Antigen is substance causing disease derived from pathogen. Living organism has the immune system in terms of defense mechanism against antigen. Antigen is processed through several pathways such as phagocytosis, antibody action, complement activation, and cytotoxins by NK or cytotoxic T lymphocyte via MHC molecule. Lymph node (LN) is comprised of the complicated 3 dimensional network and several stromal cells. Fibroblastic reticular cells (FRC) are distributed in T zone for interaction with T cells. FRC produces the extra cellular matrix (ECM) into LN for ECM reorganization against pathogen infections and secretes homing chemokines. However, it has not so much been known about the involvement of the antigen process of FRC. The present report is for the function of FRC on antigen process. For this, FRC was positioned with several infected situations such as co-culture with macrophage, T cell, lipopolysaccharide (LPS) and TNFα stimulation. When co-culture between FRC with macrophage and T cells was performed, morphological change of FRC was observed and empty space between FRCs was made by morphological change. The matrix metallo-proteinase (MMP) activity was up-regulated by Y27632 and T cells onto FRC. Furthermore, inflammatory cytokine, TNFα regulated the expression of adhesion molecules and MHC I antigen transporter in FRC by gene chip assay. NO production was elevated by FRC monolayer co-cultured with macrophage stimulated by LPS. GFP antigen was up-taken by macrophage co-cultured with FRC. Collectively, it suggests that FRC assists of the facilitation of antigen process and LN stroma is implicated into antigen process pathway.
Kim, Dong Hyun;Kim, Taesoon;Jung, Heoncheol;Jeong, Eunsung;Lee, Seung Oh;Jung, Changsam
Journal of Korea Water Resources Association
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v.53
no.spc1
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pp.785-795
/
2020
Recently, the integrated management of the quantity and quality of water was been derived by the Ministry of Environment in Korea. This reconstruction in the national government organization can be recognized as the major politic measure. For this IWRM (Integrated Water Resources Management), it is necessary to be able to fairly distribute, operate and manage water resources in a situation where related techniques are needed to fully support, such as measuring exactly the demand and supply of water resources. The reason why IWRM is difficult, despite the development of related technologies, is because the management entities are highly diverse and their interests are much complicated. Thus, this study is tried to suggest specific improvement for current policies by benchmarking the KPX (Korea Power Exchange). In the field of water management as similar to the electric industry, there is an essential need for a working-level organization that can manage, control, monitor, and regulate water resources with practical and plenipotentiary control like the non-profit organization, KPX. Such time has come for decisive policy changes through benchmarking the structure, system, productivity, and challenges of the electricity industry in the water policy.
Proceedings of the Korean Institute Of Construction Engineering and Management
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2008.11a
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pp.733-737
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2008
Construction supply chain management focused on materials in construction industry plays a critical role which controls the success and failure of a project. For the efficiency of construction supply chain management, the framework which provides project participants with the information originated from whole construction logistics steps without the omission and discontinuation of information flow is required. The new management framework that can support this environment is necessary because of setting up the complicated and distributed environment including logistics information management by intelligent equipment, co-working management with pre-framework legacy system and various devices(UMPC and PDA etc.) as the information confirmation and electrical transmission tool between the project participants different from former construction supply chain management environment while recently developing ubiquitous technologies such as RFID/USN and intelligent equipment to support logistics process. Therefore, the objective of this study is to introduce the concept of SOA (Service Oriented Architecture) as an alternative of effective information integration under the complex and distributed environment and to propose the SOA-based application model for building intelligent construction supply chain management framework.
As the construction industry becomes bigger and more complicated, standardization of terms should be established between academic and industrial fields in order to accumulate and share information technology. The aim of this study is to investigate and analyze the research trends and actual usage of construction and architectural terms in Korea. For this purpose, we examined research related to construction and architectural terms by searching RISS up to August 2014. We also analyzed document types and contents of research by year. As a result, 130 research studies related to construction and architectural terms were searched. Of document types, glossary ranks the highest, followed by academic journal papers, master's theses and research reports. Research related to construction and architectural terms began in 1939, and was actively studied between the mid-1980s to the mid-1990s. Within the research, list and opinion of related construction and architectural terms are found the most frequently, followed by standardization, analysis, alteration, dictionary and wordbook, and search system of terms. Despite these efforts and research, standardization of terms has not yet been consolidated between academic and industrial fields. Therefor, we suggest six proposals in order to standardize the terms. This study is an attempt to see the trends and conditions of construction and architectural terms and to provide base-line data and an insight for future research.
