• Molecules and Cells
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• v.45 no.12
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• pp.896-910
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• 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible and potentially fatal virus. So far, most comprehensive analyses encompassing clinical and transcriptional manifestation have concentrated on the lungs. Here, we confirmed evident signs of viral infection in the lungs and spleen of SARS-CoV-2-infected K18-hACE2 mice, which replicate the phenotype and infection symptoms in hospitalized humans. Seven days post viral detection in organs, infected mice showed decreased vital signs, leading to death. Bronchopneumonia due to infiltration of leukocytes in the lungs and reduction in the spleen lymphocyte region were observed. Transcriptome profiling implicated the meticulous regulation of distress and recovery from cytokine-mediated immunity by distinct immune cell types in a time-dependent manner. In lungs, the chemokine-driven response to viral invasion was highly elevated at 2 days post infection (dpi). In late infection, diseased lungs, post the innate immune process, showed recovery signs. The spleen established an even more immediate line of defense than the lungs, and the cytokine expression profile dropped at 7 dpi. At 5 dpi, spleen samples diverged into two distinct groups with different transcriptome profile and pathophysiology. Inhibition of consecutive host cell viral entry and massive immunoglobulin production and proteolysis inhibition seemed that one group endeavored to survive, while the other group struggled with developmental regeneration against consistent viral intrusion through the replication cycle. Our results may contribute to improved understanding of the longitudinal response to viral infection and development of potential therapeutics for hospitalized patients affected by SARS-CoV-2.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.12
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• pp.7430-7437
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• 2014

Owing to the increase in large and complex construction projects, the design paradigm of architecture and civil engineering projects has changed from 2D CAD to 3D CAD. For this reason, to meet the strong requirements of project contractors, various efforts have been made to adopt a Building Information Modeling (BIM) technology for effective construction management. On the other hand, compared to architectural projects, only a few civil engineering project cases have been conducted in the perspective of public contractors. This is because the characteristics of civil project contractors and the negative pursuit of adopting BIM technology due to the lack of a current BIM system and technologies. Recently, positive changes in adopting BIM technology for public projects were anticipated by public owners, such as the Public Procurement Service and the Ministry of Land, Infrastructure and Transport. In this regard, this study analyzed the current BIM technology status of public owners in Korea to adopt the BIM policies and guidelines of the Korean government. Strategies for adopting BIM technologies for Korean public owners are also discussed based on an analysis of civil engineering BIM project cases.

• Journal of Information Technology Applications and Management
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• v.27 no.1
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• pp.59-73
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• 2020

There is a growing interest in convergence. National R & D is also providing various policies and institutional support to promote convergence research. Convergence research, however, does not clearly specify its characteristics at the academic and government levels. This research proceeds with the process of collecting, refining, analyzing, modeling, verifying and visualizing national R & D data through the National Science and Technology Information Service (NTIS). The method is to derive the convergence research characteristics and to derive through text mining, focusing on the unstructured information of national R & D project data. The study confirmed that there was a difference in perception between the definition of converged research and the research site. In order to improve this, the research suggested that convergence among research subjects, collaboration among research topics reflecting various backgrounds and characteristics of researchers, and analysis of characteristics of convergence research using information were suggested in the process of establishing convergence policy.

• Korean Journal of Construction Engineering and Management
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• v.15 no.6
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• pp.83-91
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• 2014

The global community demands the reduction of environmental pollution such as greenhouse gas and carbon dioxide emissions. According to these requirements, the road construction project in the highest energy consuming industry is required the efficient way of reducing environmental pollution emissions. In this study, during the whole life cycle process, an environment impact assessment was performed for the several road construction projects in order to evaluate environmental stress through the road construction process. This study provides a proper process of environment impact assessment for life cycle assessment (LCA) analysis of road construction project, and figures the environmental stress regarding to the major construction materials for the case projects. In addition, this study conducted a sensitivity analysis for the key materials of environmental stress through the quantity analysis of major materials for the 1km section of a road construction. By this sensitivity analysis of total environmental stress change from the different volumes of constructing materials, it would be useful information for the environment impact assessment for the future road construction project.

• Journal of Digital Convergence
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• v.13 no.8
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• pp.91-99
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• 2015

Reviewing the previous researches related to SW quality, we find that they are mostly quality evaluation models for SW quality improvement and maturity-design models for software project management evaluation. There are few studies for the appropriateness of SW quality management by Quality Control(QC) functions. Moreover, they are bound for government's SW R&D projects in the view of the third party. Therefore, we propose means for the objective evaluation of SW quality management's appropriateness by QC functions. For this reason, there are three research proposes in our study as follows. Firstly, we produce problems for the evaluation of the existing government's SW R&D project management's appropriateness. Secondly, to overcome the drawbacks for the evaluation of the appropriateness of SW quality management, new appropriateness evaluation methods are proposed. Lastly, we investigate the availability and effectiveness of the appropriateness evaluation methods for WBS projects.

