• 아태비즈니스연구
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• 제6권2호
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• pp.97-114
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• 2015

This study classify and compare leisure activities migrants women multi-cultural family member includes husband and children. Their common leisure activities is normal daily activity life comparable non leisure daily activity life. Those of common leisure actives is watching type of leisure such as reading book, eat out, visit relatives which reflect passive and egocentric. Therefore need to ownself active, self creative, as well as its family harmony oriented is more signigicant. Future study will be find out the barrier of cultural activities and advanture activities leisure for multi-cultural family.

• 인문언어
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• 제5권
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• pp.265-289
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• 2003

This paper deals with the polysemous phenomenon of perception verbs in terms of metaphor and metonymy and suggest a model of cognitive semantic structure for them. English perception verbs are often used for representing a mental, cognitive activity as well as representing a physical, perceptive activity. This paper looks for a basis for the polysemous use in the creative system of metaphor and metonymy, especially in the meaning extension function of mind-as-body metaphor. English perception verbs show a good example of a metaphor of domain transfer from physical domain to mental or cognitive domain. This paper suggests the conceptual chain and the semantic structure for the perception verb to show the possibility of polysemy and contextual modulation.

• 한국전자거래학회:학술대회논문집
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• 한국전자거래학회 1999년도 학술대회지 vol.1
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• pp.207-213
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• 1999

When function modeling with IDEF0 which is called as a standard methodology for CALS (FIPS 183), the initial work is to determine the purpose and viewpoint, and the next work is to generate a data list and an activity list. This work requires participant's discussion and agreements. The main problems for these working are a communication between participants and efficient discussion processing. Brainstorming is the most useful method for this work. The paper is for development for the modeling assistant tool to promote the business modeling. In this paper, we will introduce the tool which name is 'MindMapper' and 'Dyna-IDEF'. Mind-mapper is software for mind-map method that is used for creative thinking. Using this tool, we refine the result of the brainstorming about activity list and translate the result into the functional model of IDEF0 using Dyna-IDEF. The translated functional model is prototype model without ICOM arrows.

• International Journal of Stem Cells
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• 제17권1호
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• pp.51-58
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• 2024

With the activity of intestinal stem cells and continuous turnover, the gut epithelium is one of the most dynamic tissues in animals. Due to its simple yet conserved tissue structure and enteric cell composition as well as advanced genetic and histologic techniques, Drosophila serves as a valuable model system for investigating the regulation of intestinal stem cells. The Drosophila gut epithelium is in constant contact with indigenous microbiota and encounters externally introduced "non-self" substances, including foodborne pathogens. Therefore, in addition to its role in digestion and nutrient absorption, another essential function of the gut epithelium is to control the expansion of microbes while maintaining its structural integrity, necessitating a tissue turnover process involving intestinal stem cell activity. As a result, the microbiome and pathogens serve as important factors in regulating intestinal tissue turnover. In this manuscript, I discuss crucial discoveries revealing the interaction between gut microbes and the host's innate immune system, closely associated with the regulation of intestinal stem cell proliferation and differentiation, ultimately contributing to epithelial homeostasis.

• 한국과학교육학회지
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• 제24권2호
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• pp.375-386
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• 2004

과학적 창의성은 창의적 사고만으로 발현될 수 없으며, 과학지식내용과 과학적 탐구기능이 함께 사용되게 마련이다. 따라서, 본 연구에서는 과학적 창의성을 위한 사고, 과학지식내용, 과학적 탐구기능의 3 요소로 구성된 인지적 측면에서의 과학적 창의성 모델을 제안하였다. 그리고 모델의 공통요소로 가치, 독창성, 정교성을 포함시켰다. 최근에는 발산적 사고가 곧 창의적 사고라고 보기보다는, 과학적 창의성에 여러 가지 다양한 사고가 필요하다고 강조해왔다. 본 연구에서는 이러한 논의들에 기초하여, 과학적 창의성을 위한 사고로 발산적 사고, 수렴적 사고, 그리고 연관적 사고를 제안하였다. 인지적 측면의 과학적 창의성 모델에 기초하여 구체적인 과학적 창의성 활동 예시를 제시하고, 어떻게 활동자료가 개발될 수 있는지에 대한 제언을 하였다. 앞으로 연구에서는 구체적으로 다양한 과학적 창의성 활동유형을 정의하고, 유형별 학습지도자료를 개발하게 될 것이다.

• 디자인학연구
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• 제17권2호
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• pp.471-478
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• 2004

현대미학의 논의는 뉴미디어의 등장으로 인한 예술과의 상호 관계, 즉 매체에 대한 새로운 미학적 해석으로 시작된다. 과거 선형적 사고체계의 문자시대와 비교할 때 매체는 반드시 현존을 증거하는 수단에 불과하였으나 이제 그것은 디지털 미디어 환경에 있어서 그 자체로서 하나의 창조적 행위이며 그 안에 미적 관념 자체를 내포하고 있는 역동체인 것이다. 매체 미학의 대표적인 이론가인 볼츠는 새로운 매체 시대의 예술은 '이미지의 복제'가 아니라 '이미지의 변형'이 주요한 관건이며, 이 예술형식은 대상에 대한 이미지를 전달하는 것이 아닌 그 자체만이 존재하는 대상 없는 이미지가 중심을 이루어지므로 결국 비선형적인 사고체계가 지배하는 기술적 환경에서의 창의성이란 선택적 테크닉의 한 효과라고 주장한다. 본 논문은 컴퓨터 환경의 레이어(layer)가 그러한 이미지 변형의 핵심적인 기술중심의 예라고 상정하고 위에서 언급된 매체 미학적 관점들을 검증하고자 했으며, 나아가 작업자인 디자이너의 창작과정에 그것이 어떤 직접적인 영향을 미치고 있는가를 밝히고자 시도하였다. 이는 새로운 시대의 미학적 개념은 새로운 미디어가 지배하는 '디자인의 과학'으로 정의되어야 한다고 하는 볼츠의 매체미학과의 조우를 통해서 디자인의 학문으로서의 이론적 토대를 확장시키고자 하는 노력의 일환으로 말할 수 있다.

