• Journal of Sensor Science and Technology
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• v.23 no.4
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• pp.217-223
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• 2014

Nerve agents are major chemical warfare agents with the "G series" and "V series" being the most widely known because of their lethal effect. Although not conspicuously used in major wars, the potential detrimental impact on modern society had been revealed from the sarin terror attack on Tokyo subway, which affected thousands of people. In this mini-review, major nerve agents of the "G series" and "V series" have been described along with various types of their detection methods. The physical properties and hydrolysis mechanisms of the major nerve agents are discussed since these are important factors to be considered in choosing detection methods, and specifying the procedures for sample preparations in order to enhance detection precision. Various types of extraction methods, including liquid-phase, solid-phase, gas-phase and solid-phase microextraction (SPME), are described. Recent development in the use of gas sensors for detecting nerve agents is also summarized.

• Journal of Microbiology and Biotechnology
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• v.25 no.11
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• pp.1773-1781
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• 2015

Environmental security is one of the major concerns for the safety of living organisms from a number of harmful pollutants in the atmosphere. Different initiatives, legislative actions, as well as scientific and social concerns have been discussed and adopted to control and regulate the threats of environmental pollution, but it still remains a worldwide challenge. Therefore, there is a need for developing certain sensitive, rapid, and selective techniques that can detect and screen the pollutants for effective bioremediation processes. In this perspective, isolated enzymes or biological systems producing enzymes, as whole cells or in immobilized state, can be used as a source for detection, quantification, and degradation or transformation of pollutants to non-polluting compounds to restore the ecological balance. Biosensors are ideal for the detection and measurement of environmental pollution in a reliable, specific, and sensitive way. In this review, the current status of different types of microbial biosensors and mechanisms of detection of various environmental toxicants are discussed.

• Journal of the Korea Institute of Military Science and Technology
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• v.18 no.4
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• pp.376-386
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• 2015

MOFs(Metal-Organic Frameworks) are new kinds of materials comprised of metal ions and functional organic ligands, and have large pores in its rigid structures which give the materials various functionalities, including gas absorption, separation, drug delivery etc. Recently photoluminescence properties of MOFs and possibilities of its application to high explosive sensing technologies are drawing attentions from scientists and engineers, because these methods are simple, cheap and easy to perform detection operations. In this article the author reviews the mechanisms of photoluminescence of MOFs, the detection methods of high explosives using MOFs and recent research progresses based on the papers published mainly during last 10 years.

• International Journal of Computer Science & Network Security
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• v.23 no.10
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• pp.209-213
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• 2023

In recent years, the image processing mechanisms are used widely in several medical areas for improving earlier detection and treatment stages, in which the time factor is very important to discover the disease in the patient as possible as fast, especially in various cancer tumors such as the liver cancer. Liver cancer has been attracting the attention of medical and sciatic communities in the latest years because of its high prevalence allied with the difficult treatment. Statistics indicate that liver cancer, throughout world, is the one that attacks the greatest number of people. Over the time, study of MR images related to cancer detection in the liver or abdominal area has been difficult. Early detection of liver cancer is very important for successful treatment. There are few methods available to detect cancerous cells. In this paper, an automatic approach that integrates the intensity-based segmentation and k-means clustering approach for detection of cancer region in MRI scan images of liver.

• Journal of Korea Multimedia Society
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• v.23 no.5
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• pp.641-649
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• 2020

As the usage of mobile devices extremely increases, malicious mobile apps(applications) that target mobile users are also increasing. It is challenging to detect these malicious apps using traditional malware detection techniques due to intelligence of today's attack mechanisms. Deep learning (DL) is an alternative technique of traditional signature and rule-based anomaly detection techniques and thus have actively been used in numerous recent studies on malware detection. In order to develop DL-based defense mechanisms against intelligent malicious apps, feeding recent datasets into DL models is important. In this paper, we develop a DL-based model for detecting intelligent malicious apps using KU-CISC 2018-Android, the most up-to-date dataset consisting of benign and malicious Android apps. This dataset has hardly been addressed in other studies so far. We extract OPcode sequences from the Android apps and preprocess the OPcode sequences using an N-gram model. We then feed the preprocessed data into LSTM and apply the concept of Information Gain to improve performance of detecting malicious apps. Furthermore, we evaluate our model with numerous scenarios in order to verify the model's design and performance.

