• Biomolecules & Therapeutics
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• v.6 no.3
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• pp.247-255
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• 1998

Carbon tetrachloride (CCI$_4$) induces the hepatotoxicity due to the reactive free radicals generated by cytochrome P-450 (CYP-450) enzyme, which result in destabilization of cellular membrane. Diltiazem, a calcium channel blocking agent, has been known to suppress the CYP-450 enzyme activities. To study the effect of diltiazem in $CCl_4$-treated rats, we measured the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and glutathione S-transferase (GST), contents of bilirubin, albumin, total protein, cholesterol, triglyceride, blood urea nitrogen, creatinine malondialdehyde and calcium. Also we conducted liver histopathologic examinations. Diltiazem, when administered 1 hour prior to CCI$_4$ treaeent, significantly reduced the activities of ALT and AST, the contents of microsomal malondialdehyde and calcium in liver and microsome as compared with those of $CCl_4$-treated rats. In addition, histopathologic examination showed that diltiazem prevented the development of centrilobular necrosis induced by CCI$_4$ in liver tissue. Our results suggested that diltiazem could inhibit the formation of free radicals and the influx of calcium. Therefore diltiazem may be applied to suppress the liver damage caused by $CCl_4$.

• The Journal of the Korea Contents Association
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• v.6 no.6
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• pp.9-15
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• 2006

To obtain realistic composite performance and availability measures, one should consider performance changes that are associated with failure recovery behavior. In this paper we address two modeling approaches, exact composite and approximate, and develop SRN models for these approaches. The former approach is to combine the performance and availability models and yields accurate results but generally faces largeness problem. To avoid the problem, the two level hierarchical model is developed. The upper level model describes the failure and repair behavior of the system and the lower level captures the pure performance aspect of the system, channel allocation and service. It models guard channel and preemptive handoff scheme. As numerical results, blocking and dropping probabilities are given for new call and handoff call, respectively.

• Journal of Information Technology Services
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• v.18 no.1
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• pp.219-234
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• 2019

Fake news threaten democratic elections and causes social conflicts, resulting in major damage. However, the concept of fake news is hard to define, as there is a saying, "News is not fake, fake is not news." Fake news, however, has irreversible characteristics that can not be recovered or reversed completely through post-punishment of economic and political benefits. It is also rapidly spreading in the early days. Therefore, it is very important to preemptively detect these types of articles and prevent their blind proliferation. The existing countermeasures are focused on reporting fake news, raising the level of punishment, and the media & academia to determine the authenticity of the news. Researchers are also trying to determine the authenticity by analyzing its contents. Apart from the contents of fake news, determining the behavioral characteristics of the promoters and its qualities can help identify the possibility of having fake news in advance. The online community has a fake news interception and response tradition through its long-standing community-based activities. As a result, I attempted to model the fake news by analyzing the affirmation-denial analysis and posting behavior by securing the web board crawl of the 'M community' bulletin board during the 2017 Korean presidential election period. Random forest algorithm deemed significant. The results of this research will help counteract fake news and focus on preemptive blocking through behavioral analysis rather than post-judgment after semantic analysis.

• The Journal of the Korea Contents Association
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• v.9 no.7
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• pp.37-44
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• 2009

Digital watermarking is a technology for preventing illegal copying, for protecting intellectual property rights and copyrights, and for suggesting grounds of the ownership by inserting watermarks into digital contents. Generally speaking, watermarking techniques cannot escape from data distortion and quality degradation due to the watermark insertion. In order to overcome the shortcoming, zero-watermarking techniques which do not change the original data have been proposed recently. This paper proposes CSMVQ(Chaotic SMVQ), a zero-watermarking system for SMVQ(Side Match Vector Quantization) which shows better compression ratio and quality and less blocking effect than VQ(Vector Quantization). In SMVQ, compression progresses from left top to right bottom in order to use the information of the two neighbor blocks, so it is impossible to insert watermarks chaotically. In the process of encoding, CSMVQ dynamically considers the information of the (1 to 4) neighbor blocks already encoded. Therefore, watermark can be inserted into digital contents in chaotic way. Experimental results show that the image quality compressed by CSMVQ is better than that of SMVQ and the inserted watermark is robust against some common attacks.

• Journal of Nutrition and Health
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• v.38 no.4
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• pp.297-306
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• 2005