CWR (continuous welded rail) tracks on high-speed railway bridges have much more complicated axial force distributions caused by track-bridge interaction than those behaviors on embankments, and additional problems caused by track-structure interaction with the axial force of the CWR. In order to analyze and limit other physical phenomena caused by track-bridge interaction, a design guideline (KR C-08080, longitudinal track-bridge interaction analysis) is used when designing CWR track on bridges. Domestic analysis and design methods for track-bridge interaction follow the UIC 774-3R, and they suggest conservative methods and deterministic properties. Recently, many studies analyzing the methods of track-bridge interaction considering the loading history are being carried out; however, there has been insufficient studies of the variation of the resistance properties with a consideration of the actual loading history. In this study, the performances of rail fastening systems used for concrete track on bridges were tested and analyzed while considering the loading history. For this purpose, longitudinal and vertical loading combinations, applied in order to simulate the practical conditions and resistance characteristics (stiffness and elastic limit displacement), are analyzed through the experimental results. Also, a comparison study was conducted with the properties in the KR Code.
Recently, a long strike by hospital labor union emerged as a serious social issue. During the Worldcup Games in June, 2002, labor strikes broke up at 'C', 'K' and other hospitals, and in 2007, 'Y' hospital suffered much from a strike. Such series of extreme labor disputes have awakened people of importance of a more stable labor-management relationship for the medical institutions responsible for people's health than any other business organization. The purpose of this study was to examine the labor-management disputes at 'Y' hospital in 2007 and 'C' and 'K' hospitals in 2002. The results of this study can be summarized as follows; First, requests of the labor union such as pay raise, reemployment of the irregular workers as regular employees and participation of the labor union in personnel affairs are the long-held or core issues suffered by the medical institutions. Such issues are not independent from each other but complicated with each other surrounding the pay raise. Accordingly, it is not easy to determine the genuine bone of issue for labor-management disputes. Second, the model type of disputes between labor and management at medical institutions may be strike. However, it is conceived that the type of disputes would be subject to change as the essential medical service area system began to be operated since 2008. Third, the common characteristic of the labor strike among the 3 sample hospitals was occupation of the hospital lobby for a sit-in strike to maximize the negative effects of strike. Article 42 (Prohibition of Violence) of Labor Union and Labor Relation Coordination Act prohibits occupation of production or other important business facilities. In addition, since Ministry of Labor interprets that the hospital lobby belongs to the important business facilities enumerated by Article 42 of the above act, occupation of the hospital lobby for a sit-in strike may be too controversial to be admitted as a fair act of labor dispute when its legitimacy should be judged. Fourth, the counter-measures taken by the hospitals against the strike were observance of the principle 'no labor no pay,' closure, legal action, accusation, claim for recovery of damage, provisional seizure, disciplinary punishment, etc., but the principle of 'no labor, no pay' was not applied in a fair manner by 'C' and 'K' hospitals. However, 'Y' hospital applied this principle thoroughly to the strike; the hospital conduced to correction of the wrong labor-management relationship by refusing inclusion in the labor collective agreement of a provision about payment of wage during the period of strike or labor union's request to that effect during a strike. In addition, 'Y' hospital took an effective measure to end the strike earlier by notifying the labor union of cancellation of the collective agreement and banning the unionists from entering the hospital.
Journal of the Korean Institute of Landscape Architecture
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v.17
no.1
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pp.1-16
/
1989
^x As mentioned above, I consider the change of role that is related with Japanese thought of Natural Environmental Conservation, and I divide each part of periods into forest, farmland, open space, urban planning, environmental conservation etc. To summary the content of each period of Natural Environmental Conservation thought is as follows. 1) Previous period before formation(before 1919) In the previous period of Meiji, it could be said that the consciousness of the Natural Environmental Conservation was coming to existence. In this, so called, Natural Environmental Conservation, the thought of Forest Preservation was the main current and it was the thought of territorial integrity for the security of resource, the forestry conservancy and flood control in the forestry farmland. Since the age of Meiji, the theory of Natural Conservation appears from the theory of Japanese landscaping and systematic management about public parks was enforced, but the regular theory of Natural Environmental Conservation did not attain full growth. 2) The period of formation(1919~ 1954) In the period of formation, the base of Natural Environmental Conservation had been established. Parks and Open spaces were admitted as a public facilities in each city, and legislations which supported it had been continuously enacted and so on. In this period, the afforestation counter plan was emphasized on the side of territorial integrity. In the mountainous district. tree planting was emphasized to recover the forest which had been destroied by war. 3) The period of development(1955~ 1974) In the period of development, varied policies was institutionalized for the Natural Environmental Conservation. However, all sorts of development policy had performed simultaneously, thus development had complicated relation with preservation. But after 1970's the framework of system of Natural Environmental Conservation improvement was constituted to control the many kinds of development, and the spontaneous campaign of nature preservation by private lead was being taken root. This is the more progressive period. 4) The pried of root(after 1975) After the latter of 1970's, the role of Natural Environmental Conservation began to take root not in the direction of control but inducement, and, getting out of development - oriented policy, aimed at relation between human being and natural environment and the side of amenity of human environment. Besides, the current of Natural Environmental Conservation had been seperately progressed in the cities and forests. Since this period, it was the character that cities and forests began to be unified as 'amenity'space of man.
