Food Science of Animal Resources (한국축산식품학회지)

Korean Society for Food Science of Animal Resources (한국축산식품학회)
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Effects of Casein Hydrolysate on the Systolic Blood Pressure and Serum Lipid Profiles in Spontaneously Hypertensive Rats

  • Received : 2009.07.17
  • Accepted : 2010.05.14
  • Published : 2010.08.31
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Abstract

The effects of casein hydrolysate on blood pressure (BP) and serum lipid profiles were investigated in spontaneously hypertensive rats (SHR). Twenty-four 6-wk old male SHRs were assigned to 3 groups in a completely randomized design. Experimental groups were as follow: control, market milk group (MLG) and casein hydrolysate group (CHG). Reference blood pressure (RBP) showed average $198.94{\pm}1.46mmHg$. Blood pressure (BP) of CHG reduced 24 mmHg after 2 wk of treatment, but these increased after 3 wk. BP of CHG was significantly lower than BP of Control in experimental time (p<0.05). Serum lipid profiles were not differ significantly among groups (p<0.05). These data suggest that casein hydrolysate may beneficially improvement of blood pressure level in SHR.

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References

  1. American Institute of Nutrition (1977) Report of the American Institute of Nutrition ad hoc committee on standards for nutritional studies. J. Nutr. 107, 1340-1348.
  2. Appel, L. J., Moore, T. J., Obarzanek, E., Vollmer, W. M., Svetkey, L. P., Sacks, F. M., Bray, G. A., Windhauser, M. M., Lin, P.H., and Karanja, N. (1997) A clinical trial of the effects of dietary patterns on blood pressure. N. Engl. J. Med. 336, 1117-1124.
  3. Cadee, J. A., Chang, C. Y., Chen, C. W., Huang, C. N., Chen, S. L., and Wang, C. K. (2007) Bovin casein hydrolysate (C12 Peptide) reduces blood pressure in prehypertensive subjects. Am. J. Hypertens. 20, 1-5. https://doi.org/10.1016/j.amjhyper.2006.06.005
  4. Cushman, D. W. and Cheung, H. S. (1971) Spectrophotometric assay and properties of the angiotensin-converting enzyme of rabbit lung. Biochem. Pharmacol. 20, 1637-1648. https://doi.org/10.1016/0006-2952(71)90292-9
  5. Do, J. R., Kim, K. J., Kim, H. K., Kim, Y. M., Park, Y. B., Lee, Y. B., and Kim, S. B. (2007) Optimization of enzymatic hydrolysis conditions for production of angiotensin I-converting enzyme inhibitory peptide from casein. Food Sci. Biotechnol. 16, 565-571.
  6. Do, J. R., Heo, I. S., Jo, J. H., Kim, D. S., Kim, H. K., Kim, S. S., and Han, C. K. (2006) Effect of antihypertensive peptides originated from various marine proteins on ACE inhibitory activity and systolic blood pressure in spontaneously hypertensive rats. Korean J. Food Sci. Technol. 38, 567-570.
  7. Han, C. K., Lee, O. H., Kim, K. I., Park, J. M., Kim, Y. C., and Lee, B. Y. (2003) Effect of powder, 50% ethanol and hot water extracts of Gastrtodiae rhizoma on serum lipids and blood pressure in SHR fed high-fat diet. J. Korean Soc. Food Sci. Nutr. 32, 1095-1101. https://doi.org/10.3746/jkfn.2003.32.7.1095
  8. Jung, B. M., Ahn, C. B., Kang, S. J., Park, J. H., and Chung, D. H. (2001) Effects of Hijikia fusiforme extracts on lipid metabolism and liver antioxidative enzyme activities in triton-induced hyperlipidemic rats. J. Korean Soc. Food Sci. Nutr. 30, 1184-1189.
  9. Kim, H. L., Son, Y. H., Kim, S. J., Kim, D. W., Ma, S. J., Cho, G. S., Kim, I. C., and Ham, K. S. (2007) Effects of chronic chitosan salt supplementation on blood pressure, plasma component, and lipid profile in healthy male and female adults. Food Sci. Biotechnol. 16, 249-254.
  10. Kim, H. S., Ham, J. S., Jeong, S. G., Yoo, Y. M., Chae, H. S., Ahn, C. N., and Lee, J. M. (2003) Production of angiotensin-I converting enzyme inhibitory hydrolysates from egg albumen. Asian-Aus. J. Anim. Sci. 16, 307-319. https://doi.org/10.5713/ajas.2003.1369
  11. Kim, H. S., In, Y. M., Jeong, S. G., and Ham, J. S. (2002) Antihypertensive effects of casein hydrolysate in spontaneously hypertensive rats. J. Anim. Sci. Technol. 44, 483-490. https://doi.org/10.5187/JAST.2002.44.4.483
