• Title/Summary/Keyword: curcuma

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인진, 울금, 구기자, 여정자 복합추출물(ACLL)의 항이상지질혈증 효능에 대한 실험적 연구 (Anti-dyslipidemic Effect of ACLL extract (Artemisia capillaris Thunb, Curcuma longa L, Lycium chinense, Ligustrum lucidum Aiton complex extract) on High Cholesterol Diet-induced Dyslipidemia in Mice)

  • 김태윤;오정민;김윤식;조현경;유호룡;설인찬
    • 혜화의학회지
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    • 제25권1호
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    • pp.133-144
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    • 2016
  • Objectives : This study was aimed to investigate the effect of ACLL extract (Artemisia capillaris Thunb, Curcuma longa L, Lycium chinense, Ligustrum lucidum Aiton complex extract) in a dyslipidemia animal model induced by a high-fat diet. Methods : ACLL extracts was administered at 200 mg/kg, and 400 mg/kg to Apoe mice, where arthritis was induced by high cholesterol diet. After mice were treated with GO for 4 weeks, we measured AST, ALT, BUN and lipid levels (total cholesterol, HDL cholesterol, LDL cholesterol, triglyceride), atherogenic index(AI) and cardiac risk factor(CRF). Results : Serum AST, ALT, creatinine, BUN levels were not changed by ACLL extract do not show any toxic effects. Also, ACLL extract groups were found to have atherogenic Index and cardiac risk factor as well as lipid metabolism improvement (total cholesterol, LDL cholesterol and triglyceride decrease). Conclusions : We suggest that ACLL extract may have the control effects of Dyslipidemia by improving lipid metabolism.

The Longevity Properties of 1,2,3,4,6-Penta-O-Galloyl-β-D-Glucose from Curcuma longa in Caenorhabditis elegans

  • Ahn, Dalrae;Cha, Dong Seok;Lee, Eun Byeol;Kim, Ban Ji;Lee, So Yeon;Jeon, Hoon;Ahn, Min-Sil;Lim, Hye Won;Lee, Heon Yong;Kim, Dae Keun
    • Biomolecules & Therapeutics
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    • 제21권6호
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    • pp.442-446
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    • 2013
  • Here in this study, we isolated 1,2,3,4,6-penta-O-galloyl-${\beta}$-D-glucose (PGG) from Curcuma longa L. and elucidated the lifespan-extending effect of PGG using Caenorhabditis elegans model system. In the present study, PGG demonstrated potent lifespan extension of worms under normal culture condition. Then, we determined the protective effects of PGG on the stress conditions such as thermal and oxidative stress. In the case of heat stress, PGG-treated worms exhibited enhanced survival rate, compared to control worms. In addition, PGG-fed worms lived longer than control worms under oxidative stress induced by paraquat. To verify the possible mechanism of PGG-mediated increased lifespan and stress resistance of worms, we investigated whether PGG might alter superoxide dismutase (SOD) activities and intracellular ROS levels. Our results showed that PGG was able to elevate SOD activities of worms and reduce intracellular ROS accumulation in a dose-dependent manner.

생약재가 살모넬라균 및 대장균의 항균에 미치는 효과 (Antibacterial Activities of Medicinal Herbs on Salmonella and E. Coli)

  • 김계엽;남기원;장성주;김정은;임종수;안병선;권두석;정현우;조경오
    • 동의생리병리학회지
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    • 제22권3호
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    • pp.619-623
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    • 2008
  • The purpose of this study was to observe the effects of antibacterial activities on various medicinal herbs. Medicinal herbs used this study was Curcuma aromatica, Scutellaria baicalensis, Angelica dahurica, Platycodon grandiflorum, Houttuynia corolata, and Forsythia saxatilis. To evaluation of the antibacterial effect, we used S. gallinarum(ATCC 9184), S. typhimurium(SAL-13, France), S. enteritidis (ATCC 10376), Escherichia coli(E-62, O78), and S. gallinarum(E. coli). Extracts from each medicinal herbs divided into 100mg/ml, 50 mg/ml, 25 mg/ml, and 12.5 mg/ml. Antibacterial activities achieved by the paper disc test. Antibacterial activities was showed at extracts from Scutellaria baicalensis, Houttuynia corolata, Forsythia saxatilis, but little found at Curcuma aromatica, Angelica dahurica, Platycodon grandiflorum.