• Mass Spectrometry Letters
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• 제8권4호
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• pp.98-104
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• 2017

Ginseng (Panax ginseng Meyer) is a well-known health functional food used as a traditional herbal drug in Asian countries owing to its diverse pharmacological effects. Herb-drug interactions may cause unexpected side effects of co-administered drugs by the alteration of pharmacokinetics through effects on cytochrome P450 activity. In this study, we investigated the herb-drug interactions between Korean red ginseng extract (KRG) and five CYP-specific probes in mice. The pharmacokinetics of KRG extract induced-drug interactions were studied by cassette dosing of five CYP substrates for CYP1A, 2B, 2C, 2D, and 3A and the LC-MS/MS analysis of the blood concentration of metabolites of each of the five probes. The linearity, precision, and accuracy of the quantification method of the five metabolites were successfully confirmed. The plasma concentrations of five metabolites after co-administration of different doses of the KRG extract (0, 0.5, 1, and 2 g/kg) were quantified by LC-MS/MS and dose-dependent pharmacokinetic parameters were determined. The pharmacokinetic parameters of the five metabolites were not significantly altered by the dose of the KRG extract. In conclusion, the single co-administration of KRG extract up to 2 g/kg in vivo did not cause any significant herb-drug interactions linked to the modulation of CYP activity.

• 한국학교수학회논문집
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• 제15권3호
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• pp.411-428
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• 2012

미래 사회에 대비하고 적응하기 위하여 창의성에 대한 요구가 한층 높아지고 있다. 이에 학교 수학에서 학생들의 창의성을 길러줄 수 있는 다양한 노력이 계속되고 있다. 특히 문제 만들기는 수학적 창의성을 길러줄 수 있는 좋은 방법이다. 따라서 본 연구에서는 수학문제 만들기 활동의 결과물을 이용하여 학생들의 수학적 창의성을 분석하였다. 이를 위해 초등학교 3학년 상 수준 5명, 중 수준 7명, 하 수준 4명을 포함한 16명 학생을 연구 대상으로 문제 만들기 활동을 하고, 학생들이 만든 문제를 이용하여 학생들의 수학적 창의성을 분석하였다. 이를 통해 다음과 같은 결과를 얻었다, 첫째, 창의성 점수의 평균에서는 상, 중, 하의 성취 수준에 비례하여 나타났다. 둘째, 학생들이 만든 문제의 수에서는 상, 중, 하 수준의 학생들 간에 큰 차이가 나타나지 않았다. 셋째, 학생들은 세 수준 모두에서 조건을 변경하여 문제를 만드는 비율이 높았고, 이런 현상은 상, 중, 하 순으로 갈수록 더 높게 나타났다.

• BMB Reports
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• 제47권11호
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• pp.625-630
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• 2014

Defensins, which are small cationic molecules produced by organisms as part of their innate immune response, share a common structural scaffold that is stabilized by three disulfide bridges. Coprisin is a 43-amino acid defensin-like peptide from Copris tripartitus. Here, we report the intramolecular disulfide connectivity of cysteine-rich coprisin, and show that it is the same as in other insect defensins. The disulfide bond pairings of coprisin were determined by combining the enzymatic cleavage and mass analysis. We found that the loss of any single disulfide bond in coprisin eliminated all antibacterial, but not antifungal, activity. Circular dichroism (CD) analysis showed that two disulfide bonds, Cys20-Cys39 and Cys24-Cys41, stabilize coprisin's ${\alpha}$-helical region. Moreover, a BLAST search against UniProtKB database revealed that coprisin's ${\alpha}$-helical region is highly homologous to those of other insect defensins.

• 공학교육연구
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• 제19권4호
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• pp.14-23
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• 2016

This study is to analyze the team interaction in accordance with the team size. Thereby, it is to reveal the team size for the attainment of the effective team interaction and the specific goals to achieve the purpose of this study are as follows. Firstly, the frequency and percentage of team interaction in accordance with the team size are presented. Secondly, the statistical verification of the team interaction in the social emotional area is conducted. Thirdly, the statistical verification of the team interaction in the task area is conducted. In order to do this study, we explain the purpose of study, confidentiality, and withdrawal right were described and then 32 persons who agreed to participate were selected as the subjects for the study. After that, the autonomous organization of team was induced and a total of 8 teams were organized - 3 teams comprised of 3 members, 3 teams of 4 members, 1 team of 5 members, and 1 team of 6 members. Further, Bales' (1950) Interaction Process Analysis (IPA) was used in order to analyze the team interaction, and Mangold INTERACT was used as a coding program. The results of study are as follows. Firstly, the highest frequency of the team interaction showed up in the case of five or six members and the lowest in the case of 3 members. Secondly, a statistically significant difference in the social emotional (positive) area showed up in accordance with the team size and the team organizations of three or four members were effective. Thirdly, a statistically significant value in the answer area showed up in accordance with the team size and the team organizations of five or six members were effective.