• 대한기계학회:학술대회논문집
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• 대한기계학회 2000년도 춘계학술대회논문집A
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• pp.304-308
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• 2000

In this work, an equation of J-integral for a penny-shaped crack at the end of the cord embedded in rubber matrix is proposed. The dimensional analysis is applied to derived to the equation of J-integral. We assume that the energy Parameter J is separated into the deformation and the geometry function, and which is proved using by separation parameter.

• 전자공학회논문지B
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• 제33B권7호
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• pp.40-50
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• 1996

An unified compliant control algorithm to regulate the force by dual arms is proposed, where tow arms are treated as one arm in a kinematic viewpoint. The force error calculated form the information of two force/torque sensors attached to the end of each arm is transferred to minimum actuator coordinates, and then is distributed to total system actuator coordinates. The position adjustment at the total actuator coordinates is computed based on the effective computed based on the effective compliance matrix with respect to total actuator coordinates, which is obtained by coordinate transformation between the task coordinates and the total actuator coordinates. An experiment is carried out for dual arms with asymmetric kinematic structure to control an interaction force between manipulators and the environment. The performances of the proposed control algorithm are experimentally compared to those of dual arms employing master/slave scheme. The proposed compliant control algorithm not only ouperforms other algorithms, but also can be treated as an unified approach n the sense that it can be applied to arbitrary dual arm systems with general kinematic structures.

• 한국전산구조공학회논문집
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• 제23권6호
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• pp.683-691
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• 2010

In this paper, using an adjoint variable method, we develop a design sensitivity analysis(DSA) method applicable to heat conduction problems in steady state. Also, a topology design optimization method is developed using the developed DSA method. Design sensitivity expressions with respect to the thermal conductivity are derived. Since the already factorized system matrix is utilized to obtain the adjoint solution, the cost for the sensitivity computation is trivial. For the topology design optimization, the design variables are parameterized into normalized bulk material densities. The objective function and constraint are the thermal compliance of structures and allowable material volume respectively. Through several numerical examples, the developed DSA method is verified to yield very accurate sensitivity results compared with finite difference ones, requiring less than 0.25% of CPU time for the finite differencing. Also, the topology optimization yields physical meaningful results.

• 한국산업보건학회지
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• 제11권2호
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• pp.126-134
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• 2001

Statistical approaches for analysis of data from the limited number of samples in ship building industry(SBI) collected by an industrial hygienist for checking compliance to an occupational standard were considered. Sampling for compliance usually has been guided by judgment selection, rather than true randomness, resulting in the creation of compliance samples which approximate a censored sample from the upper tail of the exposure distribution. Similar exposure groups(SEGs) including welding and painting process were established to assess representative values in each groups after reviewing the whole production line in SBI. For the convenient statistical approaches, the code has assigned to each SEGs. The descriptive statistics and probability plotting were used to yield the representative values in each SEGs. In the first step, SEGs of 558 were established from 5 ship building companies. The 38 SEGs showed the uncertainty are divided into each 5 companies and assessed the representative values again. The 44 SEGs in each companies was not showed the normal and lognormal distribution was analyzed each data. And also, recommendation was suggested to resolve the uncertainty in each groups.

• 한국응용과학기술학회지
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• 제29권4호
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• pp.552-560
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• 2012

약물 전달 시스템은 약물의 방출 프로파일, 흡수, 분배 및 제품의 효율성과 안전성, 환자의 편의성과 협조를 향상시키기 위한 제거를 개선하는 명백하게 보호화된 공식화 기술이다. 가장 일반적으로 쓰이는 transdermal 시스템은 다양한 종류의 기술을 사용하는 skin patch다. 다른 투약 방법과 달리, transdermal 시스템은 장기간 사용이 가능하다. 또한, 부작용이 생길 경우, 약물 투약의 중단이 가능하다. karaya gum and locust bean gum(LBG)/water-soluble chitosan oligomer(WSCO)과 같은 Polysaccharide를 TDS의 기본 물질로 선택하였다. 또한, 이 polymers들은 tacrine 물질, 강화제로 규정되어진다. 이러한 polysaccharide 중에서, karaya gum matrix의 침투율은 lipophilic drug in vitro 와 같은 tacrine 내에서 가장 빠르다. 우리는 glycerin, PEG 400, and PEG 800를 강화제로 사용하였다. 그러므로, transdermal의 tacrine 흡수율은 vehicle 구성을 바꿈으로써, 혹은 침투 강화제를 사용함으로써 향상되었을 것이다. 특히, vehicle이 스스로의 효과를 강화하는 것과 더불어, vehicle에 강화제를 첨가함으로써 높은 침투 효율이 얻어질 것으로 기대된다.