It is known that dehydroepiandrosterone (DHEA) shows a dual effect, prooxidant or antioxidant, depending on the do-sage or physiological status of animals. The purpose of this study was to determine the effects of DHEA administration at low dose on lipid peroxidation, protein carbonylation and fatty acid composition in liver. Sprague Dawley male rats were fed either com oil diet containing $15\%$ com oil or fish oil diet containing $2\%$ corn oil + $13\%$ sardine oil, with or without $0.2\%$ DHEA for 9 weeks. Atherogenic index and hepatic triglyceride and cholesterol levels were significantly reduced by DHEA administration in rats fed with fish oil diet. Hepatic lipid peroxide product (TBARS) and protein carbonyl levels were significantly higher in rats fed with fish oil diet than in rats fed with corn oil diet. However, DHEA administration significantly reduced the hepatic thiobarbituric acid-reactive substance (TBARS) and conjugated diene levels in rats fed with fish oil diet. Contents of C16 : 0, C16 : 1, C20 : 5 and C22 : 6 in hepatic microsome were higher in rats fed with fish oil diet than in rats fed with corn oil diet, and contents of C18 : 2 and C20 : 4 were lower than in rats fed with com oil diet. DHEA administration significantly increased C16 : 0 and C18 : 3 contents and reduced C18 : 2 content in rats fed with com oil diet, while it increased C16 : 0 and C18 : 1 and reduced C20 : 5 and C22 : 6 in rats fed with fish oil diet. On overall, DHEA administration increased saturated fatty acid (SFA) and reduced polyunsaturated fatty acid (PUFA) in hepatic microsome, thereby PUFA/SFA ratio was significantly (p < 0.0001) reduced without the change of n-3/n-6 ratio. Taken together, low dose of DHEA administration lowered PUFA/SFA ratio in hepatic microsomal membranes and also showed antioxidative effect especially in fish oil-induced highly oxidative stress condition through blocking increases of C20 : 5 and C22 : 6 contents.

• Journal of the Institute of Electronics Engineers of Korea CI
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• v.46 no.2
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• pp.52-57
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• 2009

Recently, the regular service of a terrestrial digital multimedia broadcasting(T-DMB) made faster distribution of T-DMB receiver. The problem of an illegal distribution is increasing owing to a large distribution of T-DMB receiver. In this paper, we propose a watermarking and encryption method on T-DMB bit-stream for a copy and Play control to prevent an illegal distribution of T-DMB contents. We implement our proposed method on a portable multimedia player (PMP) which has T-DMB receiver. The proposed method insert the encrypted information for control of copy and play after finding padding area of program map table (PMT) and program association table (PAT) from analysis of transport stream (TS) of T-DMB. In implementation result, we can control use of contents according to information of copy and play control. The proposed method can be used to content Protection software for blocking of an illegal distribution of T-DMB contents on a mobile T-DMB receivers.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.31 no.6
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• pp.1261-1266
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• 2021

Existing information security risk assessment methods focus on evaluating the vulnerability of information assets. However, when the form of information assets changes and new types of information assets emerge, there is a limitation in that the evaluation standards for them are also added or deleted. Existing methods have insufficient research on the path through which cyber threats are introduced. In particular, there is very little research on blocking the inflow path for web-based information systems with public IPs. Therefore, this paper introduces the main research contents of the BDLA (Blockade and Defense Level Analysis)-based information security risk assessment model. In addition, by applying the BDLA-based information security risk assessment model, the information security risk level was studied by measuring the blockade level and security equipment level of 17 public institutions.

• Korean Security Journal
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• no.4
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• pp.169-187
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• 2001

NGOs occupy so high international position that it is said the age of NGOs or Renaissance of NGOs has came. Recently, they continuously succeeded in hindering and blocking large-scale international events through their violent struggles. This paper studied the concept of NGO, examples of NGO struggles during recent international events and stated anticipated struggles during ASEM III and their trend. Thereafter, with future prospect of NGO activities, some measures for successful 2002 World Cup and 2005 APEC were provided in this paper. The contents of this paper is as follows ; Chapter I : Introduction Chapter II : The concept of NGO and aspects of their struggles during recent international events Chapter III : Struggles during the 3rd ASEM, Seoul and their trend Chapter IV : Future prospect of NGO activities Chapter V : Conclusion

• The Journal of Korean Medicine
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• v.21 no.1
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• pp.77-83
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• 2000

This study investigated the effects of Siegesbeckia glabrescens, an antihypertensive remedy, on the contraction evoked by phenylephrine and KCl in isolated rat thoracic arata, and also analyzed antioxidative status in vitro. Siegesbeckia glabrescens revealed dose-dependent relaxation on phenylephrine(PE)/KCl-induced arterial contraction and more markedly on PE-induced contraction. Siegesbeckia glabrescens reduced malondialdehyde(MDA)levels, Phosphatidyl choline-liposome(PC-OOH) contents, linoleic acid-induced lipid peroxidation and exerted 1,1-diphenyl-2- picryl-hydrazyl(DPPH) radical scavenging effect, in vitro. These results indicated that Siegesbeckia glabrescens doesn't relaxe artery through a blocking α-adrenergic receptor and calcium channel mediated by voltage-operated calcium channel, and it s antioxidative effects may be involved in endothelium-dependent relaxation of arteries via vascular protective properites. (J Korean Oriental Med 2000;21(1):77-83)

• The Journal of Korean Institute of Communications and Information Sciences
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• v.21 no.7
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• pp.1756-1764
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• 1996

In this paper, we propose a new switch element of buffered Banyan network and analysis it. The proposed switch element consists of CASO(Content ASsociated Output) buffers, its controller and 2*2 crossbar switch. This switch element increase the performance of buffered Banyan network by removing HOL blocking. Also, we analyze the proposed switch element by mathematical modelling method based on MY analysis model which is one of earier proposed models.