  12. Kim, H. S., In, Y. M., Jeong, S. G., Ham, J. S., Kang, K. H., and Lee, S. W. (2002) Angiotensin I- converting enzyme inhibitory properties of bovine casein hydrolysates in different enzymatic hydrolysis conditions. Korean J. Food Sci. Anim. Resour. 22, 87-93.
  13. Kim, K. J., Do, J. R., and Kim, H. K. (2005) Antimicrobial, antihypertensive and anticancer activities of garlic extracts. Korean J. Food Sci. Technol. 37, 228-232.
  14. Kim, Y. M., Han, C. K., Bang, S. J., and Park, J. H. (2006) Effects of laminaran from Eisenia bicyclis on serum lipids in rats fed high cholesterol diet. J. Korean Soc. Food Sci. Nutr. 35, 841-846. https://doi.org/10.3746/jkfn.2006.35.7.841
  15. Koike, H., Ito, K., Miyamoto, M., and Nishino, H. (1977) Effects of long-term blockade of angiotensin-converting enzyme with captopril (SQ 14, 225) on hemodynamics and circulating blood volume in SHR. Hypertension 2, 229-303.
  16. Lee, J. R., Kwon, D. Y., Shin, H. K., and Yang, C. B. (1999) Purification and identification of angiotensin-Iconverting enzyme inhibitory peptide from kidney bean protein hydrolyzate. Food Sci. Biotechnol. 8, 172-178.
  17. Lee, J. S., Park, S. J., Sung, K. S., Han, C. K., Lee, M. H., Jung, C. W., and Kwon, T. B. (2000) Effects of germinatedbuckwheat on blood pressure, plasma glucose and lipid levels of spontaneously hypertensive rats. Korean J. Food Sci. Technol. 32, 206-211.
  18. Li, G. H., Le, G. W., Shi, Y. H., and Shrestha, S. (2004) Angiotensin I-converting enzyme inhibitory peptides derived from food proteins and their physiological and pharmacological effects. Nutr. Res. 24, 469-486. https://doi.org/10.1016/j.nutres.2003.10.014
  19. Ogawa, H., Sasai, N., Kamisako, T., and Baba, K. (2007) Effects of osthol on blood pressure and lipid metabolism in stroke-prone spontaneously hypertensive rats. J. Ethnopharmacol. 112, 26-31. https://doi.org/10.1016/j.jep.2007.01.028
  20. Okamoto, K. and Aoki, K. (1963) Development of a strain of spontaneously hypertensive rats. Jpn. Circ. J. 27, 282-293. https://doi.org/10.1253/jcj.27.282
  21. Park, K. K., Ryu, J. W., Choi, E. K., and Ro, H. S. (2000) Anti-hypertensive effects of pini folium and leonuri herba extract on SHR. J. Appl. Pharmacol. 8, 27-31.
  22. Pfeffer, J. M., Pfeffer, M. A., and Frohlich, E. D. (1971) Validity of an indirect tail-cuff method for determining systolic arterial pressure in unanesthetized normotensive and spontaneously hypertensive rats. J. Lab. Clin. Med. 78, 957-962.
  23. Rader, D. J., Davidson, M. H., Caplan, R. J., and Pears, J. S. (2003) Lipid and apolipoprotein ratios: association with coronary artery disease and effects of rosuvastatin compared with atorvastatin, pravastatin, and simvastatin. Amer. J. Cardiol. 91, 20C-24C. https://doi.org/10.1016/S0002-9149(03)00005-5
  24. SAS Institute, Inc. (1992) SAS User's Guide. Statistical Analysis Systems Institute, Cary, NC, USA.
  25. Suh, H. J., Whang, J. H., Kim, Y. S., Bae, S. H., and Noh, D. O. (2003) Preparation of angiotensin I converting enzyme inhibitor from corn gluten. Process Biochem. 38, 1239-1244. https://doi.org/10.1016/S0032-9592(02)00316-3
  26. Takai, S., Jin, D., Sakaguchi, M., and Miyazaki, M. (2004) Signifiant target organs for hypertension and cardiac hypertrophy by angiotensin-converting enzyme inhibitors. Hypertens. Res. 27, 213-219. https://doi.org/10.1291/hypres.27.213
  27. Wu, J. and Ding, W. (2001) Hypotensive and physiological effect of angiotensin converting enzyme inhibitory peptides derived from soy protein on spontaneously hypertensive rats. J. Agric. Food Chem. 49, 501-506. https://doi.org/10.1021/jf000695n
  28. Xuan, G. D., Ruan, H., Chen, Q. H., and Xu, Y. (2005) Optimization of angiotensin I-converting enzyme (ACE) inhibition by rice dregs hydrolysates using response surface methodology. J. Zhejiang Univ. Sci. 6, 508-513.
  29. Yamamoto, N., Akino, A., and Takano, T. (1994) Antihypertensive effect of the peptides derived from casein by an extracellular proteinase from Lactobacillus helveticus CP790. J. Dairy Technol. 77, 917-922.