• 제어로봇시스템학회논문지
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• 제6권2호
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• pp.190-196
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• 2000

A hybrid position/force control scheme to regulate the force and position by dual arms is proposed where two arms are treated as one rm in a kinematic viewpoint. The force error calculated from the information of two force/torque sensors attached to the end of each arm is transferred to minimum configuration space coordinates and then is distributed to total system joint coordinates, The position adjustment at the total con-figuration coordinates is computed based on the effective compliance matrix with respect to total joint coordinates which is obtained by coordinate transformation between the task coordinates and the total joint coordinates. The proposed scheme is applied to sawing task. When the trajectory of the saw is planned to follow a line in a horizontal plane 2 position parameters are to be controlled(i.e., two translational positions) Also a certain level of contact force has to be controlled along the vertical direction(i.e. minus z-direction) not to loose the contact with the object to be sawn. We experimentally show that the performance of the velocity and force response are satisfactory. The proposed hybrid control scheme can be applied to arbitrary two cooperating arm system regardless of their kinematic structure and the number of actuated joints.

• Architectural research
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• 제11권2호
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• pp.27-34
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• 2009

The purpose of this study is to investigate the problem of crack repair materials and methods in existing concrete structure and to propose the effective injection method on crack repair by packer type. The result of this study is as follows. It is investigated that the crack width in the inner matrix of concrete structure is decreased about 30-40% than that in the surface of the concrete structure. Also it is showed that the possibility which could be monolithic with injection part became higher if the injection part is installed near to surface of concrete on the punching method to vertical direction against crack area. The injection of repair material can be poured smoothly under about $10N/mm^2$ pressure on the condition that cracks are monolithic with injection part without dust by drill. The method which is effective injection for a repair material is the punching method in compliance with coredrill. But, the research continuously is necessary about minimum injection pressure.

• 한국항공운항학회지
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• 제32권3호
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• pp.189-195
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• 2024

K-drone delivery system is a commercial delivery system that ensures compliance with aviation safety. It is equipped with flight routes for automated deliveries and features a drone identification device along with a real-time monitoring system for drone positions. This study proposes the application of an ICAO SMS-based safety management system as an appropriate safety management framework that non-aviation personnel drone operators can adopt. It suggests that applying an ICAO SMS-based safety management system to the K-drone delivery system, similar to Europe and the USA, is valid. To introduce ICAO SMS into the K-drone delivery system, procedures must be established for building a drone safety management system, from business registration to drone operation and training. The main components of the drone safety management system are presented, including 8 items: safety policy and authority and responsibility, risk management, safety assurance, safety promotion, drone control system, drone delivery operation manual, drone maintenance manual, and accident response, incorporating the four fundamental elements of ICAO SMS and European Light UAV operator Certificate standards. Additionally, as a core aspect of the drone safety management system, a seven-step risk assessment procedure is proposed, which includes basic risk identification, hazard identification, risk scenario development, calculation of severity and likelihood, SMS matrix risk assessment, mitigation measures, and implementation determination.

