• 한국축산식품학회지
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• 제39권6호
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• pp.980-987
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• 2019

This study was conducted to investigate the hypotensive effect of egg white protein (EWP) hydrolysate (EWH) in spontaneously hypertensive rats (SHRs). The hydrolysis of EWP was effectively performed with a combination of 0.5% bromelain and 1% papain at 50℃ for 60 min. The resulting hydrolysate did not elicit an allergic reaction as confirmed by human mast cell activation test. The systolic and diastolic blood pressures of the SHRs fed the EWH diet were observed to be significantly or numerically lower than those of the other groups during the experimental period of 28 d. EWH treatment significantly (p<0.05) upregulated the nitric oxide levels in hCMEC/D3 cells and the plasma of the SHRs compared to those in the control. Moreover, EWH ingestion significantly (p<0.01) reduced the plasma angiotensin II level of the SHRs compared with that in the control. In conclusion, beyond its basic nutritional value, EWH prevents and manages hypertension, and thus can be an invaluable resource for functional food development.

• 지역사회간호학회지
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• 제22권3호
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• pp.342-354
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• 2011

Purpose: This study was to estimate the effectiveness of an intervention program using the trans-theoretical model on the stages of change, the process of change, decisional balance, self-efficacy, the levels of medication adherence, and blood pressure difference. Methods: A similar experiment was conducted using a nonequivalent control group pre- and post-test design. The study subjects were 108 hypertensive patients. The program was administered to the experimental group while educational materials were given to the control group. Descriptive analysis, 2-test, t-test, and repeated measures ANOVA were used with SPSS 17.0 to analyze collected data. Results: After treatment with this program, the experimental group showed stage of change ($x^2=52.917$, p<.001), cognitive (F=13,528, p<.001), behavioral process of change (F=10.808, p<.001), benefits (F=5.569, p=.012), loss of medication adherence (F=15.661, p<.001), self-efficacy (F=5.407, p=.011), levels of medication adherence (F=51.442, p<.001). Conclusion: There was a significant improvement in the experimental group who participated in the TTM medication adherence intervention program. Given that this intervention program motivated and stimulated hypertensive patients to adhere to the prescribed medications, the TTM medication adherence intervention program is expected to be an effective and practical intervention method for health improvement.

• 한국축산식품학회지
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• 제30권4호
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• pp.545-550
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• 2010

The effects of casein hydrolysate on blood pressure (BP) and serum lipid profiles were investigated in spontaneously hypertensive rats (SHR). Twenty-four 6-wk old male SHRs were assigned to 3 groups in a completely randomized design. Experimental groups were as follow: control, market milk group (MLG) and casein hydrolysate group (CHG). Reference blood pressure (RBP) showed average $198.94{\pm}1.46mmHg$. Blood pressure (BP) of CHG reduced 24 mmHg after 2 wk of treatment, but these increased after 3 wk. BP of CHG was significantly lower than BP of Control in experimental time (p<0.05). Serum lipid profiles were not differ significantly among groups (p<0.05). These data suggest that casein hydrolysate may beneficially improvement of blood pressure level in SHR.

• 대한간호학회지
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• 제34권5호
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• pp.829-837
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• 2004

Purpose: The purpose of this study was to determine the effects of a 6-week Tai Chi exercise program on reducing blood pressure for hypertensive patients. Method: A non-equivalent pretest-posttest experimental design was used. Participants were recruited from the Community Health Center in Busan, Korea. Twenty-eight hypertensive patients participated in this study. Among them, fourteen were in the experimental group and the rest are in the control group. Members in the experimental group participated in a 6- week program of Tai Chi exercise. In order to evaluate the effects of the Tai Chi program, blood pressure, total cholesterol, and cortisol level were measured before and after week 6. Result: After the 6-week Tai Chi program, there were significant differences in systolic pressure (t=-3.13, p=.004) and diastolic blood pressure (t=-4.75, p=.000) in the experimental group when compared to the control group. However there were no significant differences in the total cholesterol (t=1.07, p=.294) and cortisol level (F=1.35, p=.256). Conclusion: These results suggest that a 6-week Tai Chi program can be utilized as an effective nursing program to reduce blood pressure for hypertensive patients.