Suppressive Effect of Curcuma Zedoaria Roscoe on Pulmonary Metastasis of B16 Melanoma Cells

  • Hwang Jae-Cheol;Kim Mi-Rang;Jung Young-Jae;Lee Young-Ja;Jung Wun-Suk;Seo Un-Kyo
    • 대한한의학회지
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    • 제26권1호
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    • pp.1-10
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    • 2005
  • Objective: We examined the antimetastatic effect of Curcuma zedoaria Roscoe (CZ) on pulmonary metastasis of B 16 cells. Methods: For 6 weeks, Zedoariae Rhizoma made from dried CZ were dissolved in distilled water and administered to mice 2 weeks before they were injected with B]6 melanoma cells. Mice were given CZ at doses of 250 and 500 mg/kg, and were compared for lung weight, survival days, and NO production. Results: Intake of CZ throughout the experiment extended the average survival time. Intake after B16 cell injection slightly prolonged survival time, but intake before B]6 cell injection did not influence life span. We examined the effect of CZ on macrophage function by measuring NO production. After the macrophages were given CZ for 6 weeks, the amount of NO generated by the macrophages stimulated with LPS in culture medium increased. NO generated by the macrophages also served as a cytotoxic factor against B16 melanoma cells. B16 melanoma-conditioned medium reduced NO production by macrophages. However, CZ treatment reversed the reduction in NO production by the conditioned medium significantly. Conclusion : These findings may suggest that macrophage function-modulating activity by CZ appears to underlie its antimetastatic activity, which leads to a decrease in the number of lung metastatic surface nodules and the extension of life span.

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황색계 천연염료에 의한 셀룰로스, 단백질계 섬유의 염색 (The Dyeing Properties of Cellulose and Protein Fabrics by Yellow Natural Dyes)

  • 신영준
    • 한국의상디자인학회지
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    • 제19권1호
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    • pp.135-145
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    • 2017
  • In order to analysis on color difference of yellow natural dyes, I have dyed cellulose and protein fabrics. The results of experiment have been analysed by wavelength of maximum absorption, amounts of dye uptake, color difference, Hunter's value and Munsell's value. The results from these analyses are as follows : Bud of pagoda tree, Amur cork, and Curcuma showed greenish yellow color, Gardenia Jasminoides showed reddish yellow color. Barberry root showed reddish yellow color with post-mordanting method on cellulose fabric. Moreover, Dupioni silk was dyed in reddish yellow color by Barberry root and Rhubarb. In addition to Chroma index, Gardenia Jasminoides and Curcuma showed clear color overall. However, dyeing rayon and silk by Barberry root, and dyeing silk by Rhubarb showed clear color. Comparing all the results to actual dyed materials, Bud of pagoda tree had small dye uptake, and both ${\Delta}a$ and ${\Delta}b$ value were short which can't recognized the yellow color easily. Dye uptake of Amur cork and Gardenia Jasminoides was small just like Bud of pagoda tree. However, ${\Delta}b$ value order was Gardenia Jasminoides>Amur cork>Bud of pagoda tree. Therefore, Gardenia Jasminoides recognized reddish yellow because of big value of red color and yellow color. In case of Barberry root and Rhubarb which have larger dye uptake, Baberry root recognized yellow color on rayon only, and couldn't recognized yellow color on bleached cotton fabric, ramie, silk, and dupioni silk. Rhubarb recognized yellow color on rayon with pre-mordanting method only, but recognized silk and dupioni silk as brown like color. Moreover, we could not analyze color by dye uptake, Lab, and H(v/c) for Barberry root and Rhubarb. As a result, I think we need to attach color table for the research paper which handled the color of dyeing materials.

