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http://dx.doi.org/10.12925/jkocs.2012.29.4.552

Percutaneous Absorption Characteristics of Tacrine in Alzheimer-type Dementia Treatment  

Lee, Han-Seob (Department of Environment, University of YongIn)
Publication Information
Journal of the Korean Applied Science and Technology / v.29, no.4, 2012 , pp. 552-560 More about this Journal
Abstract
Drug delivery technologies are patent protected formulation technologies that modify drug release profile, absorption, distribution, and elimination for the benefit of improving product efficacy and safety, as well as patient convenience and compliance. The most commonly used transdermal system is the skin patch using various types of technologies. Compared with other method of dosage, it is possible to use for a long term. It is also possible to stop the drug dosage are stop if the drug dosage lead to side effect. Polysaccharide, such as karaya gum and locust bean gum(LBG)/water-soluble chitosan oligomer(WSCO) were selected as base materials of TDS. Also, these polymers were characterized in terms of enhancers, tacrine contents. Among these polysaccharide, the permeation rate of karaya gum matrix was fastest in tacrine such as lipophilic drug in vitro. We used glycerin, PEG 400, and PEG 800 as enhancers. Therefore, transdermal absorption of tacrine could be improved by changing vehicle composition or by using penetration enhancers. Especially it would be anticipated that the high permeation efficacy could be obtained by using vehicle that has enhancing effect for itself and by adding enhancers to it.
Keywords
Tacrine; Alzheimer-type dementia; percutaneous absorption;
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