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Anti-hypertensive Activity of New Potato(Solanum tuberosum) Variety of Gui Valley Via Inhibition of Angiotensin Converting Enzyme  

Kim, Kwan-Hyun (Cancer Preventive Material Development Research Center, Kyunghee University)
Kim, Sun-Hee (Cancer Preventive Material Development Research Center, Kyunghee University)
Lee, Eun-Ok (Cancer Preventive Material Development Research Center, Kyunghee University)
Kwon, Hyun-Jung (Cancer Preventive Material Development Research Center, Kyunghee University)
Choi, Jong-Won (College of Pharmacy, Kyungsung University)
Lim, Hak-Tae (Potato valley Co., Ltd & Kangwon National University)
Kim, Sung-Hoon (Cancer Preventive Material Development Research Center, Kyunghee University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.23, no.1, 2009 , pp. 93-96 More about this Journal
Abstract
This study was attempted to investigate the anti-hypertensive activity of Solanum tuberosum, cv. Gui valley. Ethanol extract of Gui vally (EGV) increased free radical scarvenge activity up to 91.6% of control at $200{\mu}g/m{\ell}$. It's anti-oxidant activity is similar to 10 uM of ascorbic acid, well known as antioxidant. EGV inhibited Angiotensin-I-converting enzyme (ACE) activity in vitro. ACE plays a important role in regulation of blood pressure and ACE inhibitors are important for the treatment of hypertension. Anti-hypertensive activity of EGV in vivo was assessed in lead acetate (LAT)-induced hypertensive rats for 8 weeks. Elevated blood pressure in control group was significantly decreased by EGV at 200 mg/kg. Also, ACE activity in blood was also suppressed by EGV treatment. Taken together, these results suggest that EGV has an anti-hypersive activity via inhibition of ACE and can be used for the treatment or prevention of hypertension.
Keywords
Solanum tuberosum; CV. Gui valley; hypertension; angiotensin I - converting enzyme (ACE); lead acetate;
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