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Quantification of the Bioactive Components of the Rhizomes of Curcuma wenyujin and Assessment of Its Anti-inflammatory Effect in Benign Prostatic Hyperplasia-1 Cells

  • Seo, Chang-Seob;Park, Eunsook;Lee, Mee-Young;Shin, Hyeun-Kyoo
    • Natural Product Sciences
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    • 제25권3호
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    • pp.238-243
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    • 2019
  • In this study, the marker compounds of Curcumae Rhizoma (CR) were simultaneously quantified by high-performance liquid chromatography equipped with a photodiode array detector and the anti-inflammatory effects of CR extract and marker compounds in human benign prostatic hyperplasia epithelial-1 (BPH-1) cell lines were investigated. The marker components (4S,5S)-(+)-germacrone-4,5-epoxide, furanodienone, and germacrone, were separated on Gemini $C_{18}$ columns ($250mm{\times}4.6mm$, $5{\mu}m$) at $40^{\circ}C$ by using a gradient of two mobile phases eluting at 1.0 mL/min. Prostaglandin $E_2$ ($PGE_2$) levels in Human BPH-1 cells were determined with an ELISA kit. The coefficients of determination in a calibration curve of each analyte were all 0.9997. The limits of detection and quantification of the three compounds were $0.10-0.32{\mu}g/mL$ and $0.30-0.98{\mu}g/mL$, respectively. The content of three compounds, (4S,5S)-(+)-germacrone-4,5-epoxide, furanodienone, and germacrone, in the CR sample were found to be 5.79 - 5.92 mg/g, 4.72 - 4.86 mg/g, and 1.06 - 1.09 mg/g, respectively. Regarding pharmacological activity against benign prostatic hyperplasia, CR and its components significantly suppressed $PGE_2$ levels of BPH-1 cells. The established analysis method will help to improve quality assessment of CR samples and related products. In addition, CR and its components exhibit antiinflammatory activity in BPH-1 cells, suggesting the inhibitory efficacy of these compounds against the pathogenesis of BPH.

응고제에 따른 강황 두부의 품질 특성 (The Quality Characteristics of Kanghwang(Curcuma aromatica Salab.) Tofu Prepared with Various Coagulants)

  • 박금순;이신호;박경남
    • 동아시아식생활학회지
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    • 제17권4호
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    • pp.547-553
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    • 2007
  • 강황 첨가 두부의 응고제 종류에 따른 품질 특성을 살펴본 결과는 다음과 같다. 강황 첨가 두부의 수율은 Milky-Mg, 복합 응고제, GDL첨가 두부의 순으로 높은 수율을 나타냈으며, $MgCl_2$ 첨가 두부가 가장 낮은 수율을 나타내었다. 응고제별 강황 첨가 두부의 산도는 0.005$\sim$0.012이었으며 각 시료간의 유의한 차이가 없었다. pH는 복합 응고제를 첨가한 강황 두부가 가장 낮았고, $MgCl_2$ 첨가 두부가 가장 높았다. (p<.001). 탁도는 응고속도가 늦은 GDL 첨가 두부가 가장 높았으며 p<0.01에서 유의한 차이가 나타났다. 수분 함량은 $CaCl_2$ 첨가 두부가 가장 높게 나타났으며, Milky-Mg 첨가 두부가 가장 낮게 나타났다(p<0.001). 강황 첨가 두부의 기계적 특성 중 색도에서 L값(명도)은 Milky-Mg 첨가 두부가 가장 밝았으며, a값(적색도)은 GDL 첨가 두부가 가장 높게 나타났으나 b값(황색도)은 가장 낮게 나타났다. 강황 첨가 두부의 texture 측정결과 견고성은 $CaSO_4$ > $CaCl_2$ > $MgCl_2$ > 복합응고제 > GDL > Milky-Mg 순이었으며, 응집성은 시료간에 p>.05에서 유의한 차이를 보였다. 탄력성, 검성, 부서짐성은 견고성이 높은 $CaSO_4$, $CaCl_2$, $MgCl_2$ 첨가 두부가 높게 나타났다. 외관과 질감의 기호도에서 복합 응고제와 GDL 첨가 두부가 가장 높은 점수를 얻었으며, 맛과 향의 기호도에서도 복합 응고제와 $CaSO_4$, GDL 첨가 두부가 높은 평가를 얻어 전반적으로 강황 0.01% 첨가 두유에 복합 응고제 0.45% 첨가와 GDL 0.3% 첨가 시 시각적 기호도와 기능적인 면에서 우수한 강황 두부로 제조될 것으로 사료된다.