• Toxicological Research
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• v.32 no.1
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• pp.47-56
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• 2016

The identification of biomarkers for the early detection of acute kidney injury (AKI) is clinically important. Acute kidney injury (AKI) in critically ill patients is closely associated with increased morbidity and mortality. Conventional biomarkers, such as serum creatinine (SCr) and blood urea nitrogen (BUN), are frequently used to diagnose AKI. However, these biomarkers increase only after significant structural damage has occurred. Recent efforts have focused on identification and validation of new noninvasive biomarkers for the early detection of AKI, prior to extensive structural damage. Furthermore, AKI biomarkers can provide valuable insight into the molecular mechanisms of this complex and heterogeneous disease. Our previous study suggested that pyruvate kinase M2 (PKM2), which is excreted in the urine, is a sensitive biomarker for nephrotoxicity. To appropriately and optimally utilize PKM2 as a biomarker for AKI requires its complete characterization. This review highlights the major studies that have addressed the diagnostic and prognostic predictive power of biomarkers for AKI and assesses the potential usage of PKM2 as an early biomarker for AKI. We summarize the current state of knowledge regarding the role of biomarkers and the molecular and cellular mechanisms of AKI. This review will elucidate the biological basis of specific biomarkers that will contribute to improving the early detection and diagnosis of AKI.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.10 no.8
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• pp.3865-3883
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• 2016

Infrastructure as a Service (IaaS) encapsulates computer hardware into a large amount of virtual and manageable instances mainly in the form of virtual machine (VM), and provides rental service for users. Currently, VM anomaly incidents occasionally occur, which leads to performance issues and even downtime. This paper aims at detecting anomalous VMs based on performance metrics data of VMs. Due to the dynamic nature and increasing scale of IaaS, detecting anomalous VMs from voluminous correlated and non-Gaussian monitored performance data is a challenging task. This paper designs an anomaly detection framework to solve this challenge. First, it collects 53 performance metrics to reflect the running state of each VM. The collected performance metrics are testified not to follow the Gaussian distribution. Then, it employs independent components analysis (ICA) instead of principal component analysis (PCA) to extract independent components from collected non-Gaussian performance metric data. For anomaly detection, it employs multi-class Bayesian classification to determine the current state of each VM. To evaluate the performance of the designed detection framework, four types of anomalies are separately or jointly injected into randomly selected VMs in a campus-wide testbed. The experimental results show that ICA-based detection mechanism outperforms PCA-based and LDA-based detection mechanisms in terms of sensitivity and specificity.

• Journal of Sensor Science and Technology
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• v.19 no.6
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• pp.403-420
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• 2010

Nano and micro structure-based biosensors are promising tool for label-free detection of biomolecular interactions with great accuracy. This review gives a brief survey on nano and micro platforms to sense a variety of analytes such as DNA, proteins and viruses. Among incredible nano and micro structure for bio-analytical applications, the scope of this paper will be limited to micro and nano resonators and nanowire field-effect transistors. Nanomechanical motion of the resonators transducers biological information to readable signals. They are commonly combined with an optical, capacitive or piezo-resistive detection systems. Binding of target molecule to the modified surface of nanowire modulates the current of the nanowire through electrical field-effect. Both detection methods have advantages of label-free, real-time and high sensitive detection. These structures can be extended to fabricate array-type sensors for multiplexed detection and high-throughput analysis. The biosensors based on these structures will be applied to lab-on-a-chip platforms and point-of-care diagnostics. Basic concepts including detection mechanisms and trends in their fields will be covered in this review.

• Journal of Information Processing Systems
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• v.14 no.1
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• pp.239-251
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• 2018

In existing cloud services, information security and privacy concerns have been worried, and have become one of the major factors that hinder the popularization and promotion of cloud computing. As the cloud computing infrastructure, the security of virtual machine systems is very important. This paper presents an immune-inspired intrusion detection model in virtual machines of cloud computing environment, denoted I-VMIDS, to ensure the safety of user-level applications in client virtual machines. The model extracts system call sequences of programs, abstracts them into antigens, fuses environmental information of client virtual machines into danger signals, and implements intrusion detection by immune mechanisms. The model is capable of detecting attacks on processes which are statically tampered, and is able to detect attacks on processes which are dynamically running. Therefore, the model supports high real time. During the detection process, the model introduces information monitoring mechanism to supervise intrusion detection program, which ensures the authenticity of the test data. Experimental results show that the model does not bring much spending to the virtual machine system, and achieves good detection performance. It is feasible to apply I-VMIDS to the cloud computing platform.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.4 no.6
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• pp.1273-1293
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• 2010

Immune-inspired intrusion detection is a promising technology for network security, and well known for its diversity, adaptation, self-tolerance, etc. However, scalability and coverage are two major drawbacks of the immune-inspired intrusion detection systems (IIDSes). In this paper, we propose an IIDS framework, named GEP-IIDS, with improved basic system elements to address these two problems. First, an additional bio-inspired technique, gene expression programming (GEP), is introduced in detector (corresponding to detection rules) representation. In addition, inspired by the avidity model of immunology, new avidity/affinity functions taking the priority of attributes into account are given. Based on the above two improved elements, we also propose a novel immune algorithm that is capable of integrating two bio-inspired mechanisms (i.e., negative selection and positive selection) by using a balance factor. Finally, a pruning algorithm is given to reduce redundant detectors that consume footprint and detection time but do not contribute to improving performance. Our experimental results show the feasibility and effectiveness of our solution to handle the scalability and coverage problems of IIDS.