• 분석과학
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• 제33권6호
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• pp.262-273
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• 2020

식품 중 대표적인 오일 제형인 크릴오일 중에 불소 시험법 개발을 위해 식약처 "식품등 시험법 마련 표준절차에 관한 가이드라인"에 따라서 연소-이온크로마토그래피를 사용하여 크릴오일 중 불소 시험법을 개발하였다. 기존 크릴오일 중 불소 시험법은 전통적인 습식 전위차법이 사용되었으나, 신뢰성이 높지 않았고 국내에서는 이러한 오일 제형에 대해서는 불소 시험을 하는 식품검사기관이 없는 상황이었다. 이에 할로젠 시험법 관련 국가 및 국제표준으로 개발된 시험규격을 확인하였으며, 이 중에 오일 제형에 충분히 적용 가능한 연소-이온크로마토그래프 장비를 선택하여 크릴오일에 적합한 시험법을 개발하였다. 오일 제형의 특성상 시료준비 및 도입 시에 손실 및 각종 방해 (interference) 관련 우려를 사전 검토하여 다양한 실험을 통해서 최적의 시험법을 확립하였다. 개발된 오일 중 불소 시험법을 활용하여 유통되는 크릴오일 제품 11 개를 구입하여 불소함량 시험을 하였으며, 1개 시료를 제외한 대부분 제품들은 시험법에서 제시한 보고서 검출한계 미만으로 불검출을 확인하였다. 또한 불소가 검출되는 부분을 확인하기 위해 진행한 크릴새우 자체 시험한 결과, 크릴 부위에 따라서 농도가 다르긴 하지만, 몸통을 제외한 크릴 껍질부는 약 2,000 mg/kg ~ 3,000 mg/kg의 높은 불소함량이 검출됨을 확인하였다. 이후 확립된 시험법을 국제공인 시험기관 (ISO/IEC 17025) 2 곳에 시료를 의뢰하여 본 수행기관과 시험결과를 비교해 본 결과, 3개 실험실 간에 분산분석 통계처리에서 결과의 유의차가 없음을 확인하였고, 이에 본 내용을 토대로 크릴오일 중 불소함량 분석법 관련 시험법으로 적합함을 확인하였다.

• 생명과학회지
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• 제32권2호
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• pp.175-188
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• 2022

혈관과 섬유증 기관들의 평활근과 세포외기질에 대한 릴랙신의 조절기능이 입증되어왔다. 본 총설에서는 저항성 소동맥과 방광을 포함한 섬유증 기관들의 세포외기질에 작용하는 릴랙신의 다양한 기전들을 고찰한다. 릴랙신은 혈관 평활근육의 수축을 억제하고, 콜라겐과 같은 세포외기질의 구성성분들을 감소키켜 혈관벽의 수동적 신전성을 증가시킴으로써, 혈관확장을 유도한다. 릴랙신이 동맥의 혈관확장을 유도하는 주된 세포기전은 RXFP1/PI3K의 활성화, Akt 인산화 및 eNOS 활성화를 통한 내피세포-의존성 산화질소의 생성에 의해 매개된다. 추가적으로, 릴랙신은 또한 다른 대체경로들을 작동하여 신장과 장간막 동맥의 혈관확장을 증가시킨다. 신장 소동맥에서, 릴랙신은 내피세포의 MMPs 및 EtB 수용체의 활성화와 VEGF 및 PlGF의 생성을 촉진하여, 평활근의 수축성과 콜라겐의 침착을 억제함으로써 혈관확장을 초래한다. 이와 달리, 장간막 소동맥에서, 릴랙신은 bradykinin (BK)-유도 이완을 시간-의존적으로 증강시킨다. BK-매개 이완의 신속 증가는 IK_Ca 이온통로와 뒤이은 EDH 유발에 의존하는 반면, BK에 의한 지속적 이완은 COX 활성과 PGI₂에 의존한다. 릴랙신의 항섬유화 효과는 염증유발 면역세포의 침투, endothelial-to-mesenchymal transition (EndMT) 및 근섬유아세포의 분화와 활성을 억제하여 매개된다. 릴랙신은 또한 근섬유아세포 내 NOS/NO/cGMP/PKG-1 경로를 활성화하여, TGF-β1-유도 ERK1/2 및 Smad2/3 신호의 활성과 ECM 콜라겐의 침착을 억제한다.