Enzymatic Hydrolysis of Egg White Protein Exerts a Hypotensive Effect in Spontaneously Hypertensive Rats |
Lee, Da-Eon
(Department of Food and Biotechnology, Sahmyook University)
Jung, Tae-Hwan (Convergence Research Center, Sahmyook University) Jo, Yu-Na (Department of Food and Biotechnology, Sahmyook University) Yun, Sung-Seob (R&D Department, Bioprofoods Co. Ltd.) Han, Kyoung-Sik (Department of Food and Biotechnology, Sahmyook University) |
1 | Okamoto K, Aoki K. 1963. Development of a strain of spontaneously hypertensive rats. Jpn Circ J 27:282-293. DOI |
2 | Phelan M, Kerins D. 2011. The potential role of milk-derived peptides in cardiovascular disease. Food Funct 2:153-167. DOI |
3 | Rajapakse NW, Head GA, Kaye DM. 2016. Say NO to obesity-related hypertension: Role of the l-Arginine-Nitric oxide pathway. Hypertension 67:813-819. DOI |
4 | Viera AJ. 2012. Resistant hypertension. J Am Board Fam Med 25:487-495. DOI |
5 | Wu J, Liao W, Udenigwe CC. 2017. Revisiting the mechanisms of ACE inhibitory peptides from food proteins. Trends Food Sci Technol 69:214-219. DOI |
6 | Aluko RE. 2015. Antihypertensive peptides from food proteins. Annu Rev Food Sci Technol 6:235-262. DOI |
7 | Chockalingam A. 2008. World hypertension day and global awareness. Can J Cardiol 24:441-444. DOI |
8 | Behrendt D, Ganz P. 2002. Endothelial function. From vascular biology to clinical applications. Am J Cardiol 90:40L-48L. DOI |
9 | Boonla O, Kukongviriyapan U, Pakdeechote P, Kukongviriyapan V, Pannangpetch P, Thawornchinsombut S. 2015. Peptidesderived from thai rice bran improves endothelial function in 2K-1C renovascular hypertensive rats. Nutrients 7:5783-5799. DOI |
10 | Chen S, Chen G, Shu S, Xu Y, Ma X. 2019. Metabolomics analysis of baicalin on ovalbumin-sensitized allergic rhinitis rats. R Soc Open Sci 6:181081. DOI |
11 | Danaei G, Singh GM, Paciorek CJ, Lin JK, Cowan MJ, Finucane MM, Farzadfar F, Stevens GA, Riley LM, Lu Y, Rao M, Ezzati M. 2013. The global cardiovascular risk transition: Associations of four metabolic risk factors with national income, urbanization, and western diet in 1980 and 2008. Circulation 127:1493-1502. DOI |
12 | Davalos A, Miguel M, Bartolome B, Lopez-Fandino R. 2004. Antioxidant activity of peptides derived from egg white proteins by enzymatic hydrolysis. J Food Prot 67:1939-1944. DOI |
13 | Duan X, Wu F, Li M, Yang N, Wu C, Jin Y, Yang Y, Jin Z, Xu X. 2014. Naturally occurring angiotensin I-converting enzyme inhibitory peptide from a fertilized egg and its inhibitory mechanism. J Agric Food Chem 62:5500-5506. DOI |
14 | Endemann DH, Schiffrin EL. 2004. Endothelial dysfunction. J Am Soc Nephrol 15:1983-1992. DOI |
15 | Heiss C, Rodriguez-Mateos A, Kelm M. 2015. Central role of eNOS in the maintenance of endothelial homeostasis. Antioxid Redox Signal 22:1230-1242. DOI |
16 | Bader M, Ganten D. 2008. Update on tissue renin-angiotensin systems. J Mol Med 86:615-621. DOI |
17 | FitzGerald RJ, Murray BA, Walsh DJ. 2004. Hypotensive peptides from milk proteins. J Nutr 134:980S-988S. DOI |
18 | Ganguly A, Sharma K, Majumder K. 2019. Food-derived bioactive peptides and their role in ameliorating hypertension and associated cardiovascular diseases. Adv Food Nutr Res 89:165-207. DOI |
19 | Gobbetti M, Minervini F, Rizzello CG. 2004. Angiotensin I-converting-enzyme-inhibitory and antimicrobial bioactive peptides. Int J Dairy Technol 57:173-188. DOI |
20 | Grootaert C, Matthijs B, Voorspoels S, Possemiers S, Smagghe G, Van Camp J. 2017. Egg-derived bioactive peptides with ACE-inhibitory properties: A literature update. Food Funct 8:3847-3855. DOI |
21 | Hermann M, Flammer A, Luscher TF. 2006. Nitric oxide in hypertension. J Clin Hypertens 8:17-29. DOI |
22 | Ikarashi N, Toda T, Hatakeyama Y, Kusunoki Y, Kon R, Mizukami N, Kaneko M, Ogawa S, Sugiyama K. 2018. Antihypertensive effects of acacia polyphenol in spontaneously hypertensive rats. Int J Mol Sci 19:700. DOI |
23 | Jahandideh F, Chakrabarti S, Majumder K, Li Q, Panahi S, Morton JS, Davidge ST, Wu J. 2016. Egg white protein hydrolysate reduces blood pressure, improves vascular relaxation and modifies aortic angiotensin II receptors expression in spontaneously hypertensive rats. J Funct Foods 27:667-673. DOI |
24 | Manso MA, Miguel M, Even J, Hernandex R, Aleixandre A, Lopez-Fandino R. 2008. Effect of the long-term intake of an egg white hydrolysate on the oxidative status and blood lipid profile of spontaneously hypertensive rats. Food Chem 109:361-367. DOI |
25 | Jahandideh F, Majumder K, Chakrabarti S, Morton JS, Panahi S, Kaufman S, Davidge ST, Wu J. 2014. Beneficial effects of simulated gastro-intestinal digests of fried egg and its fractions on blood pressure, plasma lipids and oxidative stress in spontaneously hypertensive rats. PLOS ONE 9:e115006. DOI |
26 |
Jung TH, Hwang HJ, Yun SS, Lee WJ, Kim JW, Ahn JY, Jeon WM, Han KS. 2017. Hypoallergenic and physicochemical properties of the A2 |
27 | Khanna A, Lefkowitz L, White WB. 2008. Evaluation of recent fixed-dose combination therapies in the management of hypertension. Curr Opin Nephrol Hypertens 17:477-483. DOI |
28 | Kishi T, Hirooka Y, Sakai K, Shigematsu H, Shimokawa H, Takeshita A. 2001. Overexpression of eNOS in the RVLM causes hypotension and bradycardia via GABA release. Hypertension 38:896-901. DOI |
29 | Laemmli UK. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685. DOI |
30 | Miguel M, Alvarez Y, Lopez-Fandino R, Alonso MJ, Salaices M. 2007. Vasodilator effects of peptides derived from egg white proteins. Regul Pept 140:131-135. DOI |
31 | Miguel M, Lopez-Fandino R, Ramos M, Aleixandre A. 2005. Short-term effect of egg-white hydrolysate products on the arterial blood pressure of hypertensive rats. Br J Nutr 94:731-737. DOI |
![]() |