the cell cycle. Results : Upon treatments with Ailanthus altissima, the concentration-dependent inhibitions of cell viability were observed as compared to untreated control group. The capability of Ailanthus altissima to induce apoptosis was associated with proteolytic cleavage of specific target proteins such as poly(ADP-ribose)polymerase (PARP) and beta-catenin proteins suggesting the possible involvement of caspases. Ailanthus altissima also caused apoptosis as measured by cell morphology and DNA fragmentation. Conclusions : These results indicate that the increase of apoptotic cell death by Ailanthus altissima may be due to the inhibition of cell cycle in human Jurkat lymphocytes. Conclusively, these current and further findings will provide novel approaches to understanding and treating major diseases.

• Advances in Computational Design
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• v.2 no.4
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• pp.313-331
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• 2017

In this study, teaching-learning based optimization (TLBO) is improved by incorporating model of multiple teachers, adaptive teaching factor, self-motivated learning, and learning through tutorial. Modified TLBO (MTLBO) is applied for simultaneous topology, shape, and size optimization of space and planar trusses to study its effectiveness. All the benchmark problems are subjected to stress, displacement, and kinematic stability constraints while design variables are discrete and continuous. Analyses of unacceptable and singular topologies are prohibited by seeing element connectivity through Grubler's criterion and the positive definiteness. Performance of MTLBO is compared to TLBO and state-of-the-art algorithms available in literature, such as a genetic algorithm (GA), improved GA, force method and GA, ant colony optimization, adaptive multi-population differential evolution, a firefly algorithm, group search optimization (GSO), improved GSO, and intelligent garbage can decision-making model evolution algorithm. It is observed that MTLBO has performed better or found nearly the same optimum solutions.