Transactions of the Korean Society of Mechanical Engineers B
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v.39
no.5
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pp.455-461
/
2015
A high-pressure fuel pump is a key component in a gasoline direct injection (GDI) engine; thus, understanding its flow characteristics is essential for improving the engine power and fuel efficiency. In this study, AMESim, which is a hydraulic analysis program, was used to analyze the performance of the high-pressure fuel pump. However, since AMESim uses a one-dimensional model for the system analysis, it does not accurately analyze the complicated flow characteristics. Thus, Fluent, computational fluid dynamics (CFD) software, was used to calculate the flow rates and net forces at the intake and discharge ports of the high-pressure fuel pump where turbulent flow occurs. The CFD analysis results for various pressure conditions and valve lifts were used as look-up tables for the AMEsim model. The CFD analysis results complemented the AMEsim results, and thus, improved the accuracy of the performance analysis results for the high-pressure fuel pump.
Many etiological factors playa significant role in the development of tracheal stenosis; too high tracheostomy (Jackson, 1921), too small stoma (Greisen, 1966), the treatment with respirator using cuffed tube (Pearson et al., 1968; Lindholm, 1966; Bryce, 1972) and infection (Pearson, 1968). Although the incidence has been reduced due to development of surgical technique and antibiotics, the frequency of tracheal stenosis which produces symptoms after tracheostomy ranges from 1.5 per cent (Lindholm, 1967). In the management of the stenosis, mild cases are treated by mechanical dilatation with silicon tube or stent (Schmigelow, 1929; Montgomery, 1965) combined steroid (Birck, 1970), and in the cases of stenosis causes, these removed under the are bronchoscopy. But in severe stenosis, transverse resection with subsequent end-to-end anastomosis has been used in recent years (Pearson et al., 1968). During about 10 years, 1967 to 1977, a total of 23 patients with tracheal stenosis complicated among the 1, 514 tracheostomies have been treated in Severance Hospital. Now, we have obtained following conclusions by means of clinical analysis of 23 cases of tracheal stenosis. 1. The frequency of tracheal stenosis was 23 cases among 1, 514 cases of tracheostomy (1.5%). 2. Under the age of 5, these are 12 cases (52.2 %). 3. The sex incidence was comprised of 18 males and 5 females. 4. The duration of tracheostomy ranges from 4 days to 16 months. 5. The primary diseases requiring tracheostomy were following; central nerve system lesions 11 cases, upper air way obstruction 10 cases, extrinsic respiratory failure 2 cases. 6. Severe wound infections were only 2 cases. 7. The methods of treatment applied to tracheal stenosis were following; closed observation only 5 cases, nasotracheal intubation combined steroid 5 cases, T-tube stent combined steroid 3 cases, fenestration op. 4 cases, revision 4 cases and transverse resection and end-to-end anastomosis 2 cases.
Journal of the Institute of Electronics Engineers of Korea SD
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v.39
no.11
/
pp.24-32
/
2002
In this paper we implemented various image processing filtering using the format converter. This design method is based on realized the large processor-per-pixel array by integrated circuit technology. These two types of integrated structure are can be classify associative parallel processor and parallel process DRAM(or SRAM) cell. Layout pitch of one-bit-wide logic is identical memory cell pitch to array high density PEs in integrate structure. This format converter design has control path implementation efficiently, and can be utilize the high technology without complicated controller hardware. Sequence of array instruction are generated by host computer before process start, and instructions are saved on unit controller. Host computer is executed the pixel-parallel operation starting at saved instructions after processing start. As a result, we obtained three result that 1)simple smoothing suppresses higher spatial frequencies, reducing noise but also blurring edges, 2) a smoothing and segmentation process reduces noise while preserving sharp edges, and 3) median filtering, like smoothing and segmentation, may be applied to reduce image noise. Median filtering eliminates spikes while maintaining sharp edges and preserving monotonic variations in pixel values.
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