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재배(栽培) 울금(鬱金)의 쿨쿠민 함량(含量) (Curcumin Content of Cultivated Tumeric in Korea)

  • 지형준;김현수
    • 생약학회지
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    • 제14권2호
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    • pp.67-69
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    • 1983
  • Tumeric, Curcuma longa L.(Zingiberaceae) is native to the southern Asia, cultivated mainly in India and has been used for the treatment of hemorrhages in oriental medicine. The ground powder has also been used for flavouring and dyeing agents. In this report, the results of trial cultivation of tumeric in the middle portion of Korea (Kyungi, Shihung) are summarized. The rhizomes used for this trial cultivation were purchased from the Takii Seed Co. (Japan) and planted in the late of April and harvested in the middle of November. The curcumin contents of harvested tumeric were about 0.1% and 0.24% from finger type and bulb type respectively and these are comparable with those of commercial tumerics.

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Lipase Catalyzed Kinetic Resolution of rac-2-(3-Methoxy-4-methylphenyl) propan-1-ol and rac-2-(3-Hydroxy-4-methylphenyl)propyl propanoate for S-(+)-Xanthorrhizol

  • Shafioul, Azam Sharif Mohammed;Cheong, Chan-Seong
    • Bulletin of the Korean Chemical Society
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    • 제33권2호
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    • pp.409-414
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    • 2012
  • Xanthorrhizol is a bisabolane type of natural sesquiterpene, the major component of essential oils of Curcuma xanthorrhiza. 2-(3-Methoxy-4-methylphenyl)propan-1-ol and 2-(3-hydroxy-4-methyl phenyl)propan-1-ol could be essential building block for enantioselective synthesis of xanthorrhizol. Enantioselective (c = 53%, E = $80{\pm}3$) for R-(+)-2-(3-hydroxy-4-methylphenyl) propan-1-ol and (c = 58%, E = $27{\pm}1$) for R-(+)-2-(3-methoxy-4-methylphenyl) propan-1-ol resolution processes were developed via lipase-catalyzed reaction. We found lipase Aspergillus oryzae (AOL) and Porcine pancreas (PPL) are selective to transesterification and hydrolysis in organic and aqueous phase. Modified demethylated substrate is appropriate for enantioselective hydrolysis reaction without any additives. Enantiopure chiral alcohol was crystallized from ethyl acetate/n-hexane co-solvent system. Gram scale resolved chiral intermediate will facilitate the synthesis of the unnatural S-(+)-xanthorrhizol, the corresponding isomer of the natural one.

Evaluation of Antibacterial Efficacy of Certain Botanicals Against Bacterial Pathogen Bacillus sp. of Silkworm, Bombyx mori L.

  • Pachiappan, Priyadharshini;Aruchamy, Mahalingam C;Ramanna, Shashidhar Kaluvarahalli
    • International Journal of Industrial Entomology and Biomaterials
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    • 제18권1호
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    • pp.49-52
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    • 2009
  • An in vitro and in vivo studies were conducted to evaluate the antibacterial efficacy of certain botanicals viz., rhizomes of turmeric (Curcuma longa) and leaves of amla (Phyllanthus emblica), asparagus (Asparagus racemosus), bael (Aegle marmelos), boerhavia (Boerhavia diffusa), garlic (Allium sativum) and basil (Oscimum basicilum) against bacterial pathogens viz., Staphylococcus sp., Bacillus sp. and Klebsiella cloacae, of silkworm, Bombyx mori. Asparagus and basil, amla and boerhavia, basil and bael at concentration of 20, 000 ppm showed higher antibacterial activity against Staphylococcus sp., Bacillus sp., K. cloacae respectively, both in vitro and in vivo studies.