• 한국산학기술학회논문지
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• 제17권11호
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• pp.708-715
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• 2016

본 연구의 목적은 자연적으로 유발된 고혈압 쥐의 지질 수준에서 혈압의 변화 및 안지오텐신 II, 안지오텐신 전환효소, 알도스테론 농도변화에 대한 Dendropanax morbifera 추출물의 항고혈압 효과를 확인하고자 하였다. 실험용 동물은 실험에 사용하기 위해 정상대조군, 고혈압대조군, 물 추출물, 에탄올추출물, n-헥산 분획물, 에틸아세테이트 분획물, n-부탄올 분획물, 물 분획물 투여군 등, 8개 군으로 분리하였다. 실험 결과, 혈압 및 안지오텐신 II 농도, 안지오텐신 전환효소 농도, 알도스테론 농도 수준은 고혈압 대조군보다 에틸 아세테이트 분획 투여군에서 낮았다. 혈압변화 수준은 고혈압대조군보다 에탄올추출물, 에틸아세테이트분획물, n-헥산 분획물, n-부탄올 분획물 투여군에서 감소하였음을 확인하였다. 안지오텐신 II 농도 수준은 고혈압 대조군보다 에틸아세테이트 분획물, n-헥산 분획물, n-부탄올 분획물, 에탄올 추출물 투여군에서 유의적으로 낮았다(p<0.05). 안지오텐신 전환효소 농도 수준은 고혈압대조군보다 에틸아세테이트 분획물, 에탄올추출물, n-헥산 분획물, n-부탄올 분획물 투여군에서 감소하였음을 확인하였다. 알도스테론 농도 수준은 고혈압 대조군보다 에틸아세테이트 분획물, n-부탄올 분획물에서 유의적으로 낮은 농도를 보였다(p<0.05). 또한, 물 추출물 에탄올추출물, n-헥산 분획물에서도 낮아졌다. 따라서 본 실험 대상 일부 시료들이 고혈압유발 실험동물에 높은 고혈압 억제 효과를 입증하므로, 황칠나무 추출물이 고혈압의 예방과 치료용 조성물 또는 기능성건강식품으로 유용성이 확인 되었다.

• 한국간호교육학회지
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• 제5권1호
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• pp.39-57
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• 1999

Essential hypertension is a typical chronic disease requiring adequate and continuous management. And many studies supported that self-care was the essential factor to promote the wellbeing. The purpose of this study is to identify and understand the behavior patterns of self-care in hypertensives. As a research method, 35 Q-statements were collected through Individual interviews and review of the related literatures. 21 subjects were interviewed and the data were analyzed by the PC QUANL program with principal component analysis. There were 6 different self-care types classified as follows 1) Type 1 was the self-oriented control type, monitoring the blood pressure and taking the low salt diet. But they didn't take the anti -hypertensive drug and visit the health agency regularly. 2) Type 2 was the stress-control type. Their main activities were meditation to relieve the stress and communication with family. 3) Type 3 was called daily-life control type. This type tried to make their mind comfort and think positively. They also preferred walking and exercise regularly. 4) Type 4 was the medical-oriented control type, taking the anti-hypertensive drug, visiting the medical personnel and following the medical regimens. 5) Type 5 was the medication-oriented type. They only took the anti -hypertensive drug regularly and didn't any other self-care like as monitoring the blood pressure, taking the low salt diet and exercise. 6) Type 6 was called non-medication control type. This type had no medication, but tried to visit the health agency and health personnel. From the above results, it can be concluded that the self-care types were very various and self-care education have to provide individually according to the characteristics of self-care type. Another repeated study can be recommended to improve the nursing intervention the self-care behavior in chronic patient like as diabetics or rheumatoid arthritis.

