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http://dx.doi.org/10.5762/KAIS.2016.17.11.708

A Study on the Effect of the Dendropanax Mobifera Extract on Anti-Hypertensive  

Jo, Yong-Bok (Department of Convergence Engineering, The Graduate School of Venture Hoseo University)
Lee, Jang-Hoon (Department of Environmental Engineering, Hoseo University)
Publication Information
Journal of the Korea Academia-Industrial cooperation Society / v.17, no.11, 2016 , pp. 708-715 More about this Journal
Abstract
This study examined the effects of an extract of Dendropanax morbifera on blood pressure, Angiotensin II, Angiotensin Converting Enzyme, Aldosterone, and lipid levels of spontaneously hypertensive rats. The groups were as follows: Control group, Hypertension control group, Water extract treated group, Ethanol extract treated group, n- hexane fraction treated group, Ethyl acetate fraction treated group, n- butanol fraction treated group, and Water fraction treated group. The blood pressure, and Angiotensin II, and Angiotensin Converting Enzyme, and Aldosterone levels were lower in the Ethyl acetate fraction treated group than in the hypertension control group. The change in blood pressure was lower in the Water extract treated group, Ethyl acetate fraction treated group, Ethanol extract treated group, n- hexane fraction treated group, and n- butanol fraction treated group than the hypertension control group. The concentration of Angiotensin II was lower in the Ethyl acetate fraction treated group, Ethanol extract treated group, n- hexane fraction treated group, and n- butanol fraction treated group than the hypertension control group(p<0.05). The level of Angiotensin Converting Enzyme was lower in the Ethyl acetate fraction treated group, Ethanol extract treated group, n- hexane fraction treated group, and n- butanol fraction treated group than the hypertension control group. The concentration of Aldosterone was lower in the Ethyl acetate fraction treated group, and n- butanol fraction treated group than the hypertension control group(p<0.05). In addition, the concentration lower in the Water extract treated group, Ethanol extract treated group, n- hexane fraction treated group than the hypertension control group. Overall, the effect of the Dendropanax morbifera extracts might be useful as anti-hypertensive, and functional food agents.
Keywords
ACE; Aldosterone; Angiotensin II; Blood pressure; Dendropanax Mobifera; Hypertensive;
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Times Cited By KSCI : 1  (Citation Analysis)
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