• Journal of the Korea Convergence Society
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• v.10 no.6
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• pp.1-6
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• 2019

This paper examines the complexity of recent SW development such as the 4th industry to apply the requirement engineering and redimimn application to the project to solve the difficulty of scope management during project management of medium and small businesses. These engineering techniques were applied to mid-sized and small-sized SW development projects. It was verified through supervision of 15 SW development projects. As a result, we observed about 30% reduction in related issues. In addition, Redmimn was introduced to SW development projects involving medium and small sized companies, and it proved that it has the effect of shortening delivery time through requirement management and tracking management. In order to secure the safety of the SW system development project, it is necessary to apply the required engineering techniques and tools, and it is necessary to continuously cultivate professional manpower to carry out this.

• Journal of Convergence for Information Technology
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• v.8 no.6
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• pp.31-41
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• 2018

The purpose of this study was to investigate the applicability of project - based learning as a teaching method for 'Dental Hygiene Practice' in the community dental hygiene department at G city S university. The subjects were 30 students in the fourth grade in 2018. Data collection period was from March 12 to June 27, and mean and standard deviation were compared using SPSS 20.0 program. The results of the analysis showed that the score of the team with high team performance was high ($3.91{\pm}0.82$), the students were required to practice ($4.10{\pm}0.88$), and the feedback from the professor ($3.73{\pm}0.86$) Satisfaction was high. It was determined that the application of project - based learning classes in the 'Community Dental Hygienic Field Practice' course was appropriate for the class.

• Journal of Digital Convergence
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• v.9 no.6
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• pp.1-11
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• 2011

It is time to review the direction of R&D investment which is the source of change in knowledge information ages. The DEA(Data Envelopment Analysis) is a efficient method by using the ratio of input and output elements. In this paper, we analyzed industry relationship and efficiency by DEA in order to analyze ripple effect of the regional industry technology development project. According to these results, we found the primary affected factor in performance of this project was human resource, and the turnover of participated company was not on the rise yet. On types of the project, we could find the efficiency quotient of critical technique development project was higher than of common technique development project because project period or budget scale infected to project performance. We expect the enhancement of technique developer, tenn and budget, and it is necessary the project results should lead performance such as sales force and employee growth.

• Journal of Digital Convergence
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• v.15 no.4
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• pp.35-42
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• 2017

Information strategy planning(ISP) is an analysis of the organization's work, information flow, and current information systems, and planning information structures to achieve organizational strategies and objectives. In addition to the systematic promotion of the information sector in the public sector, the government is required to establish an information strategy plan in order to enhance the efficiency of the information sector. However, there are many cases in which the IT project budget is reflected without establishing the information strategy planning. The purpose of this study is to clarify the criteria for establishing the information strategy planning in order to enhance the effectiveness of the information strategy planning. For this purpose, we set up a judgment model for Information strategy planning through expert group review (FGI) and conducted questionnaires on public sector experts. In addition, we proposed a project to establish an information strategy planning and an exceptional project based on the size of iinformatization project and characteristics of informatization project.

• Journal of Technology Innovation
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• v.22 no.3
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• pp.1-35
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• 2014

This study analyzed convergence status among input technologies used in technology development with Technology I-O analysis. It was another version of industry input-output analysis which is used in technology planning. This case is an analysis of association between technology an product. The subjects of analysis were 401 tasks that applied to '2012 Convergence Technology Development Project for Small and Medium Businesses' promoted by Korea Technology & Information Promotion Agency for Small and Medium Enterprises. The process of analysis is as followed. First step, we made a matrix table as an input of technology input-output analysis. Input was defined by technology and output was defined by the product. Input technology was defined in a 3-digit code under National Science Technology Classification and output products were defined in a 5-digit under National Standard Industry Code. Second, the Spillover ratio among technologies were calculated and was used to make a picture of technology linkage. As a result of analysis, technology spillover of embedded S/W was the highest in IT convergence, mold product in ET convergence, and functional cosmetics development technology in BT convergence. In general, IT convergence had many element technologies with high technology spillover, and ET had a small number of element technologies with high technology spillover. Therefore, investment effect of element technology is expected to be large if investment on element technologies with high technology spillover is important for vitalizing convergence.