• 한국산학기술학회논문지
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• 제14권9호
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• pp.4388-4393
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• 2013

만성질환관리사업에서 건강 인센티브 프로그램에 따른 고혈압 환자의 특성을 분석하고, 고혈압 환자의 혈압 조절에 미치는 영향을 고찰하였다. 인천광역시의 웹기반 만성질환등록관리체계(iCDMS)에 등록관리된 고혈압 환자의 진료정보에서 고혈압 환자의 성, 연령, 건강포인트 적립 수준, 의원 방문 횟수 등의 변수가 혈압 조절이 이루어지고 있는 환자((n=17,278)와 그렇지 않은 환자(n=5,020)에서 통계적으로 유의한 차이를 나타냈으며, 성, 연령, 건강포인트 적립 수준이 고혈압 환자의 혈압 조절에 통계적으로 유의하게 영향을 주었다. 본 연구는 고혈압 환자의 자가 관리역량을 강화하고 지속치료를 유도하기 위한 다양한 만성질환관리사업의 개발에 활용될 수 있으며, 특히 향후 만성질환관리사업에서 건강포인트제도와 유사한 인센티브 시스템의 체계적인 개발에 유용한 자료가 될 것으로 기대된다.

• 동의생리병리학회지
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• 제23권1호
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• pp.93-96
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• 2009

This study was attempted to investigate the anti-hypertensive activity of Solanum tuberosum, cv. Gui valley. Ethanol extract of Gui vally (EGV) increased free radical scarvenge activity up to 91.6% of control at $200{\mu}g/m{\ell}$. It's anti-oxidant activity is similar to 10 uM of ascorbic acid, well known as antioxidant. EGV inhibited Angiotensin-I-converting enzyme (ACE) activity in vitro. ACE plays a important role in regulation of blood pressure and ACE inhibitors are important for the treatment of hypertension. Anti-hypertensive activity of EGV in vivo was assessed in lead acetate (LAT)-induced hypertensive rats for 8 weeks. Elevated blood pressure in control group was significantly decreased by EGV at 200 mg/kg. Also, ACE activity in blood was also suppressed by EGV treatment. Taken together, these results suggest that EGV has an anti-hypersive activity via inhibition of ACE and can be used for the treatment or prevention of hypertension.

• 한국콘텐츠학회논문지
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• 제20권10호
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• pp.401-410
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• 2020

본 연구에서는 심혈관계 질환 합병증을 동반하지 않은 국내 본태성 고혈압 환자의 안정시 심박수에 따른 대사증후군 세부요인 변화에 대한 12개월 추적 조사 결과를 확인해 보고자 한다. 2013년부터 국내 25개 대학병원에서 진행되어 온 대규모 전향적 관찰 연구인 KorHR(Korean Hypertension Registry) 자료를 이용하였고 총 951명의 데이터를 R 통계 프로그램을 이용하여 분석하였다. 본 연구결과 초진과 재진 고혈압 환자의 안정시 심박수 그룹에 따라 대사증후군 세부요인의 변화 및 대사증후군 세부요인 증가 위험이 다른 것으로 나타났다. 따라서 초진과 재진 고혈압 환자에 따른 맞춤형 안정시 심박수 조절을 위한 지침 마련과 안정시 심박수 조절을 위한 다양한 중재방안 마련이 필요하다고 생각된다. 이를 통해 대표적인 만성질환인 고혈압에 따른 심혈관계 질환 발생을 예방하여 환자 및 가족의 삶의 질을 향상시킬 뿐만 아니라 보건 의료 분야에서의 효율성을 증대시키는데 기여하고자 한다.

• 동의생리병리학회지
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• 제24권1호
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• pp.165-170
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• 2010

This study assessed effects of magnetic acu-point therapy as an add-on to conventional antihypertensive managements such as medication or lifestyle modification for hypertensive or pre-hypertensive subjects. This study was conducted with the purpose to evaluate the decreasing effect of the blood pressure on the hypertensive patients who were given to magnetic acu-point therapy. A single-blind, placebo-controlled trial by cross matching was conducted at Daejeon University Oriental Hospital. The washout periods of cross matching are 10 days. 22 hypertensive (systolic BP>140 mmHg or diastolic BP>90 mmHg) volunteers were recruited and treatments were donemagnetic acu-points on Oegwan(TE 5), Jogimeup(GB 41), Naegwan(PC 6), Gongson(SP 4), Hugye(SI 3), Sinmaek(BL 62). The treated group was statistically significant decrease of the blood pressure, while control group show no statistically significant difference of BP. From the results, magnetic acu-point therapy seems to offer a benefit to the treatment of hypertensive patients.